Skip to main content
Erschienen in: Journal of General Internal Medicine 10/2009

01.10.2009 | Original Article

Perceived Susceptibility to Chronic Kidney Disease among High-risk Patients Seen in Primary Care Practices

verfasst von: L. Ebony Boulware, MD, MPH, Kathryn A. Carson, ScM, Misty U. Troll, MPH, Neil R. Powe, MD, MPH, MBA, Lisa A. Cooper, MD, MPH

Erschienen in: Journal of General Internal Medicine | Ausgabe 10/2009

Einloggen, um Zugang zu erhalten

Abstract

BACKGROUND

Patients’ views of their risk for the development or progression of chronic kidney disease (CKD) are poorly characterized.

OBJECTIVE

To assess perceived risk and concern regarding CKD development or progression among high-risk patients seen in primary care, identify predictors of perceptions, and correlate perceptions with adherence to high blood pressure management.

DESIGN AND PARTICIPANTS

Cross-sectional study of 195 patients enrolled in a randomized controlled trial on hypertension management in 40 Maryland primary care practices.

MEASUREMENTS

We assessed independent predictors (sociodemographics, health literacy, clinical presence of CKD, co-morbid conditions, and health behaviors) of perceived susceptibility (assessed via questionnaire) and adherence (assessed via Hill-Bone blood pressure adherence scale) in multivariable analyses.

MAIN RESULTS

In this hypertensive majority African American (63%) population, many participants had uncontrolled blood pressure (44%) or diabetes (42%). Few (20%) felt “very likely” to develop CKD and one third (33%) were “very concerned” about developing CKD. Participants who were female and had low health literacy had lower perceived susceptibility to CKD compared to males and those with higher health literacy. Race and diabetes were also associated with perceived susceptibility. Greater perceived susceptibility was associated with poorer blood pressure management adherence scores.

CONCLUSIONS

Many high-risk patients have low perceived susceptibility to CKD. Poor blood pressure therapy adherence scores among those with greatest perceived susceptibility suggest fatalistic attitudes about CKD. If our findings are confirmed in larger studies, interventions targeting patient perceptions of CKD risk and other attitudes associated with these perceptions could impact adherence to therapies and health outcomes.
Literatur
1.
Zurück zum Zitat Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17):2038–47.CrossRefPubMed Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17):2038–47.CrossRefPubMed
2.
Zurück zum Zitat Shlipak MG, Sarnak MJ, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352(20):2049–60.CrossRefPubMed Shlipak MG, Sarnak MJ, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352(20):2049–60.CrossRefPubMed
3.
Zurück zum Zitat Sarnak MJ, Katz R, Stehman-Breen CO, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005;142(7):497–505.PubMed Sarnak MJ, Katz R, Stehman-Breen CO, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005;142(7):497–505.PubMed
4.
Zurück zum Zitat Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol. 2003;14(11):2934–41.CrossRefPubMed Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol. 2003;14(11):2934–41.CrossRefPubMed
5.
Zurück zum Zitat Jee SH, Boulware LE, Guallar E, Suh I, Appel LJ, Miller ER 3rd. Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) study. Arch Intern Med. 2005;165(19):2299–304.CrossRefPubMed Jee SH, Boulware LE, Guallar E, Suh I, Appel LJ, Miller ER 3rd. Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) study. Arch Intern Med. 2005;165(19):2299–304.CrossRefPubMed
6.
Zurück zum Zitat Hostetter TH, Lising M. National kidney disease education program. J Am Soc Nephrol. 2003;14(7 Suppl 2):S114–116.CrossRefPubMed Hostetter TH, Lising M. National kidney disease education program. J Am Soc Nephrol. 2003;14(7 Suppl 2):S114–116.CrossRefPubMed
8.
Zurück zum Zitat Peralta CA, Hicks LS, Chertow GM, et al. Control of hypertension in adults with chronic kidney disease in the United States. Hypertension. 2005;45(6):1119–24.CrossRefPubMed Peralta CA, Hicks LS, Chertow GM, et al. Control of hypertension in adults with chronic kidney disease in the United States. Hypertension. 2005;45(6):1119–24.CrossRefPubMed
9.
Zurück zum Zitat Pathman DE, Konrad TR, Freed GL, Freeman VA, Koch GG. The awareness-to-adherence model of the steps to clinical guideline compliance. The case of pediatric vaccine recommendations. Med Care. 1996;34(9):873–89.CrossRefPubMed Pathman DE, Konrad TR, Freed GL, Freeman VA, Koch GG. The awareness-to-adherence model of the steps to clinical guideline compliance. The case of pediatric vaccine recommendations. Med Care. 1996;34(9):873–89.CrossRefPubMed
10.
Zurück zum Zitat Kirkman MS, Williams SR, Caffrey HH, Marrero DG. Impact of a program to improve adherence to diabetes guidelines by primary care physicians. Diabetes Care. 2002;25(11):1946–51.CrossRefPubMed Kirkman MS, Williams SR, Caffrey HH, Marrero DG. Impact of a program to improve adherence to diabetes guidelines by primary care physicians. Diabetes Care. 2002;25(11):1946–51.CrossRefPubMed
11.
Zurück zum Zitat Cooper LA, Roter DL, Bone LR, et al. A randomized controlled trial of interventions to enhance patient-physician partnership, patient adherence and high blood pressure control among ethnic minorities and poor persons: study protocol NCT00123045. Implement Sci. 2009;4:7.CrossRefPubMed Cooper LA, Roter DL, Bone LR, et al. A randomized controlled trial of interventions to enhance patient-physician partnership, patient adherence and high blood pressure control among ethnic minorities and poor persons: study protocol NCT00123045. Implement Sci. 2009;4:7.CrossRefPubMed
12.
Zurück zum Zitat Davis TC, Crouch MA, Long SW, et al. Rapid assessment of literacy levels of adult primary care patients. Fam Med. 1991;23(6):433–5.PubMed Davis TC, Crouch MA, Long SW, et al. Rapid assessment of literacy levels of adult primary care patients. Fam Med. 1991;23(6):433–5.PubMed
13.
Zurück zum Zitat Kim MT, Hill MN, Bone LR, Levine DM. Development and testing of the Hill-Bone Compliance to High Blood Pressure Therapy Scale. Prog Cardiovasc Nurs. 2000;15(3):90–6.CrossRefPubMed Kim MT, Hill MN, Bone LR, Levine DM. Development and testing of the Hill-Bone Compliance to High Blood Pressure Therapy Scale. Prog Cardiovasc Nurs. 2000;15(3):90–6.CrossRefPubMed
14.
Zurück zum Zitat Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72.CrossRefPubMed Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560–72.CrossRefPubMed
15.
Zurück zum Zitat Expert Panel on the Identification E, Treatment of Overweight in A. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Am J Clin Nutr. 1998;68(4):899–917. Expert Panel on the Identification E, Treatment of Overweight in A. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Am J Clin Nutr. 1998;68(4):899–917.
16.
Zurück zum Zitat Zhang J, Yu KF. What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA. 1998;280(19):1690–1.CrossRefPubMed Zhang J, Yu KF. What’s the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA. 1998;280(19):1690–1.CrossRefPubMed
17.
Zurück zum Zitat Huber PJ. The Behavior of Maximum Likelihood Estimates under Nonstandard Conditions. Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability. Berkeley, CA: University of California Press;1967:221–3. Huber PJ. The Behavior of Maximum Likelihood Estimates under Nonstandard Conditions. Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability. Berkeley, CA: University of California Press;1967:221–3.
18.
Zurück zum Zitat White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica. 48:817–30. White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica. 48:817–30.
19.
Zurück zum Zitat Williams RL. A note on robust variance estimation for cluster-correlated data. Biometrics. 2000;56:645–6.CrossRefPubMed Williams RL. A note on robust variance estimation for cluster-correlated data. Biometrics. 2000;56:645–6.CrossRefPubMed
20.
Zurück zum Zitat Rogers WH. Regressions standard errors in clustered samples. Stata Tech Bull. 1993;13:19–23. Rogers WH. Regressions standard errors in clustered samples. Stata Tech Bull. 1993;13:19–23.
21.
Zurück zum Zitat Coresh J, Byrd-Holt D, Astor BC, et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol. 2005;16(1):180–8.CrossRefPubMed Coresh J, Byrd-Holt D, Astor BC, et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol. 2005;16(1):180–8.CrossRefPubMed
22.
Zurück zum Zitat Waterman AD, Browne T, Waterman BM, Gladstone EH, Hostetter T. Attitudes and behaviors of African Americans regarding early detection of kidney disease. Am J Kidney Dis. 2008;51(4):554–62.CrossRefPubMed Waterman AD, Browne T, Waterman BM, Gladstone EH, Hostetter T. Attitudes and behaviors of African Americans regarding early detection of kidney disease. Am J Kidney Dis. 2008;51(4):554–62.CrossRefPubMed
23.
Zurück zum Zitat National Kidney F. Annual data report: Kidney Early Evaluation Program. American Jounal of Kidney Diseases. 2003;42(5):Supplement 4. National Kidney F. Annual data report: Kidney Early Evaluation Program. American Jounal of Kidney Diseases. 2003;42(5):Supplement 4.
24.
Zurück zum Zitat Lea JP, McClellan WM, Melcher C, Gladstone E, Hostetter T. CKD risk factors reported by primary care physicians: do guidelines make a difference? Am J Kidney Dis. 2006;47(1):72–7.CrossRefPubMed Lea JP, McClellan WM, Melcher C, Gladstone E, Hostetter T. CKD risk factors reported by primary care physicians: do guidelines make a difference? Am J Kidney Dis. 2006;47(1):72–7.CrossRefPubMed
25.
Zurück zum Zitat Boulware LE, Troll MU, Jaar BG, Myers DI, Powe NR. Identification and referral of patients with progressive CKD: a national study. Am J Kidney Dis. 2006;48(2):192–204.CrossRefPubMed Boulware LE, Troll MU, Jaar BG, Myers DI, Powe NR. Identification and referral of patients with progressive CKD: a national study. Am J Kidney Dis. 2006;48(2):192–204.CrossRefPubMed
26.
Zurück zum Zitat Davis RE, Dolan G, Thomas S, et al. Exploring doctor and patient views about risk communication and shared decision-making in the consultation. Health Expect. 2003;6(3):198–207.CrossRefPubMed Davis RE, Dolan G, Thomas S, et al. Exploring doctor and patient views about risk communication and shared decision-making in the consultation. Health Expect. 2003;6(3):198–207.CrossRefPubMed
27.
Zurück zum Zitat Royak-Schaler R, Lemkau JP, Ahmed SM. Discussing breast cancer risk in primary care. J Am Med Womens Assoc. 2002;57(2):115–6.PubMed Royak-Schaler R, Lemkau JP, Ahmed SM. Discussing breast cancer risk in primary care. J Am Med Womens Assoc. 2002;57(2):115–6.PubMed
28.
Zurück zum Zitat Buchanan AH, Skinner CS, Rawl SM, et al. Patients’ interest in discussing cancer risk and risk management with primary care physicians. Patient Educ Couns. 2005;57(1):77–87.CrossRefPubMed Buchanan AH, Skinner CS, Rawl SM, et al. Patients’ interest in discussing cancer risk and risk management with primary care physicians. Patient Educ Couns. 2005;57(1):77–87.CrossRefPubMed
30.
Zurück zum Zitat Boulware LE. Challenges for public campaigns to improve the health of persons at high risk of developing CKD. Am J Kidney Dis. 2008;51(4):535–8.CrossRefPubMed Boulware LE. Challenges for public campaigns to improve the health of persons at high risk of developing CKD. Am J Kidney Dis. 2008;51(4):535–8.CrossRefPubMed
31.
Zurück zum Zitat Niederdeppe J, Levy AG. Fatalistic beliefs about cancer prevention and three prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2007;16(5):998–1003.CrossRefPubMed Niederdeppe J, Levy AG. Fatalistic beliefs about cancer prevention and three prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2007;16(5):998–1003.CrossRefPubMed
32.
Zurück zum Zitat Farmer D, Reddick B, D'Agostino R, Jackson SA. Psychosocial correlates of mammography screening in older African American women. Oncol Nurs Forum. 2007;34(1):117–23.CrossRefPubMed Farmer D, Reddick B, D'Agostino R, Jackson SA. Psychosocial correlates of mammography screening in older African American women. Oncol Nurs Forum. 2007;34(1):117–23.CrossRefPubMed
33.
Zurück zum Zitat Russell KM, Perkins SM, Zollinger TW, Champion VL. Sociocultural context of mammography screening use. Oncol Nurs Forum. 2006;33(1):105–12.CrossRefPubMed Russell KM, Perkins SM, Zollinger TW, Champion VL. Sociocultural context of mammography screening use. Oncol Nurs Forum. 2006;33(1):105–12.CrossRefPubMed
34.
Zurück zum Zitat Greiner KA, James AS, Born W, et al. Predictors of fecal occult blood test (FOBT) completion among low-income adults. Prev Med. 2005;41(2):676–84.CrossRefPubMed Greiner KA, James AS, Born W, et al. Predictors of fecal occult blood test (FOBT) completion among low-income adults. Prev Med. 2005;41(2):676–84.CrossRefPubMed
35.
Zurück zum Zitat Burkhart PV, Rayens MK. Self-concept and health locus of control: factors related to children’s adherence to recommended asthma regimen. Pediatr Nurs. 2005;31(5):404–9.PubMed Burkhart PV, Rayens MK. Self-concept and health locus of control: factors related to children’s adherence to recommended asthma regimen. Pediatr Nurs. 2005;31(5):404–9.PubMed
36.
Zurück zum Zitat Cvengros JA, Christensen AJ, Lawton WJ. The role of perceived control and preference for control in adherence to a chronic medical regimen. Ann Behav Med. 2004;27(3):155–61.CrossRefPubMed Cvengros JA, Christensen AJ, Lawton WJ. The role of perceived control and preference for control in adherence to a chronic medical regimen. Ann Behav Med. 2004;27(3):155–61.CrossRefPubMed
37.
Zurück zum Zitat O’Hea EL, Grothe KB, Bodenlos JS, Boudreaux ED, White MA, Brantley PJ. Predicting medical regimen adherence: the interactions of health locus of control beliefs. J Health Psychol. 2005;10(5):705–17.CrossRefPubMed O’Hea EL, Grothe KB, Bodenlos JS, Boudreaux ED, White MA, Brantley PJ. Predicting medical regimen adherence: the interactions of health locus of control beliefs. J Health Psychol. 2005;10(5):705–17.CrossRefPubMed
38.
Zurück zum Zitat Dunbar-Jacob JM, Schlenk EA, Burke LE, Matthews JT. Predictors of patient adherence: patient characteristics. In: Schumamer SA, Schron EB, Ockene JK, McBee WL, eds. The Handbook of Health Behavior Change. 2nd ed. New York: Springer Publishing Company; 1998: 491–511. Dunbar-Jacob JM, Schlenk EA, Burke LE, Matthews JT. Predictors of patient adherence: patient characteristics. In: Schumamer SA, Schron EB, Ockene JK, McBee WL, eds. The Handbook of Health Behavior Change. 2nd ed. New York: Springer Publishing Company; 1998: 491–511.
39.
Zurück zum Zitat Glanz K, Lewis FM, Rimer BK. Part Two: Models of Indivudial Health Behavior. Health Behavior and Health Education. Theory, Research and Practice. San Francisco: Jossey-Bass, Inc.; 1997. Glanz K, Lewis FM, Rimer BK. Part Two: Models of Indivudial Health Behavior. Health Behavior and Health Education. Theory, Research and Practice. San Francisco: Jossey-Bass, Inc.; 1997.
40.
Zurück zum Zitat DiMatteo MR, Haskard KB, Williams SL. Health beliefs, disease severity, and patient adherence: a meta-analysis. Med Care. 2007;45(6):521–8.CrossRefPubMed DiMatteo MR, Haskard KB, Williams SL. Health beliefs, disease severity, and patient adherence: a meta-analysis. Med Care. 2007;45(6):521–8.CrossRefPubMed
41.
Zurück zum Zitat Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837–47.PubMed Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837–47.PubMed
42.
Zurück zum Zitat Wolf PA, D’Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. Stroke. 1991;22(3):312–8.PubMed Wolf PA, D’Agostino RB, Belanger AJ, Kannel WB. Probability of stroke: a risk profile from the Framingham Study. Stroke. 1991;22(3):312–8.PubMed
43.
Zurück zum Zitat Officers A, Coordinators for the ACRG. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA. 2002;288(23):2998–3007.CrossRef Officers A, Coordinators for the ACRG. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA. 2002;288(23):2998–3007.CrossRef
44.
Zurück zum Zitat Rahman M, Pressel S, Davis BR, et al. Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med. 2005;165(8):936–46.CrossRefPubMed Rahman M, Pressel S, Davis BR, et al. Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med. 2005;165(8):936–46.CrossRefPubMed
Metadaten
Titel
Perceived Susceptibility to Chronic Kidney Disease among High-risk Patients Seen in Primary Care Practices
verfasst von
L. Ebony Boulware, MD, MPH
Kathryn A. Carson, ScM
Misty U. Troll, MPH
Neil R. Powe, MD, MPH, MBA
Lisa A. Cooper, MD, MPH
Publikationsdatum
01.10.2009
Verlag
Springer-Verlag
Erschienen in
Journal of General Internal Medicine / Ausgabe 10/2009
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-009-1086-6

Weitere Artikel der Ausgabe 10/2009

Journal of General Internal Medicine 10/2009 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.