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Cancer Causes & Control

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01.11.2008 | Review Article

A review of the relationship between tooth loss, periodontal disease, and cancer

verfasst von: Mara S. Meyer, Kaumudi Joshipura, Edward Giovannucci, Dominique S. Michaud

Erschienen in: Cancer Causes & Control | Ausgabe 9/2008

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Abstract

Recent studies have investigated the association between periodontal disease, tooth loss, and several systemic diseases including cancer, cardiovascular disease, and preterm birth. Periodontal disease, a chronic inflammatory condition, is highly prevalent in adult populations around the world, and may be preventable. Estimates of prevalence vary between races and geographic regions, with a marked increase in the occurrence of periodontal disease with advancing age. Worldwide estimates for the prevalence of severe periodontal disease generally range from 10 to 15%. The relationship between oral health and cancer has been examined for a number of specific cancer sites. Several studies have reported associations between periodontal disease or tooth loss and risk of oral, upper gastrointestinal, lung, and pancreatic cancer in different populations. In a number of studies, these associations persisted after adjustment for major risk factors, including cigarette smoking and socioeconomic status. This review provides a summary of these findings, discusses possible biological mechanisms involved, and raises methodological issues related to studying these relationships.

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Titel: A review of the relationship between tooth loss, periodontal disease, and cancer
verfasst von: Mara S. Meyer
Kaumudi Joshipura
Edward Giovannucci
Dominique S. Michaud
Publikationsdatum: 01.11.2008
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 9/2008
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-008-9163-4

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