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Erschienen in: Pediatric Drugs 4/2014

01.08.2014 | Review Article

The Pharmacologic Management of Delirium in Children and Adolescents

verfasst von: Susan Beckwitt Turkel, Alan Hanft

Erschienen in: Pediatric Drugs | Ausgabe 4/2014

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Abstract

Delirium is a serious and common problem in severely medically ill patients of all ages. It has been less addressed in children and adolescents. Treatment of delirium is predicated on addressing its underlying cause. The management of its symptoms depends on the off-label use of antipsychotics, while avoiding agents that precipitate or worsen delirium. Olanzapine, quetiapine, and risperidone are presently considered first-line drugs, usually replacing haloperidol. Other agents have shown promise, including melatonin to address the sleep disturbance characteristic of delirium, and dexmedetomidine, an α2-agonist, that may facilitate lower doses of benzodiazepines and opioids that may worsen delirium.
Literatur
1.
Zurück zum Zitat Engel GL, Romano J. Delirium, a syndrome of cerebral insufficiency. J Chronic Dis. 1959;9:260–77.PubMedCrossRef Engel GL, Romano J. Delirium, a syndrome of cerebral insufficiency. J Chronic Dis. 1959;9:260–77.PubMedCrossRef
2.
Zurück zum Zitat Romano J, Engel GL. Delirium I. Electroencephalographic data. Arch Neurol Psychiatr. 1944;51:356–77.CrossRef Romano J, Engel GL. Delirium I. Electroencephalographic data. Arch Neurol Psychiatr. 1944;51:356–77.CrossRef
3.
Zurück zum Zitat Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobsen P. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatr. 1996;153:231–7.PubMed Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobsen P. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatr. 1996;153:231–7.PubMed
4.
Zurück zum Zitat Trzepacz PT, Breitbart W, Levenson J, Franklin J, Martini DR. Practice guideline for the treatment of patients with delirium. Am J Psychiatr. 1999;156(5):1–20. Trzepacz PT, Breitbart W, Levenson J, Franklin J, Martini DR. Practice guideline for the treatment of patients with delirium. Am J Psychiatr. 1999;156(5):1–20.
5.
Zurück zum Zitat Harrison AM, Lugo RA, Lee EW, Appachi E, Bourdakos D, Davis SJ, McHugh MJ, Weise KL. The use of haloperidol in agitated critically ill children. Clin Pediatr. 2002;41:51–4.CrossRef Harrison AM, Lugo RA, Lee EW, Appachi E, Bourdakos D, Davis SJ, McHugh MJ, Weise KL. The use of haloperidol in agitated critically ill children. Clin Pediatr. 2002;41:51–4.CrossRef
6.
Zurück zum Zitat Deksnytė A, Aranauskas R, Budrys V, Kasieulevicė V, Ŝapoka V. Delirium: its historical evolution and current interpretation. Eur J Int Med. 2012;23:483–6.CrossRef Deksnytė A, Aranauskas R, Budrys V, Kasieulevicė V, Ŝapoka V. Delirium: its historical evolution and current interpretation. Eur J Int Med. 2012;23:483–6.CrossRef
7.
Zurück zum Zitat Smeets IAP, Tan EYL, Vossen HGM, Leroy PLJM, Lousberg RHB, van Os J, Schieveld JNM. Prolonged stay at the pediatric intensive care unit associated with pediatric delirium. Eur Child Adolesc Psychiatr. 2010;19:389–93.CrossRef Smeets IAP, Tan EYL, Vossen HGM, Leroy PLJM, Lousberg RHB, van Os J, Schieveld JNM. Prolonged stay at the pediatric intensive care unit associated with pediatric delirium. Eur Child Adolesc Psychiatr. 2010;19:389–93.CrossRef
8.
Zurück zum Zitat Eisendrath SJ, Shim JJ. Management of psychiatric problems in critically ill patients. Am J Med. 2006;119:22–9.PubMedCrossRef Eisendrath SJ, Shim JJ. Management of psychiatric problems in critically ill patients. Am J Med. 2006;119:22–9.PubMedCrossRef
9.
Zurück zum Zitat Lacasse H, Perreault MM, Williamson DR. Systemic review of antipsychotics for the treatment of hospital associated delirium in medically and surgically ill patients. Ann Pharmacother. 2006;40:1966–73.PubMedCrossRef Lacasse H, Perreault MM, Williamson DR. Systemic review of antipsychotics for the treatment of hospital associated delirium in medically and surgically ill patients. Ann Pharmacother. 2006;40:1966–73.PubMedCrossRef
10.
Zurück zum Zitat Prugh DC, Wagonfield S, Metcalf D, Jordan K. A clinical study of delirium in children and adolescents. Psychosom Med. 1980;42 suppl:177–95.CrossRef Prugh DC, Wagonfield S, Metcalf D, Jordan K. A clinical study of delirium in children and adolescents. Psychosom Med. 1980;42 suppl:177–95.CrossRef
11.
Zurück zum Zitat Girard TD, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Ely EW. Duration of delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Am J Respir Crit Care Med. 2009;179:A5477. Girard TD, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Ely EW. Duration of delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Am J Respir Crit Care Med. 2009;179:A5477.
12.
Zurück zum Zitat Hatherill S, Flisher AJ. Delirium in children and adolescents: a systematic review of the literature. J Psychosom Res. 2010;68:337–44.PubMedCrossRef Hatherill S, Flisher AJ. Delirium in children and adolescents: a systematic review of the literature. J Psychosom Res. 2010;68:337–44.PubMedCrossRef
13.
Zurück zum Zitat Rummans TA, Evans JM, Krahn LE, Fleming KC. Delirium in elderly patients: evaluation and management. Mayo Clin Proc. 1995;70:989–98.PubMedCrossRef Rummans TA, Evans JM, Krahn LE, Fleming KC. Delirium in elderly patients: evaluation and management. Mayo Clin Proc. 1995;70:989–98.PubMedCrossRef
14.
Zurück zum Zitat de Rooij SE, van Munster BC, Korevaar JC, Levi M. Cytokines and acute phase response in delirium. J Psychosom Res. 2007;62:521–5.PubMedCrossRef de Rooij SE, van Munster BC, Korevaar JC, Levi M. Cytokines and acute phase response in delirium. J Psychosom Res. 2007;62:521–5.PubMedCrossRef
15.
Zurück zum Zitat Maldonado JR. Pathoetiological model of delirium: a comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment. Crit Care Clin. 2008;24:789–856.PubMedCrossRef Maldonado JR. Pathoetiological model of delirium: a comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment. Crit Care Clin. 2008;24:789–856.PubMedCrossRef
16.
Zurück zum Zitat Rudolph JL, Ramlawi B, Kuchel GA, McElhaney JE, Xie D, Sellke FW, Khabbaz K, Levkoff SE, Marcantonio ER. Chemokines are associated with delirium after cardiac surgery. J Gerontol A Biol Med Sci. 2008;63:184–9. Rudolph JL, Ramlawi B, Kuchel GA, McElhaney JE, Xie D, Sellke FW, Khabbaz K, Levkoff SE, Marcantonio ER. Chemokines are associated with delirium after cardiac surgery. J Gerontol A Biol Med Sci. 2008;63:184–9.
17.
Zurück zum Zitat Silver GH, Kearney JA, Kutko MC, Bartell AS. Infant delirium in pediatric critical care settings. Am J Psychiatr. 2010;167:1172–7.PubMedCrossRef Silver GH, Kearney JA, Kutko MC, Bartell AS. Infant delirium in pediatric critical care settings. Am J Psychiatr. 2010;167:1172–7.PubMedCrossRef
18.
19.
Zurück zum Zitat Cerejeira J, Nogueira V, Luis P, Vaz-Serra A, Mukaetova-Ladinska EB. The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc. 2012;60:669–75.PubMedCrossRef Cerejeira J, Nogueira V, Luis P, Vaz-Serra A, Mukaetova-Ladinska EB. The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc. 2012;60:669–75.PubMedCrossRef
20.
Zurück zum Zitat Eikelenboom P, Hoogendijk WJG, Jonker C, van Tilburg W. Immunologic mechanisms and the spectrum of psychiatric syndromes in Alzheimer’s disease. J Psychiatr Res. 2002;36:269–80.PubMedCrossRef Eikelenboom P, Hoogendijk WJG, Jonker C, van Tilburg W. Immunologic mechanisms and the spectrum of psychiatric syndromes in Alzheimer’s disease. J Psychiatr Res. 2002;36:269–80.PubMedCrossRef
21.
Zurück zum Zitat Seaman JS, Schillerstrom J, Carroll D, Brown TM. Impaired oxidative metabolism precipitates delirium: a study of 101 ICU patients. Psychosomatics. 2006;47:56–61.PubMedCrossRef Seaman JS, Schillerstrom J, Carroll D, Brown TM. Impaired oxidative metabolism precipitates delirium: a study of 101 ICU patients. Psychosomatics. 2006;47:56–61.PubMedCrossRef
22.
Zurück zum Zitat MacLullich AMJ, Ferguson KJ, Miller T, de Rooij SEJA, Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress response. J Psychosom Res. 2008;65:229–38.PubMedCrossRef MacLullich AMJ, Ferguson KJ, Miller T, de Rooij SEJA, Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress response. J Psychosom Res. 2008;65:229–38.PubMedCrossRef
23.
Zurück zum Zitat Tune L, Carr S, Hoag E, Cooper T. Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium. Am J Psychiatr. 1992;149:1393–4.PubMed Tune L, Carr S, Hoag E, Cooper T. Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium. Am J Psychiatr. 1992;149:1393–4.PubMed
25.
Zurück zum Zitat Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Aging. 2011;40:23–9.CrossRef Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Aging. 2011;40:23–9.CrossRef
26.
Zurück zum Zitat Stoddard FJ, Usher CT, Abrams AN. Psychopharmacology in pediatric critical care. Child Adolesc Clin North Am. 2006;15:611–55.CrossRef Stoddard FJ, Usher CT, Abrams AN. Psychopharmacology in pediatric critical care. Child Adolesc Clin North Am. 2006;15:611–55.CrossRef
27.
Zurück zum Zitat Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous IV sedation is associated with prolongation of mechanical ventilation. Chest. 1998;114:541–8.PubMedCrossRef Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous IV sedation is associated with prolongation of mechanical ventilation. Chest. 1998;114:541–8.PubMedCrossRef
28.
Zurück zum Zitat Tobias JD. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med. 2000;28:2122–32.PubMedCrossRef Tobias JD. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med. 2000;28:2122–32.PubMedCrossRef
29.
Zurück zum Zitat Schieveld JN, Staal M, Voogd L, Fioncken J, Vos G, van Os J. Refractory agitation as a marker for pediatric delirium in very young infants in the intensive care unit. Intensive Care Med. 2010;36:1982–3.PubMedCentralPubMedCrossRef Schieveld JN, Staal M, Voogd L, Fioncken J, Vos G, van Os J. Refractory agitation as a marker for pediatric delirium in very young infants in the intensive care unit. Intensive Care Med. 2010;36:1982–3.PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Kean J, Trzepacz PT, Murray LL, Abell M, Trexler L. Initial validation of a brief provisional diagnostic scale for delirium. Brain Injury. 2010;24:1222–30.PubMedCrossRef Kean J, Trzepacz PT, Murray LL, Abell M, Trexler L. Initial validation of a brief provisional diagnostic scale for delirium. Brain Injury. 2010;24:1222–30.PubMedCrossRef
31.
Zurück zum Zitat American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, revised (DSM-TR-IV). Washington, DC: American Psychiatric Press; 2000.CrossRef American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, revised (DSM-TR-IV). Washington, DC: American Psychiatric Press; 2000.CrossRef
32.
Zurück zum Zitat American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Washington, DC: American Psychiatric Press; 2013. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Washington, DC: American Psychiatric Press; 2013.
33.
Zurück zum Zitat Turkel SB, Trzepacz PT, Tavare CJ. Comparing symptoms of delirium in adults and children. Psychosomatics. 2006;47:320–4.PubMedCrossRef Turkel SB, Trzepacz PT, Tavare CJ. Comparing symptoms of delirium in adults and children. Psychosomatics. 2006;47:320–4.PubMedCrossRef
34.
Zurück zum Zitat Grover S, Kate N, Malhotra S, Chakrabarti S, Mattoo SK, Avasthi A. Symptom profile of delirium in children and adolescent—does it differ from adults and elderly? Gen Hosp Psychiatr. 2012;34:626–32.CrossRef Grover S, Kate N, Malhotra S, Chakrabarti S, Mattoo SK, Avasthi A. Symptom profile of delirium in children and adolescent—does it differ from adults and elderly? Gen Hosp Psychiatr. 2012;34:626–32.CrossRef
35.
Zurück zum Zitat Leentjens AFG, Schieveld JNM, Leonard M, Lousberg R, Verhey FRJ, Meagher DJ. A comparison of the phenomenology of pediatric, adult, and geriatric delirium. J Psychosom Res. 2008;64:219–23.PubMedCrossRef Leentjens AFG, Schieveld JNM, Leonard M, Lousberg R, Verhey FRJ, Meagher DJ. A comparison of the phenomenology of pediatric, adult, and geriatric delirium. J Psychosom Res. 2008;64:219–23.PubMedCrossRef
36.
Zurück zum Zitat Turkel SB, Tavare CJ. Delirium in children and adolescents. J Neuropsychiatr Clin Neurosci. 2003;15:431–5.CrossRef Turkel SB, Tavare CJ. Delirium in children and adolescents. J Neuropsychiatr Clin Neurosci. 2003;15:431–5.CrossRef
37.
Zurück zum Zitat Turkel SB, Jacobson J, Tavaré CJ. The diagnosis and management of delirium in infancy. J Child Adolesc Psychopharmacol. 2013;25:352–6.CrossRef Turkel SB, Jacobson J, Tavaré CJ. The diagnosis and management of delirium in infancy. J Child Adolesc Psychopharmacol. 2013;25:352–6.CrossRef
38.
Zurück zum Zitat Holditch-Davis D, Scher M, Schwartz T, Hudson-Barr D. Sleeping and waking state development in preterm infants. Early Hum Dev. 2004;80:43–64.PubMedCrossRef Holditch-Davis D, Scher M, Schwartz T, Hudson-Barr D. Sleeping and waking state development in preterm infants. Early Hum Dev. 2004;80:43–64.PubMedCrossRef
39.
Zurück zum Zitat Meagher DJ, O’Hanlon D, O’Mahoney E, Casey PR, Trzepacz PT. Relationship between symptoms and motoric subtype of delirium. Meagher DJ, O’Hanlon D, O’Mahoney E, Casey PR, Trzepacz PT. Relationship between symptoms and motoric subtype of delirium.
40.
Zurück zum Zitat Hart RP, Levenson JL, Sessler CN, Best AM, Schwartz SM, Rutherford LE. Validation of a cognitive test for delirium in medical intensive care patients. Psychosomatics. 1996;37:533–46.PubMedCrossRef Hart RP, Levenson JL, Sessler CN, Best AM, Schwartz SM, Rutherford LE. Validation of a cognitive test for delirium in medical intensive care patients. Psychosomatics. 1996;37:533–46.PubMedCrossRef
41.
Zurück zum Zitat Grover S, Ghosh A, Kate N, Malhotra S, Mattoo SK, Chakrabarti S, Avasthi A. Do motor subtypes of delirium in child and adolescent have a different clinical and phenomenologic profile? Gen Hosp Psychiatry. 2014;36:187–91.PubMedCrossRef Grover S, Ghosh A, Kate N, Malhotra S, Mattoo SK, Chakrabarti S, Avasthi A. Do motor subtypes of delirium in child and adolescent have a different clinical and phenomenologic profile? Gen Hosp Psychiatry. 2014;36:187–91.PubMedCrossRef
42.
Zurück zum Zitat van der Mast RC. Pathophysiology of delirium. J Geriatr Psychiatr Neurol. 1998;11:138–45.CrossRef van der Mast RC. Pathophysiology of delirium. J Geriatr Psychiatr Neurol. 1998;11:138–45.CrossRef
43.
Zurück zum Zitat Grace JB, Holmes J. The management of behavioural and psychiatric symptoms in delirium. Expert Opin Pharmacother. 2006;7:555–61.PubMedCrossRef Grace JB, Holmes J. The management of behavioural and psychiatric symptoms in delirium. Expert Opin Pharmacother. 2006;7:555–61.PubMedCrossRef
44.
Zurück zum Zitat Meagher DJ, O’Hanlon D, O’Mahony E, Casey PR. The use of environmental strategies and psychotropic medication in the management of delirium. Br J Psychiatry. 1996;168:512–5.PubMedCrossRef Meagher DJ, O’Hanlon D, O’Mahony E, Casey PR. The use of environmental strategies and psychotropic medication in the management of delirium. Br J Psychiatry. 1996;168:512–5.PubMedCrossRef
45.
Zurück zum Zitat Martini DR. Commentary: the diagnosis of delirium in pediatric patients. J Am Acad Child Adolesc Psychiatry. 2005;44:395–8.PubMedCrossRef Martini DR. Commentary: the diagnosis of delirium in pediatric patients. J Am Acad Child Adolesc Psychiatry. 2005;44:395–8.PubMedCrossRef
46.
Zurück zum Zitat Schieveld JN, Leeroy PL, van Os J, Nicolai J, Vos GD, Leentjens AP. Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit. Intensive Care Med. 2009;33:1033–40.CrossRef Schieveld JN, Leeroy PL, van Os J, Nicolai J, Vos GD, Leentjens AP. Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit. Intensive Care Med. 2009;33:1033–40.CrossRef
47.
Zurück zum Zitat Bourne RS, Tahir TA, Borthwick M, Sampson EL. Drug treatment of delirium: past, present and future. J Psychosom Res. 2008;65:273–82.PubMedCrossRef Bourne RS, Tahir TA, Borthwick M, Sampson EL. Drug treatment of delirium: past, present and future. J Psychosom Res. 2008;65:273–82.PubMedCrossRef
48.
Zurück zum Zitat Devlin JW, Al-Qadhee NS, Skrobik Y. Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalized patients: a review of data from prospective, randomized studies. Best Pract Res Clin Anaesthesiol. 2012;26:289–309.PubMedCrossRef Devlin JW, Al-Qadhee NS, Skrobik Y. Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalized patients: a review of data from prospective, randomized studies. Best Pract Res Clin Anaesthesiol. 2012;26:289–309.PubMedCrossRef
49.
Zurück zum Zitat Maldonado JR. Delirium in the acute care setting: characteristics, diagnosis, and treatment. Crit Care Clin. 2008;24:657–722.PubMedCrossRef Maldonado JR. Delirium in the acute care setting: characteristics, diagnosis, and treatment. Crit Care Clin. 2008;24:657–722.PubMedCrossRef
50.
Zurück zum Zitat DeMaso DR, Martini DR, Cahen LA, Bukstein O, Walter HJ, Benson S, Chrisman A, Farchione T, Hamilton J, Keable H, Kinlan J, Schoettle U, Siegel M, Stock S, Ptakowski KK, Medicus J, Work Group on Quality Issues. Practice parameter for the psychiatric assessment and management of physically ill children and adolescents. J Am Acad Child Adolesc Psychiatry. 2009;48:213–33.PubMedCrossRef DeMaso DR, Martini DR, Cahen LA, Bukstein O, Walter HJ, Benson S, Chrisman A, Farchione T, Hamilton J, Keable H, Kinlan J, Schoettle U, Siegel M, Stock S, Ptakowski KK, Medicus J, Work Group on Quality Issues. Practice parameter for the psychiatric assessment and management of physically ill children and adolescents. J Am Acad Child Adolesc Psychiatry. 2009;48:213–33.PubMedCrossRef
51.
Zurück zum Zitat Yoon H-J, Park K-M, Choi W-J, Choi S-H, Park J-Y, Kim J-J, Seok J-H. Efficacy and safety of haloperidol versus atypical antipsychotic medications in the treatment of delirium. Br Med J Psychiatry. 2013;13:240–51. Yoon H-J, Park K-M, Choi W-J, Choi S-H, Park J-Y, Kim J-J, Seok J-H. Efficacy and safety of haloperidol versus atypical antipsychotic medications in the treatment of delirium. Br Med J Psychiatry. 2013;13:240–51.
52.
Zurück zum Zitat Smith HB, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin. 2009;25:593–614.PubMedCentralPubMedCrossRef Smith HB, Fuchs DC, Pandharipande PP, Barr FE, Ely EW. Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin. 2009;25:593–614.PubMedCentralPubMedCrossRef
53.
Zurück zum Zitat Smith HAB, Brink E, Fuchs DC, Ely EW, Pandharipande PP. Pediatric delirium: monitoring and management in the pediatric intensive care unit. Pediatr Clin North Am. 2013;60:741–60.PubMedCrossRef Smith HAB, Brink E, Fuchs DC, Ely EW, Pandharipande PP. Pediatric delirium: monitoring and management in the pediatric intensive care unit. Pediatr Clin North Am. 2013;60:741–60.PubMedCrossRef
54.
Zurück zum Zitat Turkel SB, Jacobson JR, Munzig E, Tavaré CJ. Atypical antipsychotic medications to control symptoms of delirium in children and adolescents. J Child Adolesc Psychopharmacol. 2012;22:126–30.PubMedCrossRef Turkel SB, Jacobson JR, Munzig E, Tavaré CJ. Atypical antipsychotic medications to control symptoms of delirium in children and adolescents. J Child Adolesc Psychopharmacol. 2012;22:126–30.PubMedCrossRef
55.
Zurück zum Zitat Maneeton B, Maneeton N, Srisurapanont M, Chittawatanarat K. Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial. Drug Design Dev Ther. 2013;7:657–67.CrossRef Maneeton B, Maneeton N, Srisurapanont M, Chittawatanarat K. Quetiapine versus haloperidol in the treatment of delirium: a double-blind, randomized, controlled trial. Drug Design Dev Ther. 2013;7:657–67.CrossRef
56.
Zurück zum Zitat Tahir TA, Eeles E, Karapareddy V, Muthuvelu P, Chappie S, Phillips B, Adyemo T, Farewell D, Bisson JI. A randomized controlled trial of quetiapine versus placebo in the treatment of delirium. J Psychosom Res. 2010;69:485–90.PubMedCrossRef Tahir TA, Eeles E, Karapareddy V, Muthuvelu P, Chappie S, Phillips B, Adyemo T, Farewell D, Bisson JI. A randomized controlled trial of quetiapine versus placebo in the treatment of delirium. J Psychosom Res. 2010;69:485–90.PubMedCrossRef
57.
Zurück zum Zitat Grover S, Kumar V, Chakrabarti S. Comparative efficacy study of haloperidol, olanzapine, and risperidone in delirium. J Psychosom Res. 2011;71:277–81.PubMedCrossRef Grover S, Kumar V, Chakrabarti S. Comparative efficacy study of haloperidol, olanzapine, and risperidone in delirium. J Psychosom Res. 2011;71:277–81.PubMedCrossRef
58.
Zurück zum Zitat Traube C, Witcher R, Mendez-Rico E, Silver G. Quetiapine as treatment for delirium in critically ill children: a case report. J Pediatr Intensive Care. 2013;2(3):121–6. Traube C, Witcher R, Mendez-Rico E, Silver G. Quetiapine as treatment for delirium in critically ill children: a case report. J Pediatr Intensive Care. 2013;2(3):121–6.
59.
Zurück zum Zitat Meagher DJ. Delirium: optimizing management. Br Med J. 2001;322:144–9.CrossRef Meagher DJ. Delirium: optimizing management. Br Med J. 2001;322:144–9.CrossRef
60.
Zurück zum Zitat Sloof V. Adverse events of haloperidol for the treatment of delirium in critically ill children. Crit Care Med. 2012;40(12 Suppl):1–338. Sloof V. Adverse events of haloperidol for the treatment of delirium in critically ill children. Crit Care Med. 2012;40(12 Suppl):1–338.
61.
Zurück zum Zitat Boettger S, Breitbart W. Atypical antipsychotics in the management of delirium: a review of the empirical literature. Palliat Support Care. 2005;3:227–37.PubMedCrossRef Boettger S, Breitbart W. Atypical antipsychotics in the management of delirium: a review of the empirical literature. Palliat Support Care. 2005;3:227–37.PubMedCrossRef
62.
Zurück zum Zitat Michaud L, Bula C, Berney A, Camus V, Voellinger R, Stiefel F, Burnand B, Delirium Guidelines Development Group. Delirium: guidelines for general hospitals. J Psychosom Res. 2007;62:371–83.PubMedCrossRef Michaud L, Bula C, Berney A, Camus V, Voellinger R, Stiefel F, Burnand B, Delirium Guidelines Development Group. Delirium: guidelines for general hospitals. J Psychosom Res. 2007;62:371–83.PubMedCrossRef
63.
Zurück zum Zitat Alici-Evcimen Y, Breitbart W. An update on the use of antipsychotics in the treatment of delirium. Palliat Support Care. 2008;6:177–82.PubMedCrossRef Alici-Evcimen Y, Breitbart W. An update on the use of antipsychotics in the treatment of delirium. Palliat Support Care. 2008;6:177–82.PubMedCrossRef
64.
