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Erschienen in: Current Rheumatology Reports 4/2015

01.04.2015 | Antiphospholipid Syndrome (D Erkan, Section Editor)

Pediatric Antiphospholipid Syndrome

verfasst von: Cassyanne L. Aguiar, Arzu Soybilgic, Tadej Avcin, Barry L. Myones

Erschienen in: Current Rheumatology Reports | Ausgabe 4/2015

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Abstract

Antiphospholipid syndrome (APS) is a multisystem autoimmune condition characterized by vascular thromboses associated with persistently positive antiphospholipid antibodies. There is currently a paucity of data (incidence, prevalence, thrombosis risk, and effective treatment) in pediatric APS. The purpose of this report is to review the current literature on APS in children and neonates, identify the gaps in current knowledge, and suggest avenues for studies to fill those gaps.
Literatur
1.
Zurück zum Zitat Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295–306.PubMed Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295–306.PubMed
2.
Zurück zum Zitat Avcin T, Ambrozic A, Kuhar M, et al. Anticardiolipin and anti-beta(2) glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits. Rheumatology (Oxford). 2001;40(5):565–73. Avcin T, Ambrozic A, Kuhar M, et al. Anticardiolipin and anti-beta(2) glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits. Rheumatology (Oxford). 2001;40(5):565–73.
3.
Zurück zum Zitat Berkun Y, Simchen M, Strauss T, et al. Antiphospholipid antibodies in neonates with stroke–a unique entity or variant of antiphospholipid syndrome? Lupus. 2014;23(10):986–93.PubMed Berkun Y, Simchen M, Strauss T, et al. Antiphospholipid antibodies in neonates with stroke–a unique entity or variant of antiphospholipid syndrome? Lupus. 2014;23(10):986–93.PubMed
4.
Zurück zum Zitat Avcin T, Toplak N. Antiphospholipid antibodies in response to infection. Curr Rheumatol Rep. 2007;9(3):212–8.PubMed Avcin T, Toplak N. Antiphospholipid antibodies in response to infection. Curr Rheumatol Rep. 2007;9(3):212–8.PubMed
5.
Zurück zum Zitat Gharavi AE, Pierangeli SS, Espinola RG, et al. Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo. Arthritis Rheum. 2002;46(2):545–52.PubMed Gharavi AE, Pierangeli SS, Espinola RG, et al. Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus-derived peptide cause thrombosis and activation of endothelial cells in vivo. Arthritis Rheum. 2002;46(2):545–52.PubMed
6.
Zurück zum Zitat Gharavi AE, Pierangeli SS. Origin of antiphospholipid antibodies: induction of aPL by viral peptides. Lupus. 1998;7 Suppl 2:S52–4.PubMed Gharavi AE, Pierangeli SS. Origin of antiphospholipid antibodies: induction of aPL by viral peptides. Lupus. 1998;7 Suppl 2:S52–4.PubMed
7.
Zurück zum Zitat Gharavi AE, Vega-Ostertag M, Espinola RG, et al. Intrauterine fetal death in mice caused by cytomegalovirus-derived peptide induced aPL antibodies. Lupus. 2004;13(1):17–23.PubMed Gharavi AE, Vega-Ostertag M, Espinola RG, et al. Intrauterine fetal death in mice caused by cytomegalovirus-derived peptide induced aPL antibodies. Lupus. 2004;13(1):17–23.PubMed
8.
Zurück zum Zitat Wenzel C, Stoiser B, Locker G, et al. Frequent development of lupus anticoagulants in critically ill patients treated under intensive care conditions. Crit Care Med. 2002;30(4):763–70.PubMed Wenzel C, Stoiser B, Locker G, et al. Frequent development of lupus anticoagulants in critically ill patients treated under intensive care conditions. Crit Care Med. 2002;30(4):763–70.PubMed
9.
Zurück zum Zitat Cruz-Tapias P, Blank M, Anaya JM, et al. Infections and vaccines in the etiology of antiphospholipid syndrome. Curr Opin Rheumatol. 2012;24(4):389–93.PubMed Cruz-Tapias P, Blank M, Anaya JM, et al. Infections and vaccines in the etiology of antiphospholipid syndrome. Curr Opin Rheumatol. 2012;24(4):389–93.PubMed
10.
Zurück zum Zitat Blank M, Israeli E, Shoenfeld Y. When APS (Hughes syndrome) met the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Lupus. 2012;21(7):711–4.PubMed Blank M, Israeli E, Shoenfeld Y. When APS (Hughes syndrome) met the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Lupus. 2012;21(7):711–4.PubMed
11.
Zurück zum Zitat Andreoli L, Nalli C, Motta M, et al. Anti-B2-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: might it be the reason for their ‘innocent’ profile? Ann Rheum Dis. 2011;70(2):380–3.PubMed Andreoli L, Nalli C, Motta M, et al. Anti-B2-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: might it be the reason for their ‘innocent’ profile? Ann Rheum Dis. 2011;70(2):380–3.PubMed
12.
Zurück zum Zitat Wahezi DM, Ilowite NT, Wu XX, et al. Annexin A5 anticoagulant activity in children with systemic lupus erythematosus and the association with antibodies to domain I of β2-glycoprotein I. Lupus. 2013;22(7):702–11.PubMedCentralPubMed Wahezi DM, Ilowite NT, Wu XX, et al. Annexin A5 anticoagulant activity in children with systemic lupus erythematosus and the association with antibodies to domain I of β2-glycoprotein I. Lupus. 2013;22(7):702–11.PubMedCentralPubMed
13.
Zurück zum Zitat Guerin J, Casey E, Feighery C, et al. Anti-Beta 2-glycoprotein I antibody isotype and IgG subclass in antiphospholipid syndrome patients. Autoimmunity. 1999;31(2):109–16.PubMed Guerin J, Casey E, Feighery C, et al. Anti-Beta 2-glycoprotein I antibody isotype and IgG subclass in antiphospholipid syndrome patients. Autoimmunity. 1999;31(2):109–16.PubMed
14.
Zurück zum Zitat Kumar S, Papalardo E, Sunkureddi P, et al. Isolated elevation of IgA anti-Beta2glycoprotein I antibodies with manifestations of antiphospholipid syndrome: a case series of five patients. Lupus. 2009;18(11):1011–4.PubMed Kumar S, Papalardo E, Sunkureddi P, et al. Isolated elevation of IgA anti-Beta2glycoprotein I antibodies with manifestations of antiphospholipid syndrome: a case series of five patients. Lupus. 2009;18(11):1011–4.PubMed
15.
Zurück zum Zitat Samarkos M, Davies K, Gordon C, et al. Clinical significance of IgA anticardiolipin and anti-beta2-GP1 antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome. Clin Rheumatol. 2006;25(2):199–204.PubMed Samarkos M, Davies K, Gordon C, et al. Clinical significance of IgA anticardiolipin and anti-beta2-GP1 antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome. Clin Rheumatol. 2006;25(2):199–204.PubMed
16.
Zurück zum Zitat Pengo V, Ruffatti A, Legnani C, et al. Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood. 2011;118(17):4714–8.PubMed Pengo V, Ruffatti A, Legnani C, et al. Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood. 2011;118(17):4714–8.PubMed
17.
Zurück zum Zitat Erkan D, Lockshin M. High risk antiphospholipid antibody profile: matter of the number or titer of tests? E-letter to the editor (re: Incidence of first thrombembolic event in asymptomatic carries of high-risk aPL profile: a multicenter prospective study, Pengo et al. Blood 2011;17:4714). Published online on 24 January 2012, available at: http://bloodjournal.hematologylibrary.org/letters. Erkan D, Lockshin M. High risk antiphospholipid antibody profile: matter of the number or titer of tests? E-letter to the editor (re: Incidence of first thrombembolic event in asymptomatic carries of high-risk aPL profile: a multicenter prospective study, Pengo et al. Blood 2011;17:4714). Published online on 24 January 2012, available at: http://​bloodjournal.​hematologylibrar​y.​org/​letters.
18.
Zurück zum Zitat Galli M, Luciani D, Bertolini G, et al. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003;101(5):1827–32.PubMed Galli M, Luciani D, Bertolini G, et al. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003;101(5):1827–32.PubMed
19.
Zurück zum Zitat Pengo V, Biasiolo A, Gresele P, et al. Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples. J Thromb Haemost. 2007;5(5):925–30.PubMed Pengo V, Biasiolo A, Gresele P, et al. Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples. J Thromb Haemost. 2007;5(5):925–30.PubMed
20.
Zurück zum Zitat Nakashima MO, Rogers HJ. Hypercoagulable states: an algorithmic approach to laboratory testing and update on monitoring of direct oral anticoagulants. Blood Res. 2014;49(2):85–94.PubMedCentralPubMed Nakashima MO, Rogers HJ. Hypercoagulable states: an algorithmic approach to laboratory testing and update on monitoring of direct oral anticoagulants. Blood Res. 2014;49(2):85–94.PubMedCentralPubMed
21.
Zurück zum Zitat Thornburg C, Pipe S. Neonatal thromboembolic emergencies. Semin Fetal Neonatol Med. 2006;11(3):198–206. Thornburg C, Pipe S. Neonatal thromboembolic emergencies. Semin Fetal Neonatol Med. 2006;11(3):198–206.
22.
Zurück zum Zitat Male C, Lechner K, Eichinger S, et al. Clinical significance of lupus anticoagulants in children. J Pediatr. 1999;134(2):199–205.PubMed Male C, Lechner K, Eichinger S, et al. Clinical significance of lupus anticoagulants in children. J Pediatr. 1999;134(2):199–205.PubMed
23.
Zurück zum Zitat Flanders MM, Crist RA, Roberts WL, et al. Pediatric reference intervals for seven common coagulation assays. Clin Chem. 2005;51(9):1738–42.PubMed Flanders MM, Crist RA, Roberts WL, et al. Pediatric reference intervals for seven common coagulation assays. Clin Chem. 2005;51(9):1738–42.PubMed
24.••
Zurück zum Zitat Avcin T, Cimaz R, Silverman ED, et al. Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry. Pediatrics. 2008;122(5):e1100–7. Most comprehensive descriptive characteristics of pediatric APS from an international registry. PubMed Avcin T, Cimaz R, Silverman ED, et al. Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry. Pediatrics. 2008;122(5):e1100–7. Most comprehensive descriptive characteristics of pediatric APS from an international registry. PubMed
25.
Zurück zum Zitat Sanna G, Bertolaccini ML, Hughes GR. Hughes syndrome, the antiphospholipid syndrome: a new chapter in neurology. Ann N Y Acad Sci. 2005;1051:465–86.PubMed Sanna G, Bertolaccini ML, Hughes GR. Hughes syndrome, the antiphospholipid syndrome: a new chapter in neurology. Ann N Y Acad Sci. 2005;1051:465–86.PubMed
26.
Zurück zum Zitat Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost. 1995;74(1):415–25.PubMed Andrew M. Developmental hemostasis: relevance to thromboembolic complications in pediatric patients. Thromb Haemost. 1995;74(1):415–25.PubMed
27.
Zurück zum Zitat Andrew M, David M, Adams M, et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood. 1994;83(5):1251–7.PubMed Andrew M, David M, Adams M, et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood. 1994;83(5):1251–7.PubMed
28.
Zurück zum Zitat Motta M, Chirico G, Rebaioli CB, et al. Anticardiolipin and anti-beta2 glycoprotein 1 antibodies in infants born to mother with antiphospholipid antibody-positive autoimmune disease: a follow-up study. Am J Perinatol. 2006;23(4):247–51.PubMed Motta M, Chirico G, Rebaioli CB, et al. Anticardiolipin and anti-beta2 glycoprotein 1 antibodies in infants born to mother with antiphospholipid antibody-positive autoimmune disease: a follow-up study. Am J Perinatol. 2006;23(4):247–51.PubMed
29.
Zurück zum Zitat Garty BZ, Ludomirsky A, Danon YL, et al. Placental transfer of immunoglobulin G subclasses. Clin Diagn Lab Immunol. 1994;1(6):667–9.PubMedCentralPubMed Garty BZ, Ludomirsky A, Danon YL, et al. Placental transfer of immunoglobulin G subclasses. Clin Diagn Lab Immunol. 1994;1(6):667–9.PubMedCentralPubMed
30.
Zurück zum Zitat Palmeira P, Quinello C, Silveira-Lessa AL, et al. IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol. 2012;2012:985646.PubMedCentralPubMed Palmeira P, Quinello C, Silveira-Lessa AL, et al. IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol. 2012;2012:985646.PubMedCentralPubMed
31.
Zurück zum Zitat Samarkos M, Davies KA, Gordon C, et al. IgG subclass distribution of antibodies against beta(2)-GP1 and cardiolipin in patients with systemic lupus erythematosus and primary antiphospholipid syndrome, and their clinical associations. Rheumatology (Oxford). 2001;40(9):1026–32. Samarkos M, Davies KA, Gordon C, et al. IgG subclass distribution of antibodies against beta(2)-GP1 and cardiolipin in patients with systemic lupus erythematosus and primary antiphospholipid syndrome, and their clinical associations. Rheumatology (Oxford). 2001;40(9):1026–32.
32.
Zurück zum Zitat Sammaritano LR, Ng S, Sobel R, et al. Anticardiolipin IgG subclases. Association of IgG2 with arterial and/or venous thrombosis. Arthritis Rheum. 1997;40(11):1998–2006.PubMed Sammaritano LR, Ng S, Sobel R, et al. Anticardiolipin IgG subclases. Association of IgG2 with arterial and/or venous thrombosis. Arthritis Rheum. 1997;40(11):1998–2006.PubMed
33.
Zurück zum Zitat Boffa MC, Lachassinne E. Infant perinatal thrombosis and antiphospholipid antibodies: a review. Lupus. 2007;16(8):634–41. Boffa MC, Lachassinne E. Infant perinatal thrombosis and antiphospholipid antibodies: a review. Lupus. 2007;16(8):634–41.
34.
Zurück zum Zitat Peixoto MV, de Carvalho JF, Rodrigues CE. Clinical, laboratory, and therapeutic analyses of 21 patients with neonatal thrombosis and antiphospholipid antibodies: a literature review. J Immunol Res. 2014;2014:672603.PubMedCentralPubMed Peixoto MV, de Carvalho JF, Rodrigues CE. Clinical, laboratory, and therapeutic analyses of 21 patients with neonatal thrombosis and antiphospholipid antibodies: a literature review. J Immunol Res. 2014;2014:672603.PubMedCentralPubMed
35.
Zurück zum Zitat Boffa MC, Aurousseau MH, Lachassinne E, et al. European register of babies born to mothers with antiphospholipid syndrome. Lupus. 2004;13(9):713–7.PubMed Boffa MC, Aurousseau MH, Lachassinne E, et al. European register of babies born to mothers with antiphospholipid syndrome. Lupus. 2004;13(9):713–7.PubMed
36.
Zurück zum Zitat Boffa MC, Lachassinne E, Boinot C, et al. European registry of babies born to mothers with antiphospholipid syndrome: a result update. Lupus. 2009;18(10):900–4.PubMed Boffa MC, Lachassinne E, Boinot C, et al. European registry of babies born to mothers with antiphospholipid syndrome: a result update. Lupus. 2009;18(10):900–4.PubMed
37.
Zurück zum Zitat Mekinian A, Carbillon L, Nicaise-Roland P, et al. Mothers’ antiphospholipid antibodies during pregnancy and the relation to offspring outcome. Clin Exp Rheumatol. 2014;32(3):446.PubMed Mekinian A, Carbillon L, Nicaise-Roland P, et al. Mothers’ antiphospholipid antibodies during pregnancy and the relation to offspring outcome. Clin Exp Rheumatol. 2014;32(3):446.PubMed
38.•
Zurück zum Zitat Mekinian A, Lachassinne E, Nicaise-Roland P, et al. European registry of babies born to mothers with antiphospholipid syndrome. Ann Rheum Dis. 2013;72(2):217–22. A prospective study aiming to describe the long-term outcomes of children born to mothers with antiphospholipid syndrome. PubMedCentralPubMed Mekinian A, Lachassinne E, Nicaise-Roland P, et al. European registry of babies born to mothers with antiphospholipid syndrome. Ann Rheum Dis. 2013;72(2):217–22. A prospective study aiming to describe the long-term outcomes of children born to mothers with antiphospholipid syndrome. PubMedCentralPubMed
39.
Zurück zum Zitat Nalli C, Iodice A, Andreoli L, et al. The effects of lupus and antiphospholipid antibody syndrome on foetal outcomes. Lupus. 2014;23(6):507–17.PubMed Nalli C, Iodice A, Andreoli L, et al. The effects of lupus and antiphospholipid antibody syndrome on foetal outcomes. Lupus. 2014;23(6):507–17.PubMed
40.
Zurück zum Zitat Ross G, Sammaritano L, Nass R, et al. Affects of mother’s autoimmune disease during pregnancy on learning disabilities and hand preference in their children. Arch Pediatr Adolesc Med. 2003;157(4):397–402.PubMed Ross G, Sammaritano L, Nass R, et al. Affects of mother’s autoimmune disease during pregnancy on learning disabilities and hand preference in their children. Arch Pediatr Adolesc Med. 2003;157(4):397–402.PubMed
41.
Zurück zum Zitat Brewster JA, Shaw NJ, Farquharson RG. Neonatal and pediatric outcome of infants born to mothers with antiphospholipid syndrome. J Perinat Med. 1999;27(3):183–7.PubMed Brewster JA, Shaw NJ, Farquharson RG. Neonatal and pediatric outcome of infants born to mothers with antiphospholipid syndrome. J Perinat Med. 1999;27(3):183–7.PubMed
42.
Zurück zum Zitat Nacinovich R, Galli J, Bomba M, et al. Neuropsychological development of children born to patients with antiphospholipid syndrome. Arthritis Rheum. 2008;59(3):345–51.PubMed Nacinovich R, Galli J, Bomba M, et al. Neuropsychological development of children born to patients with antiphospholipid syndrome. Arthritis Rheum. 2008;59(3):345–51.PubMed
43.
Zurück zum Zitat Abisror N, Mekinian A, Lachassinne E, et al. Autism spectrum disorders in babies born to mothers with antiphospholipid syndrome. Semin Arthritis Rheum. 2013;43(3):348–51.PubMed Abisror N, Mekinian A, Lachassinne E, et al. Autism spectrum disorders in babies born to mothers with antiphospholipid syndrome. Semin Arthritis Rheum. 2013;43(3):348–51.PubMed
44.•
Zurück zum Zitat Gordon O, Almagor Y, Fridler D, et al. De novo neonatal antiphospholipid syndrome: a case report and review of the literature. Semin Arthritis Rheum. 2014;44(2):241–5. A recent review of de novo neonatal APS. PubMed Gordon O, Almagor Y, Fridler D, et al. De novo neonatal antiphospholipid syndrome: a case report and review of the literature. Semin Arthritis Rheum. 2014;44(2):241–5. A recent review of de novo neonatal APS. PubMed
45.
Zurück zum Zitat Hansen K, Kong D, Moore K, et al. Risk factors associated with thrombosis in patients with antiphospholipid antibodies. J Rheumatol. 2001;28(9):2018–24.PubMed Hansen K, Kong D, Moore K, et al. Risk factors associated with thrombosis in patients with antiphospholipid antibodies. J Rheumatol. 2001;28(9):2018–24.PubMed
46.
Zurück zum Zitat Hudson M, Herr AL, Rauch J, et al. The presence of multiple prothromboitc risk factors is associated with a higher risk of thrombosis in individuals with anticardiolipin antibodies. J Rheumatol. 2003;30(11):2385–91.PubMedCentralPubMed Hudson M, Herr AL, Rauch J, et al. The presence of multiple prothromboitc risk factors is associated with a higher risk of thrombosis in individuals with anticardiolipin antibodies. J Rheumatol. 2003;30(11):2385–91.PubMedCentralPubMed
47.
Zurück zum Zitat Rosendaal F, Siscovick D, Schwartz SM, et al. Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood. 1997;89(8):2817–21.PubMed Rosendaal F, Siscovick D, Schwartz SM, et al. Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood. 1997;89(8):2817–21.PubMed
48.
Zurück zum Zitat Giron-Gonzalez J, Garcia del Rio E, Rodriguez C, et al. Antiphospholipid syndrome and asymptomatic carriers of antiphospholipid antibody: prospective analysis of 404 individuals. J Rheumatol. 2004;31(8):1560–7. Giron-Gonzalez J, Garcia del Rio E, Rodriguez C, et al. Antiphospholipid syndrome and asymptomatic carriers of antiphospholipid antibody: prospective analysis of 404 individuals. J Rheumatol. 2004;31(8):1560–7.
49.
Zurück zum Zitat Kaul M, Erkan D, Sammaritano L, et al. Assessment of the 2006 revised antiphospholipid syndrome classification criteria. Ann Rheum Dis. 2007;66(7):927–30.PubMedCentralPubMed Kaul M, Erkan D, Sammaritano L, et al. Assessment of the 2006 revised antiphospholipid syndrome classification criteria. Ann Rheum Dis. 2007;66(7):927–30.PubMedCentralPubMed
50.
Zurück zum Zitat Tolbert J, Carpenter SL. Common acquired causes of thrombosis in children. Curr Probl Pediatr Adolesc Health Care. 2013;43(7):169–77.PubMed Tolbert J, Carpenter SL. Common acquired causes of thrombosis in children. Curr Probl Pediatr Adolesc Health Care. 2013;43(7):169–77.PubMed
51.
Zurück zum Zitat Avcin T, Cimaz R, Rozman B, Ped-APS Registry Collaborative Group. The Ped-APS registry: the antiphospholipid syndrome in childhood. Lupus. 2009;18(10):894–9.PubMed Avcin T, Cimaz R, Rozman B, Ped-APS Registry Collaborative Group. The Ped-APS registry: the antiphospholipid syndrome in childhood. Lupus. 2009;18(10):894–9.PubMed
52.
Zurück zum Zitat Albisetti M, Moeller A, Waldvogel K, et al. Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses. Acta Haematol. 2007;117(3):149–55.PubMed Albisetti M, Moeller A, Waldvogel K, et al. Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses. Acta Haematol. 2007;117(3):149–55.PubMed
53.
Zurück zum Zitat Revel-Vilk S, Chan A, Bauman M, et al. Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. J Thromb Haemost. 2003;1(5):915–21.PubMed Revel-Vilk S, Chan A, Bauman M, et al. Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. J Thromb Haemost. 2003;1(5):915–21.PubMed
54.
Zurück zum Zitat Yang JY, Chan AK. Pediatric thrombophilia. Pediatr Clin North Am. 2013;60(6):1443–62.PubMed Yang JY, Chan AK. Pediatric thrombophilia. Pediatr Clin North Am. 2013;60(6):1443–62.PubMed
55.•
Zurück zum Zitat Kenet G, Aronis S, Berkun Y, et al. Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: a systematic review and meta-analysis. Semin Thromb Hemost. 2011;37(7):802–9. A meta-analysis describing the impact of antiphospholipid antibodies on the risk of thrombotic events in children. Kenet G, Aronis S, Berkun Y, et al. Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: a systematic review and meta-analysis. Semin Thromb Hemost. 2011;37(7):802–9. A meta-analysis describing the impact of antiphospholipid antibodies on the risk of thrombotic events in children.
56.
Zurück zum Zitat Manco-Johnson MJ, Nuss R. Lupus anticoagulant in children with thrombosis. Am J Hematol. 1995;48(4):240–3.PubMed Manco-Johnson MJ, Nuss R. Lupus anticoagulant in children with thrombosis. Am J Hematol. 1995;48(4):240–3.PubMed
57.
Zurück zum Zitat Tavil B, Ozyurek E, Gumruk F, et al. Antiphospholipid antibodies in Turkish children with thrombosis. Blood Coagul Fibrinolysis. 2007;18(4):347–52.PubMed Tavil B, Ozyurek E, Gumruk F, et al. Antiphospholipid antibodies in Turkish children with thrombosis. Blood Coagul Fibrinolysis. 2007;18(4):347–52.PubMed
58.
Zurück zum Zitat Muscal E, Brey RL. Antiphospholipid syndrome and the brain in pediatric and adult patients. Lupus. 2010;19(4):406–11.PubMedCentralPubMed Muscal E, Brey RL. Antiphospholipid syndrome and the brain in pediatric and adult patients. Lupus. 2010;19(4):406–11.PubMedCentralPubMed
59.
Zurück zum Zitat Lampropoulos CE, Koutroumanidis M, Reynolds PP, et al. Electroencephalography in the assessment of neuropsychiatric manifestation in antiphospholipid syndrome and systemic lupus erythematosus. Arthritis Rheum. 2005;52(3):841–6.PubMed Lampropoulos CE, Koutroumanidis M, Reynolds PP, et al. Electroencephalography in the assessment of neuropsychiatric manifestation in antiphospholipid syndrome and systemic lupus erythematosus. Arthritis Rheum. 2005;52(3):841–6.PubMed
60.
Zurück zum Zitat Biernacka-Zielinska M, Lipinska J, Szymanska-Kaluza J, et al. Recurrent arterial and venous thrombosis in a 16-year-old boy in the course of primary antiphospholipid syndrome despite treatment with low-molecular-weight heparin: a case report. J Med Case Rep. 2013;7:221.PubMedCentralPubMed Biernacka-Zielinska M, Lipinska J, Szymanska-Kaluza J, et al. Recurrent arterial and venous thrombosis in a 16-year-old boy in the course of primary antiphospholipid syndrome despite treatment with low-molecular-weight heparin: a case report. J Med Case Rep. 2013;7:221.PubMedCentralPubMed
61.
Zurück zum Zitat Brogna C, Mariotti P, Manna R. Conventional and intravenous immunoglobulin therapy in paediatric antiphospholipid antibodies-related chorea. Lupus. 2014;23:1449–51.PubMed Brogna C, Mariotti P, Manna R. Conventional and intravenous immunoglobulin therapy in paediatric antiphospholipid antibodies-related chorea. Lupus. 2014;23:1449–51.PubMed
62.
Zurück zum Zitat Avcin T, Benseler SM, Tyrrell PN, et al. A followup study of antiphospholipid antibodies and associated neuropsychiatric manifestations in 137 children with systemic lupus erythematosus. Arthritis Rheum. 2008;59(2):206–13.PubMed Avcin T, Benseler SM, Tyrrell PN, et al. A followup study of antiphospholipid antibodies and associated neuropsychiatric manifestations in 137 children with systemic lupus erythematosus. Arthritis Rheum. 2008;59(2):206–13.PubMed
63.
Zurück zum Zitat Harel L, Sandborg C, Lee T, et al. Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies. J Rheumatol. 2006;33(9):1873–7.PubMed Harel L, Sandborg C, Lee T, et al. Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies. J Rheumatol. 2006;33(9):1873–7.PubMed
64.
Zurück zum Zitat von Scheven E, Glidden DV, Elder ME. Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. Arthritis Rheum. 2002;47(4):414–20. von Scheven E, Glidden DV, Elder ME. Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome. Arthritis Rheum. 2002;47(4):414–20.
65.
Zurück zum Zitat Cimaz R, Romeo A, Scarano A, et al. Prevalence of anti-cardiolipin, anti-beta2 glycoprotein I and anti-prothrombin antibodies in young patients with epilepsy. Epilepsia. 2002;43(1):52–9.PubMed Cimaz R, Romeo A, Scarano A, et al. Prevalence of anti-cardiolipin, anti-beta2 glycoprotein I and anti-prothrombin antibodies in young patients with epilepsy. Epilepsia. 2002;43(1):52–9.PubMed
66.
Zurück zum Zitat Constantin T, Kálovics T, Ponyi A, et al. Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy. Med Sci Monit. 2009;15(4):CR164–9.PubMed Constantin T, Kálovics T, Ponyi A, et al. Prevalence of antiphospholipid and antinuclear antibodies in children with epilepsy. Med Sci Monit. 2009;15(4):CR164–9.PubMed
67.
Zurück zum Zitat Avčin T, Markelj G, Nikšič V, et al. Estimation of antiphospholipid antibodies in a prospective longitudinal study of children with migraine. Cephalalgia. 2004;24(10):831–7. Avčin T, Markelj G, Nikšič V, et al. Estimation of antiphospholipid antibodies in a prospective longitudinal study of children with migraine. Cephalalgia. 2004;24(10):831–7.
68.
Zurück zum Zitat Lampropoulos CE, Hughes GR. The antiphospholipid (Hughes’) syndrome: changing the face of neurology. Eur J Intern Med. 2004;15(3):147–50.PubMed Lampropoulos CE, Hughes GR. The antiphospholipid (Hughes’) syndrome: changing the face of neurology. Eur J Intern Med. 2004;15(3):147–50.PubMed
69.
Zurück zum Zitat Careaga M, Hansen RL, Hertz-Piccotto I, et al. Increased anti-phospholipid antibodies in autism spectrum disorders. Mediators Inflamm. 2013;2013:935608.PubMedCentralPubMed Careaga M, Hansen RL, Hertz-Piccotto I, et al. Increased anti-phospholipid antibodies in autism spectrum disorders. Mediators Inflamm. 2013;2013:935608.PubMedCentralPubMed
70.
Zurück zum Zitat Zamora-Ustaran A, Escarcega-Alarcón RO, Garcia-Carrasco M, et al. Antiphospholipid syndrome in Mexican children. Isr Med Assoc J. 2012;14(5):286–9.PubMed Zamora-Ustaran A, Escarcega-Alarcón RO, Garcia-Carrasco M, et al. Antiphospholipid syndrome in Mexican children. Isr Med Assoc J. 2012;14(5):286–9.PubMed
71.
Zurück zum Zitat Mazodier K, Arnaud L, Mathian A, et al. Lupus anticoagulant-hypoprothrombinemia syndrome: report of 8 cases and review of the literature. Medicine (Baltimore). 2012;91(5):251–60. Mazodier K, Arnaud L, Mathian A, et al. Lupus anticoagulant-hypoprothrombinemia syndrome: report of 8 cases and review of the literature. Medicine (Baltimore). 2012;91(5):251–60.
72.
Zurück zum Zitat Berkun Y, Padeh S, Barash J, et al. Antiphospholipid syndrome and recurrent thrombosis in children. Arthritis Rheum. 2006;55(6):850–5. Berkun Y, Padeh S, Barash J, et al. Antiphospholipid syndrome and recurrent thrombosis in children. Arthritis Rheum. 2006;55(6):850–5.
73.
Zurück zum Zitat Garcia-Carrasco M, Galarza C, Gómez-Ponce M, et al. Antiphospholipid syndrome in Latin American patients: clinical and immunologic characteristics and comparison with European patients. Lupus. 2007;16(5):366–73.PubMed Garcia-Carrasco M, Galarza C, Gómez-Ponce M, et al. Antiphospholipid syndrome in Latin American patients: clinical and immunologic characteristics and comparison with European patients. Lupus. 2007;16(5):366–73.PubMed
74.
Zurück zum Zitat Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002;46(4):1019–27.PubMed Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002;46(4):1019–27.PubMed
75.
Zurück zum Zitat Gattorno M, Falcini F, Ravelli A, et al. Outcome of primary antiphospholipid syndrome in childhood. Lupus. 2003;12(6):449–53.PubMed Gattorno M, Falcini F, Ravelli A, et al. Outcome of primary antiphospholipid syndrome in childhood. Lupus. 2003;12(6):449–53.PubMed
76.
Zurück zum Zitat Gómez-Puerta JA, Martín H, Amigo MC, et al. Long-term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus? Medicine (Baltimore). 2005;84(4):225–30. Gómez-Puerta JA, Martín H, Amigo MC, et al. Long-term follow-up in 128 patients with primary antiphospholipid syndrome: do they develop lupus? Medicine (Baltimore). 2005;84(4):225–30.
77.
Zurück zum Zitat Avcin T, Silverman ED. Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. Lupus. 2007;16(8):627–33.PubMed Avcin T, Silverman ED. Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome. Lupus. 2007;16(8):627–33.PubMed
78.
Zurück zum Zitat Andrews A, Hickling P. Thrombosis associated with antiphospholipid antibody in juvenile chronic arthritis. Lupus. 1997;6(6):556–7.PubMed Andrews A, Hickling P. Thrombosis associated with antiphospholipid antibody in juvenile chronic arthritis. Lupus. 1997;6(6):556–7.PubMed
79.
Zurück zum Zitat Caporali R, Ravelli A, Ramenghi B, et al. Antiphospholipid antibody associated thrombosis in juvenile chronic arthritis. Arch Dis Child. 1992;67(11):1384–5.PubMedCentralPubMed Caporali R, Ravelli A, Ramenghi B, et al. Antiphospholipid antibody associated thrombosis in juvenile chronic arthritis. Arch Dis Child. 1992;67(11):1384–5.PubMedCentralPubMed
80.
Zurück zum Zitat Abend NS, Licht DJ, Spencer CH. Lupus anticoagulant and thrombosis following Henoch-Schonlein purpura. Pediatr Neurol. 2007;36(5):345–7.PubMed Abend NS, Licht DJ, Spencer CH. Lupus anticoagulant and thrombosis following Henoch-Schonlein purpura. Pediatr Neurol. 2007;36(5):345–7.PubMed
81.
Zurück zum Zitat Monastiri K, Selmi H, Tabarki B, et al. Primary antiphospholipid syndrome presenting as complicated henoch-Schonlein purpura. Arch Dis Child. 2002;86(2):132–3.PubMedCentralPubMed Monastiri K, Selmi H, Tabarki B, et al. Primary antiphospholipid syndrome presenting as complicated henoch-Schonlein purpura. Arch Dis Child. 2002;86(2):132–3.PubMedCentralPubMed
82.
Zurück zum Zitat Meglic A, Grosek S, Benedik-Dolnicar M, et al. Atypical haemolytic uremic syndrome complicated by microangiopathic antiphospholipid-associated syndrome. Lupus. 2008;17(9):842–5. Meglic A, Grosek S, Benedik-Dolnicar M, et al. Atypical haemolytic uremic syndrome complicated by microangiopathic antiphospholipid-associated syndrome. Lupus. 2008;17(9):842–5.
83.
Zurück zum Zitat Sherer Y, Livneh A, Levy Y, et al. Dermatomyositis and polymyositis associated with the antiphospholipid syndrome: a novel overlap syndrome. Lupus. 2000;9(1):42–6. Sherer Y, Livneh A, Levy Y, et al. Dermatomyositis and polymyositis associated with the antiphospholipid syndrome: a novel overlap syndrome. Lupus. 2000;9(1):42–6.
84.
Zurück zum Zitat Fung VS, Yiannikas C, Sue CM, et al. Is Sydenham’s chorea an antiphospholipid syndrome? J Clin Neurosci. 1998;5(1):115–8.PubMed Fung VS, Yiannikas C, Sue CM, et al. Is Sydenham’s chorea an antiphospholipid syndrome? J Clin Neurosci. 1998;5(1):115–8.PubMed
85.
Zurück zum Zitat Kiechl-Kohlendorfer U, Ellemunter H, Kiechl S. Chorea as a presenting clinical feature of primary antiphospholipid syndrome in childhood. Neuropediatrics. 1999;30(2):96–8.PubMed Kiechl-Kohlendorfer U, Ellemunter H, Kiechl S. Chorea as a presenting clinical feature of primary antiphospholipid syndrome in childhood. Neuropediatrics. 1999;30(2):96–8.PubMed
86.
Zurück zum Zitat Caporali R, Ravelli A, De Gennaro F, et al. Prevalence of anticardiolipin antibodies in juvenile arthritis. Ann Rheum Dis. 1991;50(9):599–601.PubMedCentralPubMed Caporali R, Ravelli A, De Gennaro F, et al. Prevalence of anticardiolipin antibodies in juvenile arthritis. Ann Rheum Dis. 1991;50(9):599–601.PubMedCentralPubMed
87.
Zurück zum Zitat Southwood TR, Roberts-Thomson PJ, Ahern MJ, et al. Autoantibodies in patients with juvenile chronic arthritis and their immediate family relatives. Ann Rheum Dis. 1990;49(12):968–72.PubMedCentral Southwood TR, Roberts-Thomson PJ, Ahern MJ, et al. Autoantibodies in patients with juvenile chronic arthritis and their immediate family relatives. Ann Rheum Dis. 1990;49(12):968–72.PubMedCentral
88.
Zurück zum Zitat Gedalia A, Molina IF, Garcia CO, et al. Anticardiolipin antibodies in childhood rheumatic disorders. Lupus. 1998;7(8):551–3.PubMed Gedalia A, Molina IF, Garcia CO, et al. Anticardiolipin antibodies in childhood rheumatic disorders. Lupus. 1998;7(8):551–3.PubMed
89.
Zurück zum Zitat Rožiĝ M, Trampuš-Bakija A, Rener-Primec Z, et al. Clinical spectrum and outcome in 100 children with positive antiphospholipid antibodies. Arthritis Rheum. 2008;58:S711–2. Rožiĝ M, Trampuš-Bakija A, Rener-Primec Z, et al. Clinical spectrum and outcome in 100 children with positive antiphospholipid antibodies. Arthritis Rheum. 2008;58:S711–2.
90.
Zurück zum Zitat Avcin T, Cimaz R, Meroni PL. Do we need an international consensus statement on classification criteria for the antiphospholipid syndrome in paediatric population? Lupus. 2001;10(12):897–8.PubMed Avcin T, Cimaz R, Meroni PL. Do we need an international consensus statement on classification criteria for the antiphospholipid syndrome in paediatric population? Lupus. 2001;10(12):897–8.PubMed
91.
Zurück zum Zitat Cabiedes J, Trejo-Hernandez J, Loredo-Abdala A, et al. Anti-cardiolipin, anticardiolipin plus bovine, or human beta(2)glycoprotein-I and anti-human beta(2)glycoprotein-I antibodies in a healthy infant population. Arch Med Res. 2002;33(2):175–9.PubMed Cabiedes J, Trejo-Hernandez J, Loredo-Abdala A, et al. Anti-cardiolipin, anticardiolipin plus bovine, or human beta(2)glycoprotein-I and anti-human beta(2)glycoprotein-I antibodies in a healthy infant population. Arch Med Res. 2002;33(2):175–9.PubMed
92.
Zurück zum Zitat Vaarala O, Palosuo T, Kleemola M, et al. Anticardiolipin response in acute infections. Clin Immunol Immunopathol. 1986;41(1):8–15.PubMed Vaarala O, Palosuo T, Kleemola M, et al. Anticardiolipin response in acute infections. Clin Immunol Immunopathol. 1986;41(1):8–15.PubMed
93.
Zurück zum Zitat Frauenknecht K, Lackner K, von Landenberg P. Antiphospholipid antibodies in pediatric patients with prolonged activated partial thromboplastin time during infection. Immunobiology. 2005;210(10):799–805.PubMed Frauenknecht K, Lackner K, von Landenberg P. Antiphospholipid antibodies in pediatric patients with prolonged activated partial thromboplastin time during infection. Immunobiology. 2005;210(10):799–805.PubMed
94.
Zurück zum Zitat Martinuc Porobic J, Avcin T, Bozic B, et al. Anti-phospholipid antibodies following vaccination with recombinant hepatitis B vaccine. Clin Exp Immunol. 2005;142(2):377–80.PubMedCentralPubMed Martinuc Porobic J, Avcin T, Bozic B, et al. Anti-phospholipid antibodies following vaccination with recombinant hepatitis B vaccine. Clin Exp Immunol. 2005;142(2):377–80.PubMedCentralPubMed
95.
Zurück zum Zitat Toplak N, Kveder T, Trampuš-Bakija A, et al. Autoimmune response following annual influenza vaccination in 92 apparently healthy adults. Autoimmun Rev. 2008;8(2):134–8.PubMed Toplak N, Kveder T, Trampuš-Bakija A, et al. Autoimmune response following annual influenza vaccination in 92 apparently healthy adults. Autoimmun Rev. 2008;8(2):134–8.PubMed
96.
Zurück zum Zitat Rapizzi E, Ruffatti A, Tonello M, et al. Correction for age of anticardiolipin antibodies cut-off points. J Clin Lab Anal. 2000;14(3):87–90.PubMed Rapizzi E, Ruffatti A, Tonello M, et al. Correction for age of anticardiolipin antibodies cut-off points. J Clin Lab Anal. 2000;14(3):87–90.PubMed
97.
Zurück zum Zitat Siemens HJ, Gutsche S, Brückner S, et al. Antiphospholipid antibodies in children without and in adults with and without thrombophilia. Thromb Res. 2000;98(4):241–7.PubMed Siemens HJ, Gutsche S, Brückner S, et al. Antiphospholipid antibodies in children without and in adults with and without thrombophilia. Thromb Res. 2000;98(4):241–7.PubMed
98.
Zurück zum Zitat Avcin T, Cimaz R, Meroni PL. Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations. Lupus. 2002;11(1):4–10.PubMed Avcin T, Cimaz R, Meroni PL. Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations. Lupus. 2002;11(1):4–10.PubMed
99.
Zurück zum Zitat Cimaz R, Descloux E. Pediatric antiphospholipid syndrome. Rheum Dis Clin North Am. 2006;32(3):553–73.PubMed Cimaz R, Descloux E. Pediatric antiphospholipid syndrome. Rheum Dis Clin North Am. 2006;32(3):553–73.PubMed
100.
Zurück zum Zitat Ravelli A, Martini A. Antiphospholipid syndrome in pediatrics. Rheum Dis Clin North Am. 2007;33(3):499–523.PubMed Ravelli A, Martini A. Antiphospholipid syndrome in pediatrics. Rheum Dis Clin North Am. 2007;33(3):499–523.PubMed
101.
Zurück zum Zitat Becton DL, Stine KC. Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: the hemorrhagic lupus anticoagulant syndrome. J Pediatr. 1997;130(6):998–1000.PubMed Becton DL, Stine KC. Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: the hemorrhagic lupus anticoagulant syndrome. J Pediatr. 1997;130(6):998–1000.PubMed
102.
Zurück zum Zitat Lee MT, Nardi MA, Hadzi-Nesic J, et al. Transient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1½-year-old girl: report of a case and review of the literature. Am J Hematol. 1996;51(4):307–14.PubMed Lee MT, Nardi MA, Hadzi-Nesic J, et al. Transient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1½-year-old girl: report of a case and review of the literature. Am J Hematol. 1996;51(4):307–14.PubMed
103.
Zurück zum Zitat Yacobovich JR, Uziel Y, Friedman Z, et al. Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinaemia syndrome. Rheumatology (Oxford). 2001;40(5):585–7. Yacobovich JR, Uziel Y, Friedman Z, et al. Diffuse muscular haemorrhage as presenting sign of juvenile systemic lupus erythematosus and lupus anticoagulant hypoprothrombinaemia syndrome. Rheumatology (Oxford). 2001;40(5):585–7.
104.
Zurück zum Zitat Crowther MA, Ginsberg JS, Julian J, et al. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med. 2003;349(12):1133–8.PubMed Crowther MA, Ginsberg JS, Julian J, et al. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med. 2003;349(12):1133–8.PubMed
105.
Zurück zum Zitat Orsino A, Schneider R, DeVeber G, et al. Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome. J Pediatr Hematol Oncol. 2004;26(5):327–30.PubMed Orsino A, Schneider R, DeVeber G, et al. Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome. J Pediatr Hematol Oncol. 2004;26(5):327–30.PubMed
106.
Zurück zum Zitat Gómez-Puerta JA, Cervera R, Espinosa G, et al. Antiphospholipid antibodies associated with malignancies: clinical and pathological characteristics of 120 patients. Semin Arthritis Rheum. 2006;35(5):322–32.PubMed Gómez-Puerta JA, Cervera R, Espinosa G, et al. Antiphospholipid antibodies associated with malignancies: clinical and pathological characteristics of 120 patients. Semin Arthritis Rheum. 2006;35(5):322–32.PubMed
107.
Zurück zum Zitat Miesbach W. Antiphospholipid antibodies and antiphospholipid syndrome in patients with malignancies: features, incidence, identification, and treatment. Semin Thromb Hemost. 2008;34(3):282–5. Miesbach W. Antiphospholipid antibodies and antiphospholipid syndrome in patients with malignancies: features, incidence, identification, and treatment. Semin Thromb Hemost. 2008;34(3):282–5.
108.
Zurück zum Zitat Asherson RA, Cervera R, de Groot PG, et al. Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus. 2003;12(7):530–4.PubMed Asherson RA, Cervera R, de Groot PG, et al. Catastrophic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus. 2003;12(7):530–4.PubMed
109.
Zurück zum Zitat Cervera R, Font J, Gomez-Puerta JA, et al. Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome. Ann Rheum Dis. 2005;64(8):1205–9.PubMedCentralPubMed Cervera R, Font J, Gomez-Puerta JA, et al. Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome. Ann Rheum Dis. 2005;64(8):1205–9.PubMedCentralPubMed
110.
Zurück zum Zitat Manco-Johnson M, Wang M, Goldenberg N, et al. Treatment, survival, and thromboembolic outcomes of thrombotic storm in children. J Pediatr. 2012;161(4):682–8. Manco-Johnson M, Wang M, Goldenberg N, et al. Treatment, survival, and thromboembolic outcomes of thrombotic storm in children. J Pediatr. 2012;161(4):682–8.
111.
Zurück zum Zitat Erkan D, Espinosa G, Cervera R. Catastrophic antiphospholipid syndrome: updated diagnostic algorithms. Autoimmun Rev. 2010;10(2):74–9.PubMed Erkan D, Espinosa G, Cervera R. Catastrophic antiphospholipid syndrome: updated diagnostic algorithms. Autoimmun Rev. 2010;10(2):74–9.PubMed
112.•
Zurück zum Zitat Aguiar CL, Erkan D. Catastrophic antiphospholipid syndrome: how to diagnosis a rare but highly fatal disease. Ther Adv Musculoskelet Dis. 2013;5(6):305–14. A review article summarizing the diagnostic challenges and recently updated diagnostic algorithms for CAPS. PubMedCentralPubMed Aguiar CL, Erkan D. Catastrophic antiphospholipid syndrome: how to diagnosis a rare but highly fatal disease. Ther Adv Musculoskelet Dis. 2013;5(6):305–14. A review article summarizing the diagnostic challenges and recently updated diagnostic algorithms for CAPS. PubMedCentralPubMed
113.•
Zurück zum Zitat Berman H, Rodríguez-Pintó I, Cervera R, et al. Catastrophic Registry Project Group (European Forum on Antiphospholipid Antibodies). Pediatric catastrophic antiphospholipid syndrome: descriptive analysis of 45 patients from the “CAPS Registry”. Autoimmun Rev. 2014;13(2):157–62. A descriptive analysis of pediatric patients from the CAPS registry. PubMed Berman H, Rodríguez-Pintó I, Cervera R, et al. Catastrophic Registry Project Group (European Forum on Antiphospholipid Antibodies). Pediatric catastrophic antiphospholipid syndrome: descriptive analysis of 45 patients from the “CAPS Registry”. Autoimmun Rev. 2014;13(2):157–62. A descriptive analysis of pediatric patients from the CAPS registry. PubMed
114.
Zurück zum Zitat Alarcon-Segovia D, Boffa MC, Branch W, et al. Prophylaxis of the antiphospholipid syndrome: a consensus report. Lupus. 2003;12(7):499–503.PubMed Alarcon-Segovia D, Boffa MC, Branch W, et al. Prophylaxis of the antiphospholipid syndrome: a consensus report. Lupus. 2003;12(7):499–503.PubMed
115.
Zurück zum Zitat Ruiz-Irastorza G, Cuadrado MJ, Ruiz-Arruza I, et al. Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies. Lupus. 2011;20(2):206–18.PubMed Ruiz-Irastorza G, Cuadrado MJ, Ruiz-Arruza I, et al. Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies. Lupus. 2011;20(2):206–18.PubMed
116.
Zurück zum Zitat Erkan D, Harrison MJ, Levy R, et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody–positive individuals. Arthritis Rheum. 2007;56(7):2382–91.PubMed Erkan D, Harrison MJ, Levy R, et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody–positive individuals. Arthritis Rheum. 2007;56(7):2382–91.PubMed
117.
Zurück zum Zitat Wahl DG, Guillemin F, de Maistre E, et al. Risk for venous thrombosis related to antiphospholipid antibodies in systemic lupus erythematosus-a meta-analysis. Lupus. 1997;6(5):467–73.PubMed Wahl DG, Guillemin F, de Maistre E, et al. Risk for venous thrombosis related to antiphospholipid antibodies in systemic lupus erythematosus-a meta-analysis. Lupus. 1997;6(5):467–73.PubMed
118.
Zurück zum Zitat Arnaud L, Mathian A, Devilliers H, et al. Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies. Autoimmun Rev. 2015;14(3):192–200.PubMed Arnaud L, Mathian A, Devilliers H, et al. Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies. Autoimmun Rev. 2015;14(3):192–200.PubMed
119.
Zurück zum Zitat Jung H, Bobba R, Su J, et al. The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus. Arthritis Rheum. 2010;62(3):863–8.PubMed Jung H, Bobba R, Su J, et al. The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus. Arthritis Rheum. 2010;62(3):863–8.PubMed
120.
Zurück zum Zitat Ruiz-Irastorza G, Crowther M, Branch W, et al. Antiphospholipid syndrome. Lancet. 2010;376(9751):1498–509.PubMed Ruiz-Irastorza G, Crowther M, Branch W, et al. Antiphospholipid syndrome. Lancet. 2010;376(9751):1498–509.PubMed
121.
Zurück zum Zitat Erkan D. Therapeutic and prognostic considerations in catastrophic antiphospholipid syndrome. Autoimmun Rev. 2006;6(2):98–103.PubMed Erkan D. Therapeutic and prognostic considerations in catastrophic antiphospholipid syndrome. Autoimmun Rev. 2006;6(2):98–103.PubMed
122.
Zurück zum Zitat Cervera R. Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome. Curr Rheumatol Rep. 2010;12(1):70–6.PubMed Cervera R. Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome. Curr Rheumatol Rep. 2010;12(1):70–6.PubMed
123.
Zurück zum Zitat Nageswara Rao AA, Arteaga GM, Reed AM, et al. Rituximab for successful management of probable pediatric catastrophic antiphospholipid syndrome. Pediatr Blood Cancer. 2009;52(4):536–8.PubMed Nageswara Rao AA, Arteaga GM, Reed AM, et al. Rituximab for successful management of probable pediatric catastrophic antiphospholipid syndrome. Pediatr Blood Cancer. 2009;52(4):536–8.PubMed
124.
Zurück zum Zitat Iglesias-Jiménez E, Camacho-Lovillo M, Falcón-Neyra D, et al. Infant with probable catastrophic antiphospholipid syndrome successfully managed with rituximab. Pediatrics. 2010;125(6):e1523–8.PubMed Iglesias-Jiménez E, Camacho-Lovillo M, Falcón-Neyra D, et al. Infant with probable catastrophic antiphospholipid syndrome successfully managed with rituximab. Pediatrics. 2010;125(6):e1523–8.PubMed
125.•
Zurück zum Zitat Berman H, Rodriguez-Pinto I, Cervera R, et al. Rituximab use in the catastrophic syndrome: descriptive analysis of the CAPS registry patients receiving rituximab. Autoimmun Rev. 2013;12(11):1085–90. A descriptive analysis of the use of rituximab in pediatric CAPS. PubMed Berman H, Rodriguez-Pinto I, Cervera R, et al. Rituximab use in the catastrophic syndrome: descriptive analysis of the CAPS registry patients receiving rituximab. Autoimmun Rev. 2013;12(11):1085–90. A descriptive analysis of the use of rituximab in pediatric CAPS. PubMed
126.••
Zurück zum Zitat Erkan D, Aguiar CL, Andrade D, et al. 14th International congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends. Autoimmun Rev. 2014;13(6):685–96. A comprehensive review of the various treatments being used and studied for APS. PubMed Erkan D, Aguiar CL, Andrade D, et al. 14th International congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends. Autoimmun Rev. 2014;13(6):685–96. A comprehensive review of the various treatments being used and studied for APS. PubMed
127.
Zurück zum Zitat Brandt JT, Triplett DA, Alving B, et al. Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost. 1995;74(4):1185–90.PubMed Brandt JT, Triplett DA, Alving B, et al. Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost. 1995;74(4):1185–90.PubMed
128.
Zurück zum Zitat Mohr JP, Thompson JL, Lazar RM, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med. 2001;345(20):1444–51.PubMed Mohr JP, Thompson JL, Lazar RM, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med. 2001;345(20):1444–51.PubMed
129.••
Zurück zum Zitat Levine SR, Brey RL, Tilley BC, et al. Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke. JAMA. 2004;291(5):576–84. This is a prospective cohort study within the Warfarin versus Aspirin Recurrent Stroke Study (WARSS) [126] that specified in advance APS-related data and sample collection parameters and could be a model for future studies. PubMed Levine SR, Brey RL, Tilley BC, et al. Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke. JAMA. 2004;291(5):576–84. This is a prospective cohort study within the Warfarin versus Aspirin Recurrent Stroke Study (WARSS) [126] that specified in advance APS-related data and sample collection parameters and could be a model for future studies. PubMed
130.
Zurück zum Zitat Liu X-W, Pierangeli SS, Barker J, et al. RBC adhesion to cremaster endothelium in mice with abnormal hemoglobin is increased by topical endotoxin. Ann N Y Acad Sci. 1998;850:391–3.PubMed Liu X-W, Pierangeli SS, Barker J, et al. RBC adhesion to cremaster endothelium in mice with abnormal hemoglobin is increased by topical endotoxin. Ann N Y Acad Sci. 1998;850:391–3.PubMed
131.
Zurück zum Zitat Westerman M, Green D, Gilman-Sachs A, et al. Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease. J Lab Clin Med. 1999;134(4):352–62.PubMed Westerman M, Green D, Gilman-Sachs A, et al. Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease. J Lab Clin Med. 1999;134(4):352–62.PubMed
Metadaten
Titel
Pediatric Antiphospholipid Syndrome
verfasst von
Cassyanne L. Aguiar
Arzu Soybilgic
Tadej Avcin
Barry L. Myones
Publikationsdatum
01.04.2015
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 4/2015
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-015-0504-5

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Patient Reported Outcomes in Rheumatoid Arthritis Clinical Trials

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Difficult Clinical Situations in the Antiphospholipid Syndrome

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