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25.04.2019 | RENAL EPIDEMIOLOGY

Solitary kidney and risk of chronic kidney disease

verfasst von: Seolhye Kim, Yoosoo Chang, Young Rae Lee, Hyun-Suk Jung, Young Youl Hyun, Kyu-Beck Lee, Kwan Joong Joo, Kyung Eun Yun, Hocheol Shin, Seungho Ryu

Erschienen in: European Journal of Epidemiology | Ausgabe 9/2019

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Abstract

The renal outcome of solitary kidney remains controversial. We examined the longitudinal association of congenital or acquired solitary kidney with the development of chronic kidney disease (CKD). A cohort study was performed involving 271,171 Korean men and women free of CKD at baseline who underwent a health screening program and who were followed annually or biennially for an average of 5.4 years. Solitary kidney was determined based on ultrasonographic findings. CKD was defined as an estimated glomerular filtration rate of < 60 ml/min/1.73 m² and/or the presence of proteinuria in two or more consecutive visits. During 1,472,519.6 person-years of follow-up, 2989 participants developed CKD (incidence rate: 2.0 per 1000 person-years). After adjustment for potential confounders, the aHR (95% CIs) for incident CKD comparing solitary kidney to the control was 3.26 (1.63–6.54). In analyses of cause-specific solitary kidney, aHR (95% CIs) for CKD comparing unilateral nephrectomy and congenital solitary kidney to the control were 6.18 (2.31–16.49) and 2.22 (0.83–5.92), respectively. The association between solitary kidney and CKD was stronger in men. Having a solitary kidney was independently associated with an increased risk of CKD development. Therefore, preventive strategies for reducing the risk of CKD are required in individuals with a solitary kidney.

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Titel: Solitary kidney and risk of chronic kidney disease
verfasst von: Seolhye Kim
Yoosoo Chang
Young Rae Lee
Hyun-Suk Jung
Young Youl Hyun
Kyu-Beck Lee
Kwan Joong Joo
Kyung Eun Yun
Hocheol Shin
Seungho Ryu
Publikationsdatum: 25.04.2019
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 9/2019
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-019-00520-7

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Solitary kidney and risk of chronic kidney disease

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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