Zurück zum Zitat Sonnier L, Barzman D. Pharmacologic management of acutely agitated pediatric patients. Pediatr Drugs. 2011;13(1):1–10.CrossRef Sonnier L, Barzman D. Pharmacologic management of acutely agitated pediatric patients. Pediatr Drugs. 2011;13(1):1–10.CrossRef
65.
66.
Zurück zum Zitat Sassano-Higgins S, Freudenberg N, Jacobson J, Turkel S. Olanzapine reduces delirium symptoms in the critically ill pediatric patient. J Pediatr Intensive Care. 2013;2:49–54. Sassano-Higgins S, Freudenberg N, Jacobson J, Turkel S. Olanzapine reduces delirium symptoms in the critically ill pediatric patient. J Pediatr Intensive Care. 2013;2:49–54.
67.
Zurück zum Zitat Ben-Amor L. Antipsychotics in pediatric and adolescent patients: a review of comparative safety data. J Affect Disord. 2012;138:S22–50.PubMedCrossRef Ben-Amor L. Antipsychotics in pediatric and adolescent patients: a review of comparative safety data. J Affect Disord. 2012;138:S22–50.PubMedCrossRef
68.
Zurück zum Zitat Perrar KM, Golla H, Voltz R. Pharmacological treatment of delirium in palliative care patients. Der Schmerz. 2013;27:190–8.PubMedCrossRef Perrar KM, Golla H, Voltz R. Pharmacological treatment of delirium in palliative care patients. Der Schmerz. 2013;27:190–8.PubMedCrossRef
69.
Zurück zum Zitat Friedman JI, Soleimani L, McGonigle DP, Egol C, Silverstein JH. Pharmacological treatments of non-substance-withdrawal delirium: a systematic review of prospective trials. Am J Psychiatry. 2014;171(2):151–9.PubMedCrossRef Friedman JI, Soleimani L, McGonigle DP, Egol C, Silverstein JH. Pharmacological treatments of non-substance-withdrawal delirium: a systematic review of prospective trials. Am J Psychiatry. 2014;171(2):151–9.PubMedCrossRef
70.
Zurück zum Zitat Seitz DP, Gill SS. Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: case reports and a review of the literature. Psychosomatics. 2009;50:8–15.PubMedCrossRef Seitz DP, Gill SS. Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: case reports and a review of the literature. Psychosomatics. 2009;50:8–15.PubMedCrossRef
71.
Zurück zum Zitat Minns AB, Clark RF. Toxicology and overdose of atypical antipsychotics. J Emerg Med. 2012;43:906–13.PubMedCrossRef Minns AB, Clark RF. Toxicology and overdose of atypical antipsychotics. J Emerg Med. 2012;43:906–13.PubMedCrossRef
72.
Zurück zum Zitat De Hert M, Detraux J, van Winkel R, Yu W, Correll CU. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nature Rev Endocrinol. 2012;8:114–26.CrossRef De Hert M, Detraux J, van Winkel R, Yu W, Correll CU. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nature Rev Endocrinol. 2012;8:114–26.CrossRef
73.
Zurück zum Zitat Correll CU, Kratochvil CJ. Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J Am Acad Child Adolesc Psychiatry. 2008;47(1):9–20.PubMedCrossRef Correll CU, Kratochvil CJ. Antipsychotic use in children and adolescents: minimizing adverse effects to maximize outcomes. J Am Acad Child Adolesc Psychiatry. 2008;47(1):9–20.PubMedCrossRef
74.
Zurück zum Zitat Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med. 2009;360:225–35.PubMedCentralPubMedCrossRef Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med. 2009;360:225–35.PubMedCentralPubMedCrossRef
75.
Zurück zum Zitat Leonard CE, Freeman CP, Newcomb CW, Bilker WB, Kimmel SE, Strom BL, Hennessy S. Antipsychotics and the risks of sudden cardiac death and all-cause death: cohort studies in Medicaid and dually-eligible Medicaid-Medicare beneficiaries of five states. J Clin Exp Cardiol. 2013;Suppl 10:1–9. Leonard CE, Freeman CP, Newcomb CW, Bilker WB, Kimmel SE, Strom BL, Hennessy S. Antipsychotics and the risks of sudden cardiac death and all-cause death: cohort studies in Medicaid and dually-eligible Medicaid-Medicare beneficiaries of five states. J Clin Exp Cardiol. 2013;Suppl 10:1–9.
76.
Zurück zum Zitat Washington NB, Brahm NC, Kissack J. Which psychotropic carry the greatest risk of QTc prolongation? Curr Psychiatr. 2012;11:36–9. Washington NB, Brahm NC, Kissack J. Which psychotropic carry the greatest risk of QTc prolongation? Curr Psychiatr. 2012;11:36–9.
77.
Zurück zum Zitat Gaertner I, Altendorf K, Batra A, Gaertner HJ. Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7263 treatment courses. J Clin Psychopharmacol. 2001;31:215–22.CrossRef Gaertner I, Altendorf K, Batra A, Gaertner HJ. Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7263 treatment courses. J Clin Psychopharmacol. 2001;31:215–22.CrossRef
78.
