Introduction
Methods
Study Populations and Design
WPAI:SHP
Statistical Analyses
Results
Biologic naïve (n = 417) | TNFi experienced (n = 363) | |
---|---|---|
Age, mean (S.D.) | 49.5 (11.9) n = 416 | 51.9 (12.0) n = 363 |
Gender, n (%) | ||
Male | 192 (46.0) | 169 (46.6) |
Race, n (%) | ||
White | 392 (94.0) n = 417 | 332 (91.7) n = 362 |
Weight (kg), mean (SD) | 85.6 (20.9) | 88.7 (21.7) |
BMI (kg/m2), mean (SD) | 30.0 (8.5) n = 413 | 30.9 (7.2) n = 361 |
Time since PsA onset (years), mean (SD) | 10.1 (9.3) | 12.2 (9.0) |
Prior TNFi experience, n (%) | ||
Inadequate response to 1 TNFi | – | 204 (56.2) |
Inadequate response to 2 TNFis | – | 128 (35.3) |
Intolerance to a TNFi | – | 31 (8.5) |
cDMARD use, n (%) | ||
Naïve | 61 (14.6) | – |
Past | 89 (21.3) | 178 (49.0) |
Current | 267 (64.0) | 185 (51.0) |
Methotrexate current use, n (%) | 226 (54.2) | 149 (41.0) |
Current plaque psoriasis, n (%) | 394 (94.5) | 339 (93.4) |
BSA ≥ 3%, n (%) | 267 (69.5) n = 384 | 203 (62.5) n = 325 |
BSA ≥ 10%, n (%) | 159 (41.4) n = 384 | 106 (32.6) n = 325 |
Tender joint counts (68 joints), mean (S.D.) | 20.1 (13.4) n = 417 | 23.4 (15.9) n = 362 |
Swollen joint counts (66 joints), mean (S.D.) | 11.0 (7.4) n = 417 | 12.3 (10.3) n = 362 |
HAQ-DI, mean (S.D.) | 1.17 (0.6) n = 405 | 1.20 (0.6) n = 357 |
SF-36, mean (S.D.) | ||
PCS | 33.6 (9.0) n = 404 | 34.3 (8.9) n = 354 |
MCS | 47.1 (11.9) n = 404 | 48.9 (12.0) n = 354 |
Employment status, n (%) | ||
Work for pay (full time) | 211 (50.6) | 162 (44.6) |
Work for pay (part time) | 47 (11.3) | 37 (10.2) |
Unable to work (due to PsA) | 41 (9.8) | 50 (13.8) |
Unable to work (other than PsA) | 25 (6.0) | 24 (6.6) |
Other | 93 (22.3)a | 90 (24.8)b |
WPAI, mean (S.D.) | ||
Absenteeism | 8.6 (22.3) n = 228 | 10.8 (26.0) n = 188 |
Presenteeism | 36.6 (23.8) n = 220 | 40.8 (26.6) n = 176 |
Work productivity loss | 38.9 (24.9) n = 220 | 42.5 (27.7) n = 176 |
Activity impairment | 47.0 (25.1) n = 405 | 52.4 (25.8) n = 353 |
Biologic-naïve patients | TNFi-experienced patients | |||||||
---|---|---|---|---|---|---|---|---|
Baseline S.D. | Reliabilitya | 0.5 × S.D. | S.E.M. | Baseline S.D. | Reliabilitya | 0.5 × S.D. | S.E.M. | |
WPAI:SHP domain | ||||||||
Presenteeism | 23.71 | 0.7 | 11.85 | 12.99 | 26.59 | 0.7 | 13.29 | 14.56 |
Work productivity loss | 24.88 | 0.7 | 12.44 | 13.63 | 27.69 | 0.7 | 13.85 | 15.17 |
Activity impairment | 25.01 | 0.7 | 12.51 | 13.70 | 25.77 | 0.7 | 12.89 | 14.12 |