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Erschienen in: International Urogynecology Journal 8/2012

01.08.2012 | Review Article

Pathophysiology of overactive bladder

verfasst von: Mai A. Banakhar, Tariq F. Al-Shaiji, Magdy M. Hassouna

Erschienen in: International Urogynecology Journal | Ausgabe 8/2012

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Abstract

Overactive bladder (OAB) is a common disorder that negatively affects the quality of life of our patients and carries a large socioeconomic burden. According to the International Continence Society, it is characterized as urinary urgency, with or without urge incontinence, usually, with frequency and nocturia in the absence of causative infection. The pathophysiology of this disease entity varies between neurogenic, myogenic, or idiopathic factors. This paper provides a review of the contemporary theories behind the pathophysiology of OAB.
Literatur
1.
Zurück zum Zitat Kreder KJ, Dmochowski RR (2007) The overactive bladder: evaluation and management. Informa Healthcare, London Kreder KJ, Dmochowski RR (2007) The overactive bladder: evaluation and management. Informa Healthcare, London
2.
Zurück zum Zitat Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, Wein A (2002) The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Am J Obstet Gynecol 187:116–126PubMedCrossRef Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Victor A, Wein A (2002) The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Am J Obstet Gynecol 187:116–126PubMedCrossRef
3.
Zurück zum Zitat van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S, Jennum P, Johnson T, Lose G, Mattiasson A, Robertson G, Weiss J (2002) The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:179–183PubMedCrossRef van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S, Jennum P, Johnson T, Lose G, Mattiasson A, Robertson G, Weiss J (2002) The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:179–183PubMedCrossRef
6.
Zurück zum Zitat Milsom I, Abrams P, Cardozo L, Roberts RG, Thuroff J, Wein AJ (2001) How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 87:760–766PubMedCrossRef Milsom I, Abrams P, Cardozo L, Roberts RG, Thuroff J, Wein AJ (2001) How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 87:760–766PubMedCrossRef
7.
Zurück zum Zitat Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, Hunt TL, Wein AJ (2003) Prevalence and burden of overactive bladder in the United States. World J Urol 20:327–336PubMed Stewart WF, Van Rooyen JB, Cundiff GW, Abrams P, Herzog AR, Corey R, Hunt TL, Wein AJ (2003) Prevalence and burden of overactive bladder in the United States. World J Urol 20:327–336PubMed
8.
Zurück zum Zitat Goepel M, Hoffmann JA, Piro M, Rubben H, Michel MC (2002) Prevalence and physician awareness of symptoms of urinary bladder dysfunction. Eur Urol 41:234–239PubMedCrossRef Goepel M, Hoffmann JA, Piro M, Rubben H, Michel MC (2002) Prevalence and physician awareness of symptoms of urinary bladder dysfunction. Eur Urol 41:234–239PubMedCrossRef
9.
Zurück zum Zitat Steers WD (2002) Pathophysiology of overactive bladder and urge urinary incontinence. Rev Urol 4(Suppl 4):S7–S18PubMed Steers WD (2002) Pathophysiology of overactive bladder and urge urinary incontinence. Rev Urol 4(Suppl 4):S7–S18PubMed
10.
11.
Zurück zum Zitat Shefchyk SJ (2001) Sacral spinal interneurones and the control of urinary bladder and urethral striated sphincter muscle function. J Physiol 533:57–63PubMedCrossRef Shefchyk SJ (2001) Sacral spinal interneurones and the control of urinary bladder and urethral striated sphincter muscle function. J Physiol 533:57–63PubMedCrossRef
12.
Zurück zum Zitat Yoshimura N, Chancellor MB (2003) Neurophysiology of lower urinary tract function and dysfunction. Rev Urol 5(Suppl 8):S3–S10PubMed Yoshimura N, Chancellor MB (2003) Neurophysiology of lower urinary tract function and dysfunction. Rev Urol 5(Suppl 8):S3–S10PubMed
13.
Zurück zum Zitat Miller J, Hoffman E (2006) The causes and consequences of overactive bladder. J Womens Health (Larchmt) 15:251–260CrossRef Miller J, Hoffman E (2006) The causes and consequences of overactive bladder. J Womens Health (Larchmt) 15:251–260CrossRef
14.
Zurück zum Zitat Andersson KE, Pehrson R (2003) CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention. Drugs 63:2595–2611PubMedCrossRef Andersson KE, Pehrson R (2003) CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention. Drugs 63:2595–2611PubMedCrossRef
15.
Zurück zum Zitat Chancellor MB (2002) New frontiers in the treatment of overactive bladder and incontinence. Rev Urol 4(Suppl 4):S50–S56PubMed Chancellor MB (2002) New frontiers in the treatment of overactive bladder and incontinence. Rev Urol 4(Suppl 4):S50–S56PubMed
16.
Zurück zum Zitat Andersson KE (1997) The overactive bladder: pharmacologic basis of drug treatment. Urology 50:74–84, discussion 5–9PubMedCrossRef Andersson KE (1997) The overactive bladder: pharmacologic basis of drug treatment. Urology 50:74–84, discussion 5–9PubMedCrossRef
17.
Zurück zum Zitat Andersson KE (2004) Antimuscarinics for treatment of overactive bladder. Lancet Neurol 3:46–53PubMedCrossRef Andersson KE (2004) Antimuscarinics for treatment of overactive bladder. Lancet Neurol 3:46–53PubMedCrossRef
18.
Zurück zum Zitat Morrison J, Steers WD, Brading AF et al (2002) Neurophysiology and neuropharmacology. In: Abrams P, Cardoza L, Khoury S, Wein A (eds) Incontinence, 2nd edn. Health Publications, Plymouth, pp 86–163 Morrison J, Steers WD, Brading AF et al (2002) Neurophysiology and neuropharmacology. In: Abrams P, Cardoza L, Khoury S, Wein A (eds) Incontinence, 2nd edn. Health Publications, Plymouth, pp 86–163
19.
Zurück zum Zitat Fetscher C, Fleichman M, Schmidt M, Krege S, Michel MC (2002) M(3) muscarinic receptors mediate contraction of human urinary bladder. Br J Pharmacol 136:641–643PubMedCrossRef Fetscher C, Fleichman M, Schmidt M, Krege S, Michel MC (2002) M(3) muscarinic receptors mediate contraction of human urinary bladder. Br J Pharmacol 136:641–643PubMedCrossRef
20.
Zurück zum Zitat Chancellor MB, Yoshimura N (2004) Neurophysiology of stress urinary incontinence. Rev Urol 6(Suppl 3):S19–S28PubMed Chancellor MB, Yoshimura N (2004) Neurophysiology of stress urinary incontinence. Rev Urol 6(Suppl 3):S19–S28PubMed
21.
Zurück zum Zitat de Groat WC, Booth AM, Yoshirnura N (1993) Neurophysiology of micturition and its modification in animal models of human disease. In: Maui CA (ed) The autonomic nervous system. Harwood Academic Publishers, London, pp 227–289 de Groat WC, Booth AM, Yoshirnura N (1993) Neurophysiology of micturition and its modification in animal models of human disease. In: Maui CA (ed) The autonomic nervous system. Harwood Academic Publishers, London, pp 227–289
22.
Zurück zum Zitat Payne CK (1998) Epidemiology, pathophysiology, and evaluation of urinary incontinence and overactive bladder. Urology 51:3–10PubMedCrossRef Payne CK (1998) Epidemiology, pathophysiology, and evaluation of urinary incontinence and overactive bladder. Urology 51:3–10PubMedCrossRef
23.
Zurück zum Zitat Rick BF, Holstege A (1999) Two pontine micturition centers in the cat are not interconnected directly: implications for the central organization of micturition. J Comp Neural 402:209–218 Rick BF, Holstege A (1999) Two pontine micturition centers in the cat are not interconnected directly: implications for the central organization of micturition. J Comp Neural 402:209–218
24.
Zurück zum Zitat Fowler CJ (2001) Urinary disorders in Parkinson's disease and multiple system atrophy. Funct Neurol 16:277–282PubMed Fowler CJ (2001) Urinary disorders in Parkinson's disease and multiple system atrophy. Funct Neurol 16:277–282PubMed
25.
Zurück zum Zitat Blaivas JG (1982) The neurophysiology of micturition: a clinical study of 550 patients. J Urol 127:958–963PubMed Blaivas JG (1982) The neurophysiology of micturition: a clinical study of 550 patients. J Urol 127:958–963PubMed
26.
Zurück zum Zitat Marinkovic SP, Badlani G (2001) Voiding and sexual dysfunction after cerebrovascular accidents. J Urol 165:359–370PubMedCrossRef Marinkovic SP, Badlani G (2001) Voiding and sexual dysfunction after cerebrovascular accidents. J Urol 165:359–370PubMedCrossRef
27.
Zurück zum Zitat Yokoyama O, Yoshiyama M, Namiki M, de Groat WC (2000) Role of the forebrain in bladder overactivity following cerebral infarction in the rat. Exp Neurol 163:469–476PubMedCrossRef Yokoyama O, Yoshiyama M, Namiki M, de Groat WC (2000) Role of the forebrain in bladder overactivity following cerebral infarction in the rat. Exp Neurol 163:469–476PubMedCrossRef
28.
Zurück zum Zitat Yokoyama O, Yoshiyama M, Namiki M, de Groat WC (1999) Glutamatergic and dopaminergic contributions to rat bladder hyperactivity after cerebral artery occlusion. Am J Physiol 276:R935–R942PubMed Yokoyama O, Yoshiyama M, Namiki M, de Groat WC (1999) Glutamatergic and dopaminergic contributions to rat bladder hyperactivity after cerebral artery occlusion. Am J Physiol 276:R935–R942PubMed
29.
Zurück zum Zitat Yokoyarna, Yoshiyama M, Narniki M et al (2002) Changes in dopaminergic and glutamatergic excitatory mechanisms of micturition reflex after middle cerebral artery occlusion in conscious rats. Exp Neurol 173:129–135CrossRef Yokoyarna, Yoshiyama M, Narniki M et al (2002) Changes in dopaminergic and glutamatergic excitatory mechanisms of micturition reflex after middle cerebral artery occlusion in conscious rats. Exp Neurol 173:129–135CrossRef
30.
Zurück zum Zitat Kodama K, Yokoyama O, Komatsu K, Yotsuyanagi S, Niikura S, Namiki M (2002) Contribution of cerebral nitric oxide to bladder overactivity after cerebral infarction in rats. J Urol 167:391–396PubMedCrossRef Kodama K, Yokoyama O, Komatsu K, Yotsuyanagi S, Niikura S, Namiki M (2002) Contribution of cerebral nitric oxide to bladder overactivity after cerebral infarction in rats. J Urol 167:391–396PubMedCrossRef
31.
Zurück zum Zitat Kanie S, Yokoyama O, Komatsu K, Kodama K, Yotsuyanagi S, Niikura S, Nagasaka Y, Miyamoto KI, Namiki M (2000) GABAergic contribution to rat bladder hyperactivity after middle cerebral artery occlusion. Am J Physiol Regul Integr Comp Physiol 279:R1230–R1238PubMed Kanie S, Yokoyama O, Komatsu K, Kodama K, Yotsuyanagi S, Niikura S, Nagasaka Y, Miyamoto KI, Namiki M (2000) GABAergic contribution to rat bladder hyperactivity after middle cerebral artery occlusion. Am J Physiol Regul Integr Comp Physiol 279:R1230–R1238PubMed
32.
33.
Zurück zum Zitat Fowler O (1999) Neurological disorders of micturition and their treatment. Brain 122:1213–1231PubMedCrossRef Fowler O (1999) Neurological disorders of micturition and their treatment. Brain 122:1213–1231PubMedCrossRef
34.
Zurück zum Zitat Berger Y, Blaivas JG, DeLaRocha ER, Salinas JM (1987) Urodynamic findings in Parkinson's disease. J Urol 138:836–838PubMed Berger Y, Blaivas JG, DeLaRocha ER, Salinas JM (1987) Urodynamic findings in Parkinson's disease. J Urol 138:836–838PubMed
35.
Zurück zum Zitat Litwiller SE, Frohman EM, Zimmern PE (1999) Multiple sclerosis and the urologist. J Urol 161:743–757PubMedCrossRef Litwiller SE, Frohman EM, Zimmern PE (1999) Multiple sclerosis and the urologist. J Urol 161:743–757PubMedCrossRef
36.
Zurück zum Zitat Fernandez O (2002) Mechanisms and current treatments of urogenital dysfunction in multiple sclerosis. J Neurol 249:1–8PubMedCrossRef Fernandez O (2002) Mechanisms and current treatments of urogenital dysfunction in multiple sclerosis. J Neurol 249:1–8PubMedCrossRef
37.
Zurück zum Zitat Shefchyk SJ (2002) Spinal cord neural organization controlling the urinary bladder and striated sphincter. Prog Brain Res 137:71–82PubMedCrossRef Shefchyk SJ (2002) Spinal cord neural organization controlling the urinary bladder and striated sphincter. Prog Brain Res 137:71–82PubMedCrossRef
38.
Zurück zum Zitat Wiseman OJ, Brady CM, Hussain IF, Dasgupta P, Watt H, Fowler CJ, Landon DN (2002) The ultrastructure of bladder lamina propria nerves in healthy subjects and patients with detrusor hyperreflexia. J Urol 168:2040–2045PubMedCrossRef Wiseman OJ, Brady CM, Hussain IF, Dasgupta P, Watt H, Fowler CJ, Landon DN (2002) The ultrastructure of bladder lamina propria nerves in healthy subjects and patients with detrusor hyperreflexia. J Urol 168:2040–2045PubMedCrossRef
39.
Zurück zum Zitat Fowler CJ (2002) Bladder afferents and their role in the overactive bladder. Urology 59:37–42PubMedCrossRef Fowler CJ (2002) Bladder afferents and their role in the overactive bladder. Urology 59:37–42PubMedCrossRef
40.
Zurück zum Zitat Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A (2004) Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology 63:17–23PubMedCrossRef Yoshida M, Miyamae K, Iwashita H, Otani M, Inadome A (2004) Management of detrusor dysfunction in the elderly: changes in acetylcholine and adenosine triphosphate release during aging. Urology 63:17–23PubMedCrossRef
41.
Zurück zum Zitat Harrison SC, Hunnam GR, Farman P, Ferguson DR, Doyle PT (1987) Bladder instability and denervation in patients with bladder outflow obstruction. Br J Urol 60:519–522PubMedCrossRef Harrison SC, Hunnam GR, Farman P, Ferguson DR, Doyle PT (1987) Bladder instability and denervation in patients with bladder outflow obstruction. Br J Urol 60:519–522PubMedCrossRef
42.
Zurück zum Zitat Brading AF (1997) A myogenic basis for the overactive bladder. Urology 50:57–67, discussion 8–73PubMedCrossRef Brading AF (1997) A myogenic basis for the overactive bladder. Urology 50:57–67, discussion 8–73PubMedCrossRef
43.
Zurück zum Zitat Steers WD, De Groat WC (1988) Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol 140:864–871PubMed Steers WD, De Groat WC (1988) Effect of bladder outlet obstruction on micturition reflex pathways in the rat. J Urol 140:864–871PubMed
44.
Zurück zum Zitat Levin RM (1997) Potential future pharmacological approaches. Urology 50:87–88CrossRef Levin RM (1997) Potential future pharmacological approaches. Urology 50:87–88CrossRef
45.
Zurück zum Zitat Steers WD, Creedon DJ, Tuttle JB (1996) Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy. J Urol 155:379–385PubMedCrossRef Steers WD, Creedon DJ, Tuttle JB (1996) Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy. J Urol 155:379–385PubMedCrossRef
46.
Zurück zum Zitat Steers WD, Kolbeck S, Creedon D, Tuttle JB (1991) Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88:1709–1715PubMedCrossRef Steers WD, Kolbeck S, Creedon D, Tuttle JB (1991) Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88:1709–1715PubMedCrossRef
47.
Zurück zum Zitat Sibley GN (1997) Developments in our understanding of detrusor instability. Br J Urol 80(Suppl 1):54–61PubMed Sibley GN (1997) Developments in our understanding of detrusor instability. Br J Urol 80(Suppl 1):54–61PubMed
48.
Zurück zum Zitat Mills IW (1999) The pathophysiology of detrusor instability and the role of bladder ischemia in its etiology. Oxford University, Oxford Mills IW (1999) The pathophysiology of detrusor instability and the role of bladder ischemia in its etiology. Oxford University, Oxford
49.
Zurück zum Zitat Semins MJ, Chancellor MB (2004) Diagnosis and management of patients with overactive bladder syndrome and abnormal detrusor activity. Nat Clin Pract Urol 1:78–84, quiz 109PubMedCrossRef Semins MJ, Chancellor MB (2004) Diagnosis and management of patients with overactive bladder syndrome and abnormal detrusor activity. Nat Clin Pract Urol 1:78–84, quiz 109PubMedCrossRef
50.
Zurück zum Zitat Elbadawi A, Hailemariam S, Yalla SV, Resnick NM (1997) Structural basis of geriatric voiding dysfunction. VII. Prospective ultrastructural/urodynamic evaluation of its natural evolution. J Urol 157:1814–1822PubMedCrossRef Elbadawi A, Hailemariam S, Yalla SV, Resnick NM (1997) Structural basis of geriatric voiding dysfunction. VII. Prospective ultrastructural/urodynamic evaluation of its natural evolution. J Urol 157:1814–1822PubMedCrossRef
51.
Zurück zum Zitat Elbadawi A, Yalla SV, Resnick NM (1993) Structural basis of geriatric voiding dysfunction. III. Detrusor overactivity. J Urol 150:1668–1680PubMed Elbadawi A, Yalla SV, Resnick NM (1993) Structural basis of geriatric voiding dysfunction. III. Detrusor overactivity. J Urol 150:1668–1680PubMed
52.
Zurück zum Zitat Lackner TE, Wyman JF, McCarthy TC, Monigold M, Davey C (2008) Randomized, placebo-controlled trial of the cognitive effect, safety, and tolerability of oral extended-release oxybutynin in cognitively impaired nursing home residents with urge urinary incontinence. J Am Geriatr Soc 56:862–870PubMedCrossRef Lackner TE, Wyman JF, McCarthy TC, Monigold M, Davey C (2008) Randomized, placebo-controlled trial of the cognitive effect, safety, and tolerability of oral extended-release oxybutynin in cognitively impaired nursing home residents with urge urinary incontinence. J Am Geriatr Soc 56:862–870PubMedCrossRef
53.
Zurück zum Zitat Dupont MC, Spitsbergen JM, Kim KB, Tuttle JB, Steers WD (2001) Histological and neurotrophic changes triggered by varying models of bladder inflammation. J Urol 166:1111–1118PubMedCrossRef Dupont MC, Spitsbergen JM, Kim KB, Tuttle JB, Steers WD (2001) Histological and neurotrophic changes triggered by varying models of bladder inflammation. J Urol 166:1111–1118PubMedCrossRef
54.
Zurück zum Zitat Vizzard MA, Erdman SL, de Groat WC (1996) Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation. J Comp Neurol 370:191–202PubMedCrossRef Vizzard MA, Erdman SL, de Groat WC (1996) Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation. J Comp Neurol 370:191–202PubMedCrossRef
55.
Zurück zum Zitat Clemow DB, McCarty R, Steers WD, Tuttle JB (1997) Efferent and afferent neuronal hypertrophy associated with micturition pathways in spontaneously hypertensive rats. Neurourol Urodyn 16:293–303PubMedCrossRef Clemow DB, McCarty R, Steers WD, Tuttle JB (1997) Efferent and afferent neuronal hypertrophy associated with micturition pathways in spontaneously hypertensive rats. Neurourol Urodyn 16:293–303PubMedCrossRef
56.
Zurück zum Zitat Archer JS (1999) NAMS/Solvay Resident Essay Award. Relationship between estrogen, serotonin, and depression. Menopause 6:71–78PubMed Archer JS (1999) NAMS/Solvay Resident Essay Award. Relationship between estrogen, serotonin, and depression. Menopause 6:71–78PubMed
57.
Zurück zum Zitat Zhu Q, Ritchie J, Marouf N, Dion SB, Resnick NM, Elbadawi A, Kuchel GA (2001) Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents. J Urol 166:1136–1141PubMedCrossRef Zhu Q, Ritchie J, Marouf N, Dion SB, Resnick NM, Elbadawi A, Kuchel GA (2001) Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents. J Urol 166:1136–1141PubMedCrossRef
58.
Zurück zum Zitat Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, de Montigny C, Blier P, Diksic M (1997) Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 94:5308–5313PubMedCrossRef Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, de Montigny C, Blier P, Diksic M (1997) Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 94:5308–5313PubMedCrossRef
59.
Zurück zum Zitat Wolfe F, Russell IJ, Vipraio G, Ross K, Anderson J (1997) Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol 24:555–559PubMed Wolfe F, Russell IJ, Vipraio G, Ross K, Anderson J (1997) Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol 24:555–559PubMed
60.
Zurück zum Zitat Zorn BH, Montgomery H, Pieper K, Gray M, Steers WD (1999) Urinary incontinence and depression. J Urol 162:82–84PubMedCrossRef Zorn BH, Montgomery H, Pieper K, Gray M, Steers WD (1999) Urinary incontinence and depression. J Urol 162:82–84PubMedCrossRef
61.
Zurück zum Zitat Read KE, Sanger GJ, Ramage AG (2003) Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats. Br J Pharmacol 140:53–60PubMedCrossRef Read KE, Sanger GJ, Ramage AG (2003) Evidence for the involvement of central 5-HT7 receptors in the micturition reflex in anaesthetized female rats. Br J Pharmacol 140:53–60PubMedCrossRef
62.
Zurück zum Zitat Nygaard I (2010) Clinical practice. Idiopathic urgency urinary incontinence. N Engl J Med 363:1156–1163PubMedCrossRef Nygaard I (2010) Clinical practice. Idiopathic urgency urinary incontinence. N Engl J Med 363:1156–1163PubMedCrossRef
63.
Zurück zum Zitat Holroyd-Leduc JM, Tannenbaum C, Thorpe KE, Straus SE (2008) What type of urinary incontinence does this woman have? JAMA 299:1446–1456PubMedCrossRef Holroyd-Leduc JM, Tannenbaum C, Thorpe KE, Straus SE (2008) What type of urinary incontinence does this woman have? JAMA 299:1446–1456PubMedCrossRef
64.
Zurück zum Zitat Artibani W (1997) Diagnosis and significance of idiopathic overactive bladder. Urology 50(6A Suppl):25–32, discussion 33–5PubMedCrossRef Artibani W (1997) Diagnosis and significance of idiopathic overactive bladder. Urology 50(6A Suppl):25–32, discussion 33–5PubMedCrossRef
65.
66.
Zurück zum Zitat Burgio KL, Locher JL, Goode PS et al (1998) Behavioural vs drug treatment for urge urinary incontinence in older women. JAMA 280:1995–2000PubMedCrossRef Burgio KL, Locher JL, Goode PS et al (1998) Behavioural vs drug treatment for urge urinary incontinence in older women. JAMA 280:1995–2000PubMedCrossRef
67.
Metadaten
Titel
Pathophysiology of overactive bladder
verfasst von
Mai A. Banakhar
Tariq F. Al-Shaiji
Magdy M. Hassouna
Publikationsdatum
01.08.2012
Verlag
Springer-Verlag
Erschienen in
International Urogynecology Journal / Ausgabe 8/2012
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-012-1682-6

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