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International Urology and Nephrology

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07.04.2023 | Nephrology - Original Paper

Hyperuricemia may be associated with muscle wellness in older adults

verfasst von: Eda Oncel Yoruk, Fatma Sena Dost, Mehmet Selman Ontan, Esra Ates Bulut, Ali Ekrem Aydin, Ahmet Turan Isik

Erschienen in: International Urology and Nephrology | Ausgabe 11/2023

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Abstract

Purpose

Sarcopenia, associated with morbidity and mortality, is a common geriatric syndrome in older adults. In this study, we investigated the relationship between uric acid, which is a powerful antioxidant and has intracellular proinflammatory activity, and sarcopenia in older adults.

Methods

This is a cross-sectional retrospective study involving a total of 936 patients. The diagnosis of sarcopenia was evaluated based on the EGWSOP 2 criteria. The patients were divided into two groups according to hyperuricemia (for females > 6 mg/dl, for males > 7 mg/dl); hyperuricemia and control.

Results

The frequency of hyperuricemia was 65.40%. Patients with hyperuricemia were older than the control group and female gender frequency was higher (p = 0.001, p < 0.001, respectively). Sarcopenia was negatively associated with hyperuricemia as a result of the adjustment analysis made according to demographic characteristics, comorbidities, laboratory results, malnutrition, and malnutrition risk. (p = 0.034). Besides, muscle mass and muscle strength were associated with hyperuricemia (p = 0.026 and p = 0.009, respectively).

Conclusions

Considering the positive effect of hyperuricemia on sarcopenia, avoiding aggressive uric acid-lowering therapy may be a good option in older adults with asymptomatic hyperuricemia.

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Titel: Hyperuricemia may be associated with muscle wellness in older adults
verfasst von: Eda Oncel Yoruk
Fatma Sena Dost
Mehmet Selman Ontan
Esra Ates Bulut
Ali Ekrem Aydin
Ahmet Turan Isik
Publikationsdatum: 07.04.2023
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 11/2023
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-023-03588-z

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Hyperuricemia may be associated with muscle wellness in older adults