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01.06.2013

Effects of Canavalia lectins on Acute Inflammation in Sensitized and Non-sensitized Rats

verfasst von: Nilson Vieira Pinto, Benildo Sousa Cavada, Lucas Ferreira Brito, Ronniery Ilario Pereira, Mayara Torquato Lima da Silva, Rondinelle Ribeiro Castro, Alana de Freitas Pires, Ana Maria Sampaio Assreuy

Erschienen in: Inflammation | Ausgabe 3/2013

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Abstract

The anti-inflammatory activity of Canavalia seed lectins (Canavalia gladiata [CGL], Canavalia maritima [ConM] and Canavalia brasiliensis [ConBr]) was evaluated by intravenous administration in rats. In non-sensitized rats, cellular edema elicited by carrageenan was reduced (45–51 %) by ConM and (44–59 %) by CGL. Osmotic edema elicited by dextran was reduced by ConM and CGL in 27 % and 29 %. ConM and CGL reduced the edema elicited by l-arginine in 53 % and that of prostaglandin E₂ in 48 % and 36 %. Leukocyte migration elicited by carrageenan was reduced in 49 % by ConM and in 55 % by CGL (attenuated in 4× by glucose) and peritoneal TNF-α content in 82 %. In rats sensitized, ConM inhibited the paw edema and leukocyte migration elicited by ovalbumin in 34 % and 70 %. ConM and CGL are anti-inflammatory, mainly in cellular events mediated by prostaglandin E₂, nitric oxide and TNF-α in non-sensitized rats. However, only ConM is anti-inflammatory in sensitized rats. CGL effect involves the lectin domain.

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Titel: Effects of Canavalia lectins on Acute Inflammation in Sensitized and Non-sensitized Rats
verfasst von: Nilson Vieira Pinto
Benildo Sousa Cavada
Lucas Ferreira Brito
Ronniery Ilario Pereira
Mayara Torquato Lima da Silva
Rondinelle Ribeiro Castro
Alana de Freitas Pires
Ana Maria Sampaio Assreuy
Publikationsdatum: 01.06.2013
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 3/2013
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-013-9596-0

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