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01.07.2015 | Article

Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans

verfasst von: Paul Begovatz, Chrysi Koliaki, Katharina Weber, Klaus Strassburger, Bettina Nowotny, Peter Nowotny, Karsten Müssig, Jürgen Bunke, Giovanni Pacini, Julia Szendrödi, Michael Roden

Erschienen in: Diabetologia | Ausgabe 7/2015

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Abstract

Aims/hypothesis

This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function.

Methods

Fifty-six participants (normal glucose tolerance [NGT] (n = 28), impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) (n = 14) and patients with type 2 diabetes (n = 14)) underwent a frequent-sampling OGTT and non-invasive magnetic resonance imaging (MRI; whole-body and pancreatic) and proton magnetic resonance spectroscopy (¹H-MRS; liver and pancreatic fat). Total pancreatic fat was assessed by a standard 2 cm³ ¹H-MRS method, intralobular fat by 1 cm³ ¹H-MRS that avoided interlobular fat within modified DIXON (mDIXON) water images, and parenchymal fat by a validated mDIXON-MRI fat-fraction method.

Results

Comparison of ¹H-MRS techniques revealed an inhomogeneous distribution of interlobular and intralobular adipose tissue, which increased with decreasing glucose tolerance. mDIXON-MRI measurements provided evidence against uniform steatosis, revealing regions of parenchymal tissue void of lipid accumulation in all participants. Total (r = 0.385, p < 0.01) and intralobular pancreas adipose tissue infiltration (r = 0.310, p < 0.05) positively associated with age, but not with fasting or 2 h glucose levels, BMI or visceral fat content (all p > 0.5). Furthermore, no associations were found between total and intralobular pancreatic adipose tissue infiltration and insulin secretion or beta cell function within NGT, IFG/IGT or patients with type 2 diabetes (all p > 0.2).

Conclusions/interpretation

The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage. No relationship was found between pancreatic adipose tissue infiltration and beta cell function, regardless of glucose tolerance status.

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Titel: Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans
verfasst von: Paul Begovatz
Chrysi Koliaki
Katharina Weber
Klaus Strassburger
Bettina Nowotny
Peter Nowotny
Karsten Müssig
Jürgen Bunke
Giovanni Pacini
Julia Szendrödi
Michael Roden
Publikationsdatum: 01.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 7/2015
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-015-3544-5

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Abstract

Aims/hypothesis

Methods

Results

Conclusions/interpretation

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