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01.10.2012 | Original article

High symptom improvement and local tumor control using stereotactic radiotherapy when given early after diagnosis of meningioma

A multicentre study

verfasst von: I. Compter, K. Zaugg, R.M.A. Houben, J.T.A. Dings, G. Bosmans, C. Buescher, M.M.H.M.E. Anten, B.G. Baumert, MD, PhD

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 10/2012

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Abstract

Purpose

The goal of the present study was to analyze long-term results of fractionated stereotactic radiotherapy (SRT) in patients with a meningioma.

Methods and materials

A total of 72 patients treated between 1996 and 2008 in MAASTRO clinic (n = 45) and University Hospital Zurich (n = 27) were included. SRT was given as primary treatment (n = 46), postoperatively (n = 19) or at recurrence (n = 7); 49 tumours (68%) were located in the skull base. Median total dose was 54 Gy.

Results

Median follow-up was 4.13 years (range 0.66–11 years). The 3- and 5-year overall survival were 92 and 79% for grade 0 and I meningioma. Progression-free survival for grade 0 and I was 95% at 3 and 5 years, and 40% for grade II and III at 3 years. In 98.4% of patients, clinical symptoms were stable or improved. The majority of symptoms improved within 24 months after SRT. Local control is significantly better if patients are irradiated immediately after diagnosis compared to a watchful waiting policy (p = 0.017). Grade IV toxicity was low (4.2%, n = 3)

Conclusion

SRT is an effective treatment with high local and clinical control. Early SRT resulted in better outcome than late treatment at progression.

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Titel: High symptom improvement and local tumor control using stereotactic radiotherapy when given early after diagnosis of meningioma
A multicentre study
verfasst von: I. Compter
K. Zaugg
R.M.A. Houben
J.T.A. Dings
G. Bosmans
C. Buescher
M.M.H.M.E. Anten
B.G. Baumert, MD, PhD
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 10/2012
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-012-0155-7

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Results

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