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International Urogynecology Journal
Erschienen in: International Urogynecology Journal 8/2011

01.08.2011 | Original Article

The effect of solifenacin on urethral sphincter morphology

verfasst von: Jonathan Duckett, Maya Basu

Erschienen in: International Urogynecology Journal | Ausgabe 8/2011

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Abstract

Introduction and hypothesis

The aim of the study was to determine whether a 6-week course of 5 mg of solifenacin succinate used to treat mixed incontinence, produces measurable changes in the appearance of the urethral sphincter.

Methods

Twenty-six women undergoing treatment for mixed incontinence were recruited from a urogynaecology unit after failing to improve with conservative treatments and bladder drill. All underwent dual channel subtracted cystometry, which showed mixed urodynamic stress incontinence and detrusor overactivity. All patients underwent a 3D transperineal ultrasound before solifenacin therapy was started and after 6 weeks of treatment. The urethral length, width and volume of the smooth muscle and total sphincter volume were compared before and after the treatment.

Results

Clinically, 13 reported no improvement in either stress or urge incontinence. Eight women reported improvement in their urgency symptoms but no benefit in their stress leakage. Four women reported resolution of both stress and urge incontinence. One woman reported worsening of her bladder symptoms. There was no significant change in the urethral length (p = 0.27), width (p = 0.50), volume of smooth muscle (p = 0.87) or total sphincter volume (p = 0.60) before and after treatment with solifenacin.

Conclusions

A 6-week course of solifenacin resulted in no measurable changes in the appearance of the urethral sphincter.
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Metadaten
Titel
The effect of solifenacin on urethral sphincter morphology
verfasst von
Jonathan Duckett
Maya Basu
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
International Urogynecology Journal / Ausgabe 8/2011
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-011-1410-7

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