Zurück zum Zitat Atasoy N, Erdogan A, Yalug I, Ozturk U, Konuk N, Atik L, Ustundag Y. A review of liver function tests during treatment with atypical antipsychotic drugs: a chart review study. Prog Neuro Psychopharm Biol Psychiatry. 2007;31:1255–60.CrossRef Atasoy N, Erdogan A, Yalug I, Ozturk U, Konuk N, Atik L, Ustundag Y. A review of liver function tests during treatment with atypical antipsychotic drugs: a chart review study. Prog Neuro Psychopharm Biol Psychiatry. 2007;31:1255–60.CrossRef
79.
Zurück zum Zitat Szigethy E, Wiznitzer M, Branicky LA, Maxwell K, Findling RL. Ripseridone-induced hepatotoxicity in children and adolescents? A chart review study. J Child Adolesc Psychopharmacol. 1999;9:93–8.PubMedCrossRef Szigethy E, Wiznitzer M, Branicky LA, Maxwell K, Findling RL. Ripseridone-induced hepatotoxicity in children and adolescents? A chart review study. J Child Adolesc Psychopharmacol. 1999;9:93–8.PubMedCrossRef
80.
Zurück zum Zitat Tabet N, Howard R. Pharmacological treatment for the prevention of delirium: review of current evidence. Int J Geriatr Psychiatry. 2009;24:1037–44.PubMedCrossRef Tabet N, Howard R. Pharmacological treatment for the prevention of delirium: review of current evidence. Int J Geriatr Psychiatry. 2009;24:1037–44.PubMedCrossRef
81.
Zurück zum Zitat Olofsson K, Alling C, Lundberg D, Malmros C. Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand. 2004;48:679–84.PubMedCrossRef Olofsson K, Alling C, Lundberg D, Malmros C. Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients. Acta Anaesthesiol Scand. 2004;48:679–84.PubMedCrossRef
82.
Zurück zum Zitat Bellaport J, Boots R. Potential use of melatonin in sleep and delirium in the critically ill. Br J Anaesth. 2012;108:572–80.CrossRef Bellaport J, Boots R. Potential use of melatonin in sleep and delirium in the critically ill. Br J Anaesth. 2012;108:572–80.CrossRef
83.
Zurück zum Zitat Al-Aama T, Brymer C, Gutmanis I, Woolmore-Goodwin SM, Esbaugh J, Dasgupta M. Melatonin decreases delirium in elderly patients: a randomized, placebo controlled trial. Int J Geriatr Psychiatry. 2011;26:687–94.PubMedCrossRef Al-Aama T, Brymer C, Gutmanis I, Woolmore-Goodwin SM, Esbaugh J, Dasgupta M. Melatonin decreases delirium in elderly patients: a randomized, placebo controlled trial. Int J Geriatr Psychiatry. 2011;26:687–94.PubMedCrossRef
84.
Zurück zum Zitat Furuya M, Miyaoka T, Yasuda H, Yamashita S, Tanaka I, Otsuka S, Wake R, Horiguchi J. Marked improvement in delirium with ramelteon: five case reports. Psychogeriatrics. 2012;12:259–62.PubMedCrossRef Furuya M, Miyaoka T, Yasuda H, Yamashita S, Tanaka I, Otsuka S, Wake R, Horiguchi J. Marked improvement in delirium with ramelteon: five case reports. Psychogeriatrics. 2012;12:259–62.PubMedCrossRef
85.
Zurück zum Zitat Kain ZN, MacLaren JE, Herrmann L, Mayes L, Rosenbaum A, Hata J, Lerman J. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology. 2009;111:44–9.PubMedCrossRef Kain ZN, MacLaren JE, Herrmann L, Mayes L, Rosenbaum A, Hata J, Lerman J. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology. 2009;111:44–9.PubMedCrossRef
86.
Zurück zum Zitat Hoy SM, Keating GM. Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation. Drugs. 2011;71:1481–501.PubMedCrossRef Hoy SM, Keating GM. Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation. Drugs. 2011;71:1481–501.PubMedCrossRef
87.
Zurück zum Zitat Shukry M, Clyde MC, Kalarickal PI, Ramadhyani U. Does dexmedetomidine prevent emergency delirium in children after sevoflurane-based general anesthesia? Pediatr Anesth. 2005;15:1098–104.CrossRef Shukry M, Clyde MC, Kalarickal PI, Ramadhyani U. Does dexmedetomidine prevent emergency delirium in children after sevoflurane-based general anesthesia? Pediatr Anesth. 2005;15:1098–104.CrossRef
88.
Zurück zum Zitat Tobias JD, Gupta P, Naguib A. Dexmedetomidine: applications for the pediatric patient with congenital heart disease. Pediatr Cardiol. 2011;32:1075–87.PubMedCrossRef Tobias JD, Gupta P, Naguib A. Dexmedetomidine: applications for the pediatric patient with congenital heart disease. Pediatr Cardiol. 2011;32:1075–87.PubMedCrossRef
89.
Zurück zum Zitat Buck ML, Willson DF. Use of dexmedetomidine in the pediatric intensive care unit. Pharmacotherapy. 2008;28(1):51–7.PubMedCrossRef Buck ML, Willson DF. Use of dexmedetomidine in the pediatric intensive care unit. Pharmacotherapy. 2008;28(1):51–7.PubMedCrossRef
90.
Zurück zum Zitat Mason KP, Lerman J. Dexmedetomidine in children: current knowledge and future applications. Anesth Analg. 2011;113(5):1129–42.PubMedCrossRef Mason KP, Lerman J. Dexmedetomidine in children: current knowledge and future applications. Anesth Analg. 2011;113(5):1129–42.PubMedCrossRef
91.
Zurück zum Zitat Phan H, Nahata MC. Clinical uses of dexmedetomidine in pediatric patients. Pediatr Drugs. 2008;10(1):49–69.CrossRef Phan H, Nahata MC. Clinical uses of dexmedetomidine in pediatric patients. Pediatr Drugs. 2008;10(1):49–69.CrossRef
92.
Zurück zum Zitat Honey BL, Benefield RJ, Miller JL, Johnson PN. α2-Receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. Ann Pharmacother. 2009;43:1056–511.CrossRef Honey BL, Benefield RJ, Miller JL, Johnson PN. α2-Receptor agonists for treatment and prevention of iatrogenic opioid abstinence syndrome in critically ill patients. Ann Pharmacother. 2009;43:1056–511.CrossRef
93.
Zurück zum Zitat Riker RR, Fraser GL. Adverse events associated with sedatives, analgesics, and other drugs that provide patient comfort in the intensive care unit. Pharmacotherapy. 2005;25(pt 2):8S–18S.PubMedCrossRef Riker RR, Fraser GL. Adverse events associated with sedatives, analgesics, and other drugs that provide patient comfort in the intensive care unit. Pharmacotherapy. 2005;25(pt 2):8S–18S.PubMedCrossRef
94.
Zurück zum Zitat Resnick M, Burton BT. Droperidol vs haloperidol in the initial management of acutely agitated patients. J Clin Psychiatry. 1984;45:298–9.PubMed Resnick M, Burton BT. Droperidol vs haloperidol in the initial management of acutely agitated patients. J Clin Psychiatry. 1984;45:298–9.PubMed
95.
Zurück zum Zitat Bourcher BA. Formulary decisions: then and now. Pharmacotherapy. 2010;6(Pt 2):35S–41S.CrossRef Bourcher BA. Formulary decisions: then and now. Pharmacotherapy. 2010;6(Pt 2):35S–41S.CrossRef
96.
Zurück zum Zitat Bostwick JM, Masterson BJ. Psychopharmacological treatment of delirium to restore mental capacity. Psychosomatics. 1998;39:112–7.PubMedCrossRef Bostwick JM, Masterson BJ. Psychopharmacological treatment of delirium to restore mental capacity. Psychosomatics. 1998;39:112–7.PubMedCrossRef
97.
Zurück zum Zitat Shaw GK. Detoxification: the use of benzodiazepines. Alcohol Alcohol. 1995;30:765–70.PubMed Shaw GK. Detoxification: the use of benzodiazepines. Alcohol Alcohol. 1995;30:765–70.PubMed
98.
Zurück zum Zitat Leggio L, Kenna GA, Swift RM. New developments for the pharmacological treatment of alcohol withdrawal syndrome: a focus on non-benzodiazepine GABA-ergic medications. Prog Neuro Psychopharmacol Biol Psychiatry. 2008;32:1106–17.CrossRef Leggio L, Kenna GA, Swift RM. New developments for the pharmacological treatment of alcohol withdrawal syndrome: a focus on non-benzodiazepine GABA-ergic medications. Prog Neuro Psychopharmacol Biol Psychiatry. 2008;32:1106–17.CrossRef
99.
Zurück zum Zitat Shaner R. Benzodiazepines in psychiatric emergency settings. Psychiatr Ann. 2000;30:268–75.CrossRef Shaner R. Benzodiazepines in psychiatric emergency settings. Psychiatr Ann. 2000;30:268–75.CrossRef
100.
Zurück zum Zitat Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104:21–6.PubMedCrossRef Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104:21–6.PubMedCrossRef
101.
Zurück zum Zitat Caccia S. Safety and pharmacokinetics of atypical antipsychotics in children and adolescents. Paediatr Drugs. 2013;15:217–33.PubMedCrossRef Caccia S. Safety and pharmacokinetics of atypical antipsychotics in children and adolescents. Paediatr Drugs. 2013;15:217–33.PubMedCrossRef
102.
Zurück zum Zitat Lawrence KR, Nasraway SA. Conduction disturbances associated with administration of butyrophenone antipsychotics in the critically ill: a review of the literature. Pharmacotherapy. 1997;17(3):531–7.PubMed Lawrence KR, Nasraway SA. Conduction disturbances associated with administration of butyrophenone antipsychotics in the critically ill: a review of the literature. Pharmacotherapy. 1997;17(3):531–7.PubMed
Metadaten
Titel
The Pharmacologic Management of Delirium in Children and Adolescents
verfasst von
Susan Beckwitt Turkel
Alan Hanft
Publikationsdatum
01.08.2014
Verlag
Springer International Publishing
Erschienen in
Pediatric Drugs / Ausgabe 4/2014
Print ISSN: 1174-5878
Elektronische ISSN: 1179-2019
DOI
https://doi.org/10.1007/s40272-014-0078-0

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