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Erschienen in: Journal of Nephrology 4/2017

01.08.2017 | Review

Linking acute kidney injury to chronic kidney disease: the missing links

verfasst von: Mohammed A. Kaballo, Mohamed E. Elsayed, Austin G. Stack

Erschienen in: Journal of Nephrology | Ausgabe 4/2017

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Abstract

Acute kidney injury (AKI) is considered to be a major public health problem around the globe, and it is associated with major adverse clinical outcomes and significant health care costs. There is growing evidence suggesting that AKI is associated with the subsequent development of chronic kidney disease (CKD). While recovery of kidney function occurs in the majority of patients surviving an AKI episode, a large number of patients do not recover completely. Similarly, CKD is a well-known risk factor for the development of AKI. Recent studies suggest that both AKI and CKD are not separate disease entities but are in fact components of a far more closely interconnected disease continuum. However, the true nature of this relationship is complex and poorly understood. This review explores potential relationships between AKI and CKD, and seeks to uncover a number of “missing links” in this tentative emerging relationship.
Literatur
1.
Zurück zum Zitat Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure–definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8(4):R204PubMedPubMedCentralCrossRef Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure–definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8(4):R204PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Kellum JA, Bellomo R, Ronco C (2007) The concept of acute kidney injury and the RIFLE criteria. Contrib Nephrol 156:10–16PubMedCrossRef Kellum JA, Bellomo R, Ronco C (2007) The concept of acute kidney injury and the RIFLE criteria. Contrib Nephrol 156:10–16PubMedCrossRef
3.
Zurück zum Zitat Mehta RL, Kellum JA, Shah SV et al (2007) Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31PubMedPubMedCentralCrossRef Mehta RL, Kellum JA, Shah SV et al (2007) Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Levin A, Warnock DG, Mehta RL et al (2007) Improving outcomes from acute kidney injury: report of an initiative. Am J Kidney Dis 50(1):1–4PubMedCrossRef Levin A, Warnock DG, Mehta RL et al (2007) Improving outcomes from acute kidney injury: report of an initiative. Am J Kidney Dis 50(1):1–4PubMedCrossRef
5.
Zurück zum Zitat Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C, Shah S (2007) Improving outcomes from acute kidney injury. J Am Soc Nephrol 18(7):1992–1994PubMedCrossRef Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C, Shah S (2007) Improving outcomes from acute kidney injury. J Am Soc Nephrol 18(7):1992–1994PubMedCrossRef
6.
Zurück zum Zitat Kidney Disease Outcomes Quality Initiative (2012) KDIGO Clinical practice guidelines for acute kidney injury. Kidney Int Suppl 2:1–38CrossRef Kidney Disease Outcomes Quality Initiative (2012) KDIGO Clinical practice guidelines for acute kidney injury. Kidney Int Suppl 2:1–38CrossRef
8.
Zurück zum Zitat Triverio P-A, Martin P-Y, Romand J, Pugin J, Perneger T, Saudan P (2009) Long-term prognosis after acute kidney injury requiring renal replacement therapy. Nephrol Dial Transplant 24(7):2186–2189PubMedCrossRef Triverio P-A, Martin P-Y, Romand J, Pugin J, Perneger T, Saudan P (2009) Long-term prognosis after acute kidney injury requiring renal replacement therapy. Nephrol Dial Transplant 24(7):2186–2189PubMedCrossRef
9.
Zurück zum Zitat Mehta RL, Pascual MT, Soroko S et al (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66(4):1613–1621PubMedCrossRef Mehta RL, Pascual MT, Soroko S et al (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66(4):1613–1621PubMedCrossRef
10.
Zurück zum Zitat Mehta RL, Pascual MT, Soroko S, Chertow GM (2002) Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 288(20):2547–2553PubMedCrossRef Mehta RL, Pascual MT, Soroko S, Chertow GM (2002) Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 288(20):2547–2553PubMedCrossRef
11.
Zurück zum Zitat Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE (2011) The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79(12):1361–1369PubMedPubMedCentralCrossRef Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE (2011) The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79(12):1361–1369PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Amdur RL, Chawla LS, Amodeo S, Kimmel PL, Palant CE (2009) Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis. Kidney Int 76(10):1089–1097PubMedCrossRef Amdur RL, Chawla LS, Amodeo S, Kimmel PL, Palant CE (2009) Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis. Kidney Int 76(10):1089–1097PubMedCrossRef
13.
Zurück zum Zitat Lo LJ, Go AS, Chertow GM et al (2009) Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int 76(8):893–899PubMedPubMedCentralCrossRef Lo LJ, Go AS, Chertow GM et al (2009) Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int 76(8):893–899PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Wald R, Quinn RR, Luo J et al (2009) Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. J Am Med Assoc 302(11):1179–1185. (Erratum, JAMA 2009;302:1532)CrossRef Wald R, Quinn RR, Luo J et al (2009) Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. J Am Med Assoc 302(11):1179–1185. (Erratum, JAMA 2009;302:1532)CrossRef
15.
Zurück zum Zitat Bucaloiu ID, Kirchner HL, Norfolk ER, Hartle JE II, Perkins RM (2012) Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int 81(5):477–485PubMedCrossRef Bucaloiu ID, Kirchner HL, Norfolk ER, Hartle JE II, Perkins RM (2012) Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int 81(5):477–485PubMedCrossRef
16.
Zurück zum Zitat Wald R, Quinn RR, Adhikari NK et al (2012) Risk of chronic dialysis and death following acute kidney injury. Am J Med 125(6):585–593PubMedCrossRef Wald R, Quinn RR, Adhikari NK et al (2012) Risk of chronic dialysis and death following acute kidney injury. Am J Med 125(6):585–593PubMedCrossRef
17.
Zurück zum Zitat Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. New Engl J Med 371(1):58–66PubMedCrossRef Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. New Engl J Med 371(1):58–66PubMedCrossRef
18.
Zurück zum Zitat Bedford M, Farmer C, Levin A, Ali T, Stevens P (2012) Acute kidney injury and CKD: chicken or egg?. Am J Kidney Dis 59(4):485–491PubMedCrossRef Bedford M, Farmer C, Levin A, Ali T, Stevens P (2012) Acute kidney injury and CKD: chicken or egg?. Am J Kidney Dis 59(4):485–491PubMedCrossRef
19.
Zurück zum Zitat Bellomo R, Kellum JA, Ronco C (2012) Acute kidney injury. The Lancet 380:756–766CrossRef Bellomo R, Kellum JA, Ronco C (2012) Acute kidney injury. The Lancet 380:756–766CrossRef
20.
Zurück zum Zitat Chawla LS, Kimmel PL (2012) Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int 82:516–524PubMedCrossRef Chawla LS, Kimmel PL (2012) Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int 82:516–524PubMedCrossRef
22.
Zurück zum Zitat Kheterpal S, Tremper KK, Heung M, Rosenberg AL, Englesbe M, Shanks AM et al (2009) Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set. Anesthesiology 110(3):505–515PubMedCrossRef Kheterpal S, Tremper KK, Heung M, Rosenberg AL, Englesbe M, Shanks AM et al (2009) Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set. Anesthesiology 110(3):505–515PubMedCrossRef
23.
Zurück zum Zitat Bagshaw SM, George C, Bellomo R (2008) and the ANZICS database management committee. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 12:R47PubMedPubMedCentralCrossRef Bagshaw SM, George C, Bellomo R (2008) and the ANZICS database management committee. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 12:R47PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Hoste EA, Clermont G, Kersten A et al (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:R73PubMedPubMedCentralCrossRef Hoste EA, Clermont G, Kersten A et al (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:R73PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Xue JL, Daniels F, Star RA et al (2006) Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 17:1135–1142PubMedCrossRef Xue JL, Daniels F, Star RA et al (2006) Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 17:1135–1142PubMedCrossRef
26.
27.
Zurück zum Zitat Goldberg R, Dennen P (2008) Long-term outcomes of acute kidney injury. Adv Chronic Kidney Dis 15(3):297–307PubMedCrossRef Goldberg R, Dennen P (2008) Long-term outcomes of acute kidney injury. Adv Chronic Kidney Dis 15(3):297–307PubMedCrossRef
28.
Zurück zum Zitat Panek R, Tennankore KK, Kiberd BA (2016) Incidence, etiology, and significance of acute kidney injury in the early post-kidney transplant period. Clin Transplant 30(1):66–70PubMedCrossRef Panek R, Tennankore KK, Kiberd BA (2016) Incidence, etiology, and significance of acute kidney injury in the early post-kidney transplant period. Clin Transplant 30(1):66–70PubMedCrossRef
29.
Zurück zum Zitat Wonnacott A, Meran S, Amphlett B, Talabani B, Phillips A (2014) Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol 9(6):1007–1014PubMedPubMedCentralCrossRef Wonnacott A, Meran S, Amphlett B, Talabani B, Phillips A (2014) Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol 9(6):1007–1014PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, Jaber BL (2013) Acute kidney injury advisory group of the american society of nephrology: world incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol 8:1482–1493PubMedPubMedCentralCrossRef Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, Jaber BL (2013) Acute kidney injury advisory group of the american society of nephrology: world incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol 8:1482–1493PubMedPubMedCentralCrossRef
31.
Zurück zum Zitat Thomas M, Davies A, Dawnay A (2013) Acute kidney injury prevention, detection and management of acute kidney injury up to the point of renal replacement therapy. NICE Clinical Guidelines Thomas M, Davies A, Dawnay A (2013) Acute kidney injury prevention, detection and management of acute kidney injury up to the point of renal replacement therapy. NICE Clinical Guidelines
33.
Zurück zum Zitat Saran R, Li Y, Robinson B et al (2016) US renal data system 2015 AnnuaL DATA REPORT: EPIDEMIOLOGY OF KIDNEY DISEAse in the United States. Am J Kidney Dis 67(3 suppl 1):S1–S434 Saran R, Li Y, Robinson B et al (2016) US renal data system 2015 AnnuaL DATA REPORT: EPIDEMIOLOGY OF KIDNEY DISEAse in the United States. Am J Kidney Dis 67(3 suppl 1):S1–S434
34.
Zurück zum Zitat Brück K, Stel VS, Gambaro G, Hallan S, Völzke H, Ärnlöv J, Kastarinen M, Guessous I, Vinhas J, Stengel B, Brenner H, Chudek J, Romundstad S, Tomson C, Gonzalez AO, Bello AK, Ferrieres J, Palmieri L, Browne G, Capuano V, Van Biesen W, Zoccali C, Gansevoort R, Navis G, Rothenbacher D, Ferraro PM, Nitsch D, Wanner C, Jager KJ; European CKD Burden Consortium (2016) CKD prevalence varies across the european general population. J Am Soc Nephrol 27(7):2135–2147PubMedCrossRef Brück K, Stel VS, Gambaro G, Hallan S, Völzke H, Ärnlöv J, Kastarinen M, Guessous I, Vinhas J, Stengel B, Brenner H, Chudek J, Romundstad S, Tomson C, Gonzalez AO, Bello AK, Ferrieres J, Palmieri L, Browne G, Capuano V, Van Biesen W, Zoccali C, Gansevoort R, Navis G, Rothenbacher D, Ferraro PM, Nitsch D, Wanner C, Jager KJ; European CKD Burden Consortium (2016) CKD prevalence varies across the european general population. J Am Soc Nephrol 27(7):2135–2147PubMedCrossRef
36.
Zurück zum Zitat Eknoyan G, Levin NW (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification-foreword. Am J Kidney Dis 39(2):S14–266CrossRef Eknoyan G, Levin NW (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification-foreword. Am J Kidney Dis 39(2):S14–266CrossRef
37.
Zurück zum Zitat Hsu CY, Vittinghoff E, Lin F, Shlipak MG (2004) The incidence of end-stage renal disease is increasing faster than the prevalence of chronic renal insufficiency. Ann Intern Med 141(2):95–101PubMedCrossRef Hsu CY, Vittinghoff E, Lin F, Shlipak MG (2004) The incidence of end-stage renal disease is increasing faster than the prevalence of chronic renal insufficiency. Ann Intern Med 141(2):95–101PubMedCrossRef
38.
Zurück zum Zitat Coca SG, Singanamala S, Parikh CR (2012) Chronic kidney disease after acute kidney injury: a systematic review and metaanalysis. Kidney Int 81:442–448PubMedCrossRef Coca SG, Singanamala S, Parikh CR (2012) Chronic kidney disease after acute kidney injury: a systematic review and metaanalysis. Kidney Int 81:442–448PubMedCrossRef
39.
Zurück zum Zitat Ishani A, Nelson D, Clothier B, Schult T, Nugent S, Greer N et al (2011) The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch Intern Med 171:226–233PubMedCrossRef Ishani A, Nelson D, Clothier B, Schult T, Nugent S, Greer N et al (2011) The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch Intern Med 171:226–233PubMedCrossRef
40.
Zurück zum Zitat Newsome BB, Warnock DG, McClellan WM, Herzog CA, Kiefe CI, Eggers PW, Allison JJ (2008) Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Inter Med 168(6):609–616CrossRef Newsome BB, Warnock DG, McClellan WM, Herzog CA, Kiefe CI, Eggers PW, Allison JJ (2008) Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Inter Med 168(6):609–616CrossRef
41.
Zurück zum Zitat James MT, Ghali WA, Tonelli M, Faris P, Knudtson ML, Pannu N, Klarenbach SW, Manns BJ, Hemmelgarn BR (2010) Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function. Kidney Int 78(8):803–809PubMedCrossRef James MT, Ghali WA, Tonelli M, Faris P, Knudtson ML, Pannu N, Klarenbach SW, Manns BJ, Hemmelgarn BR (2010) Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function. Kidney Int 78(8):803–809PubMedCrossRef
42.
Zurück zum Zitat James MT, Hemmelgarn BR, Wiebe N et al (2010) Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study. Lancet 376:2096–2103PubMedCrossRef James MT, Hemmelgarn BR, Wiebe N et al (2010) Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study. Lancet 376:2096–2103PubMedCrossRef
43.
Zurück zum Zitat Hsu CY, Chertow GM, McCulloch CE et al (2009) Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J Am Soc Nephrol 4:891–898PubMedPubMedCentralCrossRef Hsu CY, Chertow GM, McCulloch CE et al (2009) Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J Am Soc Nephrol 4:891–898PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Lafrance JP, Djurdjev O, Levin A (2010) Incidence and outcomes of acute kidney injury in a referred chronic kidney disease cohort. Nephrol Dial Transplant 25(7):2203–2209PubMedCrossRef Lafrance JP, Djurdjev O, Levin A (2010) Incidence and outcomes of acute kidney injury in a referred chronic kidney disease cohort. Nephrol Dial Transplant 25(7):2203–2209PubMedCrossRef
45.
Zurück zum Zitat Choi AI, Li Y, Parikh C, Volberding PA, Shlipak MG (2010) Long-term clinical consequences of acute kidney injury in the HIV-infected. Kidney Int 78(5):478–485PubMedPubMedCentralCrossRef Choi AI, Li Y, Parikh C, Volberding PA, Shlipak MG (2010) Long-term clinical consequences of acute kidney injury in the HIV-infected. Kidney Int 78(5):478–485PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat James MT, Ghali WA, Knudtson ML, Ravani P, Tonelli M, Faris P, Pannu N, Manns BJ, Klarenbach SW, Hemmelgarn BR (2011) Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography. Circulation 123(4):409–416PubMedCrossRef James MT, Ghali WA, Knudtson ML, Ravani P, Tonelli M, Faris P, Pannu N, Manns BJ, Klarenbach SW, Hemmelgarn BR (2011) Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography. Circulation 123(4):409–416PubMedCrossRef
47.
Zurück zum Zitat Thakar CV, Christianson A, Himmelfarb J, Leonard AC (2011) Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol 6:2567–2572PubMedPubMedCentralCrossRef Thakar CV, Christianson A, Himmelfarb J, Leonard AC (2011) Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol 6:2567–2572PubMedPubMedCentralCrossRef
48.
Zurück zum Zitat Steinwald B, Dummit LA (1989) Hospital case-mix change: sicker patients or DRG creep?. Health Affairs 8(2):35–47PubMedCrossRef Steinwald B, Dummit LA (1989) Hospital case-mix change: sicker patients or DRG creep?. Health Affairs 8(2):35–47PubMedCrossRef
49.
Zurück zum Zitat Vlasschaert ME, Bejaimal SA, Hackam DG, Quinn R, Cuerden MS, Oliver MJ et al (2011) Validity of administrative database coding for kidney disease: a systematic review. Am J Kidney Dis 57:29–43PubMedCrossRef Vlasschaert ME, Bejaimal SA, Hackam DG, Quinn R, Cuerden MS, Oliver MJ et al (2011) Validity of administrative database coding for kidney disease: a systematic review. Am J Kidney Dis 57:29–43PubMedCrossRef
50.
Zurück zum Zitat Bonventre JV (2010) Pathophysiology of AKI: injury and normal and abnormal repair. In: Cardiorenal syndromes in critical care 2010 Apr 20, vol 165. Karger Publishers, Berlin, pp 9–17 Bonventre JV (2010) Pathophysiology of AKI: injury and normal and abnormal repair. In: Cardiorenal syndromes in critical care 2010 Apr 20, vol 165. Karger Publishers, Berlin, pp 9–17
51.
Zurück zum Zitat Yang L, Humphreys BD, Bonventre JV (2011) Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. In: Controversies in acute kidney injury 2011 Sep 9, vol 174. Karger Publishers, Berlin, pp 149–155 Yang L, Humphreys BD, Bonventre JV (2011) Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. In: Controversies in acute kidney injury 2011 Sep 9, vol 174. Karger Publishers, Berlin, pp 149–155
52.
Zurück zum Zitat Zuk A, Bonventre JV, Brown D, Matlin KS (1998) Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 275:C711–C731PubMed Zuk A, Bonventre JV, Brown D, Matlin KS (1998) Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 275:C711–C731PubMed
53.
Zurück zum Zitat Thadhani R, Pascual M, Bonventre JV (1996) Acute renal failure. New Engl J Med 334:1448–1460PubMedCrossRef Thadhani R, Pascual M, Bonventre JV (1996) Acute renal failure. New Engl J Med 334:1448–1460PubMedCrossRef
54.
Zurück zum Zitat Kwon O, Hong SM, Ramesh G (2009) Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia–reperfusion. Am J Physiol Renal Physiol 296(1):F25–F33PubMedCrossRef Kwon O, Hong SM, Ramesh G (2009) Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia–reperfusion. Am J Physiol Renal Physiol 296(1):F25–F33PubMedCrossRef
55.
Zurück zum Zitat Conger J (1997) Hemodynamic factors in acute renal failure. Adv Ren Replace Ther 4(suppl 1):25–37PubMed Conger J (1997) Hemodynamic factors in acute renal failure. Adv Ren Replace Ther 4(suppl 1):25–37PubMed
56.
Zurück zum Zitat Conger JD (1983) Vascular abnormalities in the maintenance of acute renal failure. Circ Shock 11:235–244PubMed Conger JD (1983) Vascular abnormalities in the maintenance of acute renal failure. Circ Shock 11:235–244PubMed
57.
Zurück zum Zitat Linas S, Whittenburg D, Repine JE (1997) Nitric oxide prevents neutrophil-mediated acuterenal failure. Am J Physiol 272:F48–F54PubMed Linas S, Whittenburg D, Repine JE (1997) Nitric oxide prevents neutrophil-mediated acuterenal failure. Am J Physiol 272:F48–F54PubMed
58.
Zurück zum Zitat Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC (2008) Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PloS One 3:e3596PubMedPubMedCentralCrossRef Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC (2008) Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PloS One 3:e3596PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S (2005) Renal-associated TLR2 mediates ischemia/ reperfusion injury in the kidney. J Clin Invest 115:2894–2903PubMedPubMedCentralCrossRef Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S (2005) Renal-associated TLR2 mediates ischemia/ reperfusion injury in the kidney. J Clin Invest 115:2894–2903PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Kelly KJ, Williams WW, Colvin RB, Bonventre JV (1994) Antibody to intercellular adhesion molecule-1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 91:812–816PubMedPubMedCentralCrossRef Kelly KJ, Williams WW, Colvin RB, Bonventre JV (1994) Antibody to intercellular adhesion molecule-1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 91:812–816PubMedPubMedCentralCrossRef
61.
Zurück zum Zitat Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV (1996) Intercellular adhesion molecule-1-deficient mice are protected against renal ischemia. J Clin Invest 97:1056–1063PubMedPubMedCentralCrossRef Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV (1996) Intercellular adhesion molecule-1-deficient mice are protected against renal ischemia. J Clin Invest 97:1056–1063PubMedPubMedCentralCrossRef
62.
Zurück zum Zitat Homeister JW, Lucchesi BR (1994) Complement activation and inhibition in myocardial ischemia and reperfusion injury. Annu Rev Pharmacol Toxicol 34:17–40PubMedCrossRef Homeister JW, Lucchesi BR (1994) Complement activation and inhibition in myocardial ischemia and reperfusion injury. Annu Rev Pharmacol Toxicol 34:17–40PubMedCrossRef
63.
64.
Zurück zum Zitat Park KM, Chen A, Bonventre JV (2001) Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 276:11870–11876PubMedCrossRef Park KM, Chen A, Bonventre JV (2001) Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 276:11870–11876PubMedCrossRef
65.
Zurück zum Zitat Basile DP, Fredrich K, Chelladurai B, Leonard EC, Parrish AR (2008) Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Am J Physiol Renal Physiol 294(4):F928–F936PubMedCrossRef Basile DP, Fredrich K, Chelladurai B, Leonard EC, Parrish AR (2008) Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Am J Physiol Renal Physiol 294(4):F928–F936PubMedCrossRef
66.
Zurück zum Zitat Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Recalde A, Duriez M, Levy BI, Lutgens E, Mallat Z, Silvestre JS (2009) Regulatory T cells modulate postischemic neovascularization. Circulation 120:1415–1425PubMedCrossRef Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Recalde A, Duriez M, Levy BI, Lutgens E, Mallat Z, Silvestre JS (2009) Regulatory T cells modulate postischemic neovascularization. Circulation 120:1415–1425PubMedCrossRef
67.
Zurück zum Zitat Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV (2008) Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2:284–291PubMedCrossRef Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV (2008) Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2:284–291PubMedCrossRef
68.
Zurück zum Zitat Forbes JM, Hewitson TD, Becker GJ, Jones CL (2000) Ischemic acute renal failure: long- term histology of cell and matrix changes in the rat. Kidney Int 57:2375–2385PubMedCrossRef Forbes JM, Hewitson TD, Becker GJ, Jones CL (2000) Ischemic acute renal failure: long- term histology of cell and matrix changes in the rat. Kidney Int 57:2375–2385PubMedCrossRef
69.
Zurück zum Zitat Macedo E, Bouchard J, Mehta RL (2008) Renal recovery following acute kidney injury. Curr Opin Crit Care 14:660–665PubMedCrossRef Macedo E, Bouchard J, Mehta RL (2008) Renal recovery following acute kidney injury. Curr Opin Crit Care 14:660–665PubMedCrossRef
70.
Zurück zum Zitat Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK (2010) Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298(5):F1078–F1094PubMedPubMedCentralCrossRef Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK (2010) Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298(5):F1078–F1094PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV (2010) Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16(5):535–543PubMedPubMedCentralCrossRef Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV (2010) Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16(5):535–543PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Akhtar A (2015) The flaws and human harms of animal experimentation. Cambr Q Healthc Ethics 24(04):407–419CrossRef Akhtar A (2015) The flaws and human harms of animal experimentation. Cambr Q Healthc Ethics 24(04):407–419CrossRef
73.
Zurück zum Zitat National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2):S1–S266CrossRef National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2):S1–S266CrossRef
74.
Zurück zum Zitat Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, Zeeuw DD, Hostetter TH, Lameire N, Eknoyan G (2005) Definition and classification of chronic kidney disease: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 67(6):2089–2100PubMedCrossRef Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, Zeeuw DD, Hostetter TH, Lameire N, Eknoyan G (2005) Definition and classification of chronic kidney disease: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 67(6):2089–2100PubMedCrossRef
75.
Zurück zum Zitat Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA, Gardenswartz M, Rosen R, Appel GB (2006) Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol 1(4):718–722PubMedCrossRef Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA, Gardenswartz M, Rosen R, Appel GB (2006) Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol 1(4):718–722PubMedCrossRef
76.
Zurück zum Zitat Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW (2005) Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16(11):3365–3370PubMedCrossRef Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW (2005) Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16(11):3365–3370PubMedCrossRef
77.
Zurück zum Zitat Hobson CE, Yavas S, Segal MS et al (2009) Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation 119:2444–2453PubMedCrossRef Hobson CE, Yavas S, Segal MS et al (2009) Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation 119:2444–2453PubMedCrossRef
78.
Zurück zum Zitat Waikar SS, Liu KD, Chertow GM (2008) Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol 3:844–861PubMedCrossRef Waikar SS, Liu KD, Chertow GM (2008) Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol 3:844–861PubMedCrossRef
79.
Zurück zum Zitat Lafrance JP, Miller DR (2010) Defining acute kidney injury in database studies: the effects of varying the baseline kidney function assessment period and considering CKD status. Am J Kidney Dis 56:651–660PubMedCrossRef Lafrance JP, Miller DR (2010) Defining acute kidney injury in database studies: the effects of varying the baseline kidney function assessment period and considering CKD status. Am J Kidney Dis 56:651–660PubMedCrossRef
80.
Zurück zum Zitat Lin J, Fernandez H, Shashaty MG, Negoianu D, Testani JM, Berns JS, Parikh CR, Wilson FP (2015) False-positive rate of AKI using consensus creatinine-based criteria. Clin J Am Soc Nephrol 10:1723–1731PubMedPubMedCentralCrossRef Lin J, Fernandez H, Shashaty MG, Negoianu D, Testani JM, Berns JS, Parikh CR, Wilson FP (2015) False-positive rate of AKI using consensus creatinine-based criteria. Clin J Am Soc Nephrol 10:1723–1731PubMedPubMedCentralCrossRef
81.
Zurück zum Zitat Ejaz AA, Dass B, Lingegowda V, Shimada M, Beaver TM, Ejaz NI, Abouhamze AS, Johnson RJ (2013) Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Int Urol Nephrol 45:449–458PubMedCrossRef Ejaz AA, Dass B, Lingegowda V, Shimada M, Beaver TM, Ejaz NI, Abouhamze AS, Johnson RJ (2013) Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Int Urol Nephrol 45:449–458PubMedCrossRef
82.
Zurück zum Zitat Wilson FP, Shashaty M, Testani J, Aqeel I, Borovskiy Y, Ellenberg SS, Feldman HI, Fernandez H, Gitelman Y, Lin J, Negoianu D, Parikh CR, Reese PP, Urbani R, Fuchs B (2015) Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet 385:1966–1974PubMedPubMedCentralCrossRef Wilson FP, Shashaty M, Testani J, Aqeel I, Borovskiy Y, Ellenberg SS, Feldman HI, Fernandez H, Gitelman Y, Lin J, Negoianu D, Parikh CR, Reese PP, Urbani R, Fuchs B (2015) Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet 385:1966–1974PubMedPubMedCentralCrossRef
83.
Zurück zum Zitat Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw AD (2005) Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 46:26–34PubMedCrossRef Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw AD (2005) Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 46:26–34PubMedCrossRef
84.
Zurück zum Zitat Berger MM, Soguel L, Shenkin A, Revelly JP, Pinget C, Baines M, Chiólero R (2008) Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients. Crit Care 12:R101. doi:10.1186/cc6981 PubMedPubMedCentralCrossRef Berger MM, Soguel L, Shenkin A, Revelly JP, Pinget C, Baines M, Chiólero R (2008) Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients. Crit Care 12:R101. doi:10.​1186/​cc6981 PubMedPubMedCentralCrossRef
85.
Zurück zum Zitat Herget-Rosenthal S, Pietruck F, Volbracht L, Philipp T, Kribben A (2005) Serum cystatin C–a superior marker of rapidly reduced glomerular filtration after uninephrectomy in kidney donors compared to creatinine. Clin Nephrol 64(1):41–46PubMedCrossRef Herget-Rosenthal S, Pietruck F, Volbracht L, Philipp T, Kribben A (2005) Serum cystatin C–a superior marker of rapidly reduced glomerular filtration after uninephrectomy in kidney donors compared to creatinine. Clin Nephrol 64(1):41–46PubMedCrossRef
86.
Zurück zum Zitat Bagshaw SM, Mortis G, Doig CJ, Godinez-Luna T, Fick GH, Laupland KB (2006) One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment. Am J Kidney Dis 48:402–409PubMedCrossRef Bagshaw SM, Mortis G, Doig CJ, Godinez-Luna T, Fick GH, Laupland KB (2006) One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment. Am J Kidney Dis 48:402–409PubMedCrossRef
87.
Zurück zum Zitat Chertow GM, Soroko SH, Paganini EP, Cho KC, Himmelfarb J, Ikizler TA, Mehta RL (2006) Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int 70:1120–1126PubMedCrossRef Chertow GM, Soroko SH, Paganini EP, Cho KC, Himmelfarb J, Ikizler TA, Mehta RL (2006) Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int 70:1120–1126PubMedCrossRef
89.
Zurück zum Zitat Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C (2005) Beginning and ending supportive therapy for the kidney (BEST kidney) Investigators: acute renal failure in critically ill patients: A multinational, multicenter study. J Am Med Assoc 294:813–818CrossRef Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C (2005) Beginning and ending supportive therapy for the kidney (BEST kidney) Investigators: acute renal failure in critically ill patients: A multinational, multicenter study. J Am Med Assoc 294:813–818CrossRef
90.
Zurück zum Zitat Waikar SS, Betensky RA, Emerson SC, Bonventre JV (2012) Imperfect gold standards for kidney injury biomarker evaluation. J Am Soc Nephrol 23:13–21PubMedPubMedCentralCrossRef Waikar SS, Betensky RA, Emerson SC, Bonventre JV (2012) Imperfect gold standards for kidney injury biomarker evaluation. J Am Soc Nephrol 23:13–21PubMedPubMedCentralCrossRef
91.
Zurück zum Zitat Ricci Z, Cruz D, Ronco C (2008) The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 73(5):538–546PubMedCrossRef Ricci Z, Cruz D, Ronco C (2008) The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 73(5):538–546PubMedCrossRef
92.
Zurück zum Zitat Friedrich JO, Adhikari N, Herridge MS, Beyene J (2005) Metaanalysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142(7):510–524PubMedCrossRef Friedrich JO, Adhikari N, Herridge MS, Beyene J (2005) Metaanalysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142(7):510–524PubMedCrossRef
94.
Zurück zum Zitat Bosch JP, Lauer A, Glabman S (1984) Short-term protein loading in assessment of patients with renal disease. Am J Med 77:873–879PubMedCrossRef Bosch JP, Lauer A, Glabman S (1984) Short-term protein loading in assessment of patients with renal disease. Am J Med 77:873–879PubMedCrossRef
95.
Zurück zum Zitat Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S (1983) Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. Am J Med 75:943–950PubMedCrossRef Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S (1983) Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. Am J Med 75:943–950PubMedCrossRef
96.
Zurück zum Zitat Bosch JP, Lew S, Glabman S, Lauer A (1986) Renal hemodynamic changes in humans. Response to protein loading in normal and diseased kidneys. Am J Med 81:809–815PubMedCrossRef Bosch JP, Lew S, Glabman S, Lauer A (1986) Renal hemodynamic changes in humans. Response to protein loading in normal and diseased kidneys. Am J Med 81:809–815PubMedCrossRef
97.
Zurück zum Zitat Ronco C, Brendolan A, Bragantini L, Chiaramonte S, Fabris A, Feriani M, Dell Aquila R, Milan M, Mentasti P, La Greca G (1988) Renal functional reserve in pregnancy. Nephrol Dial Transplant 3:157–161PubMedCrossRef Ronco C, Brendolan A, Bragantini L, Chiaramonte S, Fabris A, Feriani M, Dell Aquila R, Milan M, Mentasti P, La Greca G (1988) Renal functional reserve in pregnancy. Nephrol Dial Transplant 3:157–161PubMedCrossRef
98.
Zurück zum Zitat Der Mesropian P, Othersen J, Mason D, Wang J, Asif A, Mathew RO (2016) Community acquired acute kidney injury: a challenge and opportunity for primary care in kidney health. Nephrology (Carlton) 21(9):729–735. doi:10.1111/nep.12751 CrossRef Der Mesropian P, Othersen J, Mason D, Wang J, Asif A, Mathew RO (2016) Community acquired acute kidney injury: a challenge and opportunity for primary care in kidney health. Nephrology (Carlton) 21(9):729–735. doi:10.​1111/​nep.​12751 CrossRef
99.
Zurück zum Zitat Kaufman J, Dhakal M, Patel B, Hamburger R (1991) Community-acquired acute renal failure. Am J Kidney Dis 17(2):191–198PubMedCrossRef Kaufman J, Dhakal M, Patel B, Hamburger R (1991) Community-acquired acute renal failure. Am J Kidney Dis 17(2):191–198PubMedCrossRef
100.
Zurück zum Zitat Liano F, Pascual J (1996) Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid acute renal failure study group. Kidney Int 50(3):811–818PubMedCrossRef Liano F, Pascual J (1996) Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid acute renal failure study group. Kidney Int 50(3):811–818PubMedCrossRef
101.
Zurück zum Zitat Talabani B, Zouwail S, Pyart RD, Meran S, Riley SG, Phillips AO (2014) Epidemiology and outcome of community-acquired acute kidney injury. Nephrology (Carlton) 19(5):2827CrossRef Talabani B, Zouwail S, Pyart RD, Meran S, Riley SG, Phillips AO (2014) Epidemiology and outcome of community-acquired acute kidney injury. Nephrology (Carlton) 19(5):2827CrossRef
102.
Zurück zum Zitat Obialo CI, Okonofua EC, Tayade AS, Riley LJ (2000) Epidemiology of de novo acute renal failure in hospitalized African Americans: comparing community-acquired vs hospital-acquired disease. Arch Intern Med 160(9):1309–1313PubMedCrossRef Obialo CI, Okonofua EC, Tayade AS, Riley LJ (2000) Epidemiology of de novo acute renal failure in hospitalized African Americans: comparing community-acquired vs hospital-acquired disease. Arch Intern Med 160(9):1309–1313PubMedCrossRef
103.
Zurück zum Zitat Schissler MM, Zaidi S, Kumar H, Deo D, Brier ME, McLeish KR (2013) Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology (Carlton) 18(3):183–187. doi:10.1111/nep.12036 CrossRef Schissler MM, Zaidi S, Kumar H, Deo D, Brier ME, McLeish KR (2013) Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology (Carlton) 18(3):183–187. doi:10.​1111/​nep.​12036 CrossRef
104.
Zurück zum Zitat Der Mesropian PJ, Kalamaras JS, Eisele G, Phelps KR, Asif A, Mathew RO (2014) Long-term outcomes of community-acquired versus hospital-acquired acute kidney injury: a retrospective analysis. Clin Nephrol 81(3):174–184CrossRef Der Mesropian PJ, Kalamaras JS, Eisele G, Phelps KR, Asif A, Mathew RO (2014) Long-term outcomes of community-acquired versus hospital-acquired acute kidney injury: a retrospective analysis. Clin Nephrol 81(3):174–184CrossRef
105.
Zurück zum Zitat Xu G, Player P, Shepherd D, Brunskill NJ (2016) Identifying acute kidney injury in the community—a novel informatics approach. J Nephrol 29(1):93–98PubMedCrossRef Xu G, Player P, Shepherd D, Brunskill NJ (2016) Identifying acute kidney injury in the community—a novel informatics approach. J Nephrol 29(1):93–98PubMedCrossRef
106.
Zurück zum Zitat Egan BM, Zhao Y, Axon RN (2010) US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. J Am Med Assoc 303(20):2043–2050CrossRef Egan BM, Zhao Y, Axon RN (2010) US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. J Am Med Assoc 303(20):2043–2050CrossRef
107.
Zurück zum Zitat Pascual J, Liaño F, Ortuño J (1995) The elderly patient with acute renal failure. J Am Soc Nephrol 6(2):144–153PubMed Pascual J, Liaño F, Ortuño J (1995) The elderly patient with acute renal failure. J Am Soc Nephrol 6(2):144–153PubMed
108.
110.
Zurück zum Zitat Go AS, Parikh CR, Ikizler TA et al (2010) The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study: design and methods. BMC Nephrol 11:22PubMedPubMedCentralCrossRef Go AS, Parikh CR, Ikizler TA et al (2010) The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study: design and methods. BMC Nephrol 11:22PubMedPubMedCentralCrossRef
111.
Zurück zum Zitat Horne KL, Packington R, Monaghan J, Reilly T, McIntyre CW, Selby NM (2014) The effects of acute kidney injury on long-term renal function and proteinuria in a general hospitalised population. Nephron Clin Pract 128:192–200PubMedCrossRef Horne KL, Packington R, Monaghan J, Reilly T, McIntyre CW, Selby NM (2014) The effects of acute kidney injury on long-term renal function and proteinuria in a general hospitalised population. Nephron Clin Pract 128:192–200PubMedCrossRef
114.
Zurück zum Zitat McNamara BJ, Diouf B, Douglas-Denton RN, Hughson MD, Hoy WE, Bertram JF (2010) A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Ameri-cans. Nephrol Dial Transplant 25:1514–1520. doi:10.1093/ndt/gfq030 PubMedPubMedCentralCrossRef McNamara BJ, Diouf B, Douglas-Denton RN, Hughson MD, Hoy WE, Bertram JF (2010) A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Ameri-cans. Nephrol Dial Transplant 25:1514–1520. doi:10.​1093/​ndt/​gfq030 PubMedPubMedCentralCrossRef
115.
Zurück zum Zitat Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D (1991) Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and cavalieri principle. Lab Invest 64:777–784PubMed Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D (1991) Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and cavalieri principle. Lab Invest 64:777–784PubMed
119.
Zurück zum Zitat McNamara BJ, Diouf B, Hughson MD, Hoy WE, Bertram JF (2009) Associations between age, body size and nephron number with individual glomerular volumes in urban West African males. Nephrol Dial Transplant 24:1500–1506. doi:10.1093/ndt/gfn636 PubMedCrossRef McNamara BJ, Diouf B, Hughson MD, Hoy WE, Bertram JF (2009) Associations between age, body size and nephron number with individual glomerular volumes in urban West African males. Nephrol Dial Transplant 24:1500–1506. doi:10.​1093/​ndt/​gfn636 PubMedCrossRef
121.
122.
123.
Zurück zum Zitat Brenner BM, Garcia DL, Anderson S (1988) Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1:335–347PubMedCrossRef Brenner BM, Garcia DL, Anderson S (1988) Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1:335–347PubMedCrossRef
127.
Zurück zum Zitat Bhathena DB, Julian BA, McMorrow RG, Baehler RW (1985) Focal sclerosis of hypertrophied glomeruli in solitary functioning kidneys of humans. Am J Kidney Dis 5:226–232PubMedCrossRef Bhathena DB, Julian BA, McMorrow RG, Baehler RW (1985) Focal sclerosis of hypertrophied glomeruli in solitary functioning kidneys of humans. Am J Kidney Dis 5:226–232PubMedCrossRef
130.
Zurück zum Zitat Hoy WE, Rees M, Kile E, Mathews JD, McCredie DA, Pugsley DJ, Wang Z (1998) Low birthweight and renal disease in Australian aborigines. Lancet 352:1826–1827PubMedCrossRef Hoy WE, Rees M, Kile E, Mathews JD, McCredie DA, Pugsley DJ, Wang Z (1998) Low birthweight and renal disease in Australian aborigines. Lancet 352:1826–1827PubMedCrossRef
131.
Zurück zum Zitat Hoy WE, Wang Z, VanBuynder P, Baker PR, Mathews JD (2001) The natural history of renal disease in Australian aborigines: part 1. Changes in albuminuria and glomerular filtration rate over time. Kidney Int 60:243–248PubMedCrossRef Hoy WE, Wang Z, VanBuynder P, Baker PR, Mathews JD (2001) The natural history of renal disease in Australian aborigines: part 1. Changes in albuminuria and glomerular filtration rate over time. Kidney Int 60:243–248PubMedCrossRef
132.
Zurück zum Zitat Hoy WE, Mathews JD, McCredie DA, Pugsley DJ, Hayhurst BG, Rees M, Kile E, Walker KA, Wang Z (1998) The multidimensional nature of renal disease: rates and associations of albuminuria in an Australian aboriginal community. Kidney Int 54:1296–1304PubMedCrossRef Hoy WE, Mathews JD, McCredie DA, Pugsley DJ, Hayhurst BG, Rees M, Kile E, Walker KA, Wang Z (1998) The multidimensional nature of renal disease: rates and associations of albuminuria in an Australian aboriginal community. Kidney Int 54:1296–1304PubMedCrossRef
133.
Zurück zum Zitat Hoy WE, Rees M, Kile E, Mathews JD, Wang Z (1999) A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease. Kidney Int 56:1072–1077PubMedCrossRef Hoy WE, Rees M, Kile E, Mathews JD, Wang Z (1999) A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease. Kidney Int 56:1072–1077PubMedCrossRef
134.
Zurück zum Zitat Nelson RG, Morgenstern H, Bennett PH (1998) Birth weight and renal disease in Pima Indians with type 2 diabetes mellitus. Am J Epidemiol 148:650–656PubMedCrossRef Nelson RG, Morgenstern H, Bennett PH (1998) Birth weight and renal disease in Pima Indians with type 2 diabetes mellitus. Am J Epidemiol 148:650–656PubMedCrossRef
135.
Zurück zum Zitat Yudkin JS, Martyn CN, Phillips DI, Gale CR (2001) Associations of micro-albuminuria with intra-uterine growth retardation. Nephron 89:309–314PubMedCrossRef Yudkin JS, Martyn CN, Phillips DI, Gale CR (2001) Associations of micro-albuminuria with intra-uterine growth retardation. Nephron 89:309–314PubMedCrossRef
136.
Zurück zum Zitat Painter RC, Roseboom TJ, van Montfrans GA, Bossuyt PM, Krediet RT, Osmond C, Barker DJ, Bleker OP (2005) Microalbuminuriain adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol 16:189–194PubMedCrossRef Painter RC, Roseboom TJ, van Montfrans GA, Bossuyt PM, Krediet RT, Osmond C, Barker DJ, Bleker OP (2005) Microalbuminuriain adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol 16:189–194PubMedCrossRef
137.
Zurück zum Zitat Hayslett JP (1979) Functional adaptation to reduction in renal mass. Physiol Rev 59:137–164PubMed Hayslett JP (1979) Functional adaptation to reduction in renal mass. Physiol Rev 59:137–164PubMed
138.
Zurück zum Zitat Deen WM, Maddox DA, Robertson CR, Br en ner B (1974) Dynamics of glomerular ultrafiltration in the rat. VII: response to reduced renal mass. Am J Physiol 227:556–562PubMed Deen WM, Maddox DA, Robertson CR, Br en ner B (1974) Dynamics of glomerular ultrafiltration in the rat. VII: response to reduced renal mass. Am J Physiol 227:556–562PubMed
139.
Zurück zum Zitat Kaufman JM, Siegel NJ, Hayslett JP (1975) Functional and hemodynamic adaptation to progressive renal ablation. Circ Res 36:286–293PubMedCrossRef Kaufman JM, Siegel NJ, Hayslett JP (1975) Functional and hemodynamic adaptation to progressive renal ablation. Circ Res 36:286–293PubMedCrossRef
140.
Zurück zum Zitat Purkerson ML, Hoffsten PE, Klahr S (1976) Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int 9(5):407–417PubMedCrossRef Purkerson ML, Hoffsten PE, Klahr S (1976) Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int 9(5):407–417PubMedCrossRef
141.
Zurück zum Zitat Morrison AB (1966) Experimental chronic renal insufficiency. Methods Achiev Exp Pathol 1:455–475 Morrison AB (1966) Experimental chronic renal insufficiency. Methods Achiev Exp Pathol 1:455–475
142.
Zurück zum Zitat Shea SM, Raskova J, Morrison AB (1978) A stereologic study of glomerular hypertrophy in the subtotally nephrectomized rat. Am J Pathol 90(1):201PubMedPubMedCentral Shea SM, Raskova J, Morrison AB (1978) A stereologic study of glomerular hypertrophy in the subtotally nephrectomized rat. Am J Pathol 90(1):201PubMedPubMedCentral
143.
Zurück zum Zitat Shimamura T, Morrison AB (1975) A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 79(1):95PubMedPubMedCentral Shimamura T, Morrison AB (1975) A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 79(1):95PubMedPubMedCentral
144.
Zurück zum Zitat Brenner BM, Lawler EV, Mackenzie HS (1996) The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 49(6):1774–1777PubMedCrossRef Brenner BM, Lawler EV, Mackenzie HS (1996) The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 49(6):1774–1777PubMedCrossRef
145.
Zurück zum Zitat Lam AQ, Bonventre JV (2015) Regenerating the nephron with human pluripotent stem cells. Curr Opin Organ Transplant 20(2):187–192PubMedCrossRef Lam AQ, Bonventre JV (2015) Regenerating the nephron with human pluripotent stem cells. Curr Opin Organ Transplant 20(2):187–192PubMedCrossRef
146.
Zurück zum Zitat Coca SG, King JT Jr, Rosenthal RA, Perkal MF, Parikh CR (2010) The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. Kidney Int 78(9):926–933PubMedPubMedCentralCrossRef Coca SG, King JT Jr, Rosenthal RA, Perkal MF, Parikh CR (2010) The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. Kidney Int 78(9):926–933PubMedPubMedCentralCrossRef
147.
Zurück zum Zitat Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 61(5):649–672PubMedCrossRef Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 61(5):649–672PubMedCrossRef
Metadaten
Titel
Linking acute kidney injury to chronic kidney disease: the missing links
verfasst von
Mohammed A. Kaballo
Mohamed E. Elsayed
Austin G. Stack
Publikationsdatum
01.08.2017
Verlag
Springer International Publishing
Erschienen in
Journal of Nephrology / Ausgabe 4/2017
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-016-0359-5

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Ist Fasten vor Koronarinterventionen wirklich nötig?

Wenn Eingriffe wie eine Koronarangiografie oder eine Koronarangioplastie anstehen, wird häufig empfohlen, in den Stunden zuvor nüchtern zu bleiben. Ein französisches Forscherteam hat diese Maßnahme hinterfragt.

Typ-2-Diabetes: Ernährungsunsicherheit vervierfacht Risiko für schwere Hypoglykämien

04.06.2024 Typ-2-Diabetes Nachrichten

Wenn ältere Menschen mit Typ-2-Diabetes Schwierigkeiten beim Beschaffen und Zubereiten von Mahlzeiten haben, geht dies mit einem deutlich gesteigerten Risiko für schwere Hypoglykämien einher.

Mehr Brustkrebs, aber weniger andere gynäkologische Tumoren mit Levonorgestrel-IUS

04.06.2024 Levonorgestrel Nachrichten

Unter Frauen, die ein Levonorgestrel-freisetzendes intrauterines System (IUS) verwenden, ist die Brustkrebsrate um 13% erhöht. Dafür kommt es deutlich seltener zu Endometrium-, Zervix- und Ovarialkarzinomen.

GLP-1-Agonist Semaglutid wirkt kardio- und nephroprotektiv

03.06.2024 Semaglutid Nachrichten

Der GLP-1-Agonist Semaglutid hat in der FLOW-Studie bewiesen, dass sich damit die Progression chronischer Nierenerkrankungen bei Patienten mit Typ-2-Diabetes bremsen lässt. Auch in kardiovaskulärer Hinsicht war die Therapie erfolgreich.

Update Innere Medizin

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