Skip to main content
Erschienen in: Der Nervenarzt 8/2008

01.08.2008 | Übersichten

Therapieadhärenz in der neurologischen Praxis

Beispiel: Multiple Sklerose

verfasst von: Dr. rer. nat. S. Kern, H. Reichmann, T. Ziemssen

Erschienen in: Der Nervenarzt | Ausgabe 8/2008

Einloggen, um Zugang zu erhalten

Zusammenfassung

Was nützt die wirkungsvollste Tablette, wenn der Patient sie nicht nimmt? Diese Frage trifft im Kern eines der weitreichendsten Probleme der modernen Gesundheitsversorgung. Gerade vor dem Hintergrund einer alternden Gesellschaft und einer damit verbundenen Zunahme von chronisch behandlungsbedürftigen Erkrankungen, stellt sich die Frage nach Einflussfaktoren und Interventionsmöglichkeiten bei mangelnder Therapietreue. Suchte man in der Vergangenheit die Ursache für das Adhärenzproblem zunächst ausschließlich beim Patienten, zeigen neue Ansätze, dass es sich bei der Adhärenz viel mehr um ein multikausales Konstrukt handelt, was Interventionen auf vielfältigen Ebenen erfordert. Die vorliegende Arbeit diskutiert das aktuelle Adhärenzproblem in Zahlen und erläutert Folgen und Risiken. Am Beispiel der chronisch-entzündlichen Erkrankung Multiple Sklerose werden spezifische Einflussfaktoren beschrieben und Strategien zur Verbesserung der Adhärenz aufgezeigt.
Literatur
1.
Zurück zum Zitat Andrejak M, Genes N, Vaur L et al. (2000) Electronic pill-boxes in the evaluation of antihypertensive treatment compliance: comparison of once daily versus twice daily regimen. Am J Hypertens 13: 184–190PubMedCrossRef Andrejak M, Genes N, Vaur L et al. (2000) Electronic pill-boxes in the evaluation of antihypertensive treatment compliance: comparison of once daily versus twice daily regimen. Am J Hypertens 13: 184–190PubMedCrossRef
2.
Zurück zum Zitat Baker DW, Wolf MS, Feinglass J et al. (2007) Health literacy and mortality among elderly persons. Arch Intern Med 167: 1503–1509PubMedCrossRef Baker DW, Wolf MS, Feinglass J et al. (2007) Health literacy and mortality among elderly persons. Arch Intern Med 167: 1503–1509PubMedCrossRef
3.
4.
Zurück zum Zitat Bartlett EE, Grayson M, Barker R et al. (1984) The effects of physician communications skills on patient satisfaction; recall, and adherence. J Chronic Dis 37: 755–764PubMedCrossRef Bartlett EE, Grayson M, Barker R et al. (1984) The effects of physician communications skills on patient satisfaction; recall, and adherence. J Chronic Dis 37: 755–764PubMedCrossRef
5.
Zurück zum Zitat Bell C, Graham J, Earnshaw S et al. (2007) Cost-effectiveness of four immunomodulatory therapies for relapsing-remitting multiple sclerosis: a Markov model based on long-term clinical data. J Manag Care Pharm 13: 245–261PubMed Bell C, Graham J, Earnshaw S et al. (2007) Cost-effectiveness of four immunomodulatory therapies for relapsing-remitting multiple sclerosis: a Markov model based on long-term clinical data. J Manag Care Pharm 13: 245–261PubMed
6.
Zurück zum Zitat Broderick JE, Arnold D, Kudielka BM et al. (2004) Salivary cortisol sampling compliance: comparison of patients and healthy volunteers. Psychoneuroendocrinology 29: 636–650PubMedCrossRef Broderick JE, Arnold D, Kudielka BM et al. (2004) Salivary cortisol sampling compliance: comparison of patients and healthy volunteers. Psychoneuroendocrinology 29: 636–650PubMedCrossRef
7.
Zurück zum Zitat Brody DS (1980) Physician recognition of behavioral, psychological, and social aspects of medical care. Arch Intern Med 140: 1286–1289PubMedCrossRef Brody DS (1980) Physician recognition of behavioral, psychological, and social aspects of medical care. Arch Intern Med 140: 1286–1289PubMedCrossRef
8.
Zurück zum Zitat Chan M, Nicklason F, Vial JH (2001) Adverse drug events as a cause of hospital admission in the elderly. Intern Med J 31: 199–205PubMedCrossRef Chan M, Nicklason F, Vial JH (2001) Adverse drug events as a cause of hospital admission in the elderly. Intern Med J 31: 199–205PubMedCrossRef
9.
Zurück zum Zitat Chwastiak L, Ehde DM, Gibbons LE et al. (2002) Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatry 159: 1862–1868PubMedCrossRef Chwastiak L, Ehde DM, Gibbons LE et al. (2002) Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatry 159: 1862–1868PubMedCrossRef
10.
Zurück zum Zitat Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23: 1296–1310PubMedCrossRef Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23: 1296–1310PubMedCrossRef
11.
Zurück zum Zitat Coleman VR (1985) Physician behaviour and compliance. J Hypertens Suppl 3: S69–S71PubMed Coleman VR (1985) Physician behaviour and compliance. J Hypertens Suppl 3: S69–S71PubMed
12.
Zurück zum Zitat Cox D, Stone J (2006) Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis. J Neurosci Nurs 38: 167–171PubMed Cox D, Stone J (2006) Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis. J Neurosci Nurs 38: 167–171PubMed
13.
Zurück zum Zitat D’alisa S, Miscio G, Baudo S et al. (2006) Depression is the main determinant of quality of life in multiple sclerosis: a classification-regression (CART) study. Disabil Rehabil 28: 307–314CrossRef D’alisa S, Miscio G, Baudo S et al. (2006) Depression is the main determinant of quality of life in multiple sclerosis: a classification-regression (CART) study. Disabil Rehabil 28: 307–314CrossRef
14.
Zurück zum Zitat Dimatteo MR (1995) Patient adherence to pharmacotherapy: the importance of effective communication. Formulary 30: 596–598, 601–602, 605PubMed Dimatteo MR (1995) Patient adherence to pharmacotherapy: the importance of effective communication. Formulary 30: 596–598, 601–602, 605PubMed
15.
Zurück zum Zitat Dimatteo MR (2004) Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol 23: 207–218PubMedCrossRef Dimatteo MR (2004) Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol 23: 207–218PubMedCrossRef
16.
Zurück zum Zitat Dimatteo MR (2004) Variations in patients‘ adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 42: 200–209PubMedCrossRef Dimatteo MR (2004) Variations in patients‘ adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 42: 200–209PubMedCrossRef
17.
Zurück zum Zitat Dimatteo MR, Lepper HS, Croghan TW (2000) Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 160: 2101–2107PubMedCrossRef Dimatteo MR, Lepper HS, Croghan TW (2000) Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 160: 2101–2107PubMedCrossRef
18.
Zurück zum Zitat Durelli L, Verdun E, Barbero P et al. (2002) Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 359: 1453–1460PubMedCrossRef Durelli L, Verdun E, Barbero P et al. (2002) Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 359: 1453–1460PubMedCrossRef
19.
Zurück zum Zitat Facione NC (1999) Breast cancer screening in relation to access to health services. Oncol Nurs Forum 26: 689–696PubMed Facione NC (1999) Breast cancer screening in relation to access to health services. Oncol Nurs Forum 26: 689–696PubMed
20.
Zurück zum Zitat Farmer D, Reddick B, D’agostino R et al. (2007) Psychosocial correlates of mammography screening in older African American women. Oncol Nurs Forum 34: 117–123PubMedCrossRef Farmer D, Reddick B, D’agostino R et al. (2007) Psychosocial correlates of mammography screening in older African American women. Oncol Nurs Forum 34: 117–123PubMedCrossRef
21.
Zurück zum Zitat Feinstein A (2005) The clinical neuropsychiatry of multiple sclerosis. CNS Spectr 10: 362PubMed Feinstein A (2005) The clinical neuropsychiatry of multiple sclerosis. CNS Spectr 10: 362PubMed
22.
