nach oben

Erschienen in:

01.09.2013

Responding to a significant recruitment challenge within three nationwide psychoeducational trials for cancer patients

verfasst von: Annette L. Stanton, Marion E. Morra, Michael A. Diefenbach, Suzanne M. Miller, Rosemarie Slevin Perocchia, Peter C. Raich, Linda Fleisher, Kuang-Yi Wen, Zung Vu Tran, Nihal E. Mohamed, Roshini George, Mary Anne Bright, Alfred C. Marcus

Erschienen in: Journal of Cancer Survivorship | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

When faced with a significant recruitment challenge for three nationwide psychoeducational trials targeting prostate and breast cancer patients, the Cancer Information Service Research Consortium initiated outreach efforts to increase accrual. Recruitment is reported by major outreach strategy to inform the use of similar campaigns, either as primary recruitment efforts or to supplement “in-reach” recruitment within oncology settings.

Methods

During a 33-month period, recruitment was tracked from the National Cancer Institute’s Cancer Information Service (CIS), the American Cancer Society (ACS), Dr. Susan Love Research Foundation’s Love/Avon Army of Women (AOW), Internet advertising, press releases, radio/television interviews, recruitment materials in community venues, and outreach to churches and cancer support organizations.

Results

Across projects, the majority (89 %) of recruited participants (N = 2,134) was obtained from the CIS (n = 901, 19 months of recruitment), AOW (n = 869, 18 months), and ACS (n = 123, 12 months). Other efforts showed minimal gain in recruitment.

Conclusions

Cancer information programs (e.g., CIS and ACS) and registries of individuals willing to participate in cancer-related research (e.g., AOW) can represent exceptional resources for outreach recruitment of cancer patients, especially when the eligibility criteria are highly restrictive. However, these resources do not yield samples representative of the larger population of adults diagnosed with cancer, and conclusions from such trials must be tempered accordingly.

Implications for cancer survivors

Inadequate recruitment to randomized controlled trials limits the creation of useful interventions for cancer survivors. By enrolling in cancer registries and taking part in research, cancer survivors can contribute to the development of effective resources for the survivor population.

IOM (Institute of Medicine). Transforming clinical research in the united states: challenges and opportunities: workshop summary. Washington, DC: The National Academies Press; 2010.

IOM (Institute of Medicine). Public engagement and clinical trials: new models and disruptive technologies: workshop summary. Washington, DC: The National Academies Press; 2012.

IOM (Institute of Medicine). A national cancer clinical trials system for the 21st century: reinvigorating the NCI cooperative group program. Washington, DC: The National Academies Press; 2010.

Goodwin PJ, Leszcz M, Quirt G, et al. Lessons learned from enrollment in the BEST study—a multicenter, randomized trial of group psychosocial support in metastatic breast cancer. J Clin Epidemiol. 2000;53(1):47–55.PubMedCrossRef

Sears SR, Stanton AL, Kwan L, et al. Recruitment and retention challenges in breast cancer survivorship research. Cancer Epidemiol Biomark Prev. 2003;12(10):1087–90.

Snyder DC, Morey MC, Sloane R, et al. Reach out to ENhancE Wellness in Older Cancer Survivors (RENEW): design, methods and recruitment challenges of a home-based exercise and diet intervention to improve physical function among long-term survivors of breast, prostate, and colorectal cancer. Psycho-Oncology. 2009;18(4):429–39.PubMedCrossRef

Mertens AC, Cotter KL, Foster BM, et al. Improving health care for adult survivors of childhood cancer: Recommendations from a delphi panel of health policy experts. Health Policy. 2004;69(2):169–78.PubMedCrossRef

Fredman SJ, Baucom DH, Gremore TM, et al. Quantifying the recruitment challenges with couple-based interventions for cancer: applications to early-stage breast cancer. Psycho-Oncology. 2009;18(6):667–73.PubMedCrossRef

Boyd NR, Sutton C, Orleans CT, et al. Quit Today! A targeted communications campaign to increase use of the Cancer Information Service by African American smokers. Prev Med. 1998;27(5):S50–60.PubMedCrossRef

10.

Campbell MK, Hudson MA, Resnicow K, et al. Church-based health promotion interventions: evidence and lessons learned. Annu Rev Public Health. 2007;28:213–34.PubMedCrossRef

11.

Drake BF, Shelton R, Gilligan T, et al. A church-based intervention to promote informed decision-making for prostate cancer screening among African-American men. J Natl Med Assoc. 2010;102(3):164–71.PubMed

12.

Davis DT, Bustamante A, Brown CP, et al. The urban church and cancer control: a source of social influence in minority communities. Public Health Reports. 1994;109(4):500–6.PubMed

13.

Gilliss CL, Lee KA, Gutierrez Y, et al. Recruitment and retention of healthy minority women into community-based longitudinal research. J Womens Health Gend Based Med. 2001;10(1):77–85.PubMedCrossRef

14.

Paskett ED, Reeves KW, McLaughlin JM, et al. Recruitment of minority and underserved populations in the United States: the centers for population health and health disparities experience. Contemp Clin Trials. 2008;29:847–61.PubMedCrossRef

15.

Gordon JS, Akers L, Severson HH, et al. Successful participant recruitment strategies for an online smokeless tobacco cessation program. Nicotine Tobacco Res. 2006;8 Suppl 1:S35–41.CrossRef

16.

Carroll J, Yancey A, Spring B, et al. What are successful recruitment and retention strategies for underserved populations? Examining physical activity interventions in primary care and community settings. Transl Behav Med. 2011;1(2):234–51.CrossRef

17.

McKay HG, Danaher GB, Seeley RJ, et al. Comparing two web-based smoking cessation programs: randomized controlled trial. J Med Internet Res. 2008;10(5):e40.PubMedCrossRef

18.

Burns EK, Levinson AH. Reaching Spanish-speaking smokers: state-level evidence of untapped potential for quitline utilization. Am J Public Health. 2010;100:S165–70.PubMedCrossRef

19.

Farrelly MC, Hussin A, Bauer UE. Effectivenss and cosst effectiveness of television, radio and print advertisements in promoting the New York smokers’ quitline. Tob Control. 2007;16 Suppl 1:i21–3.PubMedCrossRef

20.

Mosbaek CH, Austin DF, Stark MJ, et al. The association between advertising and calls to a tobacco quitline. Tob Control. 2007;16(Suppl1):i24–9.PubMedCrossRef

21.

Wetter DW, Mazas C, Daza P, et al. Reaching and treating Spanish-speaking smokers through the National Cancer Institute’s Cancer Information Service. A randomized controlled trial. Cancer. 2007;109 Suppl 2:406–13.PubMedCrossRef

22.

Glasgow RE, Nelson CC, Kearney KA, et al. Reach, engagement, and retention in an Internet-based weight loss program in a multi-site randomized controlled trial. J Med Internet Res. 2007;9(2):e11.PubMedCrossRef

23.

Stoy DB, Curtis RC, Dameworth KS, et al. The successful recruitment of elderly black subjects in a clinical trial. The CRISP experience. J Natl Med Assoc. 1995;87:280–7.PubMed

24.

Coleman EA, LaCroix AZ, Allen C, et al. Recruiting African American older adults for a community-based health promotion intervention: which strategies are effective? Am J Prev Med. 1997;13 Suppl 6:51–6.PubMed

25.

Lewis CE, George V, Fouad M, et al. Recruitment strategies in the Women’s Health Trial: feasibility study in minority populations. Control Clin Trials. 1998;19(5):461–76.PubMedCrossRef

26.

Marcus AC, Morra ME, Bettinghaus E, et al. The Cancer Information Service Research Consortium: an emerging laboratory for cancer control research. Prev Med. 1998;27(5):S3–S15.PubMedCrossRef

27.

Marcus AC, Morra ME, Bright MA, et al. The CIS model for collaborative research in health communications: a brief retrospective from the current generation of research. J Health Commun. 2005;10:235–45.PubMedCrossRef

28.

Marcus AC, Diefenbach MA, Stanton AL, et al. Cancer patient and survivor research from the Cancer Information Service Research Consortium: a preview of three large randomized trials and initial lessons learned. J Health Commun. 2013. doi:10.1080/10810730.2012.743629

29.

Wen K-Y, Miller SM, Stanton A, et al. The development and preliminary testing of a multimedia patient-provider survivorship communication module for breast cancer survivors. Patient Educ Couns. 2012;88:344–9.PubMedCrossRef

30.

Personal Communication, Dr. Susan Love. For more information about Love/Avon Army of Women. Available from www.armyofwomen.org.

31.

For more information about the National Black Church Initiative. Available from www.natlblackchurch.com.

32.

American Cancer Society. Cancer facts and figures. Atlanta (GA): American Cancer Society; 2011.

33.

Curry L, Jackson J. Recruitment and retention of diverse ethnic and racial groups in health research. An evolving science. In: Curry L, Jackson J, editors. The science of inclusion: recruiting and retaining racial and ethnic elders in health research. Washington (DC): The Gerontological Society of America; 2003. p. 1–7.

34.

Rosner B. Fundamentals of biostatistics. 7th ed. Boston, MA: Brooks/Cole; 2010.

35.

Ashing-Giwa K, Ganz PA. Effect of timed incentives on subject participation in a study of long-term breast cancer survivors: are there ethnic differences? J Natl Med Assoc. 2000;92:528–32.PubMed

36.

Satia JA, Galanko JA, Rimer BK. Methods and strategies to recruit African Americans into cancer prevention surveillance studies. Cancer Epidemiol Biomark Prev. 2005;14(3):718–21.CrossRef

37.

Brown DR, Fouad MN, Basen-Engquist K, Tortolero-Luna G. Recruitment and retention of minority women in cancer screening, prevention, and treatment trials. Ann Epidemiol. 2000;10(8)(suppl 1):S13–21.PubMedCrossRef

38.

Zhu K, Hunter S, Bernard LJ, et al. Recruiting elderly African Amearican women in cancer prevention and control studies: a multifaceted approach and its effectiveness. J Natl Med Assoc. 2000;92:169–75.PubMed

39.

Blumenthal DS, Sung J, Coates R, Williams J, Liff J. Recruitment and retention of subjects for a longitudinal cancer prevention study in an inner-city black community. Health Serve Res. 1995;30:195–205.

40.

Shavers VL, Lynch CF, Burmeister LF. Racial differences in factors that influence the willingness to participate in medical research studies. Ann Epidemiol. 2002;12:248–56.PubMedCrossRef

41.

Swanson GM, Ward AJ. Recruitng minorities into clinical trials: toward a participant-friendly system. J Natl Cancer Inst. 1995;87(23):1747–59.PubMedCrossRef

42.

Cooley ME, Sarna L, Brown JK, et al. Challenges of recruitment and retention in multisite clinical research. Cancer Nursing. 2003;26(5):376–86.PubMedCrossRef

Titel: Responding to a significant recruitment challenge within three nationwide psychoeducational trials for cancer patients
verfasst von: Annette L. Stanton
Marion E. Morra
Michael A. Diefenbach
Suzanne M. Miller
Rosemarie Slevin Perocchia
Peter C. Raich
Linda Fleisher
Kuang-Yi Wen
Zung Vu Tran
Nihal E. Mohamed
Roshini George
Mary Anne Bright
Alfred C. Marcus
Publikationsdatum: 01.09.2013
Verlag: Springer US
Erschienen in: Journal of Cancer Survivorship / Ausgabe 3/2013
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-013-0282-x

Neu im Fachgebiet Onkologie

„Überwältigende“ Evidenz für Tripeltherapie beim metastasierten Prostata-Ca.

22.05.2024 Prostatakarzinom Nachrichten

Patienten mit metastasiertem hormonsensitivem Prostatakarzinom sollten nicht mehr mit einer alleinigen Androgendeprivationstherapie (ADT) behandelt werden, mahnt ein US-Team nach Sichtung der aktuellen Datenlage. Mit einer Tripeltherapie haben die Betroffenen offenbar die besten Überlebenschancen.

So sicher sind Tattoos: Neue Daten zur Risikobewertung

22.05.2024 Melanom Nachrichten

Das größte medizinische Problem bei Tattoos bleiben allergische Reaktionen. Melanome werden dadurch offensichtlich nicht gefördert, die Farbpigmente könnten aber andere Tumoren begünstigen.

CAR-M-Zellen: Warten auf das große Fressen

22.05.2024 Onkologische Immuntherapie Nachrichten

Auch myeloide Immunzellen lassen sich mit chimären Antigenrezeptoren gegen Tumoren ausstatten. Solche CAR-Fresszell-Therapien werden jetzt für solide Tumoren entwickelt. Künftig soll dieser Prozess nicht mehr ex vivo, sondern per mRNA im Körper der Betroffenen erfolgen.

Blutdrucksenkung könnte Uterusmyome verhindern

21.05.2024 Krebsvorsorge in der Gynäkologie Nachrichten

Frauen mit unbehandelter oder neu auftretender Hypertonie haben ein deutlich erhöhtes Risiko für Uterusmyome. Eine Therapie mit Antihypertensiva geht hingegen mit einer verringerten Inzidenz der gutartigen Tumoren einher.

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Responding to a significant recruitment challenge within three nationwide psychoeducational trials for cancer patients