nach oben

Current Dermatology Reports

Erschienen in:

22.04.2017 | Psoriasis (J Wu, Section Editor)

The Role of the Skin and Gut Microbiome in Psoriatic Disease

verfasst von: Di Yan, Naiem Issa, Ladan Afifi, Caleb Jeon, Hsin-Wen Chang, Wilson Liao

Erschienen in: Current Dermatology Reports | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

To understand the changes in the microbiome in psoriatic disease, we conducted a systematic review of studies comparing the skin and gut microbiota in psoriatic individuals and healthy controls.

Recent Findings

Our review of studies pertaining to the cutaneous microbiome showed a trend towards an increased relative abundance of Streptococcus and a decreased level of Propionibacterium in psoriasis patients compared to controls. In the gut microbiome, the ratio of Firmicutes and Bacteroidetes was perturbed in psoriatic individuals compared to healthy controls. Actinobacteria was also relatively underrepresented in psoriasis patients relative to healthy individuals.

Summary

Although the field of the psoriatic microbiome is relatively new, these first studies reveal interesting differences in microbiome composition that may be associated with the development of psoriatic comorbidities and serve as novel therapeutic targets.

Clements SJ, Carding SR. Diet, the intestinal microbiota and immune health in ageing. Crit Rev food Sci Nutr. 2016; doi:10.1080/10408398.2016.1211086.PubMed

Cheng J, Palva AM, de Vos WM, et al. Contribution of the intestinal microbiota to human health: from birth to 100 years of age. Curr Top Microbiol Immunol. 2013;358:323–46. doi:10.1007/82_2011_189.PubMed

Scher JU, Littman DR, Abramson SB. Microbiome in inflammatory arthritis and human rheumatic diseases. Arthritis & Rheumatology (Hoboken, NJ). 2016;68(1):35–45. doi:10.1002/art.39259.CrossRef

Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13(4):260–70. doi:10.1038/nrg3182.PubMedPubMedCentral

David LA, Materna AC, Friedman J, et al. Host lifestyle affects human microbiota on daily timescales. Genome Biol. 2014;15(7):R89. doi:10.1186/gb-2014-15-7-r89.CrossRefPubMedPubMedCentral

Salim SY, Kaplan GG, Madsen KL. Air pollution effects on the gut microbiota: a link between exposure and inflammatory disease. Gut Microbes. 2014;5(2):215–9. doi:10.4161/gmic.27251.CrossRefPubMed

Yeoh N, Burton JP, Suppiah P, et al. The role of the microbiome in rheumatic diseases. Curr Rheumatol Rep. 2013;15(3):314. doi:10.1007/s11926-012-0314-y.CrossRefPubMed

Longman RS, Littman DR. The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity. Curr Opin Rheumatol. 2015;27(4):381–7. doi:10.1097/bor.0000000000000190.CrossRefPubMedPubMedCentral

Costello EK, Lauber CL, Hamady M, et al. Bacterial community variation in human body habitats across space and time. Science (New York, NY). 2009;326(5960):1694–7. doi:10.1126/science.1177486.CrossRef

10.

Grice EA, Kong HH, Renaud G, et al. A diversity profile of the human skin microbiota. Genome Res. 2008;18(7):1043–50. doi:10.1101/gr.075549.107.CrossRefPubMedPubMedCentral

11.

Peterson J, Garges S, Giovanni M, et al. The NIH Human Microbiome Project. Genome Res. 2009;19(12):2317–23. doi:10.1101/gr.096651.109.CrossRefPubMedPubMedCentral

12.

Aagaard K, Petrosino J, Keitel W, et al. The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2013;27(3):1012–22. doi:10.1096/fj.12-220806.CrossRef

13.

Fahlen A, Engstrand L, Baker BS, et al. Comparison of bacterial microbiota in skin biopsies from normal and psoriatic skin. Arch Dermatol Res. 2012;304(1):15–22. doi:10.1007/s00403-011-1189-x.CrossRefPubMed

14.

Drago L, De Grandi R, Altomare G, et al. Skin microbiota of first cousins affected by psoriasis and atopic dermatitis. Clinical and molecular allergy : CMA. 2016;14:2. doi:10.1186/s12948-016-0038-z.CrossRefPubMedPubMedCentral

15.

Gao Z, Tseng CH, Strober BE, et al. Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS One. 2008;3(7):e2719. doi:10.1371/journal.pone.0002719.CrossRefPubMedPubMedCentral

16.

Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9(4):244–53. doi:10.1038/nrmicro2537.CrossRefPubMedPubMedCentral

17.

Jovel J, Patterson J, Wang W, et al. Characterization of the gut microbiome using 16S or shotgun metagenomics. Front Microbiol. 2016;7:459. doi:10.3389/fmicb.2016.00459.CrossRefPubMedPubMedCentral

18.

Meisel JS, Hannigan GD, Tyldsley AS, et al. Skin microbiome surveys are strongly influenced by experimental design. The Journal of investigative dermatology. 2016;136(5):947–56. doi:10.1016/j.jid.2016.01.016.CrossRefPubMedPubMedCentral

19.

Zakostelska Z, Malkova J, Klimesova K, et al. Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response. PLoS One. 2016;11(7):e0159539. doi:10.1371/journal.pone.0159539.CrossRefPubMedPubMedCentral

20.

Horton DB, Scott FI, Haynes K, et al. Antibiotic exposure, infection, and the development of pediatric psoriasis: a nested case-control study. JAMA dermatology. 2016;152(2):191–9. doi:10.1001/jamadermatol.2015.3650.CrossRefPubMedPubMedCentral

21.

• Alekseyenko AV, Perez-Perez GI, De Souza A, et al. Community differentiation of the cutaneous microbiota in psoriasis. Microbiome. 2013;1(1):31. doi:10.1186/2049-2618-1-31. Here Alekseyenko et al. report the results of the largest study profiling the cutaneous microbiome in psoriasis to date. This study is also the only one to profile changes in the cutaneous microbiome after treatment for psoriasis.CrossRefPubMedPubMedCentral

22.

Paulino LC, Tseng CH, Strober BE, et al. Molecular analysis of fungal microbiota in samples from healthy human skin and psoriatic lesions. J Clin Microbiol. 2006;44(8):2933–41. doi:10.1128/jcm.00785-06.CrossRefPubMedPubMedCentral

23.

Paulino LC, Tseng CH, Blaser MJ. Analysis of Malassezia microbiota in healthy superficial human skin and in psoriatic lesions by multiplex real-time PCR. FEMS Yeast Res. 2008;8(3):460–71. doi:10.1111/j.1567-1364.2008.00359.x.CrossRefPubMed

24.

Jagielski T, Rup E, Ziolkowska A, et al. Distribution of Malassezia species on the skin of patients with atopic dermatitis, psoriasis, and healthy volunteers assessed by conventional and molecular identification methods. BMC Dermatol. 2014;14:3. doi:10.1186/1471-5945-14-3.CrossRefPubMedPubMedCentral

25.

Takemoto A, Cho O, Morohoshi Y, et al. Molecular characterization of the skin fungal microbiome in patients with psoriasis. J Dermatol. 2015;42(2):166–70. doi:10.1111/1346-8138.12739.CrossRefPubMed

26.

Wolf P, Seidl H, Back B, et al. Increased prevalence of human papillomavirus in hairs plucked from patients with psoriasis treated with psoralen-UV-A. Arch Dermatol. 2004;140(3):317–24. doi:10.1001/archderm.140.3.317.CrossRefPubMed

27.

Simeone P, Teson M, Latini A, et al. Human papillomavirus type 5 in primary keratinocytes from psoriatic skin. Exp Dermatol. 2005;14(11):824–9. doi:10.1111/j.1600-0625.2005.00358.x.CrossRefPubMed

28.

