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Erschienen in: Clinical Drug Investigation 8/2022

01.08.2022 | Research Letter

Paxlovid-Tacrolimus Drug–Drug Interaction in a 23-Year-Old Female Kidney Transplant Patient with COVID-19

verfasst von: Noa Berar Yanay, Ido Bogner, Khader Saker, Elias Tannous

Erschienen in: Clinical Drug Investigation | Ausgabe 8/2022

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Excerpt

Kidney transplant patients are at a high risk for adverse severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection outcomes in terms of morbidity and mortality. Therefore, these patients are candidates for additional pharmacotherapy. Paxlovid was authorized as such a therapy in December 2021. Because of potential paxlovid drug–drug interactions, transplanted patients receiving calcineurin inhibitors must be monitored. We report on a case of a kidney transplant patient who received paxlovid for SARS-CoV-2 infection who developed a drug–drug interaction with tacrolimus. …
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Literatur
1.
Zurück zum Zitat Sheiner LB, Beal SL. Bayesian individualization of pharmacokinetics. Simple implementation and comparison with non-Bayesian methods. J Pharm Sci. 1982;71:1344–8.CrossRef Sheiner LB, Beal SL. Bayesian individualization of pharmacokinetics. Simple implementation and comparison with non-Bayesian methods. J Pharm Sci. 1982;71:1344–8.CrossRef
2.
Zurück zum Zitat Størset E, Holford N, Hennig S, Bergmann TK, Bergan S, Bremer S, et al. Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. Br J Clin Pharmacol. 2014;78(3):509–23.CrossRef Størset E, Holford N, Hennig S, Bergmann TK, Bergan S, Bremer S, et al. Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling. Br J Clin Pharmacol. 2014;78(3):509–23.CrossRef
Metadaten
Titel
Paxlovid-Tacrolimus Drug–Drug Interaction in a 23-Year-Old Female Kidney Transplant Patient with COVID-19
verfasst von
Noa Berar Yanay
Ido Bogner
Khader Saker
Elias Tannous
Publikationsdatum
01.08.2022
Verlag
Springer International Publishing
Erschienen in
Clinical Drug Investigation / Ausgabe 8/2022
Print ISSN: 1173-2563
Elektronische ISSN: 1179-1918
DOI
https://doi.org/10.1007/s40261-022-01180-4

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