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Journal of Clinical Immunology

Erschienen in:

01.01.2010

B-Cell Reconstitution and BAFF After Alemtuzumab (Campath-1H) Treatment of Multiple Sclerosis

verfasst von: Sara A. J. Thompson, Joanne L. Jones, Amanda L. Cox, D. Alastair S. Compston, Alasdair J. Coles

Erschienen in: Journal of Clinical Immunology | Ausgabe 1/2010

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Abstract

Introduction

Treatment with alemtuzumab is highly effective in relapsing–remitting multiple sclerosis; however, 30% of patients develop autoimmunity. Alemtuzumab (previously called Campath 1-H) induces a prolonged T-cell lymphopenia with memory cells dominating the reconstituting T-cell pool for at least 3 months.

Results

Here we show that B-cell recovery is rapid, returning to baseline by 3 months and rising to 165% of baseline by 12 months after treatment. Immature transitional 1 B cells are the predominant cell type 1 month after treatment. This coincides with a surge in serum B-cell activating factor (BAFF), which remains elevated by 33% for at least 12 months after alemtuzumab. BAFF is critical for transition to the mature naive B-cell phenotype, which dominates from 3 months after alemtuzumab. Differentiation to memory B cells is slow so there are radical and prolonged alterations to the B-cell pool after alemtuzumab.

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Titel: B-Cell Reconstitution and BAFF After Alemtuzumab (Campath-1H) Treatment of Multiple Sclerosis
verfasst von: Sara A. J. Thompson
Joanne L. Jones
Amanda L. Cox
D. Alastair S. Compston
Alasdair J. Coles
Publikationsdatum: 01.01.2010
Verlag: Springer US
Erschienen in: Journal of Clinical Immunology / Ausgabe 1/2010
Print ISSN: 0271-9142
Elektronische ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-009-9327-3

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