Introduction
Methods
Participants
Lean (n = 13) | Obese (n = 10) | |
---|---|---|
Age (years) | 43 ± 3 | 54 ± 3 |
BMI (kg/m2) | 23.0 ± 0.5 | 31.9 ± 0.6a
|
FM (kg) | 15.2 ± 0.8 | 32.4 ± 1.2a
|
WHR | 0.91 ± 0.01 | 1.01 ± 0.01a
|
Systolic blood pressure (mmHg) | 126 ± 3 | 137 ± 4 |
Diastolic blood pressure (mmHg) | 77 ± 2 | 85 ± 3 |
HOMA-IR | 1.8 ± 0.2 | 3.4 ± 0.3a
|
Experimental protocol
Clinical methods
Analytical methods
Isotope enrichment
Calculations
Statistical analysis
Results
Characteristics
Lean | Obese | |||
---|---|---|---|---|
Baseline (n = 13) | Isoprenaline (n = 10) | Baseline (n = 10) | Isoprenaline (n = 7) | |
TAG (μmol/l) | 701 ± 66 | 648 ± 64 | 1,464 ± 190b
| 1,667 ± 217a
|
NEFA (μmol/l) | 661 ± 41 | 942 ± 53 | 638 ± 42 | 1,124 ± 82a
|
Glycerol (μmol/l) | 102 ± 5 | 118 ± 7 | 106 ± 4 | 147 ± 10a
|
Glycerol R
a (μmol/min) | 199 ± 12 | 311 ± 28 | 220 ± 15 | 391 ± 30 |
Glycerol R
a/FM [μmol (kg FM)−1 min−1] | 13.1 ± 0.9 | 20.9 ± 1.6 | 7.3 ± 0.6b
| 12.9 ± 1.1a
|
Glucose (mmol/l) | 5.3 ± 0.1 | 5.4 ± 0.1 | 5.5 ± 0.2 | 5.4 ± 0.1 |
Insulin (pmol/l) | 50 ± 4 | 74 ± 6 | 94 ± 7b
| 167 ± 16a
|
Tracer/tracee ratio
Circulating metabolites
Abdominal SAT lipolysis
Lean | Obese | |||
---|---|---|---|---|
Baseline (n = 13) | Isoprenaline (n = 10) | Baseline (n = 10) | Isoprenaline (n = 7) | |
ATBF [ml (100 g tissue)−1 min−1] | 2.2 ± 0.2 | 6.3 ± 1.2 | 1.4 ± 0.2a
| 3.6 ± 0.6 |
Net SAT fluxes [nmol (100 g tissue)−1 min−1] | ||||
TAG | 25 ± 8 | 43 ± 17 | 34 ± 29 | 113 ± 62 |
NEFA | −780 ± 160 | −2,101 ± 371 | −486 ± 101 | −1,824 ± 667 |
Glycerol | −229 ± 49 | −640 ± 148 | −211 ± 51 | −486 ± 128 |
Glucose | 53 ± 49 | −69 ± 151 | −143 ± 96 | −677 ± 632 |