Skip to main content
Erschienen in: Journal of Thrombosis and Thrombolysis 4/2010

01.05.2010

The role of ethnicity, age and gender in venous thromboembolism

verfasst von: Martina Montagnana, Emmanuel J. Favaloro, Massimo Franchini, Gian Cesare Guidi, Giuseppe Lippi

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

Venous thromboembolism, including both deep venous thrombosis and pulmonary embolism, is the leading cause of preventable in-hospital mortality. In the inexorable progress towards individualization of risk and personalized medicine, several congenital and acquired risk factors have been identified. However, the influence of some demographical variables, especially ethnicity, age and gender, has largely been under appreciated. Although the incidence of venous thromboembolism varies widely among diverse racial/ethnic cohorts, it appears globally highest in Blacks, is intermediate in Caucasians and is lowest in Asians. The incidence and prevalence of venous thromboembolism is also strongly age-related, increasing nearly 90 fold from <15 to >80 years old. Definitive data on the relative frequency of venous thromboembolism across genders is lacking. Some studies report that gender is not an independent risk factor of venous thromboembolism, while others conclude that female gender might be a protective variable. The purpose of this review is to assess the relationship between such demographic variables and venous thromboembolism.
Literatur
3.
Zurück zum Zitat Lippi G, Franchini M, Montagnana M, Guidi GC (2007) Genomics and proteomics in venous thromboembolism: building a bridge toward a rational personalized medicine framework. Semin Thromb Hemost 33:759–770. doi:10.1055/s-2007-1000366 PubMedCrossRef Lippi G, Franchini M, Montagnana M, Guidi GC (2007) Genomics and proteomics in venous thromboembolism: building a bridge toward a rational personalized medicine framework. Semin Thromb Hemost 33:759–770. doi:10.​1055/​s-2007-1000366 PubMedCrossRef
4.
Zurück zum Zitat Bonner L, Coker E, Wood L (2008) Preventing venous thromboembolism through risk assessment approaches. Br J Nurs 17:778–782PubMed Bonner L, Coker E, Wood L (2008) Preventing venous thromboembolism through risk assessment approaches. Br J Nurs 17:778–782PubMed
9.
Zurück zum Zitat White RH, Zhou H, Romano PS (1998) Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 128:737–740PubMed White RH, Zhou H, Romano PS (1998) Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 128:737–740PubMed
10.
Zurück zum Zitat White RH, Zhou H, Murin S, Harvey DE (2005) Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996. Thromb Haemost 93:298–305PubMed White RH, Zhou H, Murin S, Harvey DE (2005) Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996. Thromb Haemost 93:298–305PubMed
11.
Zurück zum Zitat Keenan CR, White RH (2007) The effects of race/ethnicity and sex on the risk of venous thromboembolism. Curr Opin Pulm Med 13:377–383PubMed Keenan CR, White RH (2007) The effects of race/ethnicity and sex on the risk of venous thromboembolism. Curr Opin Pulm Med 13:377–383PubMed
12.
Zurück zum Zitat Lippi G, Franchini M, Favaloro EJ (2009) Pharmacogenetics of vitamin K antagonists: useful or hype? Clin Chem Lab Med (in press) Lippi G, Franchini M, Favaloro EJ (2009) Pharmacogenetics of vitamin K antagonists: useful or hype? Clin Chem Lab Med (in press)
14.
Zurück zum Zitat Kishimoto M, Lim HY, Tokuda Y et al (2005) Prevalence of venous thromboembolism at a teaching hospital in Okinawa, Japan. Thromb Haemost 93:876–879PubMed Kishimoto M, Lim HY, Tokuda Y et al (2005) Prevalence of venous thromboembolism at a teaching hospital in Okinawa, Japan. Thromb Haemost 93:876–879PubMed
15.
Zurück zum Zitat Dhillon KS, Askander A, Doraisamy S (1996) Postoperative deep-vein thrombosis in Asian patients is not a rarity. J Bone Joint Surg Br 78:427–430PubMed Dhillon KS, Askander A, Doraisamy S (1996) Postoperative deep-vein thrombosis in Asian patients is not a rarity. J Bone Joint Surg Br 78:427–430PubMed
18.
Zurück zum Zitat Fujimura H, Kambayash J, Monden M et al (1995) Coagulation factor V Leiden mutation may have a racial background. Thromb Haemost 74:1381–1382PubMed Fujimura H, Kambayash J, Monden M et al (1995) Coagulation factor V Leiden mutation may have a racial background. Thromb Haemost 74:1381–1382PubMed
19.
20.
Zurück zum Zitat Angchaisuksiri P, Atichartakarn V, Aryurachai K, Archararit N, Rachakom B, Atamasirikul K, Tiraganjana A (2007) Risk factors of venous thromboembolism in thai patients. Int J Hematol 86:397–402. doi:10.1007/BF02983995 PubMedCrossRef Angchaisuksiri P, Atichartakarn V, Aryurachai K, Archararit N, Rachakom B, Atamasirikul K, Tiraganjana A (2007) Risk factors of venous thromboembolism in thai patients. Int J Hematol 86:397–402. doi:10.​1007/​BF02983995 PubMedCrossRef
21.
Zurück zum Zitat Kim TM, Kim JS, Han SW, et al. (2008) Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. Thromb Res 123:436–443PubMedCrossRef Kim TM, Kim JS, Han SW, et al. (2008) Clinical predictors of recurrent venous thromboembolism: a single institute experience in Korea. Thromb Res 123:436–443PubMedCrossRef
22.
24.
Zurück zum Zitat Chuansumrit A, Jarutwachirakul W, Sasanakul W, Rurgkhum S, Kadegasem P, Kitpoka P, Sirachainan N (2004) Absence of factor V arg306–thr and low factor V arg306->gly mutation prevalence in Thai blood donors. Southeast Asian J Trop Med Public Health 35:450–452PubMed Chuansumrit A, Jarutwachirakul W, Sasanakul W, Rurgkhum S, Kadegasem P, Kitpoka P, Sirachainan N (2004) Absence of factor V arg306–thr and low factor V arg306->gly mutation prevalence in Thai blood donors. Southeast Asian J Trop Med Public Health 35:450–452PubMed
25.
Zurück zum Zitat Tanaka K, Davie EW, Ikeda Y, Iwanaga S, Saito H, Sueishi K (2008) Clinical role of protein S deficiency in Asian population. In: Tanaka K, Davie EW (eds) Recent advances in thrombosis and hemostasis. Springer, USA, pp 597–613CrossRef Tanaka K, Davie EW, Ikeda Y, Iwanaga S, Saito H, Sueishi K (2008) Clinical role of protein S deficiency in Asian population. In: Tanaka K, Davie EW (eds) Recent advances in thrombosis and hemostasis. Springer, USA, pp 597–613CrossRef
26.
27.
Zurück zum Zitat Akkawat B, Rojnuckarin P (2005) Protein S deficiency is common in a healthy Thai population. J Med Assoc Thai 88(Suppl 4):S249–S254PubMed Akkawat B, Rojnuckarin P (2005) Protein S deficiency is common in a healthy Thai population. J Med Assoc Thai 88(Suppl 4):S249–S254PubMed
28.
Zurück zum Zitat Ko L, Hsu LA, Hsu TS et al (2006) Functional polymorphisms of FGA, encoding alpha fibrinogen, are associated with susceptibility to venous thromboembolism in a Taiwanese population. Hum Genet 119:84–91. doi:10.1007/s00439-005-0102-0 PubMedCrossRef Ko L, Hsu LA, Hsu TS et al (2006) Functional polymorphisms of FGA, encoding alpha fibrinogen, are associated with susceptibility to venous thromboembolism in a Taiwanese population. Hum Genet 119:84–91. doi:10.​1007/​s00439-005-0102-0 PubMedCrossRef
31.
Zurück zum Zitat Miyata T, Sato Y, Ishikawa J, et al. (2008) Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis. Thromb Res 124:14–18PubMedCrossRef Miyata T, Sato Y, Ishikawa J, et al. (2008) Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis. Thromb Res 124:14–18PubMedCrossRef
33.
Zurück zum Zitat Mok CC, Tang SS, To CH, Petri M (2005) Incidence and risk factors of thromboembolism in systemic lupus erythematosus: a comparison of three ethnic groups. Arthritis Rheum 52:2774–2782. doi:10.1002/art.21224 PubMedCrossRef Mok CC, Tang SS, To CH, Petri M (2005) Incidence and risk factors of thromboembolism in systemic lupus erythematosus: a comparison of three ethnic groups. Arthritis Rheum 52:2774–2782. doi:10.​1002/​art.​21224 PubMedCrossRef
36.
Zurück zum Zitat Patel RK, Ford E, Thumpston J et al (2003) Risk factors for venous thrombosis in the black population. The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study. Thromb Haemost 90:835–888PubMed Patel RK, Ford E, Thumpston J et al (2003) Risk factors for venous thrombosis in the black population. The epidemiology of venous thromboembolism in Caucasians and African-Americans: the GATE Study. Thromb Haemost 90:835–888PubMed
37.
Zurück zum Zitat Miller CH, Dilley A, Richardson L et al (2001) Population differences in von Willebrand factor levels affect the diagnosis of von Willebrands disease in African-American women. Am J Hematol 67:125–129. doi:10.1002/ajh.1090 PubMedCrossRef Miller CH, Dilley A, Richardson L et al (2001) Population differences in von Willebrand factor levels affect the diagnosis of von Willebrands disease in African-American women. Am J Hematol 67:125–129. doi:10.​1002/​ajh.​1090 PubMedCrossRef
39.
Zurück zum Zitat Cox Gill JC, Endres-Brooks J, Bauer PJ et al (1987) The effect of ABO blood group in the diagnosis of von Willebrand disease. Blood 69:1691–1695 Cox Gill JC, Endres-Brooks J, Bauer PJ et al (1987) The effect of ABO blood group in the diagnosis of von Willebrand disease. Blood 69:1691–1695
40.
Zurück zum Zitat Mwangi J (1999) Blood group distribution in an urban population of patient targeted blood donors. East Afr Med J 76:615–618PubMed Mwangi J (1999) Blood group distribution in an urban population of patient targeted blood donors. East Afr Med J 76:615–618PubMed
41.
Zurück zum Zitat James A (2003) Allelic frequencies of thrombophilic polymorphisms among African-Americans. J Thromb Haemost 1(suppl):P0946 James A (2003) Allelic frequencies of thrombophilic polymorphisms among African-Americans. J Thromb Haemost 1(suppl):P0946
43.
Zurück zum Zitat Carter AM, Catto AJ, Kohler HP, Ariens RA, Strickland MH, Grant PJ (2000) Alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism. Blood 96:1177–1179PubMed Carter AM, Catto AJ, Kohler HP, Ariens RA, Strickland MH, Grant PJ (2000) Alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism. Blood 96:1177–1179PubMed
44.
Zurück zum Zitat Hooper WC, Lally C, Austin H et al (1999) The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. Chest 116:880–886. doi:10.1378/chest.116.4.880 PubMedCrossRef Hooper WC, Lally C, Austin H et al (1999) The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. Chest 116:880–886. doi:10.​1378/​chest.​116.​4.​880 PubMedCrossRef
45.
Zurück zum Zitat Dilley A, Austin H, Hooper WC et al (1998) Prevalence of the prothrombin 20210 G-to-A variant in blacks: infants, patients with venous thrombosis, patients with myocardial infarction, and control subjects. J Lab Clin Med 132:452–455. doi:10.1016/S0022-2143(98)90121-4 PubMedCrossRef Dilley A, Austin H, Hooper WC et al (1998) Prevalence of the prothrombin 20210 G-to-A variant in blacks: infants, patients with venous thrombosis, patients with myocardial infarction, and control subjects. J Lab Clin Med 132:452–455. doi:10.​1016/​S0022-2143(98)90121-4 PubMedCrossRef
46.
Zurück zum Zitat Rahimy MC, Krishnamoorthy R, Ahouignan G, Laffan M, Vulliamy T (1998) The 20210A allele of prothrombin is not found among sickle cell disease patients from West Africa. Thromb Haemost 79:444PubMed Rahimy MC, Krishnamoorthy R, Ahouignan G, Laffan M, Vulliamy T (1998) The 20210A allele of prothrombin is not found among sickle cell disease patients from West Africa. Thromb Haemost 79:444PubMed
47.
53.
Zurück zum Zitat Tosetto A, Missiaglia E, Gatto E, Rodeghiero F (1997) The VITA project: phenotypic resistance to activated protein C and FV Leiden mutation in the general population. Vicenza thrombophilia and atherosclerosis. Thromb Haemost 78:859–863PubMed Tosetto A, Missiaglia E, Gatto E, Rodeghiero F (1997) The VITA project: phenotypic resistance to activated protein C and FV Leiden mutation in the general population. Vicenza thrombophilia and atherosclerosis. Thromb Haemost 78:859–863PubMed
54.
Zurück zum Zitat Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH (1995) High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 85:1504–1508PubMed Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH (1995) High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 85:1504–1508PubMed
55.
Zurück zum Zitat Mikovic D, Rakicevic LJ, Kovac M, Radojkovic D (2000) Prevalence of factor V Leiden mutation in Yugoslav thrombophilic patients and its relationship to the laboratory diagnosis of APC resistance. Thromb Haemost 84:723–724PubMed Mikovic D, Rakicevic LJ, Kovac M, Radojkovic D (2000) Prevalence of factor V Leiden mutation in Yugoslav thrombophilic patients and its relationship to the laboratory diagnosis of APC resistance. Thromb Haemost 84:723–724PubMed
56.
Zurück zum Zitat Djordjevic V, Rakicevic LJ, Mikovic D et al (2004) Prevalence of factor V Leiden, factor V Cambridge, factor II G20210A and methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populations. Acta Haematol 112:227–229. doi:10.1159/000081280 PubMedCrossRef Djordjevic V, Rakicevic LJ, Mikovic D et al (2004) Prevalence of factor V Leiden, factor V Cambridge, factor II G20210A and methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populations. Acta Haematol 112:227–229. doi:10.​1159/​000081280 PubMedCrossRef
57.
59.
Zurück zum Zitat Poort RS, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698–3703PubMed Poort RS, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698–3703PubMed
60.
Zurück zum Zitat Leroyer C, Mercier B, Oger E et al (1998) Prevalence of 20210A allele of the prothrombin gene in venous thromboembolism patients. Thromb Haemost 80:49–51PubMed Leroyer C, Mercier B, Oger E et al (1998) Prevalence of 20210A allele of the prothrombin gene in venous thromboembolism patients. Thromb Haemost 80:49–51PubMed
61.
Zurück zum Zitat Rosendaal FR, Doggen CJ, Zivelin A et al (1998) Geographic distribution of the 20210G to A prothrombin variant. Thromb Haemost 79:706–708PubMed Rosendaal FR, Doggen CJ, Zivelin A et al (1998) Geographic distribution of the 20210G to A prothrombin variant. Thromb Haemost 79:706–708PubMed
62.
Zurück zum Zitat Zalavras CG, Giotopoulou S, Dokou E et al (2003) Prevalence of the G20210A prothrombin gene mutation in Northwestern Greece and association with venous thromboembolism. Int Angiol 22:55–57PubMed Zalavras CG, Giotopoulou S, Dokou E et al (2003) Prevalence of the G20210A prothrombin gene mutation in Northwestern Greece and association with venous thromboembolism. Int Angiol 22:55–57PubMed
63.
Zurück zum Zitat Collaboration HomocysteineLoweringTrialists’ (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. BMJ 316:894–898 Collaboration HomocysteineLoweringTrialists’ (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. BMJ 316:894–898
64.
Zurück zum Zitat Tucker KL, Olson B, Bakun P, Dallal GE, Selhub J, Rosenberg IH (2004) Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr 79:805–811PubMed Tucker KL, Olson B, Bakun P, Dallal GE, Selhub J, Rosenberg IH (2004) Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr 79:805–811PubMed
66.
67.
Zurück zum Zitat Steffen LM, Folsom AR, Cushman M, Jacobs DR Jr, Rosamond WD (2007) Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the longitudinal investigation of thromboembolism etiology. Circulation 115:188–195. doi:10.1161/CIRCULATIONAHA.106.641688 PubMedCrossRef Steffen LM, Folsom AR, Cushman M, Jacobs DR Jr, Rosamond WD (2007) Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the longitudinal investigation of thromboembolism etiology. Circulation 115:188–195. doi:10.​1161/​CIRCULATIONAHA.​106.​641688 PubMedCrossRef
70.
Zurück zum Zitat Hammerschmidt DE (1980) Szechwan purpura. N Engl J Med 302:1191–1193PubMed Hammerschmidt DE (1980) Szechwan purpura. N Engl J Med 302:1191–1193PubMed
71.
Zurück zum Zitat Okuyama T, Shibata S, Hoson M (1986) Effect of oriental plant drugs on human platelet aggregation: III. Effect of Chinese drug “Xiebai” on human platelet aggregation. Planta Med 3:171–175. doi:10.1055/s-2007-969113 PubMedCrossRef Okuyama T, Shibata S, Hoson M (1986) Effect of oriental plant drugs on human platelet aggregation: III. Effect of Chinese drug “Xiebai” on human platelet aggregation. Planta Med 3:171–175. doi:10.​1055/​s-2007-969113 PubMedCrossRef
72.
Zurück zum Zitat Pomp ER, Rosendaal FR, Doggen CJ (2008) Alcohol consumption is associated with a decreased risk of venous thrombosis. Thromb Haemost 99:59–63PubMed Pomp ER, Rosendaal FR, Doggen CJ (2008) Alcohol consumption is associated with a decreased risk of venous thrombosis. Thromb Haemost 99:59–63PubMed
86.
Zurück zum Zitat Baccarelli A, Zanobetti A, Martinelli I et al (2007) Air pollution, smoking, and plasma homocysteine. Environ Health Perspect 115:176–181PubMedCrossRef Baccarelli A, Zanobetti A, Martinelli I et al (2007) Air pollution, smoking, and plasma homocysteine. Environ Health Perspect 115:176–181PubMedCrossRef
90.
Zurück zum Zitat Kosch A, Koch HG, Heinecke A, Kurnik K, Heller C, Nowak-Göttl U, Childhood Thrombophilia Study Group (2004) Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children. Thromb Haemost 91:308–314PubMed Kosch A, Koch HG, Heinecke A, Kurnik K, Heller C, Nowak-Göttl U, Childhood Thrombophilia Study Group (2004) Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children. Thromb Haemost 91:308–314PubMed
92.
Zurück zum Zitat Zuern CS, Lindemann S, Gawaz M (2009) Platelet Function and Response to Aspirin: Gender-specific features and implications for female thrombotic risk and management. Semin Thromb Hemost, 35, (in press) Zuern CS, Lindemann S, Gawaz M (2009) Platelet Function and Response to Aspirin: Gender-specific features and implications for female thrombotic risk and management. Semin Thromb Hemost, 35, (in press)
93.
Zurück zum Zitat Anderson FA Jr, Wheeler HB, Goldberg RJ et al (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: the Worcester DVT study. Arch Intern Med 151:933–938. doi:10.1001/archinte.151.5.933 PubMedCrossRef Anderson FA Jr, Wheeler HB, Goldberg RJ et al (1991) A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism: the Worcester DVT study. Arch Intern Med 151:933–938. doi:10.​1001/​archinte.​151.​5.​933 PubMedCrossRef
94.
Zurück zum Zitat Nordstrom M, Lindblad B, Bergqvist D, Kjellstrom T (1992) A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med 232:155–160PubMedCrossRef Nordstrom M, Lindblad B, Bergqvist D, Kjellstrom T (1992) A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med 232:155–160PubMedCrossRef
96.
Zurück zum Zitat Oger E (2000) Incidence of venous thromboembolism: a community-based study in western France. EPI-GETBP study group. Groupe d’Etude de la Thrombose de Bretagne Occidentale. Thromb Haemost 83:657–660PubMed Oger E (2000) Incidence of venous thromboembolism: a community-based study in western France. EPI-GETBP study group. Groupe d’Etude de la Thrombose de Bretagne Occidentale. Thromb Haemost 83:657–660PubMed
97.
102.
Zurück zum Zitat Battaglioli T, Martinelli I (2007) Hormone therapy and thromboembolic disease. Curr Opin Hematol 14:488–493PubMed Battaglioli T, Martinelli I (2007) Hormone therapy and thromboembolic disease. Curr Opin Hematol 14:488–493PubMed
103.
106.
Zurück zum Zitat White RH, Dager WE, Zhou H, Murin S (2006) Racial and gender differences in the incidence of recurrent venous thromboembolism. Thromb Haemost 96:267–273PubMed White RH, Dager WE, Zhou H, Murin S (2006) Racial and gender differences in the incidence of recurrent venous thromboembolism. Thromb Haemost 96:267–273PubMed
Metadaten
Titel
The role of ethnicity, age and gender in venous thromboembolism
verfasst von
Martina Montagnana
Emmanuel J. Favaloro
Massimo Franchini
Gian Cesare Guidi
Giuseppe Lippi
Publikationsdatum
01.05.2010
Verlag
Springer US
Erschienen in
Journal of Thrombosis and Thrombolysis / Ausgabe 4/2010
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-009-0365-8

Weitere Artikel der Ausgabe 4/2010

Journal of Thrombosis and Thrombolysis 4/2010 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Bei seelischem Stress sind Checkpoint-Hemmer weniger wirksam

03.06.2024 NSCLC Nachrichten

Wie stark Menschen mit fortgeschrittenem NSCLC von einer Therapie mit Immun-Checkpoint-Hemmern profitieren, hängt offenbar auch davon ab, wie sehr die Diagnose ihre psychische Verfassung erschüttert

Antikörper mobilisiert Neutrophile gegen Krebs

03.06.2024 Onkologische Immuntherapie Nachrichten

Ein bispezifischer Antikörper formiert gezielt eine Armee neutrophiler Granulozyten gegen Krebszellen. An den Antikörper gekoppeltes TNF-alpha soll die Zellen zudem tief in solide Tumoren hineinführen.

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.