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Current Diabetes Reports

Erschienen in:

01.10.2018 | Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)

Early-Life Exposures and Risk of Diabetes Mellitus and Obesity

verfasst von: Véronique Gingras, Marie-France Hivert, Emily Oken

Erschienen in: Current Diabetes Reports | Ausgabe 10/2018

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Abstract

Purpose of Review

Type 2 diabetes is a growing concern worldwide with increasing incidence in youth. Development of preventive strategies in earlier stages of life is crucial. We aimed to examine epidemiological evidence of early-life exposures and their associations with childhood and later risk of obesity and diabetes, and to discuss potential mechanisms.

Recent Findings

Parental obesity and diabetes in the preconception period may influence offspring’s obesity risk via epigenetic mechanisms influencing gametogenesis and early development that could have significant transgenerational effects. A more comprehensive understanding of these effects is needed to identify possible avenues for interventions in both fathers and mothers to be. In addition, current evidence suggests that growth and body weight trajectories in infancy and childhood are useful indicators of later obesity and type 2 diabetes. Moreover, the composition and variations in the microbiome in early life are associated with long-term health and could mediate associations between several early-life exposures and later risk of diseases.

Summary

Altogether, the epidemiological evidence supports the need for preconception and early-life interventions to reduce the obesity and diabetes burden in later life.

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Titel: Early-Life Exposures and Risk of Diabetes Mellitus and Obesity
verfasst von: Véronique Gingras
Marie-France Hivert
Emily Oken
Publikationsdatum: 01.10.2018
Verlag: Springer US
Erschienen in: Current Diabetes Reports / Ausgabe 10/2018
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-018-1050-0

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Early-Life Exposures and Risk of Diabetes Mellitus and Obesity

Abstract

Purpose of Review

Recent Findings

Summary

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Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Abstract

Purpose of Review

Recent Findings

Summary

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Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

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Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin