Skip to main content
Erschienen in: AIDS and Behavior 8/2022

04.02.2022 | Original Paper

Implementation of South Africa’s Central Chronic Medicine Dispensing and Distribution Program for HIV Treatment: A Qualitative Evaluation

verfasst von: Laura M. Bogart, Zinhle Shazi, Sarah MacCarthy, Alexandra Mendoza-Graf, Nafisa J. Wara, Dani Zionts, Nduduzo Dube, Sabina Govere, Ingrid V. Bassett

Erschienen in: AIDS and Behavior | Ausgabe 8/2022

Einloggen, um Zugang zu erhalten

Abstract

We used the Practical, Robust Implementation and Sustainability Model to evaluate implementation of South Africa’s Central Chronic Medicine Dispensing and Distribution (CCMDD) program, a differentiated service delivery program which allows clinically stable HIV-positive patients to receive antiretroviral therapy refills at clinic- or community-based pick-up points. Across ten clinics, we conducted 109 semi-structured interviews with stakeholders (pick-up point staff, CCMDD service providers and administrators) and 16 focus groups with 138 patients. Participants had highly favorable attitudes and said CCMDD decreased stigma concerns. Patient-level barriers included inadequate education about CCMDD and inability to get refills on designated dates. Organizational-level barriers included challenges with communication and transportation, errors in medication packaging and tracking, rigid CCMDD rules, and inadequate infrastructure. Recommendations included: (1) provide patient education and improve communication around refills (at the patient level); (2) provide dedicated space and staff, and ongoing training (at the organizational/clinic level); and (3) allow for prescription renewal at pick-up points and less frequent refills, and provide feedback to clinics (at the CCMDD program level).
Literatur
4.
Zurück zum Zitat Nachega JB, Adetokunboh O, Uthman OA, Knowlton AW, Altice FL, Schechter M, et al. Community-based interventions to improve and sustain antiretroviral therapy adherence, retention in HIV care and clinical outcomes in low-and middle-income countries for achieving the UNAIDS 90-90-90 targets. Curr HIV/AIDS Rep. 2016;13(5):241–55.PubMedPubMedCentralCrossRef Nachega JB, Adetokunboh O, Uthman OA, Knowlton AW, Altice FL, Schechter M, et al. Community-based interventions to improve and sustain antiretroviral therapy adherence, retention in HIV care and clinical outcomes in low-and middle-income countries for achieving the UNAIDS 90-90-90 targets. Curr HIV/AIDS Rep. 2016;13(5):241–55.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Okoboi S, Ding E, Persuad S, Wangisi J, Birungi J, Shurgold S, et al. Community-based ART distribution system can effectively facilitate long-term program retention and low-rates of death and virologic failure in rural Uganda. AIDS Res Ther. 2015;12(1):1–9.CrossRef Okoboi S, Ding E, Persuad S, Wangisi J, Birungi J, Shurgold S, et al. Community-based ART distribution system can effectively facilitate long-term program retention and low-rates of death and virologic failure in rural Uganda. AIDS Res Ther. 2015;12(1):1–9.CrossRef
6.
Zurück zum Zitat Chimukangara B, Manasa J, Mitchell R, Nyabadza G, Katzenstein D, Masimirembwa C. Community based antiretroviral treatment in rural Zimbabwe. AIDS Res Hum Retroviruses. 2017;33(12):1185–91.PubMedCrossRef Chimukangara B, Manasa J, Mitchell R, Nyabadza G, Katzenstein D, Masimirembwa C. Community based antiretroviral treatment in rural Zimbabwe. AIDS Res Hum Retroviruses. 2017;33(12):1185–91.PubMedCrossRef
7.
Zurück zum Zitat Grimsrud A, Lesosky M, Kalombo C, Bekker L-G, Myer L. Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study. J Acquir Immune Defic Syndr. 2016;71(1):e16–23.PubMedCrossRef Grimsrud A, Lesosky M, Kalombo C, Bekker L-G, Myer L. Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study. J Acquir Immune Defic Syndr. 2016;71(1):e16–23.PubMedCrossRef
8.
