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Current Atherosclerosis Reports
Erschienen in: Current Atherosclerosis Reports 6/2013

01.06.2013 | Genetics (AJ Marian, Section Editor)

Pro-Inflammatory Genetic Markers of Atherosclerosis

verfasst von: Egle Incalcaterra, Giulia Accardi, Carmela Rita Balistreri, Gregorio Caimi, Giuseppina Candore, Marco Caruso, Calogero Caruso

Erschienen in: Current Atherosclerosis Reports | Ausgabe 6/2013

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Abstract

Atherosclerosis (AS) is a chronic, progressive, multifactorial disease mostly affecting large and medium-sized elastic and muscular arteries. It has formerly been considered a bland lipid storage disease. Currently, multiple independent pathways of evidence suggest this pathological condition is a peculiar form of inflammation, triggered by cholesterol-rich lipoproteins and influenced both by environmental and genetic factors. The Human Genome Project opened up the opportunity to dissect complex human traits and to understand basic pathways of multifactorial diseases such as AS. Population-based association studies have emerged as powerful tools for examining genes with a role in common multifactorial diseases that have a strong environmental component. These association studies often estimate the risk of developing a certain disease in carriers and non-carriers of a particular genetic polymorphism. Dissecting out the influence of pro-inflammatory genes within the complex pathophysiology of AS and its complications will help to provide a more complete risk assessment and complement known classical cardiovascular risk factors. The detection of a risk profile will potentially allow both the early identification of individuals susceptible to disease and the possible discovery of potential targets for drug or lifestyle modification; i.e. it will open the door to personalized medicine.
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Metadaten
Titel
Pro-Inflammatory Genetic Markers of Atherosclerosis
verfasst von
Egle Incalcaterra
Giulia Accardi
Carmela Rita Balistreri
Gregorio Caimi
Giuseppina Candore
Marco Caruso
Calogero Caruso
Publikationsdatum
01.06.2013
Verlag
Current Science Inc.
Erschienen in
Current Atherosclerosis Reports / Ausgabe 6/2013
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-013-0329-5

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