Zurück zum Zitat Fraser C, Hadjimichael O, Vollmer T (2001) Predictors of adherence to Copaxone therapy in individuals with relapsing-remitting multiple sclerosis. J Neurosci Nurs 33: 231–239PubMed Fraser C, Hadjimichael O, Vollmer T (2001) Predictors of adherence to Copaxone therapy in individuals with relapsing-remitting multiple sclerosis. J Neurosci Nurs 33: 231–239PubMed
23.
Zurück zum Zitat Fraser C, Morgante L, Hadjimichael O et al. (2004) A prospective study of adherence to glatiramer acetate in individuals with multiple sclerosis. J Neurosci Nurs 36: 120–129PubMedCrossRef Fraser C, Morgante L, Hadjimichael O et al. (2004) A prospective study of adherence to glatiramer acetate in individuals with multiple sclerosis. J Neurosci Nurs 36: 120–129PubMedCrossRef
24.
Zurück zum Zitat Gray SL, Mahoney JE, Blough DK (2001) Medication adherence in elderly patients receiving home health services following hospital discharge. Ann Pharmacother 35: 539–545PubMedCrossRef Gray SL, Mahoney JE, Blough DK (2001) Medication adherence in elderly patients receiving home health services following hospital discharge. Ann Pharmacother 35: 539–545PubMedCrossRef
25.
Zurück zum Zitat Haynes RB, Yao X, Degani A et al. (2005) Interventions to enhance medication adherence. Cochrane Database Syst Rev 4: CD000011PubMed Haynes RB, Yao X, Degani A et al. (2005) Interventions to enhance medication adherence. Cochrane Database Syst Rev 4: CD000011PubMed
26.
Zurück zum Zitat Hunot VM, Horne R, Leese MN et al. (2007) A cohort study of adherence to antidepressants in primary care: the influence of antidepressant concerns and treatment preferences. Prim Care Companion J Clin Psychiatry 9: 91–99PubMed Hunot VM, Horne R, Leese MN et al. (2007) A cohort study of adherence to antidepressants in primary care: the influence of antidepressant concerns and treatment preferences. Prim Care Companion J Clin Psychiatry 9: 91–99PubMed
27.
Zurück zum Zitat Julian L, Merluzzi NM, Mohr DC (2007) The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis. Mult Scler 13: 81–86PubMedCrossRef Julian L, Merluzzi NM, Mohr DC (2007) The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis. Mult Scler 13: 81–86PubMedCrossRef
28.
Zurück zum Zitat Katapodi MC, Facione NC, Miaskowski C et al. (2002) The influence of social support on breast cancer screening in a multicultural community sample. Oncol Nurs Forum 29: 845–852PubMedCrossRef Katapodi MC, Facione NC, Miaskowski C et al. (2002) The influence of social support on breast cancer screening in a multicultural community sample. Oncol Nurs Forum 29: 845–852PubMedCrossRef
29.
Zurück zum Zitat Kobelt G, Berg J, Lindgren P et al. (2006) Costs and quality of life of multiple sclerosis in Germany. Eur J Health Econ [Suppl 2] 7: S34–S44 Kobelt G, Berg J, Lindgren P et al. (2006) Costs and quality of life of multiple sclerosis in Germany. Eur J Health Econ [Suppl 2] 7: S34–S44
30.
Zurück zum Zitat Kudielka BM, Broderick JE, Kirschbaum C (2003) Compliance with saliva sampling protocols: electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects. Psychosom Med 65: 313–319PubMedCrossRef Kudielka BM, Broderick JE, Kirschbaum C (2003) Compliance with saliva sampling protocols: electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects. Psychosom Med 65: 313–319PubMedCrossRef
31.
Zurück zum Zitat Lee JY, Kusek JW, Greene PG et al. (1996) Assessing medication adherence by pill count and electronic monitoring in the African American Study of Kidney Disease and Hypertension (AASK) Pilot Study. Am J Hypertens 9: 719–725PubMedCrossRef Lee JY, Kusek JW, Greene PG et al. (1996) Assessing medication adherence by pill count and electronic monitoring in the African American Study of Kidney Disease and Hypertension (AASK) Pilot Study. Am J Hypertens 9: 719–725PubMedCrossRef
32.
Zurück zum Zitat Liebl A, Neiss A, Spannheimer A et al. (2001) [Costs of type 2 diabetes in Germany. Results of the CODE-2 study]. Dtsch Med Wochenschr 126: 585–589PubMedCrossRef Liebl A, Neiss A, Spannheimer A et al. (2001) [Costs of type 2 diabetes in Germany. Results of the CODE-2 study]. Dtsch Med Wochenschr 126: 585–589PubMedCrossRef
33.
Zurück zum Zitat Macintyre CR, Goebel K, Brown GV (2005) Patient knows best: blinded assessment of nonadherence with antituberculous therapy by physicians, nurses, and patients compared with urine drug levels. Prev Med 40: 41–45PubMedCrossRef Macintyre CR, Goebel K, Brown GV (2005) Patient knows best: blinded assessment of nonadherence with antituberculous therapy by physicians, nurses, and patients compared with urine drug levels. Prev Med 40: 41–45PubMedCrossRef
34.
Zurück zum Zitat Maclaughlin EJ, Raehl CL, Treadway AK et al. (2005) Assessing medication adherence in the elderly: which tools to use in clinical practice? Drugs Aging 22: 231–255PubMedCrossRef Maclaughlin EJ, Raehl CL, Treadway AK et al. (2005) Assessing medication adherence in the elderly: which tools to use in clinical practice? Drugs Aging 22: 231–255PubMedCrossRef
35.
Zurück zum Zitat Malhotra S, Karan RS, Pandhi P et al. (2001) Drug related medical emergencies in the elderly: role of adverse drug reactions and non-compliance. Postgrad Med J 77: 703–707PubMedCrossRef Malhotra S, Karan RS, Pandhi P et al. (2001) Drug related medical emergencies in the elderly: role of adverse drug reactions and non-compliance. Postgrad Med J 77: 703–707PubMedCrossRef
36.
Zurück zum Zitat Meichenbaum D, Turk DC (1994) Therapiemotivation des Patienten. Huber, Bern Meichenbaum D, Turk DC (1994) Therapiemotivation des Patienten. Huber, Bern
37.
Zurück zum Zitat Mohr DC, Boudewyn AC, Likosky W et al. (2001) Injectable medication for the treatment of multiple sclerosis: the influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann Behav Med 23: 125–132PubMedCrossRef Mohr DC, Boudewyn AC, Likosky W et al. (2001) Injectable medication for the treatment of multiple sclerosis: the influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann Behav Med 23: 125–132PubMedCrossRef
38.
Zurück zum Zitat Mohr DC, Cox D, Epstein L et al. (2002) Teaching patients to self-inject: pilot study of a treatment for injection anxiety and phobia in multiple sclerosis patients prescribed injectable medications. J Behav Ther Exp Psychiatry 33: 39–47PubMedCrossRef Mohr DC, Cox D, Epstein L et al. (2002) Teaching patients to self-inject: pilot study of a treatment for injection anxiety and phobia in multiple sclerosis patients prescribed injectable medications. J Behav Ther Exp Psychiatry 33: 39–47PubMedCrossRef
39.
Zurück zum Zitat Mohr DC, Cox D, Merluzzi N (2005) Self-injection anxiety training: a treatment for patients unable to self-inject injectable medications. Mult Scler 11: 182–185PubMedCrossRef Mohr DC, Cox D, Merluzzi N (2005) Self-injection anxiety training: a treatment for patients unable to self-inject injectable medications. Mult Scler 11: 182–185PubMedCrossRef
40.
Zurück zum Zitat Mohr DC, Goodkin DE, Likosky W et al. (1997) Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Arch Neurol 54: 531–533PubMed Mohr DC, Goodkin DE, Likosky W et al. (1997) Treatment of depression improves adherence to interferon beta-1b therapy for multiple sclerosis. Arch Neurol 54: 531–533PubMed
41.
Zurück zum Zitat Mohr DC, Goodkin DE, Likosky W et al. (1996) Therapeutic expectations of patients with multiple sclerosis upon initiating interferon beta-1b: relationship to adherence to treatment. Mult Scler 2: 222–226PubMed Mohr DC, Goodkin DE, Likosky W et al. (1996) Therapeutic expectations of patients with multiple sclerosis upon initiating interferon beta-1b: relationship to adherence to treatment. Mult Scler 2: 222–226PubMed
42.
Zurück zum Zitat Mohr DC, Goodkin DE, Masuoka L et al. (1999) Treatment adherence and patient retention in the first year of a Phase-III clinical trial for the treatment of multiple sclerosis. Mult Scler 5: 192–197PubMed Mohr DC, Goodkin DE, Masuoka L et al. (1999) Treatment adherence and patient retention in the first year of a Phase-III clinical trial for the treatment of multiple sclerosis. Mult Scler 5: 192–197PubMed
43.
Zurück zum Zitat Mohr DC, Hart SL, Fonareva I et al. (2006) Treatment of depression for patients with multiple sclerosis in neurology clinics. Mult Scler 12: 204–208PubMedCrossRef Mohr DC, Hart SL, Fonareva I et al. (2006) Treatment of depression for patients with multiple sclerosis in neurology clinics. Mult Scler 12: 204–208PubMedCrossRef
44.
Zurück zum Zitat Mohr DC, Likosky W, Boudewyn AC et al. (1998) Side effect profile and adherence to in the treatment of multiple sclerosis with interferon beta-1a. Mult Scler 4: 487–489PubMed Mohr DC, Likosky W, Boudewyn AC et al. (1998) Side effect profile and adherence to in the treatment of multiple sclerosis with interferon beta-1a. Mult Scler 4: 487–489PubMed
45.
Zurück zum Zitat Morris AB, Li J, Kroenke K et al. (2006) Factors associated with drug adherence and blood pressure control in patients with hypertension. Pharmacotherapy 26: 483–492PubMedCrossRef Morris AB, Li J, Kroenke K et al. (2006) Factors associated with drug adherence and blood pressure control in patients with hypertension. Pharmacotherapy 26: 483–492PubMedCrossRef
46.
Zurück zum Zitat Morris LA, Halperin JA (1979) Effects of written drug information on patient knowledge and compliance: a literature review. Am J Public Health 69: 47–52PubMed Morris LA, Halperin JA (1979) Effects of written drug information on patient knowledge and compliance: a literature review. Am J Public Health 69: 47–52PubMed
47.
Zurück zum Zitat Morrow D, Leirer V, Sheikh J (1988) Adherence and medication instructions. Review and recommendations. J Am Geriatr Soc 36: 1147–1160PubMed Morrow D, Leirer V, Sheikh J (1988) Adherence and medication instructions. Review and recommendations. J Am Geriatr Soc 36: 1147–1160PubMed
48.
Zurück zum Zitat Ownby RL (2006) Medication adherence and cognition. Medical, personal and economic factors influence level of adherence in older adults. Geriatrics 61: 30–35PubMed Ownby RL (2006) Medication adherence and cognition. Medical, personal and economic factors influence level of adherence in older adults. Geriatrics 61: 30–35PubMed
49.
Zurück zum Zitat Ownby RL, Hertzog C, Crocco E et al. (2006) Factors related to medication adherence in memory disorder clinic patients. Aging Ment Health 10: 378–385PubMedCrossRef Ownby RL, Hertzog C, Crocco E et al. (2006) Factors related to medication adherence in memory disorder clinic patients. Aging Ment Health 10: 378–385PubMedCrossRef
50.
Zurück zum Zitat Prosser LA, Kuntz KM, Bar-Or A et al. (2004) Cost-effectiveness of interferon beta-1a, interferon beta-1b, and glatiramer acetate in newly diagnosed non-primary progressive multiple sclerosis. Value Health 7: 554–568PubMedCrossRef Prosser LA, Kuntz KM, Bar-Or A et al. (2004) Cost-effectiveness of interferon beta-1a, interferon beta-1b, and glatiramer acetate in newly diagnosed non-primary progressive multiple sclerosis. Value Health 7: 554–568PubMedCrossRef
51.
Zurück zum Zitat Pullar T, Birtwell AJ, Wiles PG et al. (1988) Use of a pharmacologic indicator to compare compliance with tablets prescribed to be taken once, twice, or three times daily. Clin Pharmacol Ther 44: 540–545PubMedCrossRef Pullar T, Birtwell AJ, Wiles PG et al. (1988) Use of a pharmacologic indicator to compare compliance with tablets prescribed to be taken once, twice, or three times daily. Clin Pharmacol Ther 44: 540–545PubMedCrossRef
52.
Zurück zum Zitat Pullar T, Kumar S, Tindall H et al. (1989) Time to stop counting the tablets? Clin Pharmacol Ther 46: 163–168PubMedCrossRef Pullar T, Kumar S, Tindall H et al. (1989) Time to stop counting the tablets? Clin Pharmacol Ther 46: 163–168PubMedCrossRef
53.
Zurück zum Zitat Pullar T, Peaker S, Martin MF et al. (1988) The use of a pharmacological indicator to investigate compliance in patients with a poor response to antirheumatic therapy. Br J Rheumatol 27: 381–384PubMedCrossRef Pullar T, Peaker S, Martin MF et al. (1988) The use of a pharmacological indicator to investigate compliance in patients with a poor response to antirheumatic therapy. Br J Rheumatol 27: 381–384PubMedCrossRef
54.
Zurück zum Zitat Raehl CL, Bond CA, Woods T et al. (2002) Individualized drug use assessment in the elderly. Pharmacotherapy 22: 1239–1248PubMedCrossRef Raehl CL, Bond CA, Woods T et al. (2002) Individualized drug use assessment in the elderly. Pharmacotherapy 22: 1239–1248PubMedCrossRef
55.
Zurück zum Zitat Roter DL, Hall JA, Merisca R et al. (1998) Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care 36: 1138–1161PubMedCrossRef Roter DL, Hall JA, Merisca R et al. (1998) Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care 36: 1138–1161PubMedCrossRef
56.
Zurück zum Zitat Rudd P, Byyny RL, Zachary V et al. (1988) Pill count measures of compliance in a drug trial: variability and suitability. Am J Hypertens 1: 309–312PubMed Rudd P, Byyny RL, Zachary V et al. (1988) Pill count measures of compliance in a drug trial: variability and suitability. Am J Hypertens 1: 309–312PubMed
57.
Zurück zum Zitat Ruggieri RM, Settipani N, Viviano L et al. (2003) Long-term interferon-beta treatment for multiple sclerosis. Neurol Sci 24: 361–364PubMedCrossRef Ruggieri RM, Settipani N, Viviano L et al. (2003) Long-term interferon-beta treatment for multiple sclerosis. Neurol Sci 24: 361–364PubMedCrossRef
58.
Zurück zum Zitat Siegel D, Lopez J, Meier J (2007) Antihypertensive medication adherence in the Department of Veterans Affairs. Am J Med 120: 26–32PubMedCrossRef Siegel D, Lopez J, Meier J (2007) Antihypertensive medication adherence in the Department of Veterans Affairs. Am J Med 120: 26–32PubMedCrossRef
59.
Zurück zum Zitat Van Dulmen S, Sluijs E, Van Dijk L et al. (2007) Patient adherence to medical treatment: a review of reviews. BMC Health Serv Res 7: 55CrossRef Van Dulmen S, Sluijs E, Van Dijk L et al. (2007) Patient adherence to medical treatment: a review of reviews. BMC Health Serv Res 7: 55CrossRef
60.
Zurück zum Zitat Van Eijken M, Tsang S, Wensing M et al. (2003) Interventions to improve medication compliance in older patients living in the community: a systematic review of the literature. Drugs Aging 20: 229–240CrossRef Van Eijken M, Tsang S, Wensing M et al. (2003) Interventions to improve medication compliance in older patients living in the community: a systematic review of the literature. Drugs Aging 20: 229–240CrossRef
61.
