Skip to main content
Erschienen in: Der Urologe 10/2013

01.10.2013 | CME Zertifizierte Fortbildung

Infektions- und Sepsisprävention bei Prostatabiopsie

verfasst von: Prof. Dr. F.M.E. Wagenlehner, A. Pilatz, P. Waliszewski, T. Dansranjavin, W. Weidner

Erschienen in: Die Urologie | Ausgabe 10/2013

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Prostatabiopsie stellt derzeit den Goldstandard der Diagnostik eines Prostatakarzinoms dar. Europaweit werden jährlich schätzungsweise 1 Mio. Prostatastanzbiopsien durchgeführt. Die weltweit am meisten angewandte Form der Prostatastanzbiopsie ist die transrektale Prostatastanzbiopsie unter Antibiotikaprophylaxe mit Fluorchinolonen. In den letzten Jahren fand sich jedoch eine zunehmende Rate an infektiösen Komplikationen nach transrektaler Prostatastanzbiopsie, deren Ursache hauptsächlich fluorchinolonresistente fäkale Bakterien sind. Die vorliegende Übersichtsarbeit soll den derzeitigen Stand der Prostatastanzbiopsie hinsichtlich infektiöser Komplikationen und Strategien zur Vermeidung symptomatischer Infektionen und der Urosepsis darstellen.
Literatur
1.
Zurück zum Zitat Wagenlehner FM, Oostrum E van, Tenke P et al (2013) Infective complications after prostate biopsy: outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, a prospective multinational multicentre prostate biopsy study. Eur Urol 63(3):521–527PubMedCrossRef Wagenlehner FM, Oostrum E van, Tenke P et al (2013) Infective complications after prostate biopsy: outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, a prospective multinational multicentre prostate biopsy study. Eur Urol 63(3):521–527PubMedCrossRef
2.
Zurück zum Zitat Zani EL, Clark OA, Rodrigues Netto N Jr (2011) Antibiotic prophylaxis for transrectal prostate biopsy. Cochrane Database Syst Rev 5:CD006576PubMed Zani EL, Clark OA, Rodrigues Netto N Jr (2011) Antibiotic prophylaxis for transrectal prostate biopsy. Cochrane Database Syst Rev 5:CD006576PubMed
3.
Zurück zum Zitat Lindstedt S, Lindstrom U, Ljunggren E et al (2006) Single-dose antibiotic prophylaxis in core prostate biopsy: impact of timing and identification of risk factors. Eur Urol 50(4):832–837PubMedCrossRef Lindstedt S, Lindstrom U, Ljunggren E et al (2006) Single-dose antibiotic prophylaxis in core prostate biopsy: impact of timing and identification of risk factors. Eur Urol 50(4):832–837PubMedCrossRef
4.
Zurück zum Zitat Loeb S, Carter HB, Berndt SI et al (2011) Complications after prostate biopsy: data from SEER-Medicare. J Urol 186(5):1830–1834PubMedCrossRef Loeb S, Carter HB, Berndt SI et al (2011) Complications after prostate biopsy: data from SEER-Medicare. J Urol 186(5):1830–1834PubMedCrossRef
5.
Zurück zum Zitat Loeb S, Heuvel S van den, Zhu X et al (2012) Infectious complications and hospital admissions after prostate biopsy in a European randomized trial. Eur Urol 61(6):1110–1114PubMedCrossRef Loeb S, Heuvel S van den, Zhu X et al (2012) Infectious complications and hospital admissions after prostate biopsy in a European randomized trial. Eur Urol 61(6):1110–1114PubMedCrossRef
6.
Zurück zum Zitat Nam RK, Saskin R, Lee Y et al (2010) Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol 183(3):963–968PubMedCrossRef Nam RK, Saskin R, Lee Y et al (2010) Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol 183(3):963–968PubMedCrossRef
7.
Zurück zum Zitat Wagenlehner FM, Hoyme U, Kaase M et al (2011) Uncomplicated urinary tract infections. Dtsch Arztebl Int 108(24):415–423PubMed Wagenlehner FM, Hoyme U, Kaase M et al (2011) Uncomplicated urinary tract infections. Dtsch Arztebl Int 108(24):415–423PubMed
8.
Zurück zum Zitat Heidenreich A, Bastian PJ, Bellmunt J et al (2013) Guidelines on prostate cancer. European Association of Urology Guidelines. Arnhem Heidenreich A, Bastian PJ, Bellmunt J et al (2013) Guidelines on prostate cancer. European Association of Urology Guidelines. Arnhem
9.
Zurück zum Zitat Wirth M, Weißbach L, Ackermann R et al (2011) Interdisziplinäre Leitlinie der Qualität S3 zur Früherkennung, Diagnose und Therapie der verschiedenen Stadien des Prostatakarzinoms. AWMF-Register-Nummer 043-022OL, Version 2.0, 1. Aktualisierung 2011 Wirth M, Weißbach L, Ackermann R et al (2011) Interdisziplinäre Leitlinie der Qualität S3 zur Früherkennung, Diagnose und Therapie der verschiedenen Stadien des Prostatakarzinoms. AWMF-Register-Nummer 043-022OL, Version 2.0, 1. Aktualisierung 2011
10.
Zurück zum Zitat Wagenlehner FM, Grabe M, Naber KG et al (2011) Antibiotic prophylaxis in urology. Urologe A 50(11):1469–1478PubMedCrossRef Wagenlehner FM, Grabe M, Naber KG et al (2011) Antibiotic prophylaxis in urology. Urologe A 50(11):1469–1478PubMedCrossRef
11.
Zurück zum Zitat Grabe M, Bjerklund-Johansen TE, Botto H et al (2012) Guidelines on urological infections. European Association of Urology, Arnhem, S 1–110 Grabe M, Bjerklund-Johansen TE, Botto H et al (2012) Guidelines on urological infections. European Association of Urology, Arnhem, S 1–110
12.
Zurück zum Zitat Grabe M, Botto H, Cek M et al (2012) Preoperative assessment of the patient and risk factors for infectious complications and tentative classification of surgical field contamination of urological procedures. World J Urol 30(1):39–50PubMedCrossRef Grabe M, Botto H, Cek M et al (2012) Preoperative assessment of the patient and risk factors for infectious complications and tentative classification of surgical field contamination of urological procedures. World J Urol 30(1):39–50PubMedCrossRef
13.
Zurück zum Zitat Steensels D, Slabbaert K, De Wever L et al (2012) Fluoroquinolone-resistant E. coli in intestinal flora of patients undergoing transrectal ultrasound-guided prostate biopsy – should we reassess our practices for antibiotic prophylaxis? Clin Microbiol Infect 18(6):575–581PubMedCrossRef Steensels D, Slabbaert K, De Wever L et al (2012) Fluoroquinolone-resistant E. coli in intestinal flora of patients undergoing transrectal ultrasound-guided prostate biopsy – should we reassess our practices for antibiotic prophylaxis? Clin Microbiol Infect 18(6):575–581PubMedCrossRef
14.
Zurück zum Zitat Taylor AK, Zembower TR, Nadler RB et al (2012) Targeted antimicrobial prophylaxis using rectal swab cultures in men undergoing transrectal ultrasound guided prostate biopsy is associated with reduced incidence of postoperative infectious complications and cost of care. J Urol 187(4):1275–1279PubMedCrossRef Taylor AK, Zembower TR, Nadler RB et al (2012) Targeted antimicrobial prophylaxis using rectal swab cultures in men undergoing transrectal ultrasound guided prostate biopsy is associated with reduced incidence of postoperative infectious complications and cost of care. J Urol 187(4):1275–1279PubMedCrossRef
15.
Zurück zum Zitat Zaytoun OM, Vargo EH, Rajan R et al (2011) Emergence of fluoroquinolone-resistant Escherichia coli as cause of postprostate biopsy infection: implications for prophylaxis and treatment. Urology 77(5):1035–1041PubMedCrossRef Zaytoun OM, Vargo EH, Rajan R et al (2011) Emergence of fluoroquinolone-resistant Escherichia coli as cause of postprostate biopsy infection: implications for prophylaxis and treatment. Urology 77(5):1035–1041PubMedCrossRef
16.
Zurück zum Zitat Williamson DA, Roberts SA, Paterson DL et al (2012) Escherichia coli bloodstream infection after transrectal ultrasound-guided prostate biopsy: implications of fluoroquinolone-resistant sequence type 131 as a major causative pathogen. Clin Infect Dis 54(10):1406–1412PubMedCrossRef Williamson DA, Roberts SA, Paterson DL et al (2012) Escherichia coli bloodstream infection after transrectal ultrasound-guided prostate biopsy: implications of fluoroquinolone-resistant sequence type 131 as a major causative pathogen. Clin Infect Dis 54(10):1406–1412PubMedCrossRef
17.
Zurück zum Zitat Williamson DA, Masters J, Freeman J, Roberts S (2012) Travel-associated extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infection following transrectal ultrasound-guided prostate biopsy. BJU Int 109(7):E21–E22PubMedCrossRef Williamson DA, Masters J, Freeman J, Roberts S (2012) Travel-associated extended-spectrum beta-lactamase-producing Escherichia coli bloodstream infection following transrectal ultrasound-guided prostate biopsy. BJU Int 109(7):E21–E22PubMedCrossRef
18.
Zurück zum Zitat Patel U, Dasgupta P, Amoroso P et al (2011) Infection after transrectal ultrasonography-guided prostate biopsy: increased relative risks after recent international travel or antibiotic use. BJU Int 109(12):1781–1785PubMedCrossRef Patel U, Dasgupta P, Amoroso P et al (2011) Infection after transrectal ultrasonography-guided prostate biopsy: increased relative risks after recent international travel or antibiotic use. BJU Int 109(12):1781–1785PubMedCrossRef
19.
Zurück zum Zitat European Centre for Disease Prevention and Control (2013) Proportion of Aminopenicillins Resistant (R+I) Enterococcus faecalis Isolates in Participating Countries in 2011. http://www.ecdc.europa.eu/en/activities/surveillance/EARS-Net/database/Pages/maps_report.aspx European Centre for Disease Prevention and Control (2013) Proportion of Aminopenicillins Resistant (R+I) Enterococcus faecalis Isolates in Participating Countries in 2011. http://​www.​ecdc.​europa.​eu/​en/​activities/​surveillance/​EARS-Net/​database/​Pages/​maps_​report.​aspx
20.
Zurück zum Zitat Roach MB, Figueroa TE, McBride D et al (1991) Ciprofloxacin versus gentamicin in prophylaxis against bacteremia in transrectal prostate needle biopsy. Urology 38(1):84–87PubMedCrossRef Roach MB, Figueroa TE, McBride D et al (1991) Ciprofloxacin versus gentamicin in prophylaxis against bacteremia in transrectal prostate needle biopsy. Urology 38(1):84–87PubMedCrossRef
21.
Zurück zum Zitat Goto T, Makinose S, Ohi Y et al (1998) Diffusion of piperacillin, cefotiam, minocycline, amikacin and ofloxacin into the prostate. Int J Urol 5(3):243–246PubMedCrossRef Goto T, Makinose S, Ohi Y et al (1998) Diffusion of piperacillin, cefotiam, minocycline, amikacin and ofloxacin into the prostate. Int J Urol 5(3):243–246PubMedCrossRef
22.
Zurück zum Zitat Wagenlehner FM, Weidner W, Sorgel F, Naber KG (2005) The role of antibiotics in chronic bacterial prostatitis. Int J Antimicrob Agents 26(1):1–7PubMedCrossRef Wagenlehner FM, Weidner W, Sorgel F, Naber KG (2005) The role of antibiotics in chronic bacterial prostatitis. Int J Antimicrob Agents 26(1):1–7PubMedCrossRef
23.
Zurück zum Zitat Wright WL, Larking P, Lovell-Smith CJ (1982) Concentrations of trimethoprim and sulphamethoxazole in the human prostate gland after intramuscular injection. Br J Urol 54(5):550–551PubMedCrossRef Wright WL, Larking P, Lovell-Smith CJ (1982) Concentrations of trimethoprim and sulphamethoxazole in the human prostate gland after intramuscular injection. Br J Urol 54(5):550–551PubMedCrossRef
24.
Zurück zum Zitat Naber KG, Kinzig M, Adam D et al (1991) Concentrations of cefpodoxime in plasma, ejaculate and in prostatic fluid and adenoma tissue. Infection 19(1):30–35PubMedCrossRef Naber KG, Kinzig M, Adam D et al (1991) Concentrations of cefpodoxime in plasma, ejaculate and in prostatic fluid and adenoma tissue. Infection 19(1):30–35PubMedCrossRef
25.
Zurück zum Zitat Nishikawa G, Ikawa K, Nakamura K et al (2013) Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation. Int J Antimicrob Agents 41(3):267–271PubMedCrossRef Nishikawa G, Ikawa K, Nakamura K et al (2013) Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation. Int J Antimicrob Agents 41(3):267–271PubMedCrossRef
26.
Zurück zum Zitat Bootsma AM, Laguna Pes MP, Geerlings SE, Goossens A (2008) Antibiotic prophylaxis in urologic procedures: a systematic review. Eur Urol 54(6):1270–1286PubMedCrossRef Bootsma AM, Laguna Pes MP, Geerlings SE, Goossens A (2008) Antibiotic prophylaxis in urologic procedures: a systematic review. Eur Urol 54(6):1270–1286PubMedCrossRef
27.
Zurück zum Zitat Wagenlehner F, Stower-Hoffmann J, Schneider-Brachert W et al (2000) Influence of a prophylactic single dose of ciprofloxacin on the level of resistance of Escherichia coli to fluoroquinolones in urology. Int J Antimicrob Agents 15(3):207–211PubMedCrossRef Wagenlehner F, Stower-Hoffmann J, Schneider-Brachert W et al (2000) Influence of a prophylactic single dose of ciprofloxacin on the level of resistance of Escherichia coli to fluoroquinolones in urology. Int J Antimicrob Agents 15(3):207–211PubMedCrossRef
28.
Zurück zum Zitat Abughosh Z, Margolick J, Goldenberg SL et al (2012) A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy. J Urol 189(4):1326–1331PubMedCrossRef Abughosh Z, Margolick J, Goldenberg SL et al (2012) A prospective randomized trial of povidone-iodine prophylactic cleansing of the rectum before transrectal ultrasound guided prostate biopsy. J Urol 189(4):1326–1331PubMedCrossRef
29.
Zurück zum Zitat Hara R, Jo Y, Fujii T et al (2008) Optimal approach for prostate cancer detection as initial biopsy: prospective randomized study comparing transperineal versus transrectal systematic 12-core biopsy. Urology 71(2):191–195PubMedCrossRef Hara R, Jo Y, Fujii T et al (2008) Optimal approach for prostate cancer detection as initial biopsy: prospective randomized study comparing transperineal versus transrectal systematic 12-core biopsy. Urology 71(2):191–195PubMedCrossRef
30.
Zurück zum Zitat Carmignani L, Picozzi S, Spinelli M et al (2012) Bacterial sepsis following prostatic biopsy. Int Urol Nephrol 44(4):1055–1063PubMedCrossRef Carmignani L, Picozzi S, Spinelli M et al (2012) Bacterial sepsis following prostatic biopsy. Int Urol Nephrol 44(4):1055–1063PubMedCrossRef
Metadaten
Titel
Infektions- und Sepsisprävention bei Prostatabiopsie
verfasst von
Prof. Dr. F.M.E. Wagenlehner
A. Pilatz
P. Waliszewski
T. Dansranjavin
W. Weidner
Publikationsdatum
01.10.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Urologie / Ausgabe 10/2013
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-013-3284-4

Weitere Artikel der Ausgabe 10/2013

Der Urologe 10/2013 Zur Ausgabe

URO-Telegramm

URO-Telegramm

Mitteilungen der DGU

Mitteilungen der DGU

Mitteilungen der DGU

Termine

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.