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Journal of Natural Medicines

Erschienen in:

18.01.2022 | Note

Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica

verfasst von: Teruhisa Manome, Yasumasa Hara, Firoj Ahmed, Samir K. Sadhu, Masami Ishibashi

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2022

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Abstract

Two new compounds, thannilignan 9-O-β-glucoside (1) and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from the methanol extract of Terminalia bellirica leaves, collected in Bangladesh. The structures of the compounds were elucidated using spectroscopic analysis. Among these isolated compounds, corilagin (3) was cytotoxic against human gastric adenocarcinoma cell line AGS at an IC₅₀ of 20.8 μM, and β-d-glucopyranose 1,3,6-trigallate (4) exhibited the ability to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance.

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Titel: Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica
verfasst von: Teruhisa Manome
Yasumasa Hara
Firoj Ahmed
Samir K. Sadhu
Masami Ishibashi
Publikationsdatum: 18.01.2022
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2022
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01593-z

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Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica

Abstract

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