Zurück zum Zitat Barnabas RV, Szpiro AA, van Rooyen H, Asiimwe S, Pillay D, Ware NC, et al. Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial. Lancet Glob Health. 2020;8(10):e1305–15.PubMedPubMedCentralCrossRef Barnabas RV, Szpiro AA, van Rooyen H, Asiimwe S, Pillay D, Ware NC, et al. Community-based antiretroviral therapy versus standard clinic-based services for HIV in South Africa and Uganda (DO ART): a randomised trial. Lancet Glob Health. 2020;8(10):e1305–15.PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Gilbert HN, Wyatt MA, Pisarski EE, Asiimwe S, Van Rooyen H, Seeley J, et al. How community ART delivery may improve HIV treatment outcomes: qualitative inquiry into mechanisms of effect in a randomized trial of community-based ART initiation, monitoring and re-supply (DO ART) in South Africa and Uganda. J Int AIDS Soc. 2021;24(10):e25821.PubMedPubMedCentralCrossRef Gilbert HN, Wyatt MA, Pisarski EE, Asiimwe S, Van Rooyen H, Seeley J, et al. How community ART delivery may improve HIV treatment outcomes: qualitative inquiry into mechanisms of effect in a randomized trial of community-based ART initiation, monitoring and re-supply (DO ART) in South Africa and Uganda. J Int AIDS Soc. 2021;24(10):e25821.PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Zakumumpa H, Rujumba J, Kwiringira J, Katureebe C, Spicer N. Understanding implementation barriers in the national scale-up of differentiated ART delivery in Uganda. BMC Health Serv Res. 2020;20(1):1–16.CrossRef Zakumumpa H, Rujumba J, Kwiringira J, Katureebe C, Spicer N. Understanding implementation barriers in the national scale-up of differentiated ART delivery in Uganda. BMC Health Serv Res. 2020;20(1):1–16.CrossRef
11.
Zurück zum Zitat Nkhata MJ, Muzambi M, Ford D, Chan AK, Abongomera G, Namata H, et al. Shifting human resources for health in the context of ART provision: qualitative and quantitative findings from the Lablite baseline study. BMC Health Serv Res. 2016;16(1):1–10.CrossRef Nkhata MJ, Muzambi M, Ford D, Chan AK, Abongomera G, Namata H, et al. Shifting human resources for health in the context of ART provision: qualitative and quantitative findings from the Lablite baseline study. BMC Health Serv Res. 2016;16(1):1–10.CrossRef
12.
Zurück zum Zitat Gcwabe L. CCMDD: “The right medicine, for the right patient, in the right parcel, in the right place, at the right time.”. Health-E News. 2021 May 3, 2021. Gcwabe L. CCMDD: “The right medicine, for the right patient, in the right parcel, in the right place, at the right time.”. Health-E News. 2021 May 3, 2021.
13.
Zurück zum Zitat Magadzire BP, Marchal B, Mathys T, Laing RO, Ward K. Analyzing implementation dynamics using theory-driven evaluation principles: lessons learnt from a South African centralized chronic dispensing model. BMC Health Serv Res. 2017;17(2):15–23. Magadzire BP, Marchal B, Mathys T, Laing RO, Ward K. Analyzing implementation dynamics using theory-driven evaluation principles: lessons learnt from a South African centralized chronic dispensing model. BMC Health Serv Res. 2017;17(2):15–23.
14.
Zurück zum Zitat Magadzire BP, Marchal B, Ward K. Improving access to medicines through centralised dispensing in the public sector: a case study of the Chronic Dispensing Unit in the Western Cape Province, South Africa. BMC Health Serv Res. 2015;15(1):1–8.CrossRef Magadzire BP, Marchal B, Ward K. Improving access to medicines through centralised dispensing in the public sector: a case study of the Chronic Dispensing Unit in the Western Cape Province, South Africa. BMC Health Serv Res. 2015;15(1):1–8.CrossRef
15.
Zurück zum Zitat Magadzire BP, Mathole T, Ward K. Reasons for missed appointments linked to a public-sector intervention targeting patients with stable chronic conditions in South Africa: results from in-depth interviews and a retrospective review of medical records. BMC Fam Pract. 2017;18(1):1–10.CrossRef Magadzire BP, Mathole T, Ward K. Reasons for missed appointments linked to a public-sector intervention targeting patients with stable chronic conditions in South Africa: results from in-depth interviews and a retrospective review of medical records. BMC Fam Pract. 2017;18(1):1–10.CrossRef
16.
Zurück zum Zitat Dorward J, Msimango L, Gibbs A, Shozi H, Tonkin-Crine S, Hayward G, et al. Understanding how community antiretroviral delivery influences engagement in HIV care: a qualitative assessment of the centralised chronic medication dispensing and distribution programme in South Africa. BMJ Open. 2020;10(5):e035412.PubMedPubMedCentralCrossRef Dorward J, Msimango L, Gibbs A, Shozi H, Tonkin-Crine S, Hayward G, et al. Understanding how community antiretroviral delivery influences engagement in HIV care: a qualitative assessment of the centralised chronic medication dispensing and distribution programme in South Africa. BMJ Open. 2020;10(5):e035412.PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Pillay B. The RK Khan Hospital pharmacy decongestion project: an innovative partnership in service delivery. 2017 International Awards. 2017;53(1):31. Pillay B. The RK Khan Hospital pharmacy decongestion project: an innovative partnership in service delivery. 2017 International Awards. 2017;53(1):31.
19.
Zurück zum Zitat Pascoe SJ, Scott NA, Fong RM, Murphy J, Huber AN, Moolla A, et al. “Patients are not the same, so we cannot treat them the same”—a qualitative content analysis of provider, patient and implementer perspectives on differentiated service delivery models for HIV treatment in South Africa. J Int AIDS Soc. 2020;23(6):e25544.PubMedPubMedCentralCrossRef Pascoe SJ, Scott NA, Fong RM, Murphy J, Huber AN, Moolla A, et al. “Patients are not the same, so we cannot treat them the same”—a qualitative content analysis of provider, patient and implementer perspectives on differentiated service delivery models for HIV treatment in South Africa. J Int AIDS Soc. 2020;23(6):e25544.PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Kanazawa JT, Saberi P, Sauceda JA, Dubé K. The LAIs are coming! Implementation science considerations for long-acting injectable antiretroviral therapy in the United States: a scoping review. AIDS Res Hum Retroviruses. 2021;37(2):75–88.PubMedPubMedCentralCrossRef Kanazawa JT, Saberi P, Sauceda JA, Dubé K. The LAIs are coming! Implementation science considerations for long-acting injectable antiretroviral therapy in the United States: a scoping review. AIDS Res Hum Retroviruses. 2021;37(2):75–88.PubMedPubMedCentralCrossRef
21.
Zurück zum Zitat Ekawati FM, Emilia O, Gunn J, Licqurish S, Lau P. The elephant in the room: an exploratory study of hypertensive disorders of pregnancy (HDP) management in Indonesian primary care settings. BMC Fam Pract. 2020;21(1):1–11.CrossRef Ekawati FM, Emilia O, Gunn J, Licqurish S, Lau P. The elephant in the room: an exploratory study of hypertensive disorders of pregnancy (HDP) management in Indonesian primary care settings. BMC Fam Pract. 2020;21(1):1–11.CrossRef
22.
Zurück zum Zitat McKay MM, Bahar OS, Ssewamala FM. Implementation science in global health settings: collaborating with governmental & community partners in Uganda. Psychiatry Res. 2020;283:112585.PubMedCrossRef McKay MM, Bahar OS, Ssewamala FM. Implementation science in global health settings: collaborating with governmental & community partners in Uganda. Psychiatry Res. 2020;283:112585.PubMedCrossRef
23.
Zurück zum Zitat Leonard C, Lawrence E, McCreight M, Lippmann B, Kelley L, Mayberry A, et al. Implementation and dissemination of a transition of care program for rural veterans: a controlled before and after study. Implement Sci. 2017;12(1):1–8.CrossRef Leonard C, Lawrence E, McCreight M, Lippmann B, Kelley L, Mayberry A, et al. Implementation and dissemination of a transition of care program for rural veterans: a controlled before and after study. Implement Sci. 2017;12(1):1–8.CrossRef
24.
Zurück zum Zitat Trinkley KE, Kahn MG, Bennett TD, Glasgow RE, Haugen H, Kao DP, et al. Integrating the practical robust implementation and sustainability model with best practices in clinical decision support design: implementation science approach. J Med Internet Res. 2020;22(10):e19676.PubMedPubMedCentralCrossRef Trinkley KE, Kahn MG, Bennett TD, Glasgow RE, Haugen H, Kao DP, et al. Integrating the practical robust implementation and sustainability model with best practices in clinical decision support design: implementation science approach. J Med Internet Res. 2020;22(10):e19676.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Magee MF, Baker KM, Bardsley JK, Wesley D, Smith KM. Diabetes to go-inpatient: pragmatic lessons learned from implementation of technology-enabled diabetes survival skills education within nursing unit workflow in an urban, tertiary care hospital. Jt Comm J Qual Patient Saf. 2021;47(2):107–19.PubMed Magee MF, Baker KM, Bardsley JK, Wesley D, Smith KM. Diabetes to go-inpatient: pragmatic lessons learned from implementation of technology-enabled diabetes survival skills education within nursing unit workflow in an urban, tertiary care hospital. Jt Comm J Qual Patient Saf. 2021;47(2):107–19.PubMed
26.
Zurück zum Zitat McCreight MS, Rabin BA, Glasgow RE, Ayele RA, Leonard CA, Gilmartin HM, et al. Using the Practical, Robust Implementation and Sustainability Model (PRISM) to qualitatively assess multilevel contextual factors to help plan, implement, evaluate, and disseminate health services programs. Transla Behav Med. 2019;9(6):1002–11.CrossRef McCreight MS, Rabin BA, Glasgow RE, Ayele RA, Leonard CA, Gilmartin HM, et al. Using the Practical, Robust Implementation and Sustainability Model (PRISM) to qualitatively assess multilevel contextual factors to help plan, implement, evaluate, and disseminate health services programs. Transla Behav Med. 2019;9(6):1002–11.CrossRef
27.
Zurück zum Zitat Liles EG, Schneider JL, Feldstein AC, Mosen DM, Perrin N, Rosales AG, et al. Implementation challenges and successes of a population-based colorectal cancer screening program: a qualitative study of stakeholder perspectives. Implement Sci. 2015;10(1):1–16.CrossRef Liles EG, Schneider JL, Feldstein AC, Mosen DM, Perrin N, Rosales AG, et al. Implementation challenges and successes of a population-based colorectal cancer screening program: a qualitative study of stakeholder perspectives. Implement Sci. 2015;10(1):1–16.CrossRef
28.
Zurück zum Zitat Guest G, Bunce A, Johnson L. How many interviews are enough? An experiment with data saturation and variability. Field Methods. 2006;18(1):59–82.CrossRef Guest G, Bunce A, Johnson L. How many interviews are enough? An experiment with data saturation and variability. Field Methods. 2006;18(1):59–82.CrossRef
29.
Zurück zum Zitat Hagaman AK, Wutich A. How many interviews are enough to identify metathemes in multisited and cross-cultural research? Another perspective on Guest, Bunce, and Johnson’s (2006) landmark study. Field Methods. 2017;29(1):23–41.CrossRef Hagaman AK, Wutich A. How many interviews are enough to identify metathemes in multisited and cross-cultural research? Another perspective on Guest, Bunce, and Johnson’s (2006) landmark study. Field Methods. 2017;29(1):23–41.CrossRef
30.
Zurück zum Zitat Vasileiou K, Barnett J, Thorpe S, Young T. Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period. BMC Med Res Methodol. 2018;18(1):1–18.CrossRef Vasileiou K, Barnett J, Thorpe S, Young T. Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period. BMC Med Res Methodol. 2018;18(1):1–18.CrossRef
31.
Zurück zum Zitat Hsieh H-F, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–88.PubMedCrossRef Hsieh H-F, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–88.PubMedCrossRef
32.
Zurück zum Zitat Dedoose Version 8.0.35, web application for managing, analyzing, and presenting qualitative and mixed method research data. Los Angeles: SocioCultural Research Consultants, LLC; 2018. Dedoose Version 8.0.35, web application for managing, analyzing, and presenting qualitative and mixed method research data. Los Angeles: SocioCultural Research Consultants, LLC; 2018.
33.
Zurück zum Zitat Health Systems Trust. Annual report 2019/20. South Africa: Health Systems Trust; 2020. Health Systems Trust. Annual report 2019/20. South Africa: Health Systems Trust; 2020.
35.
Zurück zum Zitat Grimsrud A, Wilkinson L. Acceleration of differentiated service delivery for HIV treatment in sub-Saharan Africa during COVID-19. J Int AIDS Soc. 2021;24(6):e25704.PubMedPubMedCentralCrossRef Grimsrud A, Wilkinson L. Acceleration of differentiated service delivery for HIV treatment in sub-Saharan Africa during COVID-19. J Int AIDS Soc. 2021;24(6):e25704.PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Bailey LE, Siberry GK, Agaba P, Douglas M, Clinkscales JR, Godfrey C. The impact of COVID-19 on multi-month dispensing (MMD) policies for antiretroviral therapy (ART) and MMD uptake in 21 PEPFAR-supported countries: a multi-country analysis. J Int AIDS Soc. 2021;24:e25794.PubMedPubMedCentralCrossRef Bailey LE, Siberry GK, Agaba P, Douglas M, Clinkscales JR, Godfrey C. The impact of COVID-19 on multi-month dispensing (MMD) policies for antiretroviral therapy (ART) and MMD uptake in 21 PEPFAR-supported countries: a multi-country analysis. J Int AIDS Soc. 2021;24:e25794.PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Hargreaves JR, Pliakas T, Hoddinott G, Mainga T, Mubekapi-Musadaidzwa C, Donnell D, et al. HIV stigma and viral suppression among people living with HIV in the context of universal test and treat: analysis of data from the HPTN 071 (PopART) trial in Zambia and South Africa. J Acquir Immune Defic Syndr. 2020;85(5):561.PubMedPubMedCentralCrossRef Hargreaves JR, Pliakas T, Hoddinott G, Mainga T, Mubekapi-Musadaidzwa C, Donnell D, et al. HIV stigma and viral suppression among people living with HIV in the context of universal test and treat: analysis of data from the HPTN 071 (PopART) trial in Zambia and South Africa. J Acquir Immune Defic Syndr. 2020;85(5):561.PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Sharer M, Davis N, Makina N, Duffy M, Eagan S. Differentiated antiretroviral therapy delivery: implementation barriers and enablers in South Africa. J Assoc Nurses AIDS Care. 2019;30(5):511.PubMedPubMedCentralCrossRef Sharer M, Davis N, Makina N, Duffy M, Eagan S. Differentiated antiretroviral therapy delivery: implementation barriers and enablers in South Africa. J Assoc Nurses AIDS Care. 2019;30(5):511.PubMedPubMedCentralCrossRef
40.
Zurück zum Zitat Adjetey V, Obiri-Yeboah D, Dornoo B. Differentiated service delivery: a qualitative study of people living with HIV and accessing care in a tertiary facility in Ghana. BMC Health Serv Res. 2019;19(1):1–7.CrossRef Adjetey V, Obiri-Yeboah D, Dornoo B. Differentiated service delivery: a qualitative study of people living with HIV and accessing care in a tertiary facility in Ghana. BMC Health Serv Res. 2019;19(1):1–7.CrossRef
41.
Zurück zum Zitat Mudavanhu M, West NS, Schwartz SR, Mutunga L, Keyser V, Bassett J, et al. Perceptions of community and clinic-based adherence clubs for patients stable on antiretroviral treatment: a mixed methods study. AIDS Behav. 2020;24(4):1197–206.PubMedCrossRef Mudavanhu M, West NS, Schwartz SR, Mutunga L, Keyser V, Bassett J, et al. Perceptions of community and clinic-based adherence clubs for patients stable on antiretroviral treatment: a mixed methods study. AIDS Behav. 2020;24(4):1197–206.PubMedCrossRef
42.
Zurück zum Zitat Le Roux KW, Davis EC, Gaunt CB, Young C, Koussa M, Harris C, et al. A case study of an effective and sustainable antiretroviral therapy program in rural South Africa. AIDS Patient Care STDS. 2019;33(11):466–72.PubMedPubMedCentralCrossRef Le Roux KW, Davis EC, Gaunt CB, Young C, Koussa M, Harris C, et al. A case study of an effective and sustainable antiretroviral therapy program in rural South Africa. AIDS Patient Care STDS. 2019;33(11):466–72.PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Mayosi BM, Benatar SR. Health and health care in South Africa—20 years after Mandela. N Engl J Med. 2014;371(14):1344–53.PubMedCrossRef Mayosi BM, Benatar SR. Health and health care in South Africa—20 years after Mandela. N Engl J Med. 2014;371(14):1344–53.PubMedCrossRef
Metadaten
Titel
Implementation of South Africa’s Central Chronic Medicine Dispensing and Distribution Program for HIV Treatment: A Qualitative Evaluation
verfasst von
Laura M. Bogart
Zinhle Shazi
Sarah MacCarthy
Alexandra Mendoza-Graf
Nafisa J. Wara
Dani Zionts
Nduduzo Dube
Sabina Govere
Ingrid V. Bassett
Publikationsdatum
04.02.2022
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 8/2022
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-022-03602-y

Weitere Artikel der Ausgabe 8/2022

AIDS and Behavior 8/2022 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

„Überwältigende“ Evidenz für Tripeltherapie beim metastasierten Prostata-Ca.

22.05.2024 Prostatakarzinom Nachrichten

Patienten mit metastasiertem hormonsensitivem Prostatakarzinom sollten nicht mehr mit einer alleinigen Androgendeprivationstherapie (ADT) behandelt werden, mahnt ein US-Team nach Sichtung der aktuellen Datenlage. Mit einer Tripeltherapie haben die Betroffenen offenbar die besten Überlebenschancen.

So sicher sind Tattoos: Neue Daten zur Risikobewertung

22.05.2024 Melanom Nachrichten

Das größte medizinische Problem bei Tattoos bleiben allergische Reaktionen. Melanome werden dadurch offensichtlich nicht gefördert, die Farbpigmente könnten aber andere Tumoren begünstigen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.