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16.08.2018 | Original Article

Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients

verfasst von: Cynthia S. Fok, Xiang Gao, Huaiying Lin, Krystal J. Thomas-White, Elizabeth R. Mueller, Alan J. Wolfe, Qunfeng Dong, Linda Brubaker

Erschienen in: International Urogynecology Journal | Ausgabe 12/2018

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Abstract

Introduction and hypothesis

Persistent and de novo symptoms decrease satisfaction after urogynecologic surgery. We investigated whether the preoperative bladder microbiome is associated with urinary symptoms prior to and after urogynecologic surgery.

Methods

One hundred twenty-six participants contributed responses to the validated OABq symptom questionnaire. Catheterized (bladder) urine samples and vaginal and perineal swabs were collected immediately preoperatively. Bacterial DNA in the urine samples and swabs was sequenced and classified.

Results

Preoperative symptom severity was significantly worse in sequence-positive patients. Higher OABq Symptom Severity (OABqSS) scores (more symptomatic) were associated with higher abundance in bladder urine of two bacterial species: Atopobium vaginae and Finegoldia magna. The presence of Atopobium vaginae in bladder urine also was correlated with its presence in either the vagina or perineum.

Conclusions

Two specific bacterial species detected in bladder urine, Atopobium vaginae and Finegoldia magna, are associated with preoperative urinary symptom severity in women undergoing POP/SUI surgery. The reservoir for Atopobium vaginae may be adjacent pelvic floor niches. This observation should be validated in a larger cohort to determine whether there is a microbiologic etiology for certain preoperative urinary symptoms.

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Titel: Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients
verfasst von: Cynthia S. Fok
Xiang Gao
Huaiying Lin
Krystal J. Thomas-White
Elizabeth R. Mueller
Alan J. Wolfe
Qunfeng Dong
Linda Brubaker
Publikationsdatum: 16.08.2018
Verlag: Springer London
Erschienen in: International Urogynecology Journal / Ausgabe 12/2018
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-018-3732-1

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Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients