Skip to main content
Erschienen in: Journal of General Internal Medicine 10/2011

01.10.2011 | Original Research

Regular Primary Care Plays a Significant Role in Secondary Prevention of Ischemic Heart Disease in a Western Australian Cohort

verfasst von: Kristjana Einarsdóttir, PhD, David B. Preen, PhD, Jon D. Emery, DPhil, FRACGP, C. D’Arcy J. Holman, PhD, FAFPHM

Erschienen in: Journal of General Internal Medicine | Ausgabe 10/2011

Einloggen, um Zugang zu erhalten

Abstract

Background

Secondary prevention for established ischaemic heart disease (IHD) involves medication therapy and a healthier lifestyle, but adherence is suboptimal. Simply having scheduled regular appointments with a primary care physician could confer a benefit for IHD patients possibly through increased motivation and awareness, but this has not previously been investigated in the literature.

Objective

To estimate the association between regular general practitioner (GP) visitation and rates of all-cause death, IHD death or repeat hospitalisation for IHD in older patients in Western Australia (WA).

Design

A retrospective cohort design.

Participants

Patients aged ≥ 65 years (n = 31,841) with a history of hospitalisation for IHD from 1992–2006 were ascertained through routine health data collected on the entire WA population and included in the analysis.

Main Measures

Frequency and regularity of GP visits was determined during a three-year exposure period at commencement of follow-up. A regularity score (range 0–1) measured the regularity of intervals between the GP visits and was divided into quartiles. Patients were then followed for a maximum of 11.5 years for outcome determination. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards models.

Key Results

Compared with the least regular quartile, patients with greater GP visit regularity had significantly decreased risks of all-cause death (2nd least, 2nd most and most regular: HR = 0.76, 0.71 and 0.71); and IHD death (2nd least, 2nd most and most regular: HR = 0.70, 0.68 and 0.65). Patients in the 2nd least regular quartile also appeared to experience decreased risk of any repeat IHD hospitalisation (HR = 0.83, 95%CI 0.71–0.96) as well as emergency hospitalisation (HR = 0.81, 95%CI 0.67–0.98), compared with the least regular quartile.

Conclusions

Some degree of regular GP visitation offers a small but significant protection against morbidity and mortality in older people with established IHD. The findings indicate the importance of scheduled, regular GP visits for the secondary prevention of IHD.
Literatur
1.
Zurück zum Zitat Australia’s health 2008. Australian Institute of Health and Welfare. Canberra: 2008. Cat. no. AUS 99. Australia’s health 2008. Australian Institute of Health and Welfare. Canberra: 2008. Cat. no. AUS 99.
2.
Zurück zum Zitat Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002–2030. Ann Trop Med Parasitol. 2006;100:481–99.PubMedCrossRef Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002–2030. Ann Trop Med Parasitol. 2006;100:481–99.PubMedCrossRef
3.
Zurück zum Zitat Begg S, Vos T, Barker B, Stevenson C, Stanley L, Lopez A. The burden of disease and injury in Australia 2003. Australian Institute of Health and Welfare. Canberra: 2007. AIHW cat. no. PHE 82. Begg S, Vos T, Barker B, Stevenson C, Stanley L, Lopez A. The burden of disease and injury in Australia 2003. Australian Institute of Health and Welfare. Canberra: 2007. AIHW cat. no. PHE 82.
4.
Zurück zum Zitat Briffa T, Hickling S, Knuiman M, Hobbs M, Hung J, Sanfilippo FM, et al. Long term survival after evidence based treatment of acute myocardial infarction and revascularisation: follow-up of population based Perth MONICA cohort, 1984–2005. BMJ. 2009;338:b36.PubMedCrossRef Briffa T, Hickling S, Knuiman M, Hobbs M, Hung J, Sanfilippo FM, et al. Long term survival after evidence based treatment of acute myocardial infarction and revascularisation: follow-up of population based Perth MONICA cohort, 1984–2005. BMJ. 2009;338:b36.PubMedCrossRef
5.
Zurück zum Zitat Beaglehole R, Stewart AW, Jackson R, Dobson AJ, McElduff P, D'Este K, et al. Declining rates of coronary heart disease in New Zealand and Australia, 1983–1993. Am J Epidemiol. 1997;145:707–13.PubMedCrossRef Beaglehole R, Stewart AW, Jackson R, Dobson AJ, McElduff P, D'Este K, et al. Declining rates of coronary heart disease in New Zealand and Australia, 1983–1993. Am J Epidemiol. 1997;145:707–13.PubMedCrossRef
6.
Zurück zum Zitat Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet. 1999;353:1547–57.PubMedCrossRef Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet. 1999;353:1547–57.PubMedCrossRef
7.
Zurück zum Zitat Health care expenditure on cardiovascular diseases 2004–05. Australian Institute of Health and Welfare. Canberra: 2008. Cat. no. CVD 43. Health care expenditure on cardiovascular diseases 2004–05. Australian Institute of Health and Welfare. Canberra: 2008. Cat. no. CVD 43.
8.
Zurück zum Zitat Bhatheja R, Mukherjee D. Acute coronary syndromes: unstable angina/non-ST elevation myocardial infarction. Crit Care Clin. 2007;23:709–35. v.PubMedCrossRef Bhatheja R, Mukherjee D. Acute coronary syndromes: unstable angina/non-ST elevation myocardial infarction. Crit Care Clin. 2007;23:709–35. v.PubMedCrossRef
9.
Zurück zum Zitat Junnila JL, Runkle GP. Coronary artery disease screening, treatment, and follow-up. Prim Care. 2006;33:863–85. vi.PubMedCrossRef Junnila JL, Runkle GP. Coronary artery disease screening, treatment, and follow-up. Prim Care. 2006;33:863–85. vi.PubMedCrossRef
10.
Zurück zum Zitat General practice activity in Australia 2008–09. General practice series no. 25. Australian Institute of Health and Welfare and the University of Sydney. 2009. AIHW cat. no. GEP 25. General practice activity in Australia 2008–09. General practice series no. 25. Australian Institute of Health and Welfare and the University of Sydney. 2009. AIHW cat. no. GEP 25.
11.
Zurück zum Zitat Buckley BS, Byrne MC, Smith SM. Service organisation for the secondary prevention of ischaemic heart disease in primary care. Cochrane Database Syst Rev.3:CD006772. Buckley BS, Byrne MC, Smith SM. Service organisation for the secondary prevention of ischaemic heart disease in primary care. Cochrane Database Syst Rev.3:CD006772.
12.
Zurück zum Zitat Rockson SG. deGoma EM, Fonarow GC. Reinforcing a continuum of care: in-hospital initiation of long-term secondary prevention following acute coronary syndromes. Cardiovasc Drugs Ther. 2007;21:375–88.PubMedCrossRef Rockson SG. deGoma EM, Fonarow GC. Reinforcing a continuum of care: in-hospital initiation of long-term secondary prevention following acute coronary syndromes. Cardiovasc Drugs Ther. 2007;21:375–88.PubMedCrossRef
13.
Zurück zum Zitat Brassard A. Identification of patients at risk of ischemic events for long-term secondary prevention. J Am Acad Nurse Pract. 2009;21:677–89.PubMedCrossRef Brassard A. Identification of patients at risk of ischemic events for long-term secondary prevention. J Am Acad Nurse Pract. 2009;21:677–89.PubMedCrossRef
14.
Zurück zum Zitat Chew DP, Amerena J, Coverdale S, Rankin J, Astley C, Brieger D. Current management of acute coronary syndromes in Australia: observations from the acute coronary syndromes prospective audit. Intern Med J. 2007;37:741–8.PubMed Chew DP, Amerena J, Coverdale S, Rankin J, Astley C, Brieger D. Current management of acute coronary syndromes in Australia: observations from the acute coronary syndromes prospective audit. Intern Med J. 2007;37:741–8.PubMed
15.
Zurück zum Zitat Secondary prevention and rehabilitation after coronary events or stroke: a review of monitoring issues. Australian Institute of Health and Welfare. Canberra: 2003. AIHW Cat. No. CVD 25. Secondary prevention and rehabilitation after coronary events or stroke: a review of monitoring issues. Australian Institute of Health and Welfare. Canberra: 2003. AIHW Cat. No. CVD 25.
16.
17.
Zurück zum Zitat Witt BJ, Thomas RJ, Roger VL. Cardiac rehabilitation after myocardial infarction: a review to understand barriers to participation and potential solutions. Eura Medicophys. 2005;41:27–34.PubMed Witt BJ, Thomas RJ, Roger VL. Cardiac rehabilitation after myocardial infarction: a review to understand barriers to participation and potential solutions. Eura Medicophys. 2005;41:27–34.PubMed
18.
Zurück zum Zitat Daly J, Sindone AP, Thompson DR, Hancock K, Chang E, Davidson P. Barriers to participation in and adherence to cardiac rehabilitation programs: a critical literature review. Prog Cardiovasc Nurs. 2002;17:8–17.PubMedCrossRef Daly J, Sindone AP, Thompson DR, Hancock K, Chang E, Davidson P. Barriers to participation in and adherence to cardiac rehabilitation programs: a critical literature review. Prog Cardiovasc Nurs. 2002;17:8–17.PubMedCrossRef
19.
Zurück zum Zitat Bennett K, Jennings S, Collins C, Boland M, Leahy J, Bedford D, et al. Heartwatch: a secondary prevention programme in primary care in Ireland. Eur J Cardiovasc Prev Rehabil. 2008;15:651–6.PubMedCrossRef Bennett K, Jennings S, Collins C, Boland M, Leahy J, Bedford D, et al. Heartwatch: a secondary prevention programme in primary care in Ireland. Eur J Cardiovasc Prev Rehabil. 2008;15:651–6.PubMedCrossRef
20.
Zurück zum Zitat Coleman K, Austin BT, Brach C, Wagner EH. Evidence on the Chronic Care Model in the new millennium. Health Aff (Millwood). 2009;28:75–85.CrossRef Coleman K, Austin BT, Brach C, Wagner EH. Evidence on the Chronic Care Model in the new millennium. Health Aff (Millwood). 2009;28:75–85.CrossRef
21.
Zurück zum Zitat Bazemore AW, Xierali IM, Petterson SM, Phillips RL, Jr., Rinaldo JC, Puffer JC, et al. American Board of Family Medicine (ABFM) maintenance of certification: variations in self-assessment modules uptake within the 2006 cohort. J Am Board Fam Med.23:49–58. Bazemore AW, Xierali IM, Petterson SM, Phillips RL, Jr., Rinaldo JC, Puffer JC, et al. American Board of Family Medicine (ABFM) maintenance of certification: variations in self-assessment modules uptake within the 2006 cohort. J Am Board Fam Med.23:49–58.
22.
Zurück zum Zitat Einarsdottir K, Preen DB, Emery JD, Holman CD. Regular primary care decreases the likelihood of mortality in older people with epilepsy. Med Care. 2010;48:472–6.PubMedCrossRef Einarsdottir K, Preen DB, Emery JD, Holman CD. Regular primary care decreases the likelihood of mortality in older people with epilepsy. Med Care. 2010;48:472–6.PubMedCrossRef
23.
Zurück zum Zitat Einarsdottir K, Preen DB, Emery JD, Kelman C, Holman CD. Regular primary care lowers hospitalisation risk and mortality in seniors with chronic respiratory diseases. J Gen Intern Med. 2010;25:766–73.PubMedCrossRef Einarsdottir K, Preen DB, Emery JD, Kelman C, Holman CD. Regular primary care lowers hospitalisation risk and mortality in seniors with chronic respiratory diseases. J Gen Intern Med. 2010;25:766–73.PubMedCrossRef
24.
Zurück zum Zitat Australian Demographic Statistics. Australian Bureau of Statistics. Canberra: 2010. cat. no. 3101.0. Australian Demographic Statistics. Australian Bureau of Statistics. Canberra: 2010. cat. no. 3101.0.
25.
Zurück zum Zitat Holman CD, Bass AJ, Rouse IL, Hobbs MS. Population-based linkage of health records in Western Australia: development of a health services research linked database. Aust N Z J Public Health. 1999;23:453–9.PubMedCrossRef Holman CD, Bass AJ, Rouse IL, Hobbs MS. Population-based linkage of health records in Western Australia: development of a health services research linked database. Aust N Z J Public Health. 1999;23:453–9.PubMedCrossRef
26.
Zurück zum Zitat Holman CD, Bass AJ, Rosman DL, Smith MB, Semmens JB, Glasson EJ, et al. A decade of data linkage in Western Australia: strategic design, applications and benefits of the WA data linkage system. Aust Health Rev. 2008;32:766–77.PubMedCrossRef Holman CD, Bass AJ, Rosman DL, Smith MB, Semmens JB, Glasson EJ, et al. A decade of data linkage in Western Australia: strategic design, applications and benefits of the WA data linkage system. Aust Health Rev. 2008;32:766–77.PubMedCrossRef
27.
Zurück zum Zitat Harris MG, Harris RD. The Australian health system: continuity and change. J Health Hum Serv Adm. 1998;20:442–67.PubMed Harris MG, Harris RD. The Australian health system: continuity and change. J Health Hum Serv Adm. 1998;20:442–67.PubMed
28.
Zurück zum Zitat Asthma in Australia 2008. Australian centre for asthma monitoring and Australian Institute of Health and Welfare. Canberra: 2008. AIHW cat. no. ACM 14. Asthma in Australia 2008. Australian centre for asthma monitoring and Australian Institute of Health and Welfare. Canberra: 2008. AIHW cat. no. ACM 14.
29.
Zurück zum Zitat Roberts RF, Innes KC, Walker SM. Introducing ICD-10-AM in Australian hospitals. Med J Aust. 1998;169(Suppl):S32–5.PubMed Roberts RF, Innes KC, Walker SM. Introducing ICD-10-AM in Australian hospitals. Med J Aust. 1998;169(Suppl):S32–5.PubMed
30.
Zurück zum Zitat Liu H, Wong L. Data mining tools for biological sequences. J Bioinform Comput Biol. 2003;1:139–67.PubMedCrossRef Liu H, Wong L. Data mining tools for biological sequences. J Bioinform Comput Biol. 2003;1:139–67.PubMedCrossRef
31.
Zurück zum Zitat Tamim H, Monfared AA, LeLorier J. Application of lag-time into exposure definitions to control for protopathic bias. Pharmacoepidemiol Drug Saf. 2007;16:250–8.PubMedCrossRef Tamim H, Monfared AA, LeLorier J. Application of lag-time into exposure definitions to control for protopathic bias. Pharmacoepidemiol Drug Saf. 2007;16:250–8.PubMedCrossRef
32.
Zurück zum Zitat Strom BL. Pharmacoepidemiology. 4th ed. West Sussex, England: Wiley; 2005. Strom BL. Pharmacoepidemiology. 4th ed. West Sussex, England: Wiley; 2005.
33.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.PubMedCrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.PubMedCrossRef
34.
Zurück zum Zitat Teng TH, Finn J, Hung J, Geelhoed E, Hobbs M. A validation study: how effective is the Hospital Morbidity Data as a surveillance tool for heart failure in Western Australia? Aust N Z J Public Health. 2008;32:405–7.PubMedCrossRef Teng TH, Finn J, Hung J, Geelhoed E, Hobbs M. A validation study: how effective is the Hospital Morbidity Data as a surveillance tool for heart failure in Western Australia? Aust N Z J Public Health. 2008;32:405–7.PubMedCrossRef
35.
Zurück zum Zitat Basu J, Friedman B, Burstin H. Primary care, HMO enrollment, and hospitalization for ambulatory care sensitive conditions: a new approach. Med Care. 2002;40:1260–9.PubMedCrossRef Basu J, Friedman B, Burstin H. Primary care, HMO enrollment, and hospitalization for ambulatory care sensitive conditions: a new approach. Med Care. 2002;40:1260–9.PubMedCrossRef
36.
Zurück zum Zitat Caminal J, Starfield B, Sanchez E, Casanova C, Morales M. The role of primary care in preventing ambulatory care sensitive conditions. Eur J Public Health. 2004;14:246–51.PubMedCrossRef Caminal J, Starfield B, Sanchez E, Casanova C, Morales M. The role of primary care in preventing ambulatory care sensitive conditions. Eur J Public Health. 2004;14:246–51.PubMedCrossRef
37.
Zurück zum Zitat Tsai CL, Griswold SK, Clark S, Camargo CA Jr. Factors associated with frequency of emergency department visits for chronic obstructive pulmonary disease exacerbation. J Gen Intern Med. 2007;22:799–804.PubMedCrossRef Tsai CL, Griswold SK, Clark S, Camargo CA Jr. Factors associated with frequency of emergency department visits for chronic obstructive pulmonary disease exacerbation. J Gen Intern Med. 2007;22:799–804.PubMedCrossRef
38.
Zurück zum Zitat Shi L, Samuels ME, Pease M, Bailey WP, Corley EH. Patient characteristics associated with hospitalizations for ambulatory care sensitive conditions in South Carolina. S Med J. 1999;92:989–98.CrossRef Shi L, Samuels ME, Pease M, Bailey WP, Corley EH. Patient characteristics associated with hospitalizations for ambulatory care sensitive conditions in South Carolina. S Med J. 1999;92:989–98.CrossRef
39.
Zurück zum Zitat Rizza P, Bianco A, Pavia M, Angelillo IF. Preventable hospitalization and access to primary health care in an area of Southern Italy. BMC Health Serv Res. 2007;7:134.PubMedCrossRef Rizza P, Bianco A, Pavia M, Angelillo IF. Preventable hospitalization and access to primary health care in an area of Southern Italy. BMC Health Serv Res. 2007;7:134.PubMedCrossRef
40.
Zurück zum Zitat Parchman ML, Culler SD. Preventable hospitalizations in primary care shortage areas. An analysis of vulnerable Medicare beneficiaries. Arch Fam Med. 1999;8:487–91.PubMedCrossRef Parchman ML, Culler SD. Preventable hospitalizations in primary care shortage areas. An analysis of vulnerable Medicare beneficiaries. Arch Fam Med. 1999;8:487–91.PubMedCrossRef
41.
Zurück zum Zitat Bindman AB, Grumbach K, Osmond D, Komaromy M, Vranizan K, Lurie N, et al. Preventable hospitalizations and access to health care. JAMA. 1995;274:305–11.PubMedCrossRef Bindman AB, Grumbach K, Osmond D, Komaromy M, Vranizan K, Lurie N, et al. Preventable hospitalizations and access to health care. JAMA. 1995;274:305–11.PubMedCrossRef
42.
Zurück zum Zitat Prentice JC, Pizer SD. Delayed access to health care and mortality. Health Serv Res. 2007;42:644–62.PubMedCrossRef Prentice JC, Pizer SD. Delayed access to health care and mortality. Health Serv Res. 2007;42:644–62.PubMedCrossRef
43.
Zurück zum Zitat McAlister FA, Lawson FM, Teo KK, Armstrong PW. Randomised trials of secondary prevention programmes in coronary heart disease: systematic review. BMJ. 2001;323:957–62.PubMedCrossRef McAlister FA, Lawson FM, Teo KK, Armstrong PW. Randomised trials of secondary prevention programmes in coronary heart disease: systematic review. BMJ. 2001;323:957–62.PubMedCrossRef
44.
Zurück zum Zitat Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116:682–92.PubMedCrossRef Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116:682–92.PubMedCrossRef
45.
Zurück zum Zitat Clark AM, Hartling L, Vandermeer B, McAlister FA. Meta-analysis: secondary prevention programs for patients with coronary artery disease. Ann Intern Med. 2005;143:659–72.PubMed Clark AM, Hartling L, Vandermeer B, McAlister FA. Meta-analysis: secondary prevention programs for patients with coronary artery disease. Ann Intern Med. 2005;143:659–72.PubMed
46.
Zurück zum Zitat Reducing risk in heart disease. Guidelines for preventing cardiovascular events in people with coronary heart disease. National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand; 2007. Reducing risk in heart disease. Guidelines for preventing cardiovascular events in people with coronary heart disease. National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand; 2007.
47.
Zurück zum Zitat Ades PA. Cardiac rehabilitation and secondary prevention of coronary heart disease. N Engl J Med. 2001;345:892–902.PubMedCrossRef Ades PA. Cardiac rehabilitation and secondary prevention of coronary heart disease. N Engl J Med. 2001;345:892–902.PubMedCrossRef
48.
Zurück zum Zitat Dale KS, Mann JI, McAuley KA, Williams SM, Farmer VL. Sustainability of lifestyle changes following an intensive lifestyle intervention in insulin resistant adults: Follow-up at 2-years. Asia Pac J Clin Nutr. 2009;18:114–20.PubMed Dale KS, Mann JI, McAuley KA, Williams SM, Farmer VL. Sustainability of lifestyle changes following an intensive lifestyle intervention in insulin resistant adults: Follow-up at 2-years. Asia Pac J Clin Nutr. 2009;18:114–20.PubMed
49.
Zurück zum Zitat Hedback B, Perk J, Wodlin P. Long-term reduction of cardiac mortality after myocardial infarction: 10-year results of a comprehensive rehabilitation programme. Eur Heart J. 1993;14:831–5.PubMedCrossRef Hedback B, Perk J, Wodlin P. Long-term reduction of cardiac mortality after myocardial infarction: 10-year results of a comprehensive rehabilitation programme. Eur Heart J. 1993;14:831–5.PubMedCrossRef
Metadaten
Titel
Regular Primary Care Plays a Significant Role in Secondary Prevention of Ischemic Heart Disease in a Western Australian Cohort
verfasst von
Kristjana Einarsdóttir, PhD
David B. Preen, PhD
Jon D. Emery, DPhil, FRACGP
C. D’Arcy J. Holman, PhD, FAFPHM
Publikationsdatum
01.10.2011
Verlag
Springer-Verlag
Erschienen in
Journal of General Internal Medicine / Ausgabe 10/2011
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-011-1665-1

Weitere Artikel der Ausgabe 10/2011

Journal of General Internal Medicine 10/2011 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.