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Annals of Nuclear Medicine

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01.10.2013 | Review Article

Diagnostic utility of PETCT in thyroid malignancies: an update

verfasst von: Shanmuga Sundaram Palaniswamy, Padma Subramanyam

Erschienen in: Annals of Nuclear Medicine | Ausgabe 8/2013

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Abstract

The primary clinical application of ¹⁸F FDG PET/CT (¹⁸Fluorine labeled flurodeoxyglucose positron emission tomography/computed tomography) in differentiated thyroid carcinoma is in the identification of active disease in thyroglobulin (Tg) positive (>10 ng/ml), whole body iodine scan negative patients. The impact of FDG PET/CT in diagnosis, surveillance, cure, and progression-free survival of differentiated thyroid carcinoma patients remains to be seen. Five main indications of FDG PET/CT in thyroid cancer have been recommended by revised American thyroid association guidelines 2009. This review aims to provide a complete picture of PET imaging in thyroid malignancies and enumerates each indication with literature review. This review also highlights recent advances in targeted molecular imaging. Currently differentiated thyroid cancer is best imaged using conventional single photon emission computed tomography-based radioiodine tracers (¹²³I/¹³¹I). Although the utility of FDG PET in well differentiated thyroid cancer patients who are iodine negative but with raised Tg is well established, evidence is emerging on the advantages of FDG PET/CT in other histological types of thyroid malignancy, such as Hurthle cell, medullary, and the anaplastic malignancies. Novel PET radiotracers, such as ¹²⁴Iodine (¹²⁴I), ¹⁸F-DOPA (3,4-dihydroxy-l-phenylalanine), and ⁶⁸Ga-DOTA peptides are revolutionizing the way thyroid malignancies are imaged. Newer concepts on targeted molecular imaging and theranostics are ushering in new possibilities for imaging and treating thyroid cancer.

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Titel: Diagnostic utility of PETCT in thyroid malignancies: an update
verfasst von: Shanmuga Sundaram Palaniswamy
Padma Subramanyam
Publikationsdatum: 01.10.2013
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 8/2013
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-013-0740-6

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Diagnostic utility of PETCT in thyroid malignancies: an update

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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