nach oben

Current Hypertension Reports

Erschienen in:

01.04.2020 | Hypertension and the Kidney (RM Carey, Section Editor)

New Insights on Chronotherapy in Hypertension: Is Timing Everything?

verfasst von: Christina Thoonkuzhy, Mahboob Rahman

Erschienen in: Current Hypertension Reports | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

With the wider availability and use of ambulatory blood pressure monitoring, there has been increasing interest in diurnal variations of blood pressure and its clinical significance. Nocturnal hypertension is of particular interest due to its predictive value in cardiovascular and all-cause mortality outcomes. The purpose of this paper is to review the clinical significance of nocturnal hypertension, summarize the literature regarding chronotherapy in hypertension, and explore the potential for nighttime dosing of antihypertensives to improve clinical outcomes.

Recent Findings

The results from current literature evaluating the effect of nighttime dosing of antihypertensive drugs on blood pressure are inconsistent, with some studies showing a substantial effect of nighttime administration of antihypertensive drugs on blood pressure, and others a more modest effect. Some clinical trials demonstrate a significant improvement in clinical outcomes with nighttime administration of antihypertensive medications and other large trials are currently in progress.

Summary

Chronotherapy remains an important area of research in hypertension.

Polonsky TS, Bakris GL. Ambulatory blood pressure monitoring. JAMA J Am Med Assoc. 2018;320(17):1807–8. https://doi.org/10.1001/jama.2018.14856.CrossRef

Drawz PE, Alper AB, Anderson AH, Brecklin CS, Charleston J, Chen J, et al. Masked hypertension and elevated nighttime blood pressure in CKD: prevalence and association with target organ damage. Clin J Am Soc Nephrol. 2016;11(4):642–52. https://doi.org/10.2215/CJN.08530815.CrossRefPubMedPubMedCentral

U.S. Preventative Services Task Force. Final recommendation statement: high blood pressure in adults: screening. https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/high-blood-pressure-in-adults-screening. Published 2019. Accessed 27 Sept 2019.

Stergiou GS, Kario K, Kollias A, McManus RJ, Ohkubo T, Parati G, et al. Home blood pressure monitoring in the 21st century. J Clin Hypertens. 2018;20(7):1116–21. https://doi.org/10.1111/jch.13284.CrossRef

•• Kario K. Nocturnal hypertension new technology and evidence. Hypertension. 2018;71(6):997–1009. https://doi.org/10.1161/HYPERTENSIONAHA.118.10971. An excellent source that delves into the pathophysiology and recent studies regarding nocturnal hypertension. Published within the past 2 years. CrossRefPubMed

Hansen TW, Li Y, Boggia J, Thijs L, Richart T, Staessen JA. Predictive role of the nighttime blood pressure. Hypertension. 2011;57(1):3–10. https://doi.org/10.1161/HYPERTENSIONAHA.109.133900.CrossRefPubMed

Yan B, Peng L, Han D, Sun L, Dong Q, Yang P, Zheng F, Ong H, Zeng L, Wang G. Blood pressure reverse-dipping is associated with early formation of carotid plaque in senior hypertensive patients. Medicine (Baltimore). 2015;94(10). doi:https://doi.org/10.1097/MD.0000000000000604

•• Sogunuru GP, Kario K, Shin J, Chen C, Buranakitjaroen P, Chia YC, et al. Morning surge in blood pressure and blood pressure variability in Asia: evidence and statement from the HOPE Asia Network. J Clin Hypertens. 2018;21(2):324–35. https://doi.org/10.1111/jch.13451. An indepth review of morning blood pressure surge and its implications. Published within the past 2 years. CrossRef

Bilo G, Grillo A, Guida V, Parati G. Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects. Integr Blood Press Control. 2018;11:47–56. https://doi.org/10.2147/IBPC.S130277.CrossRefPubMedPubMedCentral

10.

Cheng H-M, Wu C-L, Sung S-H, Lee J-C, Kario K, Chiang CE, Huang CJ, Hsu PF, Chuang SY, Lakatta EG, Yin FCP, Chou P, Chen C-H. Prognostic utility of morning blood pressure surge for 20-year all-cause and cardiovascular mortalities: results of a community-based study. J Am Heart Assoc. 2017;6(12). doi:https://doi.org/10.1161/JAHA.117.007667

11.

Cuspidi C, Sala C, Tadic M, Gherbesi E, De Giorgi A, Grassi G, et al. Clinical and prognostic significance of a reverse dipping pattern on ambulatory monitoring: an updated review. J Clin Hypertens. 2017;19(7):713–21. https://doi.org/10.1111/jch.13023.CrossRef

12.

Kimura G. Kidney and circadian blood pressure rhythm. Hypertension. 2008;51(4):827–8. https://doi.org/10.1161/HYPERTENSIONAHA.108.110213.CrossRefPubMed

13.

Laffin LJ, Bakris GL. Has the sun set on nighttime dosing in uncomplicated hypertension? Hypertension. 2018;72(4):836–8. https://doi.org/10.1161/HYPERTENSIONAHA.118.11207.CrossRefPubMedPubMedCentral

14.

Ziegler MG, Milic M. Sympathetic nerves and hypertension in stress, sleep apnea, and caregiving. Curr Opin Nephrol Hypertens. 2017;26(1):26–30. https://doi.org/10.1097/MNH.0000000000000288.CrossRefPubMed

15.

Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarex V, et al. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med. 2002;347(11):797–805.CrossRef

16.

Cuspidi C, Facchetti R, Bombelli M, Sala C, Negri F, Grassi G, et al. Nighttime blood pressure and new-onset left ventricular hypertrophy: findings from the Pamela population. Hypertension. 2013;62(1):78–84. https://doi.org/10.1161/HYPERTENSIONAHA.111.00682.CrossRefPubMed

17.

Staessen JA, Yang WY, Melgarejo JD, Thijs L, Zhang ZY, Boggia J, et al. Association of office and ambulatory blood pressure with mortality and cardiovascular outcomes. JAMA J Am Med Assoc. 2019;322(5):409–20. https://doi.org/10.1001/jama.2019.9811.CrossRef

18.

• Roush GC, Fapohunda J, Kostis JB. Evening dosing of antihypertensive therapy to reduce cardiovascular events: a third type of evidence based on a systematic review and meta-analysis of randomized trials. J Clin Hypertens. 2014;16(8):561–8. https://doi.org/10.1111/jch.12354. A systematic review of evening dosing trials with a special focus on the HOPE study. CrossRef

19.

Roush GC, Fagard RH, Salles GF, Pierdomenico SD, Reboldi G, Verdecchiaf P, et al. Prognostic impact from clinic, daytime, and nighttime systolic blood pressure in nine cohorts of 13844 patients with hypertension. J Hypertens. 2014;32(12):2332–40. https://doi.org/10.1097/HJH.0000000000000355.CrossRefPubMed

20.

Khodadoustan S, Nasri Ashrafi I, Vanaja Satheesh K, Kumar C, Shekar HS, Chikkalingaiah S. Evaluation of the effect of time dependent dosing on pharmacokinetic and pharmacodynamics of amlodipine in normotensive and hypertensive human subjects. Clin Exp Hypertens. 2017;39(6):520–6. https://doi.org/10.1080/10641963.2017.1281947.CrossRefPubMed

21.

Morgan T, Anderson A, Jones E. The effect on 24 h blood pressure control of an angiotensin converting enzyme inhibitor (perindopril) administered in the morning or at night. J Hypertens. 1997;15(2):205–11. https://doi.org/10.1097/00004872-199715020-00012.CrossRefPubMed

22.

Hermida RC, Ayala DE, Mojón A, Fernández JR. Bedtime dosing of antihypertensive medications reduces cardiovascular risk in CKD. J Am Soc Nephrol. 2011;22(12):2313–21. https://doi.org/10.1681/ASN.2011040361.CrossRefPubMedPubMedCentral

23.

Almirall J, Comas L, Martínez-Ocaña JC, Roca S, Arnau A. Effects of chronotherapy on blood pressure control in non-dipper patients with refractory hypertension. Nephrol Dial Transplant. 2012;27(5):1855–9. https://doi.org/10.1093/ndt/gfr557.CrossRefPubMed

24.

• Poulter NR, Savopoulos C, Anjum A, Apostolopoulou M, Chapman N, Cross M, et al. Randomized crossover trial of the impact of morning or evening dosing of antihypertensive agents on 24-hour ambulatory blood pressure the HARMONY trial. Hypertension. 2018;72(4):870–3. https://doi.org/10.1161/HYPERTENSIONAHA.118.11101. The HARMONY trial implicated that timing of antihypertensive medication administration did not affect ambulatory blood pressure measures. Published within the last two years. CrossRefPubMed

25.

Rossen NB, Knudsen ST, Fleischer J, Hvas AM, Ebbehøj E, Poulsen PL, et al. Targeting nocturnal hypertension in type 2 diabetes mellitus. Hypertension. 2014;64(5):1080–7. https://doi.org/10.1161/HYPERTENSIONAHA.114.03958.CrossRefPubMed

26.

Minutolo R, Gabbai FB, Borrelli S, Scigliano R, Trucillo P, Baldanza D, et al. Changing the timing of antihypertensive therapy to reduce nocturnal blood pressure in CKD: an 8-week uncontrolled trial. Am J Kidney Dis. 2007;50(6):908–17. https://doi.org/10.1053/j.ajkd.2007.07.020.CrossRefPubMed

27.

Rahman M, Greene T, Phillips RA, Agodoa LY, Bakris GL, Charleston J, et al. A trial of 2 strategies to reduce nocturnal blood pressure in blacks with chronic kidney disease. Hypertension. 2013;61(1):82–8. https://doi.org/10.1161/HYPERTENSIONAHA.112.200477.CrossRefPubMed

28.

Rakugi H, Kario K, Enya K, Igeta M, Ikeda Y. Effect of azilsartan versus candesartan on nocturnal blood pressure variation in Japanese patients with essential hypertension. Blood Press. 2013;22(S1):22–8. https://doi.org/10.3109/08037051.2013.818758.CrossRefPubMed

29.

Serinel Y, Yee BJ, Grunstein RR, Wong KH, Cistulli PA, Arima H, et al. Chronotherapy for hypertension in obstructive sleep apnoea (CHOSA): a randomised, double-blind, placebo-controlled crossover trial. Thorax. 2017;72(6):550–8. https://doi.org/10.1136/thoraxjnl-2016-209504.CrossRefPubMed

30.

• Zhao P, Xu P, Wan C, Wang Z. Evening versus morning dosing regimen drug therapy for hypertension (Review). 2011;(10). doi:https://doi.org/10.1002/14651858.CD004184.pub2.www.cochranelibrary.com. A systematic review of 21 randomized control trials that illustrated that bedtime dosing of blood pressure medications had better efficacy in lowering BP than morning administration.

31.

The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med. 2000;342(3):145–53.CrossRef

32.

•• Hermida RC, Ayala DE, Mojón A, Fernández JR. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int. 2010;27(8):1629–51. https://doi.org/10.3109/07420528.2010.510230. A landmark trial showing significant benefit of ingesting antihypertensives at nighttime. CrossRefPubMed

33.

•• Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, et al. Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2019. https://doi.org/10.1093/eurheartj/ehz754. Published almost 10 years after the MAPEC trial, the HYGIA trial once again highlights the importance of nighttime dosing of antihypertensives for cardiovascular disease risk reduction. Published within the past 1 year.

34.

Cardiovascular disease and risk management: standards of medical care in diabetes - 2019. Diabetes Care. 2019;42(Supplement 1):S103-S123. doi:https://doi.org/10.2337/dc19S010.

35.

Williams B, Masera G. 2018 ESC/ESH guidelines for the management of arterial hypertension the Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Vol 00.; 2018. doi:https://doi.org/10.1093/eurheartj/ehy339.

36.

•• Rorie DA, Rogers A, MacKenzie IS, Ford I, Webb DJ, Willams B, Brown M, Poulter N, Findlay E, Saywood W, MacDonald TM. Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment in Morning versus Evening (TIME) study. BMJ Open. 2016;6(2). doi:https://doi.org/10.1136/bmjopen-2015-010313. One of the largest trials regarding chronotherapy in hypertension that is currently in progress.

Titel: New Insights on Chronotherapy in Hypertension: Is Timing Everything?
verfasst von: Christina Thoonkuzhy
Mahboob Rahman
Publikationsdatum: 01.04.2020
Verlag: Springer US
Erschienen in: Current Hypertension Reports / Ausgabe 4/2020
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-020-1032-x

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

New Insights on Chronotherapy in Hypertension: Is Timing Everything?

Abstract

Purpose of Review

Recent Findings

Summary

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2020

Hypertension and Reproduction

Sleep Disordered Breathing, a Novel, Modifiable Risk Factor for Hypertensive Disorders of Pregnancy

Baroreflex Amplification and Carotid Body Modulation for the Treatment of Resistant Hypertension

Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney?

Exploring the Molecular Aetiology of Preeclampsia by Massive Parallel Sequencing of DNA

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin