Erschienen in:
14.04.2023 | Editorial
Biomarkers of Endothelial Glycocalyx Integrity for Cardiovascular Events in Individuals Without Cardiovascular Disease
verfasst von:
Tomoyuki Kawada
Erschienen in:
Journal of Cardiovascular Translational Research
|
Ausgabe 4/2023
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Excerpt
Ikonomidis et al. investigated the association between disturbance of glycocalyx integrity and incident cardiovascular events [
1]. They measured perfused boundary region (PBR5-25), which was a marker of glycocalyx integrity, in sublingual microvessels with a diameter ranging 5–25 µm. Increased PBR indicates reduced glycocalyx thickness, and cardiovascular events, which were defined as dealth by major adverse cardiovascular events, myocardial infarction, and stroke, were monitored during a 6-year follow-up. The adjusted hazard ratio (HR) of PBR5-25 for cardiovascular events significantly increased in any statistical models. The authors concluded that glycocalyx integrity was a significant predictor for cardiovascular events in individuals without cardiovascular disease. I have some comments about the study. …