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Drugs
Erschienen in: Drugs 7/2019

01.05.2019 | Therapy in Practice

The Clinician’s Guide to Proton Pump Inhibitor Related Adverse Events

verfasst von: Evan Elias, Laura E. Targownik

Erschienen in: Drugs | Ausgabe 7/2019

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Abstract

A substantial volume of literature exists linking proton pump inhibitor (PPI) use with a multitude of serious adverse events. There is uncertainty, however, over whether these associations are clinically important. Excessive concern about PPI-related adverse events may leave patients at risk of harm by leaving acid-related upper gastrointestinal disease untreated. Conversely, the risk of treatments may outweigh the benefits if any of the purported adverse events are directly caused by PPI use; this is of particular concern where indications for PPI use are not present. In this paper, we review the studies which have reported associations between adverse events and PPI use, discuss the proposed mechanisms of action, grade the confidence in whether these associations are truly causal, and provide advice regarding balancing the benefits of PPI use against their possible harms.
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Metadaten
Titel
The Clinician’s Guide to Proton Pump Inhibitor Related Adverse Events
verfasst von
Evan Elias
Laura E. Targownik
Publikationsdatum
01.05.2019
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 7/2019
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-019-01110-3

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