Introduction
Materials and methods
Search strategy
Inclusion and exclusion criteria
Data extraction
Statistical analysis
Results
Characteristics of studies
First author | Year | Country | Ethnicity | Method of genotyping | HWE of control | Type of leukemia | Source of control | Sample size (case/control) |
---|---|---|---|---|---|---|---|---|
Lv et al. [25] | 2012 | China | Asian | PCR | 0.11 | LL | HB | 176/170 |
Elghannam et al. [26] | 2013 | Egypt | African | PCR | 0.28 | ML | HB | 96/90 |
Penna et al. [27] | 2011 | Italy | Caucasian | PCR | 0.45 | LL | HB | 125/125 |
Vivona et al. [28] | 2012 | Brazil | Mix | PCR-RFLP | 0.10 | ML | HB | 118/120 |
Semsei et al. [29] | 2008 | Hungary | Caucasian | PCR | 0.08 | LL | HB | 375/189 |
Urayama et al. [30] | 2007 | USA | Mix | PCR | 0.15 | LL | HB | 294/369 |
Kaya et al. [31] | 2005 | Turkey | Caucasian | PCR-RFLP | 0.22 | ML | PB | 28/17 |
Kaya et al. [31] | 2005 | Turkey | Caucasian | PCR-RFLP | 0.22 | LL | PB | 17/17 |
Quantitative synthesis of data
Comparison | Population |
N
| Test of association | Model | Test of heterogeneity | |||
---|---|---|---|---|---|---|---|---|
OR | 95 % CI |
P
|
P
|
I
2
| ||||
T vs. G | Overall | 8 | 1.00 | 0.88–1.12 | 0.914 | R | 0.011 | 61.6 |
Caucasians | 4 | 1.13 | 0.87–1.46 | 0.377 | R | 0.029 | 66.7 | |
Mix | 2 | 1.03 | 0.92–1.15 | 0.647 | F | 0.826 | 0 | |
Others | 2 | 0.83 | 0.67–1.03 | 0.099 | R | 0.139 | 54.4 | |
ML | 3 | 0.86 | 0.73–1.02 | 0.075 | F | 0.168 | 43.9 | |
LL | 5 | 1.04 | 0.92–1.19 | 0.510 | R | 0.042 | 59.7 | |
TT vs. GG | Overall | 8 | 0.97 | 0.75–1.26 | 0.812 | R | 0.020 | 57.8 |
Caucasians | 4 | 1.28 | 0.77–2.13 | 0.334 | R | 0.034 | 64.3 | |
Mix | 2 | 1.01 | 0.78–1.31 | 0.922 | F | 0.268 | 18.6 | |
Others | 2 | 0.68 | 0.48–0.94 | 0.020 | F | 0.307 | 4.3 | |
ML | 3 | 0.66 | 0.46–0.95 | 0.026 | F | 0.452 | 0 | |
LL | 5 | 1.10 | 0.85–1.42 | 0.491 | R | 0.070 | 53.9 | |
TG vs. GG | Overall | 8 | 1.00 | 0.92–1.08 | 0.939 | F | 0.618 | 0 |
Caucasians | 4 | 0.97 | 0.784–1.11 | 0.642 | F | 0.433 | 0 | |
Mix | 2 | 1.05 | 0.93–1.18 | 0.447 | F | 0.162 | 48.9 | |
Others | 2 | 0.95 | 0.80–1.11 | 0.496 | F | 0.959 | 0 | |
ML | 3 | 1.08 | 0.88–1.32 | 0.477 | F | 0.250 | 27.9 | |
LL | 5 | 0.98 | 0.90–1.07 | 0.635 | F | 0.731 | 0 | |
TT vs. TG/GG | Overall | 8 | 0.98 | 0.67–1.43 | 0.906 | R | 0 | 73.9 |
Caucasians | 4 | 1.53 | 0.79–3.39 | 0.291 | R | 0.001 | 80.6 | |
Mix | 2 | 0.88 | 0.45–1.69 | 0.691 | R | 0.101 | 62.7 | |
Others | 2 | 0.63 | 0.43–0.92 | 0.016 | F | 0.162 | 48.9 | |
ML | 3 | 0.56 | 0.38–0.84 | 0.005 | F | 0.350 | 4.7 | |
LL | 5 | 1.19 | 0.79–1.79 | 0.411 | R | 0.004 | 74.1 | |
TT/TG vs. GG | Overall | 8 | 1.00 | 0.95–1.06 | 0.994 | F | 0.748 | 0 |
Caucasians | 4 | 1.02 | 0.93–1.11 | 0.692 | F | 0.904 | 0 | |
Mix | 2 | 1.03 | 0.94–1.13 | 0.514 | F | 0.415 | 0 | |
Others | 2 | 0.91 | 0.81–1.03 | 0.132 | F | 0.509 | 0 | |
ML | 3 | 0.98 | 0.84–1.14 | 0.792 | F | 0.243 | 29.4 | |
LL | 5 | 1.004 | 0.95–1.07 | 0.890 | F | 0.882 | 0 |