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Current Atherosclerosis Reports
Erschienen in: Current Atherosclerosis Reports 1/2017

01.01.2017 | Coronary Heart Disease (S. Virani and S. Naderi, Section Editors)

Evaluating Periodontal Treatment to Prevent Cardiovascular Disease: Challenges and Possible Solutions

verfasst von: Anwar T. Merchant, Salim S. Virani

Erschienen in: Current Atherosclerosis Reports | Ausgabe 1/2017

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Abstract

Purpose of Review

Periodontal disease is correlated with cardiovascular disease (CVD) in observational studies, but a causal connection has not been established. The empirical evidence linking periodontal disease and CVD consists of a large body of observational and mechanistic studies, but a limited number of clinical trials evaluating the effects of periodontal treatment on surrogate CVD endpoints.

Recent Findings

No randomized controlled trial has been conducted to evaluate the effect of periodontal treatment on CVD risk. In this review, we have summarized these data, described possible biological mechanisms linking periodontal disease and CVD, discussed barriers to conducting a randomized controlled trial to evaluate this hypothesis, and provided an alternative analytical approach using causal inference methods to answer the question.

Summary

The public health implications of addressing this question can be significant because periodontal disease is under-treated, and highly prevalent among adults at risk of CVD. Even a small beneficial effect of periodontal treatment on CVD risk can be important.
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Metadaten
Titel
Evaluating Periodontal Treatment to Prevent Cardiovascular Disease: Challenges and Possible Solutions
verfasst von
Anwar T. Merchant
Salim S. Virani
Publikationsdatum
01.01.2017
Verlag
Springer US
Erschienen in
Current Atherosclerosis Reports / Ausgabe 1/2017
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-017-0640-7

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