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Inflammation

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01.02.2008

Neutrophil Migration Induced by IL-1β Depends upon LTB₄ Released by Macrophages and upon TNF-α and IL-1β Released by Mast Cells

verfasst von: S. H. P. Oliveira, C. Canetti, R. A. Ribeiro, F. Q. Cunha

Erschienen in: Inflammation | Ausgabe 1/2008

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Abstract

In the present study, we investigate whether mast cells and macrophages are involved in the control of IL-1β-induced neutrophil migration, as well as the participation of chemotactic mediators. IL-1β induced a dose-dependent neutrophil migration to the peritoneal cavity of rats which depends on LTB₄, PAF and cytokines, since the animal treatment with inhibitors of these mediators (MK 886, PCA 4248 and dexamethasone respectively) inhibited IL-1β-induced neutrophil migration. The neutrophil migration induced by IL-1β is dependent on mast cells and macrophages, since depletion of mast cells reduced the process whereas the increase of macrophage population enhanced the migration. Moreover, mast cells or macrophages stimulated with IL-1β released a neutrophil chemotactic factor, which mimicked the neutrophil migration induced by IL-1β. The chemotactic activity of the supernatant of IL-1β-stimulated macrophages is due to the presence of LTB₄, since MK 886 inhibited its release. Moreover, the chemotactic activity of IL-1β-stimulated mast cells supernatant is due to the presence of IL-1β and TNF-α, since antibodies against these cytokines inhibited its activity. Furthermore, significant amounts of these cytokines were detected in the supernatant. In conclusion, our results suggest that neutrophil migration induced by IL-1β depends upon LTB₄ released by macrophages and upon IL-1β and TNFα released by mast cells.

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Titel: Neutrophil Migration Induced by IL-1β Depends upon LTB4 Released by Macrophages and upon TNF-α and IL-1β Released by Mast Cells
verfasst von: S. H. P. Oliveira
C. Canetti
R. A. Ribeiro
F. Q. Cunha
Publikationsdatum: 01.02.2008
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 1/2008
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-007-9047-x

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