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01.08.2009 | Original

Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients

verfasst von: Valentin Fuhrmann, Nikolaus Kneidinger, Harald Herkner, Gottfried Heinz, Mariam Nikfardjam, Anja Bojic, Peter Schellongowski, Bernhard Angermayr, Reinhard Kitzberger, Joanna Warszawska, Ulrike Holzinger, Peter Schenk, Christian Madl

Erschienen in: Intensive Care Medicine | Ausgabe 8/2009

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Abstract

Purpose

Hypoxic hepatitis (HH) is a frequent cause of acute hepatocellular damage at the intensive care unit. Although mortality is reported to be high, risk factors for mortality in this population are unknown.

Methods

One-hundred and seventeen consecutive patients with HH were studied prospectively at three medical intensive care units of a university hospital.

Results

The main causes of hypoxic hepatitis were low cardiac output and septic shock, and most patients (74%) had more than one underlying factor. Peak aspartate transaminase (P = 0.02), lactate dehydrogenase (P = 0.03), INR (P < 0.001) and lactate (P < 0.01) were higher in non-survivors. Prolonged duration of HH caused higher overall mortality rate (P = 0.03). INR > 2 (P = 0.02), septic shock (P = 0.01) and SOFA score >10 (P = 0.04) were risk factors of mortality in the regression model.

Conclusions

Hypoxic hepatitis is the consequence of multiorgan injury. Outcome is influenced by the severity of liver impairment and the etiology and severity of the basic disease.

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Titel: Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients
verfasst von: Valentin Fuhrmann
Nikolaus Kneidinger
Harald Herkner
Gottfried Heinz
Mariam Nikfardjam
Anja Bojic
Peter Schellongowski
Bernhard Angermayr
Reinhard Kitzberger
Joanna Warszawska
Ulrike Holzinger
Peter Schenk
Christian Madl
Publikationsdatum: 01.08.2009
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 8/2009
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1508-2

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Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients

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Purpose

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Results

Conclusions

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