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Journal of Assisted Reproduction and Genetics

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01.09.2011 | Review

The contribution of mitochondrial function to reproductive aging

verfasst von: Yaakov Bentov, Tetyana Yavorska, Navid Esfandiari, Andrea Jurisicova, Robert F. Casper

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 9/2011

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Abstract

Purpose

The number of women attempting to conceive between the ages of 36 and 44 has increased significantly in the last decade. While it is well established that women’s reproductive success dramatically declines with age, the underlying physiological changes responsible for this phenomenon are not well understood. With assisted reproductive technologies, it is clear that oocyte quality is a likely cause since women over 40 undergoing in vitro fertilization (IVF) with oocytes donated by younger women have success rates comparable to young patients. Apart from oocyte donation, there is no known intervention to improve the pregnancy outcome of older patients. The aim of this paper was the review the relevant data on the potential role of mitochondria in reproductive aging.

Method

Review of current literature on the subject.

Results

We present the current evidence that associate mitochondrial dysfunction with age related decrease in female reproductive outcome.

Conclusions

The aging process is complex, driven by a multitude of factors thought to modulate cellular and organism life span. Although the factors responsible for diminished oocyte quality remain to be elucidated, the present review focuses on the potential role of impaired mitochondrial function.

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Titel: The contribution of mitochondrial function to reproductive aging
verfasst von: Yaakov Bentov
Tetyana Yavorska
Navid Esfandiari
Andrea Jurisicova
Robert F. Casper
Publikationsdatum: 01.09.2011
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 9/2011
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9588-7

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The contribution of mitochondrial function to reproductive aging

Abstract

Purpose

Method

Results

Conclusions

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Mammakarzinom: Brustdichte beeinflusst rezidivfreies Überleben

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

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„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

Update Gynäkologie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose

Method

Results

Conclusions

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