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01.12.2012 | Original Article

Nesfatin-1 and other hormone alterations in polycystic ovary syndrome

verfasst von: Rulin Deniz, Bilgin Gurates, Suleyman Aydin, Husnu Celik, İbrahim Sahin, Yakup Baykus, Zekiye Catak, Aziz Aksoy, Cihan Citil, Sami Gungor

Erschienen in: Endocrine | Ausgabe 3/2012

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Abstract

Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman–Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.

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Titel: Nesfatin-1 and other hormone alterations in polycystic ovary syndrome
verfasst von: Rulin Deniz
Bilgin Gurates
Suleyman Aydin
Husnu Celik
İbrahim Sahin
Yakup Baykus
Zekiye Catak
Aziz Aksoy
Cihan Citil
Sami Gungor
Publikationsdatum: 01.12.2012
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2012
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-012-9638-7

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