nach oben

Erschienen in:

08.09.2016 | Original Article

The retrospective analysis of the relationship between prescribed dose and risk factor for seed migration in iodine-125 prostate brachytherapy

verfasst von: Katsumi Hirose, Masahiko Aoki, Mariko Sato, Hiroyoshi Akimoto, Yasuhiro Hashimoto, Atsushi Imai, Noritaka Kamimura, Hideo Kawaguchi, Yoshiomi Hatayama, Ichitaro Fujioka, Mitsuki Tanaka, Chikara Ohyama, Yoshihiro Takai

Erschienen in: Japanese Journal of Radiology | Ausgabe 11/2016

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The aim was to determine the dose-specific incidence and predictors of seed loss/migration after permanent seed implantation (PI) for localized prostate cancer.

Materials and methods

The records of 79 patients with T1c–T3a prostate cancer who underwent prostate brachytherapy with loose iodine-125 seeds were retrospectively reviewed. Of these patients, 33 with low or intermediate risk underwent PI with the prescribed dose of 160 Gy for the clinical target volume (CTV), and 46 with high risk underwent PI with 110 Gy for the CTV followed by external beam radiotherapy (EBRT) with 45 Gy. Each CTV was defined as a contoured prostate. After PI, the incidence of seed loss/migration was assessed by a series of radiographs.

Results

Seed migration occurred in 22 (0.479 %) of 4589 implanted seeds 1 month after implantation. In PI alone, the number of needles (P = 0.081) and the number of seeds (P = 0.071) showed a trend for a difference between those with and without seed loss. In PI + EBRT, there was a significant difference in the discrepancy between the seed numbers calculated by the nomogram and actually implanted (P = 0.032).

Conclusions

It is suggested that the discrepancy in seed numbers might be the predictor for seed migration in PI with 110 Gy.

Zhu AX, Wallner KE, Frivold GP, Ferry D, Jutzy KR, Foster GP. Prostate brachytherapy seed migration to the right coronary artery associated with an acute myocardial infarction. Brachytherapy. 2006;5:262–5.CrossRefPubMed

Blair HF, Porter A, Chen QS. In vivo detection of a 125 I seed located in the intracardiac region after prostate permanent brachytherapy. Int J Radiat Oncol Biol Phys. 2004;58:888–91.CrossRefPubMed

Davis BJ, Bresnahan JF, Stafford SL, Karon BL, King BF, Wilson TM. Prostate brachytherapy seed migration to a coronary artery found during angiography. J Urol. 2002;168:1103.CrossRefPubMed

Davis BJ, Pfeifer EA, Wilson TM, King BF, Eshleman JS, Pisansky TM. Prostate brachytherapy seed migration to the right ventricle found at autopsy following acute cardiac dysrhythmia. J Urol. 2000;164:1661.CrossRefPubMed

Chen WC, Katcher J, Nunez C, Tirgan AM, Ellis RJ. Radioactive seed migration after transperineal interstitial prostate brachytherapy and associated development of small-cell lung cancer. Brachytherapy. 2012;11:354–8.CrossRefPubMed

Miura N, Kusuhara Y, Numata K, Shirato A, Hashine K, Sumiyoshi Y, et al. Radiation pneumonitis caused by a migrated brachytherapy seed lodged in the lung. Jpn J Clin Oncol. 2008;38:623–5.CrossRefPubMed

Sommerkamp H, Rupprecht M, Wannenmacher M. Seed loss in interstitial radiotherapy of prostatic carcinoma with I-125. Int J Radiat Oncol Biol Phys. 1998;14:389–92.CrossRef

Konaka H, Egawa S, Saito S, Yorozu A, Takahashi H, Miyakoda K, et al. Tri-modality therapy with I-125 brachytherapy, external beam radiation therapy, and short- or long-term hormone therapy for high-risk localized prostate cancer (TRIP): study protocol for a phase III, multicenter, randomized, controlled trial. BMC Cancer. 2012;12:110.CrossRefPubMedPubMedCentral

Ohashi T, Yorozu A, Saito S, Momma T, Nishiyama T, Yamashita S, et al. Combined brachytherapy and external beam radiotherapy without adjuvant androgen deprivation therapy for high-risk prostate cancer. Radiat Oncol. 2014;9:13.CrossRefPubMedPubMedCentral

10.

Al-Qaisieh B, Carey B, Ash D, Bottomley D. The use of linked seeds eliminates lung embolization following permanent seed implantation for prostate cancer. Int J Radiat Oncol Biol Phys. 2004;59:397–9.CrossRefPubMed

11.

Ankem MK, DeCarvalho VS, Harangozo AM, Hartanto VH, Perrotti M, Han K, et al. Implications of radioactive seed migration to the lungs after prostate brachytherapy. Urology. 2002;59:555–9.CrossRefPubMed

12.

Eshleman JS, Davis BJ, Pisansky TM, Wilson TM, Haddock MG, King BF, et al. Radioactive seed migration to the chest after transperineal interstitial prostate brachytherapy: extraprostatic seed placement correlates with migration. Int J Radiat Oncol Biol Phys. 2004;59:419–25.CrossRefPubMed

13.

Fuller DB, Koziol JA, Feng AC. Prostate brachytherapy seed migration and dosimetry: analysis of stranded sources and other potential predictive factors. Brachytherapy. 2004;3:10–9.CrossRefPubMed

14.

Kono Y, Kubota K, Aruga T, Ishibashi A, Morooka M, Ito K, et al. Swelling of the prostate gland by permanent brachytherapy may affect seed migration. Jpn J Clin Oncol. 2010;40:1159–65.CrossRefPubMed

15.

Kunos CA, Resnick MI, Kinsella TJ, Ellis RJ. Migration of implanted free radioactive seeds for adenocarcinoma of the prostate using a Mick applicator. Brachytherapy. 2004;3:71–7.CrossRefPubMed

16.

Nag S, Vivekanandam S, Martínez-Monge R. Pulmonary embolization of permanently implanted radioactive palladium-103 seeds for carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 1997;39:667–70.CrossRefPubMed

17.

Saibishkumar EP, Borg J, Yeung I, Cummins-Holder C, Landon A, Crook J. Sequential comparison of seed loss and prostate dosimetry of stranded seeds with loose seeds in 125I permanent implant for low-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2009;73:61–8.CrossRefPubMed

18.

Stone NN, Stock RG. Reduction of pulmonary migration of permanent interstitial sources in patients undergoing prostate brachytherapy. Urology. 2005;66:119–23.CrossRefPubMed

19.

Sugawara A, Nakashima J, Shigematsu N, Kunieda E, Kubo A. Prediction of seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds. Brachytherapy. 2009;8:52–6.CrossRefPubMed

20.

Tapen EM, Blasko JC, Grimm PD, Ragde H, Luse R, Clifford S, et al. Reduction of radioactive seed embolization to the lung following prostate brachytherapy. Int J Radiat Oncol Biol Phys. 1998;42:1063–7.CrossRefPubMed

21.

Nakano M, Yorozu A, Saito S, Sugawara A, Maruo S, Kojima S, et al. Seed migration after transperineal interstitial prostate brachytherapy by using loose seeds: Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS) multi-institutional cohort study. Radiat Oncol. 2015;10:228.CrossRefPubMedPubMedCentral

22.

Ishiyama H, Satoh T, Kawakami S, Tsumura H, Komori S, Tabata KI, Hayakawa K, et al. A prospective quasi-randomized comparison of intraoperatively built custom-linked seeds versus loose seeds for prostate brachytherapy. Int J Radiat Oncol Biol Phys. 2014;90:134–9.CrossRefPubMed

23.

Nguyen BD. Cardiac and hepatic seed implant embolization after prostate brachytherapy. Urology. 2006;68:673-e17.

24.

Miyazawa K, Matoba M, Minato H, Morita N, Chikazawa I, Ota K, et al. Seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds: analysis of its incidence and risk factors. Jpn J Radiol. 2012;30:635–41.CrossRefPubMed

25.

Grimm PD, Blasko JC, Ragde H. Migration of iodine-125 and palladium-103 seeds to the lung after transperineal brachytherapy for prostate cancer. Endocuriether Hypertherm Oncol. 1993;9:50.

26.

Merrick GS, Butler WM, Dorsey AT, Lief JH, Benson ML. Seed fixity in the prostate/periprostatic region following brachytherapy. Int J Radiat Oncol Biol Phys. 2000;46:215–20.CrossRefPubMed

27.

Steinfeld AD, Donahue BR, Plaine L. Pulmonary embolization of iodine-125 seeds following prostate implantation. Urology. 1991;37:149–50.CrossRefPubMed

28.

Kono Y, Kubota K, Mitsumoto T, Tanaka A, Ishibashi A, Kobayashi K, et al. Scintigraphic detection of 125I seeds after permanent brachytherapy for prostate cancer. J Nucl Med. 2008;49:541–5.CrossRefPubMed

Titel: The retrospective analysis of the relationship between prescribed dose and risk factor for seed migration in iodine-125 prostate brachytherapy
verfasst von: Katsumi Hirose
Masahiko Aoki
Mariko Sato
Hiroyoshi Akimoto
Yasuhiro Hashimoto
Atsushi Imai
Noritaka Kamimura
Hideo Kawaguchi
Yoshiomi Hatayama
Ichitaro Fujioka
Mitsuki Tanaka
Chikara Ohyama
Yoshihiro Takai
Publikationsdatum: 08.09.2016
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 11/2016
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-016-0578-7

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

The retrospective analysis of the relationship between prescribed dose and risk factor for seed migration in iodine-125 prostate brachytherapy