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Current Rheumatology Reports
Erschienen in: Current Rheumatology Reports 5/2018

01.05.2018 | Spondyloarthritis (M Khan, Section Editor)

Functional Defects of Treg Cells: New Targets in Rheumatic Diseases, Including Ankylosing Spondylitis

verfasst von: Jinlin Miao, Ping Zhu

Erschienen in: Current Rheumatology Reports | Ausgabe 5/2018

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Abstract

Purpose of review

This study aims to review the advances of Treg cell biology, the functional defects of Treg cells, and the potential strategies for the experimental, preclinical or clinical application of Treg cell therapy in the context of autoimmune/immune-mediated rheumatic diseases.

Recent findings

CD4+CD25+ regulatory T (Treg) cells are a phenotypically and functionally heterogeneous subset of lymphocytes that prevent a variety of autoimmune diseases. As in many autoimmune diseases, the functional defects of Treg cells are supposed to play relevant roles in the pathogenesis and development of systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, and other autoimmune/immune-mediated rheumatic diseases. Consequently, manipulation and modulation of Treg cells represent a potent strategy for therapeutic benefit in many such diseases.

Summary

A further understanding of the functional defects of Treg cells in rheumatic diseases will contribute to find new targets and therapies in rheumatic diseases, including ankylosing spondylitis.
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Metadaten
Titel
Functional Defects of Treg Cells: New Targets in Rheumatic Diseases, Including Ankylosing Spondylitis
verfasst von
Jinlin Miao
Ping Zhu
Publikationsdatum
01.05.2018
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 5/2018
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-018-0729-1

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