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01.11.2011 | Original article

18F-fluoromisonidazole positron emission tomography before treatment is a predictor of radiotherapy outcome and survival prognosis in patients with head and neck squamous cell carcinoma

verfasst von: Masahiro Kikuchi, Tomohiko Yamane, Shogo Shinohara, Keizo Fujiwara, Shin-ya Hori, Yosuke Tona, Hiroshi Yamazaki, Yasushi Naito, Michio Senda

Erschienen in: Annals of Nuclear Medicine | Ausgabe 9/2011

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Abstract

Objective

To evaluate the usefulness of [¹⁸F]fluoromisonidazole ([¹⁸F]FMISO)-positron emission tomography (PET) prior to the treatment of head and neck squamous cell carcinoma.

Methods

Seventeen patients with untreated HNSCC underwent pretreatment [¹⁸F]FMISO PET. Six of them underwent definitive surgery and the remaining 11 definitive (chemo-)radiotherapy. We evaluated 30 lesions from the 17 patients. SUVmax and tumor-to-muscle ratios (TMR) were measured as hypoxia indicators. Tumors equal to or above the median value were defined as tumor with high uptake of [¹⁸F]FMISO and those below as tumor with low uptake of [¹⁸F]FMISO in both indicators. Local control rates with radiotherapy, event-free survival and disease-specific survival (DSS) rates with radiotherapy or operation were compared.

Result

[¹⁸F]FMISO-PET imaging of 30 lesions resulted in a SUVmax median value of 2.3 and a TMR median value of 1.3. Local control rates with radiotherapy (20-month median follow-up duration) were significantly lower in the tumor group with high uptake of [¹⁸F]FMISO compared to the tumor group with low uptake of [¹⁸F]FMISO using either SUVmax or TMR as the hypoxic indicator (P = 0.02 and 0.04, respectively). DSS rate with radiotherapy or operation (21-month median follow-up duration) was significantly lower in the patient group with high uptake of [¹⁸F]FMISO compared to the patient group with low uptake of [¹⁸F]FMISO defined by SUVmax (P = 0.04), but was not by TMR (P = 0.57).

Conclusions

Radiotherapy outcome and survival prognosis (radiotherapy or operation) in HNSCC may be predicted by carrying out [¹⁸F]FMISO PET before treatment.

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Titel: 18F-fluoromisonidazole positron emission tomography before treatment is a predictor of radiotherapy outcome and survival prognosis in patients with head and neck squamous cell carcinoma
verfasst von: Masahiro Kikuchi
Tomohiko Yamane
Shogo Shinohara
Keizo Fujiwara
Shin-ya Hori
Yosuke Tona
Hiroshi Yamazaki
Yasushi Naito
Michio Senda
Publikationsdatum: 01.11.2011
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 9/2011
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-011-0508-9

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

18F-fluoromisonidazole positron emission tomography before treatment is a predictor of radiotherapy outcome and survival prognosis in patients with head and neck squamous cell carcinoma

Abstract

Objective

Methods

Result

Conclusions

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Objective

Methods

Result

Conclusions

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