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Current Diabetes Reports

Erschienen in:

01.12.2012 | Genetics (T Frayling, Section Editor)

What Will Diabetes Genomes Tell Us?

verfasst von: Karen L. Mohlke, Laura J. Scott

Erschienen in: Current Diabetes Reports | Ausgabe 6/2012

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Abstract

A new generation of genetic studies of diabetes is underway. Following from initial genome-wide association (GWA) studies, more recent approaches have used genotyping arrays of more densely spaced markers, imputation of ungenotyped variants based on improved reference haplotype panels, and sequencing of protein-coding exomes and whole genomes. Experimental and statistical advances make possible the identification of novel variants and loci contributing to trait variation and disease risk. Integration of sequence variants with functional analysis is critical to interpreting the consequences of identified variants. We briefly review these methods and technologies and describe how they will continue to expand our understanding of the genetic risk factors and underlying biology of diabetes.

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Titel: What Will Diabetes Genomes Tell Us?
verfasst von: Karen L. Mohlke
Laura J. Scott
Publikationsdatum: 01.12.2012
Verlag: Current Science Inc.
Erschienen in: Current Diabetes Reports / Ausgabe 6/2012
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-012-0321-4

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