nach oben

Erschienen in:

01.11.2004 | Nuclear Medicine

Value of ¹²⁴I-PET/CT in staging of patients with differentiated thyroid cancer

verfasst von: L. S. Freudenberg, G. Antoch, W. Jentzen, R. Pink, J. Knust, R. Görges, S. P. Müller, A. Bockisch, J. F. Debatin, W. Brandau

Erschienen in: European Radiology | Ausgabe 11/2004

Einloggen, um Zugang zu erhalten

Abstract

The aim of this study is to evaluate the clinical significance of ¹²⁴I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with ¹³¹I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, ¹²⁴I-PET, and combined ¹²⁴I-PET/CT imaging, respectively. Lesion delectability of ¹³¹I-WBS was 83%. We conclude that ¹²⁴I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.

Frilling A, Görges R, Tecklenborg K et al (2000) Value of preoperative diagnostic modalities in patients with recurrent thyroid carcinoma. Surgery 28:1067–1074CrossRef

Alnafisi NS, Driedger AA, Coates G, Moote DJ, Raphael SJ (2000) FDG PET of recurrent or metastatic 131I-negative papillary thyroid carcinoma. J Nucl Med 41:1010–1015PubMed

Chung JK, So Y, Lee JS et al (1999) Value of FDG PET in papillary thyroid carcinoma with negative 131I whole-body scan. J Nucl Med 40:986–992PubMed

Grünwald F, Kalicke T, Feine U et al (1999) Fluorine-18 fluorodeoxyglucose positron emission tomography in thyroid cancer: results of a multicentre study. Eur J Nucl Med 26:1547–1552CrossRefPubMed

Hooft L, Hoekstra OS, Deville W et al (2001) Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography in the follow-up of papillary or follicular thyroid cancer. J Clin Endocrinol Metab 86:3779–3786CrossRefPubMed

Filesi M, Signore A, Ventroni G, Melacrinis FF, Ronga G (1998) Role of initial iodine-131 whole-body scan and serum thyroglobulin in differentiated thyroid carcinoma metastases. J Nucl Med 39:1542–1546PubMed

Frey P, Townsend D, Flattet A et al (1986) Tomographic imaging of the human thyroid using 124I. J Clin Endocrinol Metab 63:918–927PubMed

Lambrecht RM, Woodhouse N, Phillips R et al (1988) Investigational study of iodine-124 with a positron camera. Am J Physiol Imaging 3:197–200PubMed

Crawford DC, Flower MA, Pratt BE et al (1997) Thyroid volume measurement in thyrotoxic patients: comparison between ultrasonography and iodine-124 positron emission tomography. Eur J Nucl Med 24:1470–1478CrossRefPubMed

10.

Erdi YE, Macapinlac H, Larson SM et al (1999) Radiation dose assessment for I-131 therapy of thyroid cancer using I-124 PET imaging. Clin Positron Imaging 2:41–46CrossRefPubMed

11.

Frey P, Townsend D, Jeavons A, Donath A (1985) In vivo imaging of the human thyroid with a positron camera using 124I. Eur J Nucl Med 10:472–476PubMed

12.

Pentlow KS, Graham MC, Lambrecht RM et al (1996) Quantitative imaging of iodine-124 with PET. J Nucl Med 37:1557–1562PubMed

13.

Eschmann SM, Reischl G, Bilger K et al (2000) Evaluation of dosimetry of radioiodine therapy in benign and malignant thyroid disorders by means of iodine-124 and PET. Eur J Nucl Med 29:760–767CrossRef

14.

Beyer T, Townsend DW, Brun, T et al (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41:1369–1379PubMed

15.

Townsend DW, Cherry SR (2001) Combined anatomy and function: the path of true image fusion. Eur Radiol 11:1968–1974CrossRefPubMed

16.

Freudenberg LS, Antoch G, Görges R et al (2002) Combined PET/CT with Iodine-124 in diagnosis of mediastinal micrometastases in thyroid carcinoma. Internet J Radiol 2:2

17.

Freudenberg LS, Antoch G, Gorges R et al (2003) Combined PET/CT with iodine-124 in diagnosis of spread metastatic thyroid carcinoma: a case report. Eur Radiol 13 [Suppl 4]:19–23

18.

Freudenberg LS, Antoch G, Görges R et al (2002) 124I-PET/CT in metastatic follicular thyroid carcinoma. Eur J Nucl Med 29:1106CrossRef

19.

Fleming ID, Cooper JS, Henson DE (eds) (1997) AJCC cancer staging manual. 5th edn. American Joint Committee on Cancer. Lippincott-Raven, Philadelphia

20.

Knust EJ, Dutschka K, Weinreich R (2000) Preparation of 124I solutions after thermodistillation of irradiated 124TeO2 targets. Appl Radiat Isot 52:181–184CrossRefPubMed

21.

Kinahan PE, Townsend DW, Beyer T et al (1998) Attenuation correction for a combined 3D PET/CT scanner. Med Phys 25:2046–2053CrossRefPubMed

22.

Görges R, Fotescu D, Renzing-Köhler K et al (2003) Diagnostic value of high-resolution B-mode and power-mode sonography in the follow up of thyroid cancer. Eur J Ultrasound 16:191–206CrossRefPubMed

23.

International Commission on Radiological Protection (eds) (1998) ICRP publication 80; Addendum to publication 53—radiation dose to patients from radiopharmaceuticals. Ann ICRP 28:3PubMed

24.

Shapiro B, Gross MD (2001) Follow-up of patients with well-differentiated thyroid cancer. In: Biersack HJ, Grünwald F (eds) Thyroid cancer. Spinger, Berlin Heidelberg New York

Titel: Value of 124I-PET/CT in staging of patients with differentiated thyroid cancer
verfasst von: L. S. Freudenberg
G. Antoch
W. Jentzen
R. Pink
J. Knust
R. Görges
S. P. Müller
A. Bockisch
J. F. Debatin
W. Brandau
Publikationsdatum: 01.11.2004
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 11/2004
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-004-2350-0

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Value of ¹²⁴I-PET/CT in staging of patients with differentiated thyroid cancer

Abstract

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Radiologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2004

Sir Godfrey Hounsfield - Nobel Laureate

3D time-of-flight MR angiography of the intracranial vessels: optimization of the technique with water excitation, parallel acquisition, eight-channel phased-array head coil and low-dose contrast administration

Hepatic artery embolization for treatment of patients with hereditary hemorrhagic telangiectasia and symptomatic hepatic vascular malformations

Percutaneous placement of peritoneal port-catheter in oncologic patients

Pneumatosinus dilatans, associated with meningioma: is remodelling of the skull-base triggered by local cathepsin-expression? (2004:8b)

Multislice CT and CT angiography for non-invasive evaluation of bronchopulmonary sequestration

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Radiologie