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Intensive Care Medicine

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01.06.2007 | Review

Sepsis-associated delirium

verfasst von: Marion Ebersoldt, Tarek Sharshar, Djillali Annane

Erschienen in: Intensive Care Medicine | Ausgabe 6/2007

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Abstract

Objective

Sepsis-associated delirium is a common and poorly understood neurological complication of sepsis. This review provides an update of the diagnostic criteria and treatment strategies and the current knowledge about the mechanisms involved in sepsis associated brain dysfunction.

Data sources

Articles published between 1981 and 2006 were identified through a Medline search for “encephalopathy” and “sepsis” and by hand searching of articles cited in the identified publications. The immune response to sepsis results in multiorgan failure including brain dysfunction.

Discussion

The potential mechanisms for sepsis-associated delirium include vascular damage, endothelial activation, breakdown of the blood-brain barrier, metabolic disorders, brain inflammation and apoptosis. On the other hand, there is evidence for distinct neuroprotective factors, such as anti-inflammatory mediators and glial cell activity.

Conclusions

The diagnosis of sepsis-associated delirium relies mainly on clinical and electrophysiological criteria, and its treatment is entirely based on general management of sepsis.

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Titel: Sepsis-associated delirium
verfasst von: Marion Ebersoldt
Tarek Sharshar
Djillali Annane
Publikationsdatum: 01.06.2007
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 6/2007
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0622-2

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