Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Intensive Care Medicine
Erschienen in: Intensive Care Medicine 7/2013

01.07.2013 | What's New in Intensive Care

What is new in refractory hypoxemia?

verfasst von: Jesús Villar, Robert M. Kacmarek

Erschienen in: Intensive Care Medicine | Ausgabe 7/2013

Einloggen, um Zugang zu erhalten

Excerpt

Acute respiratory distress syndrome (ARDS) is an inflammatory disease process of the lungs characterized by severe hypoxemia, reduced lung compliance, and bilateral radiographic infiltrates [1]. Mechanical ventilation (MV) is the standard life support technique during ARDS for providing adequate oxygenation and carbon dioxide elimination, while the underlying disease process is being treated to restore normal pulmonary function. However, some ARDS patients develop refractory hypoxemia and MV is unable to sustain adequate gas exchange despite the use of high inspired oxygen concentrations (FiO2) and high levels of positive end-expiratory pressure (PEEP) [2]. …
Literatur
1.
2.
Villar J, Kacmarek RM (2012) The American-European consensus conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure. Med Intensiva 36:571–575CrossRefPubMed
3.
Villar J, Blanco J, Añón JM, Santos-Bouza A, Blanch L, Ambrós A, Gandía F, Carriedo D, Mosteiro F, Basaldúa S, Fernández RL, Kacmarek RM, ALIEN Network (2011) The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 37:1932–1941 [Erratum, Intensive Care Med 37:1942]CrossRefPubMed
4.
Girgis K, Hamed H, Khater Y, Kacmarek RM (2006) A decremental PEEP trial identifies the PEEP level that maintains oxygenation after lung recruitment. Respir Care 51:1132–1139PubMed
5.
Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT, National, Heart, Lung, and Blood Institute ARDS Clinical Trials Network (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351:327–336CrossRefPubMed
6.
Meade MO, Cook DJ, Griffith LE, Hand LE, Lapinsky SE, Stewart TE, Killian KJ, Slutsky AS, Guyatt GH (2008) A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome. Respir Care 53:1441–1447PubMed
7.
Tugrul S, Ozkan A, Perihan OE, Sibel I, Figen E, Lutfi T, Kutay A, Cakar N (2003) Effects of sustained inflation and postinflation positive end-expiratory pressure in acute respiratory distress syndrome: focusing on pulmonary and extrapulmonary forms. Critical Care Med 31:738–746CrossRef
8.
Borges J, Okamoto VN, Matos GFJ, Caramez MPR, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CSV, Carvalho CRR, Amato MPB (2006) Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 174:268–278CrossRefPubMed
9.
Hodgson C, Keating JL, Holland AE, Davies AR, Smirneos L, Bradley SJ, Tuxen D (2009) Recruitment manoeuvres for adults with acute lung injury receiving mechanical ventilation. Cochrane Database Syst Rev 2:CD006667
10.
Morris A (2012) Exciting new ECMO technology awaits compelling scientific evidence for widespread use in adults with respiratory failure. Intensive Care Med 38:186–188CrossRefPubMed
11.
Madershahian N, Wittwer T, Strauch J, Franke UF, Wippermann J, Kaluza M, Wahlers T (2007) Application of ECMO in multitrauma patients with ARDS as rescue therapy. J Card Surg 22:180–184CrossRefPubMed
12.
Gariboldi V, Grisoli D, Tarmiz A, Jaussaud N, Chalvignac V, Kerbaul F, Collart F (2010) Mobile extracorporeal membrane oxygenation unit expands cardiac assist surgical programs. Ann Thorac Surg 90:1548–1552CrossRefPubMed
13.
MacLaren G, Combes A, Bartlett RH (2012) Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era. Intensive Care Med 38:210–220CrossRefPubMed
14.
Noah MA, Peek GJ, Finney SJ, Griffiths MJ, Harrison DA, Grieve R, Sadique MZ, Sekhon JS, McAuley DF, Firmin RK, Harvey C, Cordingley JJ, Price S, Vuylsteke A, Jenkins DP, Noble DW, Bloomfield R, Walsh TS, Perkins GD, Menon D, Taylor BL, Rowan KM (2011) Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A (H1N1). JAMA 306:1659–1668CrossRefPubMed
15.
