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Magnetic Resonance Materials in Physics, Biology and Medicine

Erschienen in:

05.03.2016 | Research Article

High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI

verfasst von: Chengcheng Zhu, Henrik Haraldsson, Bing Tian, Karl Meisel, Nerissa Ko, Michael Lawton, John Grinstead, Sinyeob Ahn, Gerhard Laub, Christopher Hess, David Saloner

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 3/2016

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Abstract

Objectives

High resolution MRI of the intracranial vessel wall provides important insights in the assessment of intracranial vascular disease. This study aims to refine high resolution 3D MRI techniques for intracranial vessel wall imaging at both 3 and 7 T using customized flip angle train design, and to explore their comparative abilities.

Materials and methods

11 patients with intracranial artery disease (four atherosclerotic plaques, six aneurysms and one reversible cerebral vasoconstriction syndrome) were imaged at 3 and 7 T with a 3D T ₁-weighted fast-spin-echo sequence (SPACE) both pre and post Gd contrast injection. Wall to lumen contrast ratio (CR_wall-lumen), contrast enhancement ratio (ER) and the sharpness of the vessel wall were quantified. Two experienced radiologists evaluated the image quality on a 0–5 scale.

Results

Both 3 and 7 T achieved good image quality with high resolution (nominal 0.5 mm isotropic) and whole brain coverage. The CR_wall-lumen and the ER measurements were comparable (p > 0.05). The 7 T images were significantly sharper (sharpness: 2.69 ± 0.50 vs. 1.88 ± 0.53 mm⁻¹, p < 0.001) with higher image quality (reader 1 score: 3.5 ± 1.1 vs. 2.4 ± 1.1, p = 0.002) compared to 3 T.

Conclusions

3D T ₁-weighted SPACE can be used for intracranial vessel wall evaluation at both 3 and 7 T. 7 T provides significantly better image quality and improves the confidence of diagnosis.

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Titel: High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI
verfasst von: Chengcheng Zhu
Henrik Haraldsson
Bing Tian
Karl Meisel
Nerissa Ko
Michael Lawton
John Grinstead
Sinyeob Ahn
Gerhard Laub
Christopher Hess
David Saloner
Publikationsdatum: 05.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 3/2016
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-016-0531-x

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High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI