Erschienen in:
01.04.2015 | Editorial
Association of Serotonin Transporter Promoter Polymorphism (5HTTLPR) with Microscopic Colitis and Ulcerative Colitis: Time to Be AsSERTive?
verfasst von:
Dana Goldner, Kara Gross Margolis
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 4/2015
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Excerpt
Serotonin (5-hydroxytryptamine; 5-HT) is a bioamine neurotransmitter classically recognized for its importance in central nervous system (CNS) functions. Nevertheless, most of the body’s serotonin is peripherally located, with over 95 % of the body’s 5-HT produced in the intestine, where it modulates motility and secretion [
1]. Intestinal 5-HT has also been demonstrated to play a major role in enteric nervous system development, intestinal epithelial homeostasis, and the modulation of intestinal inflammation [
2‐
5]. Despite the recognition that intestinal inflammatory diseases such as ulcerative colitis (UC) can have strong genetic components [
6], genetic polymorphisms linked with serotonin have not been associated with these disease states. In this issue of
Digestive Diseases and Sciences, Sikander et al. [
7] conducted the first prospective case–control study to demonstrate that there may be a potential association between polymorphisms in the 5-HT transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) of the serotonin transporter (SERT) gene promoter and the intestinal inflammatory diseases UC and microscopic colitis (MC). …