Zurück zum Zitat Vik SA, Hogan DB, Patten SB et al. (2006) Medication nonadherence and subsequent risk of hospitalisation and mortality among older adults. Drugs Aging 23: 345–356PubMedCrossRef Vik SA, Hogan DB, Patten SB et al. (2006) Medication nonadherence and subsequent risk of hospitalisation and mortality among older adults. Drugs Aging 23: 345–356PubMedCrossRef
62.
Zurück zum Zitat Who (2003) Adherence to Long-term Therapies. WHO, Genf Who (2003) Adherence to Long-term Therapies. WHO, Genf
63.
Zurück zum Zitat Yiannakopoulou E, Papadopulos JS, Cokkinos DV et al. (2005) Adherence to antihypertensive treatment: a critical factor for blood pressure control. Eur J Cardiovasc Prev Rehabil 12: 243–249PubMedCrossRef Yiannakopoulou E, Papadopulos JS, Cokkinos DV et al. (2005) Adherence to antihypertensive treatment: a critical factor for blood pressure control. Eur J Cardiovasc Prev Rehabil 12: 243–249PubMedCrossRef
64.
Zurück zum Zitat Tremlett HI, Oger J (2003) Interrupted therapy: stopping and switching of the beta-interferons prescribed for MS. Neurology 61: 551–554PubMed Tremlett HI, Oger J (2003) Interrupted therapy: stopping and switching of the beta-interferons prescribed for MS. Neurology 61: 551–554PubMed
65.
Zurück zum Zitat Milanese C, La Mantia L, Palombo R et al. (2003) A post-marketing study on interferon beta 1b and 1a treatment in relapsing-remitting multiple sclerosis: different response in drop-outs and treated patients. J Neurol Neurosurg Psychiatry 74: 1689–1692PubMedCrossRef Milanese C, La Mantia L, Palombo R et al. (2003) A post-marketing study on interferon beta 1b and 1a treatment in relapsing-remitting multiple sclerosis: different response in drop-outs and treated patients. J Neurol Neurosurg Psychiatry 74: 1689–1692PubMedCrossRef
66.
Zurück zum Zitat Rio J, Porcel J, Tellez N et al. (2005) Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis. Mult Scler 11: 306–309PubMedCrossRef Rio J, Porcel J, Tellez N et al. (2005) Factors related with treatment adherence to interferon beta and glatiramer acetate therapy in multiple sclerosis. Mult Scler 11: 306–309PubMedCrossRef
67.
Zurück zum Zitat Haas J, Firzlaff M (2005) Twenty-four-month comparison of immunomodulatory treatments – a retrospective open label study in 308 RRMS patients treated with beta interferons or glatiramer acetate (Copaxone). Eur J Neurol 12: 425–431PubMedCrossRef Haas J, Firzlaff M (2005) Twenty-four-month comparison of immunomodulatory treatments – a retrospective open label study in 308 RRMS patients treated with beta interferons or glatiramer acetate (Copaxone). Eur J Neurol 12: 425–431PubMedCrossRef
68.
Zurück zum Zitat O’Rourke KE, Hutchinson M (2005) Stopping beta-interferon therapy in multiple sclerosis: an analysis of stopping patterns. Mult Scler 11: 46–50CrossRef O’Rourke KE, Hutchinson M (2005) Stopping beta-interferon therapy in multiple sclerosis: an analysis of stopping patterns. Mult Scler 11: 46–50CrossRef
Metadaten
Titel
Therapieadhärenz in der neurologischen Praxis
Beispiel: Multiple Sklerose
verfasst von
Dr. rer. nat. S. Kern
H. Reichmann
T. Ziemssen
Publikationsdatum
01.08.2008
Verlag
Springer-Verlag
Erschienen in
Der Nervenarzt / Ausgabe 8/2008
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-008-2419-0

Weitere Artikel der Ausgabe 8/2008

Der Nervenarzt 8/2008 Zur Ausgabe

Neu in den Fachgebieten Neurologie und Psychiatrie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.