Pham T, Combes A, Rozé H, Chevret S, Mercat A, Roch A, Mourvillier B, Ara-somohano C, Bastien O, Zogheib E, Clavel M, Constan A, Richard JCM, Brun-Buisson C, Brochard L, For the REVA Research Network (2013) Extracorporeal membrane oxygenation for pandemic influenza A (H1N1)-induced acute respiratory distress syndrome. Am J Respir Crit Care Med 187:276–285CrossRefPubMed
16.
Peek GJ, Mugford M, Tiruvoipati R, Wilson A, Allen E, Thalanany MM, Hibbert CL, Truesdale A, Clemens F, Cooper N, Firmin RK, Elbourne D, CESAR trial collaboration (2009) Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 374:1351–1363 [Erratum, Lancet 374:1330]CrossRefPubMed
17.
Ferguson ND, Villar J, Slutsky AS (2007) Understanding high-frequency oscillation: lessons from the animal kingdom. Intensive Care Med 33:1316–1318CrossRefPubMed
18.
Young D, Lamb S, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH, For the OSCAR Study Group (2013) High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 368:806–813CrossRefPubMed
19.
Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter S, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade M, For the OSCILLATE trial investigators and the Canadian Critical Care Trials Group (2013) High frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 368:795–805CrossRefPubMed
20.
Lamm WJ, Graham MM, Albert RK (1994) Mechanisms by which the prone position improves oxygenation in acute lung injury. Am J Respir Crit Care Med 150:184–193CrossRefPubMed
21.
Abroug F, Ouanes-Besbes L, Elastrous S, Brochard L (2008) The effect of prone positioning in acute respiratory distress syndrome or acute lung injury: a meta-analysis. Areas of uncertainty and recommendations for research. Intensive Care Med 34:1002–1011CrossRefPubMed
22.
Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK, Latini R, Pesenti A, Guérin C, Mancebo J, Curley MA, Fernandez R, Chan MC, Beuret P, Voggenreiter G, Sud M, Tognoni G, Gattinoni L (2010) Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med 36:585–599CrossRefPubMed
23.
Guerin C, Reignier J, Beuret P, Gacouin A, Ayzac L, Boulain T, Mercier E, Badet M, Mercat A, Desachy A, Clavel M, Robert R, Jaber S, Rosselli S, Mancebo J, Sirodot M, Bayle F, Richard JC (2012) Effect du decubitus ventral sur la survie des maladies avec SDRA confirmé et severe. Essai prospectif randomise, contrôlé, multicentrique. Réanimation 22:S64–S67 [Abstract SO096]
24.
Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR, Notter RH (2008) Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem 15:1911–1924CrossRefPubMed
25.
Adhikari NK, Burns KEA, Friedrich JO, Granton JT, Cook DJ (2007) Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 334:779CrossRefPubMed
Metadaten
Titel
What is new in refractory hypoxemia?
verfasst von
Jesús Villar
Robert M. Kacmarek
Publikationsdatum
01.07.2013
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 7/2013
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-013-2905-0

Weitere Artikel der Ausgabe 7/2013

Intensive Care Medicine 7/2013 Zur Ausgabe

Original

The flow dependency of Tie2 expression in endotoxemia

Original

Impact of organizational culture on preventability assessment of selected adverse events in the ICU: evaluation of morbidity and mortality conferences

From the Inside

Farewell to a beloved grandfather

Pediatric Original

Early diffusion-weighted magnetic resonance imaging in children after cardiac arrest may provide valuable prognostic information on clinical outcome

Correspondence

Gold standard must be solid gold

Original

Clinical impact of arterial ammonia levels in ICU patients with different liver diseases

Neu im Fachgebiet AINS

23.04.2024 | Appendizitis | Nachrichten

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 | Leitsymptom Rückenschmerzen | Nachrichten

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 | Operationsvorbereitung | Nachrichten

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 | Pankreaskarzinom | Nachrichten

S3-Leitlinie zu Pankreaskrebs aktualisiert
weitere anzeigen

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren