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05.08.2021 | Original Paper

Walsogynes H–O from Walsura chrysogyne

verfasst von: Alfarius Eko Nugroho, Saori Nakajima, Chin Piow Wong, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, Takahiro Tougan, Toshihiro Horii, A. Hamid A. Hadi, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2022

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Abstract

Eight new limonoids, walsogynes H–O (1–8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H–M (1–6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc:3,4-c′]difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc:5,4-b′c′]difuran skeleton. Walsogynes H–O (1–8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 µM, respectively.

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Titel: Walsogynes H–O from Walsura chrysogyne
verfasst von: Alfarius Eko Nugroho
Saori Nakajima
Chin Piow Wong
Yusuke Hirasawa
Toshio Kaneda
Osamu Shirota
Takahiro Tougan
Toshihiro Horii
A. Hamid A. Hadi
Hiroshi Morita
Publikationsdatum: 05.08.2021
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2022
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01556-4

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Walsogynes H–O from Walsura chrysogyne

Abstract

Graphic abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Graphic abstract

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