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01.03.2008 | Original Article

The role of smooth muscle in the pathogenesis of pelvic organ prolapse—an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament

verfasst von: Christl Reisenauer, Thomas Shiozawa, Matthias Oppitz, Christian Busch, Andreas Kirschniak, Tanja Fehm, Ulrich Drews

Erschienen in: International Urogynecology Journal | Ausgabe 3/2008

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Abstract

The uterosacral ligament (USL) is part of the pelvic floor connecting the uterus to the dorsal body wall and stabilizing it. In samples obtained from hysterectomy patients, the smooth muscle component of the cervical third of the USL was studied by smooth muscle actin (SMA) immunohistochemistry as indicator for structural abnormalities and by morphometric determination of nuclear size as measure for the functional state. From a total of 40 patients, 18 were matched according to age, parity, and premenopausal status. Immunohistochemistry showed a granular patchy distribution of SMA in the pelvic organ prolapse (POP) group. In patients with POP, the size of smooth muscle cell nuclei was significantly reduced in comparison to patients without POP (25.45 ± 1.92 μm² vs 28.87 ± 2.92 μm², p < 0.05). We conclude that the smooth muscle component of the USL is impaired in POP patients, indicating a possible role of smooth muscle in the pathogenesis of POP.

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Titel: The role of smooth muscle in the pathogenesis of pelvic organ prolapse—an immunohistochemical and morphometric analysis of the cervical third of the uterosacral ligament
verfasst von: Christl Reisenauer
Thomas Shiozawa
Matthias Oppitz
Christian Busch
Andreas Kirschniak
Tanja Fehm
Ulrich Drews
Publikationsdatum: 01.03.2008
Verlag: Springer-Verlag
Erschienen in: International Urogynecology Journal / Ausgabe 3/2008
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-007-0447-0

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