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Molecular Diagnosis & Therapy
Erschienen in: Molecular Diagnosis & Therapy 2/2012

01.04.2012 | Review Article

Molecular Diagnosis and Management of Viral Infections in Hematopoietic Stem Cell Transplant Recipients

verfasst von: Sabine Breuer, Margit Rauch, Susanne Matthes-Martin, Professor Thomas Lion

Erschienen in: Molecular Diagnosis & Therapy | Ausgabe 2/2012

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Abstract

Viral infections after allogeneic hematopoietic stem cell transplantation (HSCT) are important complications associated with high morbidity and mortality. In this setting, reactivations of persisting latent viral pathogens from donor and/or recipient cells play a central role whereas the sterile environment of transplant units renders new infections less likely. The viruses currently regarded as most relevant in the HSCT setting include particularly the herpes virus family—specifically cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6 (HHV-6) —as well as human adenoviruses (AdVs) and the polyoma virus BK (BKV). Timely detection and monitoring of virus copy numbers are prerequisites for successful preemptive treatment approaches. Pre- and post-transplant surveillance by sensitive and quantitative molecular methods has therefore become an essential part of the diagnostic routine. In this review, we discuss diagnostic aspects and the clinical management of the most important viral infections in HSCT recipients, with a focus on pediatric patients.
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Metadaten
Titel
Molecular Diagnosis and Management of Viral Infections in Hematopoietic Stem Cell Transplant Recipients
verfasst von
Sabine Breuer
Margit Rauch
Susanne Matthes-Martin
Professor Thomas Lion
Publikationsdatum
01.04.2012
Verlag
Springer International Publishing
Erschienen in
Molecular Diagnosis & Therapy / Ausgabe 2/2012
Print ISSN: 1177-1062
Elektronische ISSN: 1179-2000
DOI
https://doi.org/10.1007/BF03256431

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