Skip to main content
Erschienen in: Current Atherosclerosis Reports 9/2021

01.09.2021 | Reviews and New Research Implications (S. Virani, Section Editor)

Highlights from Studies Presented at the Virtual American College of Cardiology Scientific Sessions 2021: Staying Updated with the Latest Advancements in Prevention

verfasst von: Vardhmaan Jain, Mahmoud Al Rifai, Dhruv Mahtta, Jing Liu, Aliza Hussain, Salim S. Virani

Erschienen in: Current Atherosclerosis Reports | Ausgabe 9/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

This review highlights late-breaking science presented at the Virtual American College of Cardiology Scientific Sessions 2021 that demonstrated advancements in preventative cardiology and introduced novel therapeutic modalities for the management of chronic kidney disease, heart failure, and COVID-19.

Recent Findings

The studies reviewed include clinical trials that assessed the use of dapagliflozin in patients with respiratory failure due to COVID-19 (DARE-19 trial); evinacumab for patients with severe hypertriglyceridemia and pancreatitis; effect of genotype-guided oral P2y12 inhibitors vs conventional clopidogrel on long-term ischemic outcomes after percutaneous coronary intervention (TAILOR-PCI trial); anticoagulation in patients hospitalized with COVID-19 (ACTION trial); atorvastatin vs placebo in patients with COVID-19 admitted to the ICU (INSPIRATION-S trial); rehabilitation therapy in older acute heart failure patients (REHAB-HF trial); and aspirin dosing: a patient-centric trial assessing benefits and long-term effectiveness (ADAPTABLE trial). In addition, we review the results of the American College of Cardiology Global Heart Attack Initiative (GHATI). Finally, we discuss the secondary analysis of the STRENGTH trial assessing the association of achieved levels of omega-3 fatty acid levels and major cardiovascular outcomes.