Cronin JG, Mesher D, Purdie K, et al. Beta-papillomaviruses and psoriasis: an intra-patient comparison of human papillomavirus carriage in skin and hair. Br J Dermatol. 2008;159(1):113–9. doi:10.1111/j.1365-2133.2008.08627.x.CrossRefPubMedPubMedCentral

29.

Salem SA, Zuel-Fakkar NM, Fathi G, et al. Comparative study of human papilloma virus in untreated and ultraviolet-treated psoriatic patients. Photodermatology, photoimmunology & photomedicine. 2010;26(2):78–82. doi:10.1111/j.1600-0781.2010.00492.x.CrossRef

30.

de Koning MN, Polderman MC, Waterboer T, et al. Marked differences in Betapapillomavirus DNA and antibody prevalence between patients with psoriasis and those with atopic dermatitis. Br J Dermatol. 2011;164(4):771–5. doi:10.1111/j.1365-2133.2010.10182.x.CrossRefPubMed

31.

Bellaud G, Gheit T, Pugin A, et al. Prevalence of human papillomavirus DNA in eyebrow hairs plucked from patients with psoriasis treated with TNF inhibitors. Journal of the European Academy of Dermatology and Venereology : JEADV. 2014;28(12):1816–20. doi:10.1111/jdv.12308.CrossRefPubMed

32.

Prignano G, Ferraro C, Mussi A, et al. Prevalence of human papilloma virus type 5 DNA in lesional and non-lesional skin scales of Italian plaque-type psoriatic patients: association with disease severity. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2005;11(1):47–51. doi:10.1111/j.1469-0691.2004.01040.x.CrossRef

33.

Masallat D, Moemen D, State AF. Gut bacterial microbiota in psoriasis: a case control study. Afr J Microbiol Res. 2016;10(33):1337–43. doi:10.5897/AJMR2016.8046.CrossRef

34.

• Scher JU, Ubeda C, Artacho A, et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis & rheumatology (Hoboken, NJ). 2015;67(1):128–39. doi:10.1002/art.38892. The study by Scher et al., is the only comprehensive, genus-level, profiling study of the gut microbiome in psoriatic disease to date. This study is also significant in that it correlates fecal metabolites with shifts in gut microbiome composition, providing the foundation for a mechanistic understanding of how bacteria can influence the host.CrossRef

35.

Harwood CA, Surentheran T, McGregor JM, et al. Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. J Med Virol. 2000;61(3):289–97.CrossRefPubMed

36.

Struijk L, Bouwes Bavinck JN, Wanningen P, et al. Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma. The Journal of investigative dermatology. 2003;121(6):1531–5. doi:10.1046/j.1523-1747.2003.12632.x.CrossRefPubMed

37.

Majewski S, Jablonska S. Do epidermodysplasia verruciformis human papillomaviruses contribute to malignant and benign epidermal proliferations? Arch Dermatol. 2002;138(5):649–54.CrossRefPubMed

38.

Sahebjamiee M, Sand L, Karimi S, et al. Prevalence of human papillomavirus in oral lichen planus in an Iranian cohort. Journal of oral and maxillofacial pathology: JOMFP. 2015;19(2):170–4. doi:10.4103/0973-029x.164528.CrossRefPubMedPubMedCentral

39.

Dekio I, Hayashi H, Sakamoto M, et al. Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling. J Med Microbiol. 2005;54(Pt 12):1231–8. doi:10.1099/jmm.0.46075-0.CrossRefPubMed

40.

Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (New York, NY). 2013;341(6145):569–73. doi:10.1126/science.1241165.CrossRef

41.

Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9(5):313–23. doi:10.1038/nri2515.CrossRefPubMedPubMedCentral

42.

Gudjonsson JE, Thorarinsson AM, Sigurgeirsson B, et al. Streptococcal throat infections and exacerbation of chronic plaque psoriasis: a prospective study. Br J Dermatol. 2003;149(3):530–4.CrossRefPubMed

43.

Naik S, Bouladoux N, Linehan JL, et al. Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature. 2015;520(7545):104–8. doi:10.1038/nature14052.CrossRefPubMedPubMedCentral

44.

Schirmer M, Smeekens SP, Vlamakis H, et al. Linking the human gut microbiome to inflammatory cytokine production capacity. Cell. 2016;167(4):1125–36.e8. doi:10.1016/j.cell.2016.10.020.CrossRefPubMed

45.

Cantini F, Niccoli L, Nannini C, et al. Psoriatic arthritis: a systematic review. Int J Rheum Dis. 2010;13(4):300–17. doi:10.1111/j.1756-185X.2010.01540.x.CrossRefPubMed

46.

Calcinaro F, Dionisi S, Marinaro M, et al. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse. Diabetologia. 2005;48(8):1565–75. doi:10.1007/s00125-005-1831-2.CrossRefPubMed

47.

Lavasani S, Dzhambazov B, Nouri M, et al. A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells. PLoS One. 2010;5(2):e9009. doi:10.1371/journal.pone.0009009.CrossRefPubMedPubMedCentral

48.

Groeger D, O’Mahony L, Murphy EF, et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 2013;4(4):325–39. doi:10.4161/gmic.25487.CrossRefPubMedPubMedCentral

49.

Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57–63. doi:10.1038/nature09922.CrossRefPubMedPubMedCentral

50.

Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19(5):576–85. doi:10.1038/nm.3145.CrossRefPubMedPubMedCentral

51.

Tang WH, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575–84. doi:10.1056/NEJMoa1109400.CrossRefPubMedPubMedCentral

52.

Cho CE, Taesuwan S, Malysheva OV, et al. Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: a randomized controlled trial. Mol Nutr Food Res. 2016; doi:10.1002/mnfr.201600324.

53.

Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022–3. doi:10.1038/4441022a.CrossRefPubMed

54.

Duarte GV, Silva LP. Correlation between psoriasis’ severity and waist-to-height ratio. An Bras Dermatol. 2014;89(5):846–7.CrossRefPubMedPubMedCentral

55.

Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies. Nutrition & diabetes. 2012;2:e54. doi:10.1038/nutd.2012.26.CrossRef

56.

Toussirot E, Aubin F, Dumoulin G. Relationships between adipose tissue and psoriasis, with or without arthritis. Front Immunol. 2014;5:368. doi:10.3389/fimmu.2014.00368.CrossRefPubMedPubMedCentral

57.

Abuabara K, Azfar RS, Shin DB, et al. Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K. Br J Dermatol. 2010;163(3):586–92. doi:10.1111/j.1365-2133.2010.09941.x.CrossRefPubMedPubMedCentral

58.

Gelfand JM, Yeung H. Metabolic syndrome in patients with psoriatic disease. The Journal of rheumatology Supplement. 2012;89:24–8. doi:10.3899/jrheum.120237.CrossRefPubMedPubMedCentral

59.

De Preter V, Machiels K, Joossens M, et al. Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD. Gut. 2015;64(3):447–58. doi:10.1136/gutjnl-2013-306423.CrossRefPubMed

60.

Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease: current status and the future ahead. Gastroenterology. 2014;146(6):1489–99. doi:10.1053/j.gastro.2014.02.009.CrossRefPubMedPubMedCentral

61.

Eppinga H, Konstantinov SR, Peppelenbosch MP, et al. The microbiome and psoriatic arthritis. Curr Rheumatol Rep. 2014;16(3):407. doi:10.1007/s11926-013-0407-2.CrossRefPubMed

62.

Mueller S, Saunier K, Hanisch C, et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol. 2006;72(2):1027–33. doi:10.1128/aem.72.2.1027-1033.2006.CrossRefPubMedPubMedCentral

63.

Markle JG, Frank DN, Adeli K, et al. Microbiome manipulation modifies sex-specific risk for autoimmunity. Gut Microbes. 2014;5(4):485–93. doi:10.4161/gmic.29795.CrossRefPubMed

64.

David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–63. doi:10.1038/nature12820.CrossRefPubMed

65.

Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207–14. doi:10.1038/nature11234.

66.

O’Dell JR, Elliott JR, Mallek JA, et al. Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone. Arthritis Rheum. 2006;54(2):621–7. doi:10.1002/art.21620.CrossRefPubMed

67.

Tilley BC, Alarcon GS, Heyse SP, et al. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Ann Intern Med. 1995;122(2):81–9.CrossRefPubMed

68.

Lee CH, Steiner T, Petrof EO, et al. Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection: a randomized clinical trial. JAMA. 2016;315(2):142–9. doi:10.1001/jama.2015.18098.CrossRefPubMed

69.

Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368(14):1279–90. doi:10.1056/NEJMoa1200303.CrossRefPubMed

70.

Wang X, Thijssen B, Yu H. Target essentiality and centrality characterize drug side effects. PLoS Comput Biol. 2013;9(7):e1003119. doi:10.1371/journal.pcbi.1003119.CrossRefPubMedPubMedCentral

Titel: The Role of the Skin and Gut Microbiome in Psoriatic Disease
verfasst von: Di Yan
Naiem Issa
Ladan Afifi
Caleb Jeon
Hsin-Wen Chang
Wilson Liao
Publikationsdatum: 22.04.2017
Verlag: Springer US
Erschienen in: Current Dermatology Reports / Ausgabe 2/2017
Elektronische ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-017-0178-5

Leitlinien kompakt für die Dermatologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Dermatologie

Studienlage spricht für Isotretinoin zur Rosazea-Therapie

23.05.2024 Rosazea Nachrichten

Isotretinoin wird off-label zur Behandlung von Rosazea eingesetzt. Wie solide die Evidenz dafür ist, wurde jetzt in einem systematischen Review überprüft.

So sicher sind Tattoos: Neue Daten zur Risikobewertung

22.05.2024 Melanom Nachrichten

Das größte medizinische Problem bei Tattoos bleiben allergische Reaktionen. Melanome werden dadurch offensichtlich nicht gefördert, die Farbpigmente könnten aber andere Tumoren begünstigen.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Riesenzellarteriitis: 15% der Patienten sind von okkulter Form betroffen

16.05.2024 Riesenzellarteriitis Nachrichten

In einer retrospektiven Untersuchung haben Forschende aus Belgien und den Niederlanden die okkulte Form der Riesenzellarteriitis genauer unter die Lupe genommen. In puncto Therapie und Rezidivraten stellten sie keinen sehr großen Unterschied zu Erkrankten mit kranialen Symptomen fest.

Update Dermatologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Bildnachweise

Die Leitlinien für Ärztinnen und Ärzte, Nahaufnahme Rosazea auf der Wange/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Eine Tätowierung wird mit roter Farbe ausgefüllt/© nagaets / stock.adobe.com (Symbolbild mit Fotomodell), Operation/© Peakstock / Stock.adobe.com (Symbolbild mit Fotomodellen), Rechte Aa. carotis interna mit Wandverdickung bei Riesenzellarteriitis/© Kisyova H et al. | all rights reserved Springer Medizin Verlag GmbH

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2017

Dupilumab Use in Atopic Conditions and Its Side Effects

Omalizumab for Chronic Urticaria: Aftermarket Reports of Efficacy and Side Effects

Cutaneous Manifestations of Connective Tissue Disease in the Inpatient Setting

Cutaneous Side Effects and Drug Interactions Related to Immunosuppressive Therapy in Solid Organ Transplantation

Topical Therapy of AD: How to Reach Better Results