Summary

The studies presented at the virtual American College of Cardiology Scientific Session 2021 represent remarkable contributions in the field of cardiovascular disease and prevention.
Literatur
1.
Zurück zum Zitat Nissen SE, Lincoff AM, Wolski K, Ballantyne CM, Kastelein JJP, Ridker PM, Ray KK, McGuire DK, Mozaffarian D, Koenig W, Davidson MH, Garcia M, Katona BG, Himmelmann A, Loss LE, Poole M, Menon V, Nicholls SJ Association between achieved ω-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk: a secondary analysis of the STRENGTH trial. JAMA Cardiol. (2021) https://doi.org/10.1001/jamacardio.2021.1157 Nissen SE, Lincoff AM, Wolski K, Ballantyne CM, Kastelein JJP, Ridker PM, Ray KK, McGuire DK, Mozaffarian D, Koenig W, Davidson MH, Garcia M, Katona BG, Himmelmann A, Loss LE, Poole M, Menon V, Nicholls SJ Association between achieved ω-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk: a secondary analysis of the STRENGTH trial. JAMA Cardiol. (2021) https://​doi.​org/​10.​1001/​jamacardio.​2021.​1157
2.•
Zurück zum Zitat Jones WS, Mulder H, Wruck LM, et al. Comparative effectiveness of aspirin dosing in cardiovascular disease. N Engl J Med. 2021;2021. https://doi.org/10.1056/NEJMoa2102137In a randomized trial of over 15,000 participants with established coronary artery disease randomized to receive either aspirin 81mg or aspirin 325mg, there was no difference in the rate of adverse cardiac events or major bleeding. However, there was significant dose switching in the group assigned to receive aspirin 325 mg. Jones WS, Mulder H, Wruck LM, et al. Comparative effectiveness of aspirin dosing in cardiovascular disease. N Engl J Med. 2021;2021. https://​doi.​org/​10.​1056/​NEJMoa2102137In a randomized trial of over 15,000 participants with established coronary artery disease randomized to receive either aspirin 81mg or aspirin 325mg, there was no difference in the rate of adverse cardiac events or major bleeding. However, there was significant dose switching in the group assigned to receive aspirin 325 mg.
3.••
Zurück zum Zitat Kitzman DW, Whellan DJ, Duncan P, et al. Physical rehabilitation for older patients hospitalized for heart failure. N Engl J Med. 2021;2021. https://doi.org/10.1056/NEJMoa2026141In 349 older patients who were hospitalized for acute decompensated heart failure randomized to either routine care or an early, transitional, tailored, progressive rehabilitation intervention that included multiple physical-function domains, there was a greater improvement in physical function in the group that received rehabilitation than usual care. While there was no difference in all-cause mortality or rate of readmission, the improvement in functional status was clinically meaningful. Kitzman DW, Whellan DJ, Duncan P, et al. Physical rehabilitation for older patients hospitalized for heart failure. N Engl J Med. 2021;2021. https://​doi.​org/​10.​1056/​NEJMoa2026141In 349 older patients who were hospitalized for acute decompensated heart failure randomized to either routine care or an early, transitional, tailored, progressive rehabilitation intervention that included multiple physical-function domains, there was a greater improvement in physical function in the group that received rehabilitation than usual care. While there was no difference in all-cause mortality or rate of readmission, the improvement in functional status was clinically meaningful.
4.
Zurück zum Zitat Pereira NL, Farkouh ME, So D, Lennon R, Geller N, Mathew V, et al. Effect of genotype-guided oral P2Y12 inhibitor selection vs conventional clopidogrel therapy on ischemic outcomes after percutaneous coronary intervention: the TAILOR-PCI randomized clinical trial. JAMA. 2020;324:761–71.CrossRef Pereira NL, Farkouh ME, So D, Lennon R, Geller N, Mathew V, et al. Effect of genotype-guided oral P2Y12 inhibitor selection vs conventional clopidogrel therapy on ischemic outcomes after percutaneous coronary intervention: the TAILOR-PCI randomized clinical trial. JAMA. 2020;324:761–71.CrossRef
5.
Zurück zum Zitat Hussain A, Al Rifai M, Mahtta D, Liu J, Jain V, Virani SS. Highlights from studies presented at the American Heart Association Scientific Session 2020: navigating new roads in prevention. Curr Atheroscler Rep. 2020;23:1–9. Hussain A, Al Rifai M, Mahtta D, Liu J, Jain V, Virani SS. Highlights from studies presented at the American Heart Association Scientific Session 2020: navigating new roads in prevention. Curr Atheroscler Rep. 2020;23:1–9.
6.
Zurück zum Zitat Jia X, Al Rifai M, Hussain A, Martin S, Agarwala A, Virani SS. Highlights from studies in cardiovascular disease prevention presented at the digital 2020 European Society of Cardiology Congress: prevention is alive and well. Curr Atheroscler Rep. 2020;22:72.CrossRef Jia X, Al Rifai M, Hussain A, Martin S, Agarwala A, Virani SS. Highlights from studies in cardiovascular disease prevention presented at the digital 2020 European Society of Cardiology Congress: prevention is alive and well. Curr Atheroscler Rep. 2020;22:72.CrossRef
7.
Zurück zum Zitat Jia X, Al Rifai M, Liu J, Agarwala A, Gulati M, Virani SS. Highlights of Studies in cardiovascular disease prevention presented at the 2020 American College of Cardiology Annual Scientific Session. Curr Atheroscler Rep. 2020;22:32.CrossRef Jia X, Al Rifai M, Liu J, Agarwala A, Gulati M, Virani SS. Highlights of Studies in cardiovascular disease prevention presented at the 2020 American College of Cardiology Annual Scientific Session. Curr Atheroscler Rep. 2020;22:32.CrossRef
8.••
Zurück zum Zitat Bhatt DL, Szarek M, Pitt B, et al. Sotagliflozin in patients with diabetes and chronic kidney disease. N Engl J Med. 2021;384:129–39 In a randomized trial of 10,584 heart failure patients with diabetes and chronic kidney disease, sotagliflozin (compared with placebo) was associated with a significant risk reduction in the composite end point of cardiac death and hospitalizations/urgent care visits for heart failure.CrossRef Bhatt DL, Szarek M, Pitt B, et al. Sotagliflozin in patients with diabetes and chronic kidney disease. N Engl J Med. 2021;384:129–39 In a randomized trial of 10,584 heart failure patients with diabetes and chronic kidney disease, sotagliflozin (compared with placebo) was associated with a significant risk reduction in the composite end point of cardiac death and hospitalizations/urgent care visits for heart failure.CrossRef
9.••
Zurück zum Zitat Bhatt DL, Szarek M, Steg PG, et al. Sotagliflozin in patients with diabetes and recent worsening heart failure. N Engl J Med. 2021;384:117–28 In a randomized trial of 1,222 patients with diabetes who were hospitalized for worsening heart failure, sotagliflozin (compared with placebo) was associated with a significant risk reduction in the composite end point of cardiac death and hospitalizations/urgent care visits for heart failure.CrossRef Bhatt DL, Szarek M, Steg PG, et al. Sotagliflozin in patients with diabetes and recent worsening heart failure. N Engl J Med. 2021;384:117–28 In a randomized trial of 1,222 patients with diabetes who were hospitalized for worsening heart failure, sotagliflozin (compared with placebo) was associated with a significant risk reduction in the composite end point of cardiac death and hospitalizations/urgent care visits for heart failure.CrossRef
10.
Zurück zum Zitat Yancy CW, Jessup M, Bozkurt B, Butler J, Casey de Jr, Colvin MM, et al. 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136:e137–61.CrossRef Yancy CW, Jessup M, Bozkurt B, Butler J, Casey de Jr, Colvin MM, et al. 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136:e137–61.CrossRef
11.
Zurück zum Zitat Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, et al. Regional variation in patients and outcomes in the treatment of preserved cardiac function heart failure with an aldosterone antagonist (TOPCAT) trial. Circulation. 2015;131:34–42.CrossRef Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, et al. Regional variation in patients and outcomes in the treatment of preserved cardiac function heart failure with an aldosterone antagonist (TOPCAT) trial. Circulation. 2015;131:34–42.CrossRef
13.
Zurück zum Zitat Williams DM, Evans M. Dapagliflozin for heart failure with preserved ejection fraction: will the DELIVER study deliver? Diabetes Ther. 2020;11:2207–19.CrossRef Williams DM, Evans M. Dapagliflozin for heart failure with preserved ejection fraction: will the DELIVER study deliver? Diabetes Ther. 2020;11:2207–19.CrossRef
14.
Zurück zum Zitat Anker SD, Butler J, Filippatos GS, Jamal W, Salsali A, Schnee J, et al. Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved trial. Eur J Heart Fail. 2019;21:1279–87.CrossRef Anker SD, Butler J, Filippatos GS, Jamal W, Salsali A, Schnee J, et al. Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved trial. Eur J Heart Fail. 2019;21:1279–87.CrossRef
15.
Zurück zum Zitat Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18:844–7.CrossRef Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18:844–7.CrossRef
16.
Zurück zum Zitat Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–7.CrossRef Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020;191:145–7.CrossRef
19.
Zurück zum Zitat Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018;6:691–8.CrossRef Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, et al. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018;6:691–8.CrossRef
20.
Zurück zum Zitat Gupta A, Madhavan MV, Poterucha TJ, DeFilippis EM, Hennessey JA, Redfors B, et al. Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Nat Commun. 2021;12:1325.CrossRef Gupta A, Madhavan MV, Poterucha TJ, DeFilippis EM, Hennessey JA, Redfors B, et al. Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19. Nat Commun. 2021;12:1325.CrossRef
21.
Zurück zum Zitat Ford ES, Li C, Zhao G, Pearson WS, Mokdad AH. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med. 2009;169:572–8.CrossRef Ford ES, Li C, Zhao G, Pearson WS, Mokdad AH. Hypertriglyceridemia and its pharmacologic treatment among US adults. Arch Intern Med. 2009;169:572–8.CrossRef
22.
Zurück zum Zitat Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007;115:450–8.CrossRef Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007;115:450–8.CrossRef
23.
Zurück zum Zitat Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308.CrossRef Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308.CrossRef
24.
Zurück zum Zitat Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med. 2014;25:689–94.CrossRef Valdivielso P, Ramírez-Bueno A, Ewald N. Current knowledge of hypertriglyceridemic pancreatitis. Eur J Intern Med. 2014;25:689–94.CrossRef
25.
Zurück zum Zitat Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, et al. ANGPTL3 deficiency and protection against coronary artery disease. J Am Coll Cardiol. 2017;69:2054–63.CrossRef Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, et al. ANGPTL3 deficiency and protection against coronary artery disease. J Am Coll Cardiol. 2017;69:2054–63.CrossRef
26.
Zurück zum Zitat Dewey FE, Gusarova V, Dunbar RL, O’Dushlaine C, Schurmann C, Gottesman O, et al. Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease. N Engl J Med. 2017;377:211–21.CrossRef Dewey FE, Gusarova V, Dunbar RL, O’Dushlaine C, Schurmann C, Gottesman O, et al. Genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease. N Engl J Med. 2017;377:211–21.CrossRef
27.
Zurück zum Zitat Ahmad Z, Banerjee P, Hamon S, Chan KC, Bouzelmat A, Sasiela WJ, et al. Inhibition of angiopoietin-like protein 3 with a monoclonal antibody reduces triglycerides in hypertriglyceridemia. Circulation. 2019;140:470–86.CrossRef Ahmad Z, Banerjee P, Hamon S, Chan KC, Bouzelmat A, Sasiela WJ, et al. Inhibition of angiopoietin-like protein 3 with a monoclonal antibody reduces triglycerides in hypertriglyceridemia. Circulation. 2019;140:470–86.CrossRef
28.
Zurück zum Zitat Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380:11–22.CrossRef Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, Ketchum SB, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med. 2019;380:11–22.CrossRef
29.
Zurück zum Zitat Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: The STRENGTH randomized clinical trial. JAMA. 2020;324:2268–80.CrossRef Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: The STRENGTH randomized clinical trial. JAMA. 2020;324:2268–80.CrossRef
30.
Zurück zum Zitat Virani SS, Nambi V, Ballantyne CM. Has the ‘strength’ of fish oil therapy been ‘reduced’? Reconciling the results of REDUCE-IT and STRENGTH. European Heart Journal - Cardiovascular Pharmacotherapy. 2021;7:e7–8.CrossRef Virani SS, Nambi V, Ballantyne CM. Has the ‘strength’ of fish oil therapy been ‘reduced’? Reconciling the results of REDUCE-IT and STRENGTH. European Heart Journal - Cardiovascular Pharmacotherapy. 2021;7:e7–8.CrossRef
31.
Zurück zum Zitat Levenson B, Herrera C, Wilson BH. New ACC global heart attack treatment initiative: improving STEMI Care worldwide. J Am Coll Cardiol. 2020;75:1605–8.CrossRef Levenson B, Herrera C, Wilson BH. New ACC global heart attack treatment initiative: improving STEMI Care worldwide. J Am Coll Cardiol. 2020;75:1605–8.CrossRef
32.
Zurück zum Zitat Mega JL, Simon T, Collet J-P, Anderson JL, Antman EM, Bliden K, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA. 2010;304:1821–30.CrossRef Mega JL, Simon T, Collet J-P, Anderson JL, Antman EM, Bliden K, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA. 2010;304:1821–30.CrossRef
33.
Zurück zum Zitat Jones WS, Mulder H, Wruck LM, et al (2021) Comparative effectiveness of aspirin dosing in cardiovascular disease. New England Journal of Medicine 0:null Jones WS, Mulder H, Wruck LM, et al (2021) Comparative effectiveness of aspirin dosing in cardiovascular disease. New England Journal of Medicine 0:null
Metadaten
Titel
Highlights from Studies Presented at the Virtual American College of Cardiology Scientific Sessions 2021: Staying Updated with the Latest Advancements in Prevention
verfasst von
Vardhmaan Jain
Mahmoud Al Rifai
Dhruv Mahtta
Jing Liu
Aliza Hussain
Salim S. Virani
Publikationsdatum
01.09.2021
Verlag
Springer US
Erschienen in
Current Atherosclerosis Reports / Ausgabe 9/2021
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-021-00952-1

Weitere Artikel der Ausgabe 9/2021

Current Atherosclerosis Reports 9/2021 Zur Ausgabe

Cardiometabolic Disease and Treatment (E. Brinton, Section Editor)

Lipoprotein (a): When to Measure and How to Treat?

Coronary Heart Disease (S. Virani and S. Naderi, Section Editors)

Polygenic Risk Scores to Identify CVD Risk and Tailor Therapy: Hope or Hype?

Women and Ischemic Heart Disease (J.M. Peña and F. Lin, Section Editors)

Coronary Microvascular Dysfunction: A Practical Approach to Diagnosis and Management

Women and Ischemic Heart Disease (J.M. Peña and F. Lin, Section Editors)

Management of Ischemic Heart Disease in Pregnancy

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

29.05.2024 Larynxkarzinom Nachrichten

Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.